Ivan K Chinn

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. pmc Thymus transplantation restores the repertoires of forkhead box protein 3 (FoxP3)+ and FoxP3- T cells in complete DiGeorge anomaly
    I K Chinn
    Department of Pediatrics, Division of Allergy and Immunology, Duke University Medical Center, Durham, NC, USA
    Clin Exp Immunol 173:140-9. 2013
  2. pmc Long-term tolerance to allogeneic thymus transplants in complete DiGeorge anomaly
    Ivan K Chinn
    Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA
    Clin Immunol 126:277-81. 2008
  3. pmc Mechanisms of tolerance to parental parathyroid tissue when combined with human allogeneic thymus transplantation
    Ivan K Chinn
    Department of Pediatrics, Division of Allergy and Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Allergy Clin Immunol 126:814-820.e8. 2010
  4. pmc Induction of tolerance to parental parathyroid grafts using allogeneic thymus tissue in patients with DiGeorge anomaly
    Ivan K Chinn
    Department of Pediatrics, Division of Allergy and Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Allergy Clin Immunol 127:1351-5. 2011
  5. pmc Review of 54 patients with complete DiGeorge anomaly enrolled in protocols for thymus transplantation: outcome of 44 consecutive transplants
    M Louise Markert
    Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA
    Blood 109:4539-47. 2007
  6. pmc First use of thymus transplantation therapy for FOXN1 deficiency (nude/SCID): a report of 2 cases
    M Louise Markert
    Department of Pediatrics, Duke University Medical Center, Durham, NC, USA
    Blood 117:688-96. 2011
  7. doi request reprint Thymus transplantation in complete DiGeorge anomaly
    M Louise Markert
    Departments of Pediatrics and Immunology, Duke University Medical Center, Box 3068, Durham, NC, 27710, USA
    Immunol Res 44:61-70. 2009

Detail Information

Publications7

  1. pmc Thymus transplantation restores the repertoires of forkhead box protein 3 (FoxP3)+ and FoxP3- T cells in complete DiGeorge anomaly
    I K Chinn
    Department of Pediatrics, Division of Allergy and Immunology, Duke University Medical Center, Durham, NC, USA
    Clin Exp Immunol 173:140-9. 2013
    ..Thus, post-transplantation thymic function was associated with the development of a diverse repertoire of FoxP3(+) T cells in cDGA, corresponding with immunological and clinical recovery...
  2. pmc Long-term tolerance to allogeneic thymus transplants in complete DiGeorge anomaly
    Ivan K Chinn
    Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA
    Clin Immunol 126:277-81. 2008
    ..This study provides in vitro evidence for long-term tolerance of complete DiGeorge anomaly thymus transplantation recipients toward their HLA-nonmatched thymus grafts...
  3. pmc Mechanisms of tolerance to parental parathyroid tissue when combined with human allogeneic thymus transplantation
    Ivan K Chinn
    Department of Pediatrics, Division of Allergy and Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Allergy Clin Immunol 126:814-820.e8. 2010
    ..The induction of tolerance toward third-party solid organ grafts with allogeneic thymus tissue transplantation has not been previously demonstrated in human subjects...
  4. pmc Induction of tolerance to parental parathyroid grafts using allogeneic thymus tissue in patients with DiGeorge anomaly
    Ivan K Chinn
    Department of Pediatrics, Division of Allergy and Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Allergy Clin Immunol 127:1351-5. 2011
    ..Further work is needed to determine the optimal means for using combined allogeneic thymus and parental parathyroid transplantation to correct hypoparathyroidism in patients with both complete and partial DiGeorge anomaly...
  5. pmc Review of 54 patients with complete DiGeorge anomaly enrolled in protocols for thymus transplantation: outcome of 44 consecutive transplants
    M Louise Markert
    Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA
    Blood 109:4539-47. 2007
    ..In summary, diagnosis of complete DiGeorge anomaly is challenging because of the variability of presentation. Thymus transplantation was well tolerated and resulted in stable immunoreconstitution in these infants...
  6. pmc First use of thymus transplantation therapy for FOXN1 deficiency (nude/SCID): a report of 2 cases
    M Louise Markert
    Department of Pediatrics, Duke University Medical Center, Durham, NC, USA
    Blood 117:688-96. 2011
    ..Both subjects developed antigen-specific proliferative responses and have discontinued immunoglobulin replacement. In summary, thymus transplantation led to T-cell reconstitution and function in these FOXN1 deficient infants...
  7. doi request reprint Thymus transplantation in complete DiGeorge anomaly
    M Louise Markert
    Departments of Pediatrics and Immunology, Duke University Medical Center, Box 3068, Durham, NC, 27710, USA
    Immunol Res 44:61-70. 2009
    ..Immunosuppression is necessary to control the oligoclonal T cells. The results of thymus transplantation are reported for a series of 50 patients, of whom 36 survive. The survivors develop naïve T cells and a diverse T cell repertoire...