D Chin

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. ncbi Calmodulin: a prototypical calcium sensor
    D Chin
    Dept of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Trends Cell Biol 10:322-8. 2000
  2. ncbi Mechanisms for regulation of calmodulin kinase IIalpha by Ca(2+)/calmodulin and autophosphorylation of threonine 286
    David Chin
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Biochemistry 41:14001-9. 2002
  3. ncbi Characterization of substrate phosphorylation and use of calmodulin mutants to address implications from the enzyme crystal structure of calmodulin-dependent protein kinase I
    D Chin
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 272:31235-40. 1997
  4. ncbi Coronary-artery bypass surgery in patients with left ventricular dysfunction
    Eric J Velazquez
    Division of Cardiovascular Medicine, Duke University Medical Center, Durham, NC, USA
    N Engl J Med 364:1607-16. 2011
  5. ncbi Cyclosporin and Timothy syndrome increase mode 2 gating of CaV1.2 calcium channels through aberrant phosphorylation of S6 helices
    Christian Erxleben
    Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Proc Natl Acad Sci U S A 103:3932-7. 2006

Collaborators

  • I Lang
  • F Horkay
  • Yasuo Mori
  • Eric J Velazquez
  • Christian Erxleben
  • R Michler
  • F Asch
  • G Sorensen
  • C Demers
  • P Carson
  • L Papp
  • J French
  • Dorairaj Prabhakaran
  • S Rankin
  • N Racine
  • S Vaishnav
  • L Chiariello
  • E Murphy
  • R Shemin
  • J Renton
  • M de Moraes
  • N Kon
  • J Nicolau
  • F Miller
  • P Apte
  • J Schmedtje
  • X Wang
  • C H Lim
  • S Leonard
  • F Gutierrez
  • C Selzman
  • C De Pasquale
  • N Wakeley
  • A Maitland
  • R Higgins
  • G Wells
  • S Arnold
  • N Wang
  • P Sukhum
  • M DiMaio
  • J Drozdz
  • D Berman
  • M Vukovic
  • B Roberts
  • S Agarwal
  • P Ravichandran
  • W Nawarawong
  • J Hammon
  • V Hunt
  • J Rogowski
  • J Mack
  • D Miller
  • J Wasilewski
  • M Krzeminska-Pakula
  • A Maisel
  • M Siepe
  • M Zembala
  • K Lee
  • D Leach
  • I Denis
  • S Thackray
  • Mark C Petrie
  • D Wagstaff
  • D Stapleton
  • H Steele
  • J Oh
  • P Kamath
  • P Nardi
  • K Hoffmann
  • M Diez
  • M Hlatky
  • J Herre
  • M Santos
  • S Goldstein
  • M Doyle
  • S Aston
  • R Hebeler
  • M Yii
  • V Moore
  • Y Naka
  • L Pine
  • J Panza
  • D Plicner
  • R Robbins
  • A Cherniavsky
  • C Padmanabhan
  • L Jankauskiene
  • K Golba
  • L Rittenhouse
  • R Rodeheffer

Detail Information

Publications5

  1. ncbi Calmodulin: a prototypical calcium sensor
    D Chin
    Dept of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Trends Cell Biol 10:322-8. 2000
    ..The calmodulin-dependent regulation of protein kinases illustrates the potential mechanisms by which Ca2+-sensing proteins can recognize and generate affinity and specificity for effectors in a Ca2+-dependent manner...
  2. ncbi Mechanisms for regulation of calmodulin kinase IIalpha by Ca(2+)/calmodulin and autophosphorylation of threonine 286
    David Chin
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Biochemistry 41:14001-9. 2002
    ....
  3. ncbi Characterization of substrate phosphorylation and use of calmodulin mutants to address implications from the enzyme crystal structure of calmodulin-dependent protein kinase I
    D Chin
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 272:31235-40. 1997
    ..This result demonstrates the critical role of the N-terminal domain of CaM in regulating the access of ATP to CaMKI...
  4. ncbi Coronary-artery bypass surgery in patients with left ventricular dysfunction
    Eric J Velazquez
    Division of Cardiovascular Medicine, Duke University Medical Center, Durham, NC, USA
    N Engl J Med 364:1607-16. 2011
    ..The role of coronary-artery bypass grafting (CABG) in the treatment of patients with coronary artery disease and heart failure has not been clearly established...
  5. ncbi Cyclosporin and Timothy syndrome increase mode 2 gating of CaV1.2 calcium channels through aberrant phosphorylation of S6 helices
    Christian Erxleben
    Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Proc Natl Acad Sci U S A 103:3932-7. 2006
    ..We propose that aberrant phosphorylation, or "phosphorylopathy," of the CaV1.2 channel protein contributes to the excitotoxicity associated with Timothy syndrome and with chronic cyclosporin treatment of transplant patients...