Jen Tsan Chi
Affiliation: Duke University Medical Center
KEENAN M, Ding C, Chi J. An unexpected alliance between stress responses to drive oncogenesis. Breast Cancer Res. 2014;16:471 pubmed publisher
..This study reveals a surprising hierarchy and alliance between two stress regulators with distinct transcriptional outputs to promote an aggressive oncogenic state. ..
LaMonte G, Tang X, Chen J, Wu J, Ding C, KEENAN M, et al
. Acidosis induces reprogramming of cellular metabolism to mitigate oxidative stress. Cancer Metab. 2013;1:23 pubmed publisher
..Understanding the metabolic adaptations that cancer cells make under acidosis may present opportunities to generate anti-tumor therapeutic agents that are more tumor-specific. ..
Walzer K, Kubicki D, Tang X, Chi J. Single-Cell Analysis Reveals Distinct Gene Expression and Heterogeneity in Male and Female Plasmodium falciparum Gametocytes. mSphere. 2018;3: pubmed publisher
..Similar single-cell analyses in eukaryotic pathogens using this method may uncover rare cell types and heterogeneity previously masked in population studies. ..
Tang X, Wu J, Ding C, Lu M, KEENAN M, Lin C, et al
. Cystine Deprivation Triggers Programmed Necrosis in VHL-Deficient Renal Cell Carcinomas. Cancer Res. 2016;76:1892-903 pubmed publisher
..Cancer Res; 76(7); 1892-903. Â©2016 AACR. ..
LaMonte G, Walzer K, LACSINA J, Nicchitta C, Chi J. Methods to Investigate the Regulatory Role of Small RNAs and Ribosomal Occupancy of Plasmodium falciparum. J Vis Exp. 2015;:e53214 pubmed publisher
..Together, these techniques allowed us to demonstrate that the dysregulated levels of erythrocyte microRNAs contribute to cell-intrinsic malaria resistance of sickle erythrocytes. ..
Doss J, Corcoran D, Jima D, Telen M, Dave S, Chi J. A comprehensive joint analysis of the long and short RNA transcriptomes of human erythrocytes. BMC Genomics. 2015;16:952 pubmed publisher
..Our study presents the most extensive profiling of erythrocyte RNAs to date, and describes primate-specific interactions between the key modulator miR-4732-3p and TGF-Î² signaling during human erythropoiesis. ..
Lin C, Kitagawa M, Tang X, Hou M, Wu J, Qu D, et al
. CoA synthase regulates mitotic fidelity via CBP-mediated acetylation. Nat Commun. 2018;9:1039 pubmed publisher
..Together, our findings uncover a novel mitotic regulation wherein COASY and CBP coordinate an acetylation network to enforce productive mitosis. ..