Luke F Chen

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. pmc Overview of the epidemiology and the threat of Klebsiella pneumoniae carbapenemases (KPC) resistance
    Luke F Chen
    Duke Program for Infection Prevention and Healthcare Epidemiology, Durham, NC, USA Duke Infection Control Outreach Network, Durham, NC, USA Duke University Prevention Epicenter Program, Durham, NC, USA Division of Infectious Diseases and International Health, Department of Medicine, Duke University Medical Center, Durham, NC, USA
    Infect Drug Resist 5:133-41. 2012
  2. pmc Observing and improving hand hygiene compliance: implementation and refinement of an electronic-assisted direct-observer hand hygiene audit program
    Luke F Chen
    Duke Program for Infection Prevention and Healthcare Epidemiology, Duke University Medical Center, Durham, NC, USA
    Infect Control Hosp Epidemiol 34:207-10. 2013
  3. ncbi request reprint Current use for old antibacterial agents: polymyxins, rifamycins, and aminoglycosides
    Luke F Chen
    Division of Infectious Diseases and International Health, Department of Medicine, Duke University Medical Center, Box 102359, Hanes House, Durham, NC 27710, USA
    Med Clin North Am 95:819-42, viii-ix. 2011
  4. ncbi request reprint Community-Acquired Methicillin-Resistant Staphylococcus aureus Skin and Soft Tissue Infections: Management and Prevention
    Luke F Chen
    Program for Infection Prevention and Healthcare Epidemiology, Division of Infectious Diseases and International Health, Department of Medicine, Duke University Medical Center, Erwin Road, Durham, NC, 27710, USA
    Curr Infect Dis Rep 13:442-50. 2011
  5. ncbi request reprint Pathogens resistant to antibacterial agents
    Luke F Chen
    Division of Infectious Diseases and International Health, Department of Medicine, Duke University Medical Center, Box 102359, Hanes House, Durham, NC 27710, USA
    Med Clin North Am 95:647-76, vii. 2011
  6. pmc Cluster of oseltamivir-resistant 2009 pandemic influenza A (H1N1) virus infections on a hospital ward among immunocompromised patients--North Carolina, 2009
    Luke F Chen
    Program for Infection Prevention and Healthcare Epidemiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Infect Dis 203:838-46. 2011
  7. doi request reprint Validating a 3-point prediction rule for surgical site infection after coronary artery bypass surgery
    Luke F Chen
    Division of Infectious Diseases and International Health, Duke University Medical Center, Durham, North Carolina, USA
    Infect Control Hosp Epidemiol 31:64-8. 2010
  8. doi request reprint Current use for old antibacterial agents: polymyxins, rifamycins, and aminoglycosides
    Luke F Chen
    Department of Medicine, Division of Infectious Diseases and International Health, Duke University Medical Center, Box 102359, Hanes House, Durham, NC 27710, USA
    Infect Dis Clin North Am 23:1053-75, x. 2009
  9. doi request reprint Pathogens resistant to antibacterial agents
    Luke F Chen
    Department of Medicine, Division of Infectious Diseases and International Health, Duke University Medical Center, Box 102359, Hanes House, Durham, NC 27710, USA
    Infect Dis Clin North Am 23:817-45, vii. 2009
  10. doi request reprint Patient-days: a better measure of incidence of occupational bloodborne exposures
    Luke F Chen
    Division of Infectious Diseases, Duke Infection Control Outreach Network, Duke University Medical Center, Durham, NC 27710, USA
    Am J Infect Control 37:534-40. 2009

Detail Information

Publications38

  1. pmc Overview of the epidemiology and the threat of Klebsiella pneumoniae carbapenemases (KPC) resistance
    Luke F Chen
    Duke Program for Infection Prevention and Healthcare Epidemiology, Durham, NC, USA Duke Infection Control Outreach Network, Durham, NC, USA Duke University Prevention Epicenter Program, Durham, NC, USA Division of Infectious Diseases and International Health, Department of Medicine, Duke University Medical Center, Durham, NC, USA
    Infect Drug Resist 5:133-41. 2012
    ..Thus, the emergence of KPC resistance is a major threat to global health. This article reviews the epidemiology and provides an overview of the dissemination of KPC-producing organisms...
  2. pmc Observing and improving hand hygiene compliance: implementation and refinement of an electronic-assisted direct-observer hand hygiene audit program
    Luke F Chen
    Duke Program for Infection Prevention and Healthcare Epidemiology, Duke University Medical Center, Durham, NC, USA
    Infect Control Hosp Epidemiol 34:207-10. 2013
    ..We improved the reliability and utility of the data by standardizing audit processes, regularly retraining auditors, developing an audit guidance tool, and reporting weighted composite hand hygiene compliance scores...
  3. ncbi request reprint Current use for old antibacterial agents: polymyxins, rifamycins, and aminoglycosides
    Luke F Chen
    Division of Infectious Diseases and International Health, Department of Medicine, Duke University Medical Center, Box 102359, Hanes House, Durham, NC 27710, USA
    Med Clin North Am 95:819-42, viii-ix. 2011
    ..The aminoglycosides are used mainly as companion drugs for the treatment of resistant gram-negative bacillary infections and for gram-positive coccal endocarditis...
  4. ncbi request reprint Community-Acquired Methicillin-Resistant Staphylococcus aureus Skin and Soft Tissue Infections: Management and Prevention
    Luke F Chen
    Program for Infection Prevention and Healthcare Epidemiology, Division of Infectious Diseases and International Health, Department of Medicine, Duke University Medical Center, Erwin Road, Durham, NC, 27710, USA
    Curr Infect Dis Rep 13:442-50. 2011
    ..The article also summarizes current therapeutic options for CA-MRSA as well as strategies to reduce the transmission and the impact of CA-MRSA in both community and health care settings...
  5. ncbi request reprint Pathogens resistant to antibacterial agents
    Luke F Chen
    Division of Infectious Diseases and International Health, Department of Medicine, Duke University Medical Center, Box 102359, Hanes House, Durham, NC 27710, USA
    Med Clin North Am 95:647-76, vii. 2011
    ..This article reviews the epidemiology, molecular mechanisms of resistance, and treatment options for pathogens resistant to antimicrobial drugs...
  6. pmc Cluster of oseltamivir-resistant 2009 pandemic influenza A (H1N1) virus infections on a hospital ward among immunocompromised patients--North Carolina, 2009
    Luke F Chen
    Program for Infection Prevention and Healthcare Epidemiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Infect Dis 203:838-46. 2011
    ..Oseltamivir resistance among 2009 pandemic influenza A (H1N1) viruses (pH1N1) is rare. We investigated a cluster of oseltamivir-resistant pH1N1 infections in a hospital ward...
  7. doi request reprint Validating a 3-point prediction rule for surgical site infection after coronary artery bypass surgery
    Luke F Chen
    Division of Infectious Diseases and International Health, Duke University Medical Center, Durham, North Carolina, USA
    Infect Control Hosp Epidemiol 31:64-8. 2010
    ..Investigators from Australia proposed a new, 3-point scale that assesses SSI risk on the basis of diagnosis of diabetes mellitus and body mass index...
  8. doi request reprint Current use for old antibacterial agents: polymyxins, rifamycins, and aminoglycosides
    Luke F Chen
    Department of Medicine, Division of Infectious Diseases and International Health, Duke University Medical Center, Box 102359, Hanes House, Durham, NC 27710, USA
    Infect Dis Clin North Am 23:1053-75, x. 2009
    ..The aminoglycosides are used mainly as companion drugs for the treatment of resistant gram-negative bacillary infections and for gram-positive coccal endocarditis...
  9. doi request reprint Pathogens resistant to antibacterial agents
    Luke F Chen
    Department of Medicine, Division of Infectious Diseases and International Health, Duke University Medical Center, Box 102359, Hanes House, Durham, NC 27710, USA
    Infect Dis Clin North Am 23:817-45, vii. 2009
    ..This article reviews the epidemiology, molecular mechanisms of resistance, and treatment options for pathogens resistant to antimicrobial drugs...
  10. doi request reprint Patient-days: a better measure of incidence of occupational bloodborne exposures
    Luke F Chen
    Division of Infectious Diseases, Duke Infection Control Outreach Network, Duke University Medical Center, Durham, NC 27710, USA
    Am J Infect Control 37:534-40. 2009
    ..There is currently no accepted standard denominator to calculate and to report the incidence of occupational exposures to bloodborne pathogens (OEBBPs) in health care...
  11. doi request reprint What's new in Rocky Mountain spotted fever?
    Luke F Chen
    Division of Infectious Diseases and International Health, Duke University Medical Center, DUMC Box 3824, Durham, NC, 27710, USA
    Infect Dis Clin North Am 22:415-32, vii-viii. 2008
    ..Decisions about giving empiric therapy to such patients are difficult and require skill and careful judgement...
  12. pmc Clinical and financial outcomes due to methicillin resistant Staphylococcus aureus surgical site infection: a multi-center matched outcomes study
    Deverick J Anderson
    Division of Infectious Diseases, Department of Medicine, Duke University Medical Center, Duke Infection Control Outreach Network, Durham, North Carolina, USA
    PLoS ONE 4:e8305. 2009
    ..The clinical and financial outcomes of SSIs directly attributable to MRSA and methicillin-resistance are largely uncharacterized. Previously published data have provided conflicting conclusions...
  13. pmc "What the eyes don't see, the heart doesn't grieve over": epidemiology and risk factors for bloodstream infections following cardiac catheterization
    Kristen V Dicks
    Internal Medicine Residency Program, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Infect Control Hosp Epidemiol 33:837-41. 2012
    ..We proposed a novel case definition and determined the epidemiology and risk factors of BSIs after CC procedure using this new definition...
  14. doi request reprint The network approach for prevention of healthcare-associated infections: long-term effect of participation in the Duke Infection Control Outreach Network
    Deverick J Anderson
    Duke Infection Control Outreach Network, Division of Infectious Diseases, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA
    Infect Control Hosp Epidemiol 32:315-22. 2011
    ..To describe the rates of several key outcomes and healthcare-associated infections (HAIs) among hospitals that participated in the Duke Infection Control Outreach Network (DICON)...
  15. doi request reprint Poor functional status as a risk factor for surgical site infection due to methicillin-resistant Staphylococcus aureus
    Deverick J Anderson
    Department of Medicine, Division of Infectious Diseases, Duke University Medical Center, Durham, North Carolina 27710, USA
    Infect Control Hosp Epidemiol 29:832-9. 2008
    ..To identify risk factors for surgical site infection (SSI) due to methicillin-resistant Staphylococcus aureus (MRSA)...
  16. pmc The effect of surgical site infection on older operative patients
    Keith S Kaye
    Duke University Medical Center, Durham, North Carolina, USA
    J Am Geriatr Soc 57:46-54. 2009
    ..To determine the effect of surgical site infection (SSI) on mortality, duration of hospitalization, and hospital cost in older operative patients...
  17. doi request reprint Comparison of the burdens of hospital-onset, healthcare facility-associated Clostridium difficile Infection and of healthcare-associated infection due to methicillin-resistant Staphylococcus aureus in community hospitals
    Becky A Miller
    Division of Infectious Diseases, Duke University Medical Center, Durham, North Carolina, USA
    Infect Control Hosp Epidemiol 32:387-90. 2011
    ..Our data suggest that C. difficile has replaced MRSA as the most common etiology of HAI in community hospitals in the southeastern United States...
  18. doi request reprint Risk factors for gram-negative bacterial surgical site infection: do allergies to antibiotics increase risk?
    Jane V Trinh
    Duke University Medical Center, Durham, North Carolina 27704, USA
    Infect Control Hosp Epidemiol 30:440-6. 2009
    ..To determine the relationship between inadequate antimicrobial prophylaxis and development of gram-negative bacterial (GNB) surgical site infection (SSI)...
  19. pmc Comparison of non-intensive care unit (ICU) versus ICU rates of catheter-associated urinary tract infection in community hospitals
    Sarah S Lewis
    Department of Medicine, Division of Infectious Diseases, Duke University Medical Center, Durham, North Carolina 27710, USA
    Infect Control Hosp Epidemiol 34:744-7. 2013
    ..Overall, 72% of cases of CAUTI occurred in non-ICU patients, which indicates that this population is an important target for dedicated surveillance and prevention efforts...
  20. pmc Delays in appropriate antibiotic therapy for gram-negative bloodstream infections: a multicenter, community hospital study
    Rebekah W Moehring
    Department of Medicine, Division of Infectious Diseases, Duke University Medical Center, Durham, North Carolina, United States of America Department of Medicine, Division of Infectious Diseases, Durham Veterans Affairs Medical Center, Durham, North Carolina, United States of America
    PLoS ONE 8:e76225. 2013
    ..The objective of this study was to estimate the association of prior healthcare exposure on time to appropriate antibiotic therapy in patients with gram-negative BSI...
  21. doi request reprint Complex surgical site infections and the devilish details of risk adjustment: important implications for public reporting
    Deverick J Anderson
    Duke Infection Control Outreach Network, Duke University Medical Center, Durham, North Carolina 27710, USA
    Infect Control Hosp Epidemiol 29:941-6. 2008
    ..To validate the National Nosocomial Infection Surveillance (NNIS) risk index as a tool to account for differences in case mix when reporting rates of complex surgical site infection (SSI)...
  22. ncbi request reprint Outbreak of Bacteremia Due to Burkholderia contaminans Linked to Intravenous Fentanyl From an Institutional Compounding Pharmacy
    Rebekah W Moehring
    Division of Infectious Diseases, Department of Medicine, Duke University Medical Center, Durham, North Carolina2Program for Infection Prevention and Healthcare Epidemiology, Duke University Medical Center, Durham, North Carolina3Durham Veterans Affairs Me
    JAMA Intern Med 174:606-12. 2014
    ..Health care facilities that house institutional compounding facilities must be vigilant in efforts to prevent, recognize, and terminate medication-related outbreaks. ..
  23. ncbi request reprint Surveying the surveillance: surgical site infections excluded by the january 2013 updated surveillance definitions
    Kristen V Dicks
    Department of Medicine, Division of Infectious Diseases, Duke University Medical Center, Durham, North Carolina and Duke Infection Control Outreach Network, Durham, North Carolina
    Infect Control Hosp Epidemiol 35:570-3. 2014
    ..Applying the updated 2013 SSI definitions to cases analyzed using the pre-2013 surveillance definitions excluded 10% of previously identified SSIs. ..
  24. pmc Epidemiology and outcome of major postoperative infections following cardiac surgery: risk factors and impact of pathogen type
    Luke F Chen
    Division of Infectious Diseases, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Am J Infect Control 40:963-8. 2012
    ..Major postoperative infections (MPIs) are poorly understood complications of cardiac surgery. We examined the epidemiology, microbiology, and outcome of MPIs occurring after cardiac surgery...
  25. pmc The epidemiology of ventilator-associated pneumonia in a network of community hospitals: a prospective multicenter study
    Mi Suk Lee
    Duke Infection Control Outreach Network, Division of Infectious Diseases, Department of Internal Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Infect Control Hosp Epidemiol 34:657-62. 2013
    ..To describe the epidemiology of ventilator-associated pneumonia (VAP) in community hospitals...
  26. doi request reprint Fidaxomicin for treatment of clostridium difficile-associated diarrhea and its potential role for prophylaxis
    Christopher J Hostler
    PGY 2, Duke Medical Hospital, Department of Internal Medicine, Medical Residency Office, Durham, NC 27710, USA
    Expert Opin Pharmacother 14:1529-36. 2013
    ..difficile-associated diarrhea (CDAD) compared to existing drugs and its potential role as a prophylactic agent against C. difficile infection (CDI) is being intensely studied...
  27. doi request reprint Efficacy and safety of fidaxomicin compared with oral vancomycin for the treatment of adults with Clostridium difficile-associated diarrhea: data from the OPT-80-003 and OPT-80-004 studies
    Luke F Chen
    Program for Infection Prevention and Healthcare Epidemiology, Duke University Medical Center, Durham, NC 27710, USA
    Future Microbiol 7:677-83. 2012
    ..Despite these potential advantages, the cost-effectiveness of this expensive agent remains poorly understood...
  28. pmc The impact of depth of infection and postdischarge surveillance on rate of surgical-site infections in a network of community hospitals
    David Y Ming
    Duke University Medical Center, Duke Program for Infection Prevention and Healthcare Epidemiology, Duke Infection Control Outreach Network DICON, Duke University Prevention Epicenter Program, Durham, NC 27710, USA
    Infect Control Hosp Epidemiol 33:276-82. 2012
    ....
  29. pmc Decontamination of targeted pathogens from patient rooms using an automated ultraviolet-C-emitting device
    Deverick J Anderson
    Division of Infectious Diseases, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA
    Infect Control Hosp Epidemiol 34:466-71. 2013
    ..Reductions similarly occurred in direct and indirect line of sight. CONCLUSIONS. Our data confirm that automated UV-C-emitting devices can decrease the bioburden of important pathogens in real-world settings such as hospital rooms...
  30. pmc Constructing unit-specific empiric treatment guidelines for catheter-related and primary bacteremia by determining the likelihood of inadequate therapy
    Megan E Davis
    Department of Pharmacy, Duke University Health System, Durham, North Carolina, USA
    Infect Control Hosp Epidemiol 33:416-20. 2012
    ..Our study demonstrates that LIT may reveal differences in traditional antibiograms...
  31. doi request reprint Seasonal variation in Klebsiella pneumoniae bloodstream infection on 4 continents
    Deverick J Anderson
    Duke University Medical Center, Durham, North Carolina 27710, USA
    J Infect Dis 197:752-6. 2008
    ..The objective of this study was to determine whether the incidence of K. pneumoniae bloodstream infection (BSI) was higher during warm months...
  32. pmc Widespread Dissemination of CTX-M-15 Genotype Extended-Spectrum-β-Lactamase-Producing Enterobacteriaceae among Patients Presenting to Community Hospitals in the Southeastern United States
    Luke F Chen
    Duke University Medical Center, Durham, North Carolina, USA
    Antimicrob Agents Chemother 58:1200-2. 2014
    ..coli, accounting for 48% of CTX-M-15-producing and 66% of CTX-M-14-producing isolates. In conclusion, the CTX-M genotype and ST131 E. coli were common among ESBL isolates from U.S. community hospitals. ..
  33. pmc Colonization, pathogenicity, host susceptibility, and therapeutics for Staphylococcus aureus: what is the clinical relevance?
    Steven Y C Tong
    Division of Infectious Diseases and International Health, Duke University Medical Center, Box 102359, Durham, NC 27705, USA
    Semin Immunopathol 34:185-200. 2012
    ..Although progress has been made in the past decade, we are likely to face further surprises such as the recent waves of community-associated MRSA...
  34. doi request reprint Correlation of cross-sectional diameter with image quality and radiation exposure in MDCT examinations of the neck
    Jenny K Hoang
    Department of Radiology, Duke University Medical Center, Durham, NC 27710, USA
    AJR Am J Roentgenol 197:W904-9. 2011
    ..The purpose of this study was to identify an optimal cross-sectional neck diameter that correlates with image quality and radiation exposure in MDCT examinations of the neck performed with automatic tube current modulation...
  35. doi request reprint CT mucosal window settings: a novel approach to evaluating early T-stage head and neck carcinoma
    Jenny K Hoang
    Department of Radiology, Duke University Medical Center, Durham, NC 27710, USA
    AJR Am J Roentgenol 195:1002-6. 2010
    ....
  36. ncbi request reprint Methicillin-resistant Staphylococcus aureus in hospitals: time for a culture change
    Luke F Chen
    Med J Aust 188:62-3; author reply 63-4. 2008
  37. doi request reprint Surgical site infections after laparoscopic and open cholecystectomies in community hospitals
    Luke F Chen
    Infect Control Hosp Epidemiol 29:92-4; author reply 94-5. 2008
  38. ncbi request reprint Hypovolemic shock and metabolic acidosis in a refugee secondary to O1 serotype Vibrio cholerae enteritis
    Luke F Chen
    Monash Medical Centre, Clayton, Victoria
    Commun Dis Intell Q Rep 30:233-5. 2006