Ira M Cheifetz

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. ncbi request reprint Respiratory controversies in the critical care setting. Conference summary
    Ira M Cheifetz
    Division of Pediatric Critical Care Medicine, Duke Children s Hospital, Box 3046, Durham, NC 27710, USA
    Respir Care 52:636-44. 2007
  2. doi request reprint Advances in monitoring and management of pediatric acute lung injury
    Ira M Cheifetz
    Pediatric Critical Care Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Pediatr Clin North Am 60:621-39. 2013
  3. doi request reprint Management of acute lung injury: sharing data between adults and children
    Ira M Cheifetz
    Division of Pediatric Critical Care Medicine, The Pediatric Intensive Care Unit, Pediatric Respiratory Care, Duke Children s Hospital, Durham, North Carolina 27710, USA
    Respir Care 56:1258-68; discussion 1268-72. 2011
  4. doi request reprint Pediatric acute respiratory distress syndrome
    Ira M Cheifetz
    Division of Pediatric Critical Care Medicine, The Pediatric Intensive Care Unit, Pediatric Respiratory Care, and the Extracorporeal Membrane Oxygenation Program, Duke Children s Hospital, Durham, North Carolina 27710, USA
    Respir Care 56:1589-99. 2011
  5. pmc Pharmacokinetics and safety of fluconazole in young infants supported with extracorporeal membrane oxygenation
    Kevin M Watt
    Duke University, Pediatrics, Duke Clinical Research Institute, P O Box 3499, Durham, NC 27710, USA
    Pediatr Infect Dis J 31:1042-7. 2012
  6. doi request reprint Active rehabilitation during extracorporeal membrane oxygenation as a bridge to lung transplantation
    Kyle J Rehder
    Division of Pediatric Critical Care Medicine, Department of Pediatrics, Duke Children s Hospital, Durham, North Carolina 27710, USA
    Respir Care 58:1291-8. 2013
  7. pmc End-tidal and arterial carbon dioxide measurements correlate across all levels of physiologic dead space
    S David McSwain
    Division of Pediatric Critical Care, Duke University Medical Center, Nurham, North Carolina, USA
    Respir Care 55:288-93. 2010
  8. pmc Bias flow does not affect ventilation during high-frequency oscillatory ventilation in a pediatric animal model of acute lung injury
    David A Turner
    Division of Pediatric Critical Care Medicine, Department of Pediatrics, Duke Children s Hospital, Duke University Medical Center, Durham, NC, USA
    Pediatr Crit Care Med 13:e108-12. 2012
  9. doi request reprint Technological advances in extracorporeal membrane oxygenation for respiratory failure
    Kyle J Rehder
    Department of Pediatrics, Duke Children s Hospital, Durham, NC 27710, USA
    Expert Rev Respir Med 6:377-84. 2012
  10. ncbi request reprint Carbon dioxide elimination and gas displacement vary with piston position during high-frequency oscillatory ventilation
    Donna S Hamel
    Department of Pediatric Critical Care Medicine, Duke University Medical Center, Box 3046, Durham NC 27710, USA
    Respir Care 50:361-6. 2005

Collaborators

Detail Information

Publications45

  1. ncbi request reprint Respiratory controversies in the critical care setting. Conference summary
    Ira M Cheifetz
    Division of Pediatric Critical Care Medicine, Duke Children s Hospital, Box 3046, Durham, NC 27710, USA
    Respir Care 52:636-44. 2007
    ..This Journal Conference queried the status quo to better enable clinicians to make informed decisions in the care of their critically ill patients...
  2. doi request reprint Advances in monitoring and management of pediatric acute lung injury
    Ira M Cheifetz
    Pediatric Critical Care Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Pediatr Clin North Am 60:621-39. 2013
    ..Definitive data are needed in the pediatric population to assist in the care of infants, children, and adolescents with ALI to improve survival and functional outcome...
  3. doi request reprint Management of acute lung injury: sharing data between adults and children
    Ira M Cheifetz
    Division of Pediatric Critical Care Medicine, The Pediatric Intensive Care Unit, Pediatric Respiratory Care, Duke Children s Hospital, Durham, North Carolina 27710, USA
    Respir Care 56:1258-68; discussion 1268-72. 2011
    ..In the meantime, sharing data between adult and pediatric populations seems to be an essential approach to the management of critically ill patients...
  4. doi request reprint Pediatric acute respiratory distress syndrome
    Ira M Cheifetz
    Division of Pediatric Critical Care Medicine, The Pediatric Intensive Care Unit, Pediatric Respiratory Care, and the Extracorporeal Membrane Oxygenation Program, Duke Children s Hospital, Durham, North Carolina 27710, USA
    Respir Care 56:1589-99. 2011
    ..With the collaboration of multicenter investigation networks, definitive pediatric data may be on the horizon to better guide our clinical practice...
  5. pmc Pharmacokinetics and safety of fluconazole in young infants supported with extracorporeal membrane oxygenation
    Kevin M Watt
    Duke University, Pediatrics, Duke Clinical Research Institute, P O Box 3499, Durham, NC 27710, USA
    Pediatr Infect Dis J 31:1042-7. 2012
    ..The ECMO circuit can alter drug pharmacokinetics; thus, standard fluconazole dosing in children on ECMO may result in suboptimal drug exposure. This study determined the pharmacokinetics of fluconazole in infants on ECMO...
  6. doi request reprint Active rehabilitation during extracorporeal membrane oxygenation as a bridge to lung transplantation
    Kyle J Rehder
    Division of Pediatric Critical Care Medicine, Department of Pediatrics, Duke Children s Hospital, Durham, North Carolina 27710, USA
    Respir Care 58:1291-8. 2013
    ..The aim of this report is to describe a series of patients bridged to lung transplant with extracorporeal membrane oxygenation (ECMO) and to examine the potential impact of active rehabilitation and ambulation during pre-transplant ECMO...
  7. pmc End-tidal and arterial carbon dioxide measurements correlate across all levels of physiologic dead space
    S David McSwain
    Division of Pediatric Critical Care, Duke University Medical Center, Nurham, North Carolina, USA
    Respir Care 55:288-93. 2010
    ..We hypothesized that P(ETCO(2)) would reliably predict P(aCO(2)) across all levels of physiologic dead space, provided that the expected P(ETCO(2))-P(aCO(2)) difference is considered...
  8. pmc Bias flow does not affect ventilation during high-frequency oscillatory ventilation in a pediatric animal model of acute lung injury
    David A Turner
    Division of Pediatric Critical Care Medicine, Department of Pediatrics, Duke Children s Hospital, Duke University Medical Center, Durham, NC, USA
    Pediatr Crit Care Med 13:e108-12. 2012
    ..We hypothesize that in a swine model of acute lung injury, increased bias flow rates will not affect CO(2) elimination...
  9. doi request reprint Technological advances in extracorporeal membrane oxygenation for respiratory failure
    Kyle J Rehder
    Department of Pediatrics, Duke Children s Hospital, Durham, NC 27710, USA
    Expert Rev Respir Med 6:377-84. 2012
    ..In this article, we highlight some of the recent technological advances and their impact on the utilization of ECMO in increasingly diverse patient populations...
  10. ncbi request reprint Carbon dioxide elimination and gas displacement vary with piston position during high-frequency oscillatory ventilation
    Donna S Hamel
    Department of Pediatric Critical Care Medicine, Duke University Medical Center, Box 3046, Durham NC 27710, USA
    Respir Care 50:361-6. 2005
    ..That practice may limit the clinician's ability to optimize carbon dioxide elimination. We hypothesized that varying the piston position would alter gas displacement and carbon dioxide elimination...
  11. pmc Rescue therapy in adult and pediatric patients with pH1N1 influenza infection: a tertiary center intensive care unit experience from April to October 2009
    Stephanie G Norfolk
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Duke University Medical Center, Durham, NC, USA
    Crit Care Med 38:2103-7. 2010
    ....
  12. doi request reprint Use of extracorporeal life support in adults with severe acute respiratory failure
    Kyle J Rehder
    Duke University Medical Center, Division of Pediatric Critical Care Medicine, Durham, NC, USA
    Expert Rev Respir Med 5:627-33. 2011
    ....
  13. ncbi request reprint Respiratory therapies in the critical care setting. Should every mechanically ventilated patient be monitored with capnography from intubation to extubation?
    Ira M Cheifetz
    Department of Pediatric Critical Care Medicine, Duke Children s Hospital, Durham, NC 27710, USA
    Respir Care 52:423-38; discussion 438-42. 2007
    ..We hope that as new data become available, the answer to this capnography question will become clear...
  14. doi request reprint Lung protective ventilation: a summary of the current evidence from the 2012 American Association for Respiratory Care International Congress
    David A Turner
    Division of Pediatric Critical Care Medicine, Department of Pediatrics, Duke Children s Hospital, Durham, NC 27710, USA
    Expert Rev Respir Med 7:209-12. 2013
    ..In addition, several experts reviewed the cutting edge approach of extracorporeal membrane oxygenation as a lung protective approach...
  15. doi request reprint State of the art: strategies for extracorporeal membrane oxygenation in respiratory failure
    Kyle J Rehder
    Division of Pediatric Critical Care Medicine, Department of Pediatrics, Duke Children s Hospital, Durham, NC 27710, USA
    Expert Rev Respir Med 6:513-21. 2012
    ..This manuscript provides an overview of current techniques for treating respiratory ECMO patients...
  16. ncbi request reprint Heliox administration during high-frequency jet ventilation augments carbon dioxide clearance
    Vineet K Gupta
    Division of Pediatric Critical Care, Duke University Medical Center, Durham, NC, USA
    Respir Care 49:1038-44. 2004
    ..Improvements in gas exchange occurred rapidly. The combination of heliox and high frequency jet ventilation resulted in improved carbon dioxide clearance, respiratory stabilization, and the ability to wean ventilator settings...
  17. doi request reprint Successful use of extracorporeal membrane oxygenation for pH1N1-induced refractory hypoxemia in a child with hypoplastic left heart syndrome
    Niyati N Gandhi
    Department of Pediatrics, Duke Children s Hospital, Duke University Medical Center, Durham, NC, USA
    Pediatr Crit Care Med 12:e398-401. 2011
    ..To report the first successful use of extracorporeal membrane oxygenation for acute respiratory distress syndrome secondary to 2009 pH1N1 influenza A infection in a child status post the Fontan operation for hypoplastic left heart syndrome...
  18. doi request reprint Development of a collaborative program to provide extracorporeal membrane oxygenation for adults with refractory hypoxemia within the framework of a pandemic
    David A Turner
    Division of Pediatric Critical Care Medicine, Department of Pediatrics, Duke Children s Hospital, Duke University Medical Center, Durham, NC, USA
    Pediatr Crit Care Med 12:426-30. 2011
    ..We report the process used to rapidly develop a collaborative adult respiratory extracorporeal membrane oxygenation program as a response to caring for young adult patients with refractory hypoxemia in the setting of the pH1N1 pandemic...
  19. doi request reprint A pilot, randomized, controlled clinical trial of lucinactant, a peptide-containing synthetic surfactant, in infants with acute hypoxemic respiratory failure
    Neal J Thomas
    Division of Pediatric Critical Care Medicine, Penn State Hershey Children s Hospital, Pennsylvania State University College of Medicine, Hershey, PA, USA
    Pediatr Crit Care Med 13:646-53. 2012
    ..We evaluated whether intratracheal lucinactant, a synthetic, peptide-containing surfactant, was safe and well-tolerated in infants with acute hypoxemic respiratory failure, and assessed its effects on clinical outcomes...
  20. ncbi request reprint Goal-directed therapy for severely hypoxic patients with acute respiratory distress syndrome: permissive hypoxemia
    Mohamed Abdelsalam
    Pediatric Critical Care Medicine, Duke Children s Hospital, Duke University Medical Center, Box 3046, Durham, NC 27710, USA
    Respir Care 55:1483-90. 2010
    ..We stress that the goal of this article is not to convince the reader that this approach is necessarily correct, as data are clearly lacking, but rather to provide a basis for continued thought, discussion, and potential research...
  21. doi request reprint Use of high flow nasal cannula in critically ill infants, children, and adults: a critical review of the literature
    Jan Hau Lee
    Division of Pediatric Critical Care Medicine, Department of Pediatrics, Duke Children s Hospital, Durham, NC, USA
    Intensive Care Med 39:247-57. 2013
    ..The use of HFNC as a respiratory support modality is increasing in the infant, pediatric, and adult populations as an alternative to non-invasive positive pressure ventilation...
  22. doi request reprint Successful extracorporeal membrane oxygenation for respiratory failure in an infant with DiGeorge anomaly, following thymus transplantation
    Christoph P Hornik
    Division of Pediatric Critical Care Medicine, Department of Pediatrics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Respir Care 56:866-70. 2011
    ..This case demonstrates the complex decision making process regarding initiation of ECMO in patients with severe immunodeficiency...
  23. ncbi request reprint Inhaled nitric oxide results in deteriorating hemodynamics when administered during cardiopulmonary bypass in neonatal swine
    Christopher L Hubble
    Department of Pediatrics, Division of Pediatric Critical Care Medicine, Duke University Medical Center, Durham, NC, USA
    Pediatr Crit Care Med 5:157-62. 2004
    ..To evaluate if inhaled nitric oxide (iNO) has a lung-protective effect when it is delivered during the ischemic phase of neonatal cardiopulmonary bypass (CPB)...
  24. doi request reprint Pediatric acute respiratory failure: areas of debate in the pediatric critical care setting
    David A Turner
    Division of Pediatric Critical Care, Department of Pediatrics, Duke University Medical Center, Durham, NC, USA
    Expert Rev Respir Med 5:65-73. 2011
    ..Thus, a large fraction of pediatric critical care involves a combination of institutional preference, individual experience, opinion and extrapolation of adult data...
  25. ncbi request reprint Heliox administration in the pediatric intensive care unit: an evidence-based review
    Vineet K Gupta
    Division of Pediatric Critical Care Medicine, Duke University Medical Center, Durham, NC, USA
    Pediatr Crit Care Med 6:204-11. 2005
    ..Data Source: A thorough, computerized bibliographic search of the preclinical and clinical literature regarding the properties of helium and its application in pediatric respiratory disease states...
  26. ncbi request reprint Invasive and noninvasive pediatric mechanical ventilation
    Ira M Cheifetz
    Division of Pediatric Critical Care Medicine, Duke Children s Hospital, Durham, North Carolina, USA
    Respir Care 48:442-53; discussion 453-8. 2003
    ..Furthermore, the duration of mechanical ventilation is one of the major determinants of the duration and cost of an intensive care unit stay...
  27. doi request reprint Active rehabilitation and physical therapy during extracorporeal membrane oxygenation while awaiting lung transplantation: a practical approach
    David A Turner
    Division of Pediatric Critical Care Medicine, Department of Pediatrics, Duke Children s Hospital, Durham, NC, USA
    Crit Care Med 39:2593-8. 2011
    ..In an attempt to address this issue, we developed a collaborative program to allow for active rehabilitation and physical therapy for patients requiring life support with extracorporeal membrane oxygenation before lung transplantation...
  28. doi request reprint Nontraditional modes of mechanical ventilation: progress or distraction?
    David A Turner
    Division of Pediatric Critical Care Medicine, Department of Pediatrics, Duke Children s Hospital, Duke University Medical Center, DUMC Box 3046, Durham, NC 27710, USA
    Expert Rev Respir Med 6:277-84. 2012
    ....
  29. doi request reprint The chronically critically ill patient: pediatric considerations
    Stacey L Peterson-Carmichael
    Infant Pulmonary Function Testing Laboratory, the Divisions of Pediatric Critical Care Medicine, Duke University Health System, Durham, North Carolina 27710, USA
    Respir Care 57:993-1002; discussion 1002-3. 2012
    ..Increased focus and an increasing quantity of resources for this subgroup of infants and children are needed, as the number of such pediatric patients continues to grow...
  30. doi request reprint Extracorporeal membrane oxygenation for severe refractory respiratory failure secondary to 2009 H1N1 influenza A
    David A Turner
    Division of Pediatric Critical Care Medicine, Department of Pediatrics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Respir Care 56:941-6. 2011
    ..These most critically ill patients may require extracorporeal membrane oxygenation (ECMO) for survival...
  31. ncbi request reprint Insensible water loss from the medtronic minimax oxygenator: an In Vitro study
    Plato J Alexander
    Pediatric Critical Care Medicine, Perfusion Services, and Cardiothoracic Surgery, Duke Children s Hospital, Durham, North Carolina 27710, USA
    ASAIO J 52:206-10. 2006
    ..7+/-2.2 ml for each 1 LPM of sweep gas flow for a normal saline pump flow of 300 ml/min. In a closed circuit, a faster sweep gas rate is associated with a more rapid rise in sodium concentration (p<0.0001)...
  32. ncbi request reprint Is permissive hypoxemia a beneficial strategy for pediatric acute lung injury?
    Ira M Cheifetz
    Pediatric Critical Care Medicine, Pediatric Intensive Care, Duke Children s Hospital, Duke University Medical Center, Box 3046, Durham, NC 27710, USA
    Respir Care Clin N Am 12:359-69, v-vi. 2006
    ..It must be noted that this concept is predominantly based on physiology, as data in the medical literature are very limited. Permissive hypoxemia as an approach to acute lung injury remains controversial in the clinical setting...
  33. ncbi request reprint Do all mechanically ventilated pediatric patients require continuous capnography?
    Donna S Hamel
    Pediatric Critical Care Medicine, Duke Children s Hospital, Box 3046, Durham, NC 27710, USA
    Respir Care Clin N Am 12:501-13. 2006
    ....
  34. doi request reprint Extracorporeal membrane oxygenation for neonatal and pediatric respiratory failure: an evidence-based review of the past decade (2002-2012)
    Kyle J Rehder
    All authors Division of Pediatric Critical Care Medicine, Department of Pediatrics, Duke Children s Hospital, Duke University Medical Center, Durham, NC
    Pediatr Crit Care Med 14:851-61. 2013
    ..To provide a comprehensive evidence-based review of extracorporeal membrane oxygenation for neonatal and pediatric respiratory failure...
  35. doi request reprint Perceptions of 24/7 in-hospital intensivist coverage on pediatric housestaff education
    Kyle J Rehder
    Division of Pediatric Critical Care Medicine, DUMC Box 3046, Durham, NC 27710
    Pediatrics 133:88-95. 2014
    ..We hypothesized that IH coverage would decrease perceived autonomy of housestaff and negatively affect their preparedness to be independent attending physicians on completion of training...
  36. doi request reprint Pediatric postoperative cardiac care
    George Ofori-Amanfo
    Division of Pediatric Critical Care Medicine, Duke Children s Hospital, Duke University Medical Center, DUMC 3046, 2300 Erwin Road, Durham, NC 27710, USA
    Crit Care Clin 29:185-202. 2013
    ..With continued advancements in the field of neonatal and pediatric postoperative cardiac care, continued improvements in overall outcomes for this specialized population are anticipated...
  37. ncbi request reprint Hemolytic characteristics of three commercially available centrifugal blood pumps
    D Scott Lawson
    Department of Perfusion Services, Duke University Health System, Durham, NC, USA
    Pediatr Crit Care Med 6:573-7. 2005
    ..We hypothesize that the newer generation centrifugal pumps have an incidence of hemolysis similar to the traditional roller head pumps and, thus, could be used for extracorporeal membrane oxygenation circuits...
  38. pmc Dexmedetomidine for transport of a spontaneously breathing combative child
    Kevin M Watt
    Division of Pediatric Critical Care, Department of Pediatrics, Duke University Medical Center, Box 3046, Durham, NC 27710, USA
    Pediatrics 130:e690-4. 2012
    ..Dexmedetomidine may be used for sedation in certain circumstances for the transport of a child without the need for intubation and mechanical ventilation...
  39. ncbi request reprint Neonatal thyrotoxicosis and persistent pulmonary hypertension necessitating extracorporeal life support
    Jon Oden
    Pediatric Endocrinology and Diabetes, Duke Children s Hospital, Durham, North Carolina 27710, USA
    Pediatrics 115:e105-8. 2005
    ....
  40. doi request reprint Extracorporeal membrane oxygenation for adult respiratory failure
    David A Turner
    Division of Pediatric Critical Care Medicine, Department of Pediatrics, Duke Children s Hospital, Duke University Medical Center, Durham, North Carolina 27710, USA
    Respir Care 58:1038-52. 2013
    ....
  41. pmc Fluconazole loading dose pharmacokinetics and safety in infants
    Lauren Piper
    Department of Pediatrics and Duke Clinical Research Institute, Duke University, Durham, NC, USA
    Pediatr Infect Dis J 30:375-8. 2011
    ..A loading dose of fluconazole is advised for older patients but has not been evaluated in infants. We sought to determine the pharmacokinetics and safety of a fluconazole loading dose in infants at risk for invasive fungal infection...
  42. ncbi request reprint Heliox does not affect gas exchange during high-frequency oscillatory ventilation if tidal volume is held constant
    Andrew L Katz
    Duke University Medical Center, Durham, NC, USA
    Crit Care Med 31:2006-9. 2003
    ..We hypothesized that when tidal volume delivery is held constant, heliox does not alter gas exchange...
  43. ncbi request reprint Successful treatment of acute chest syndrome with high-frequency oscillatory ventilation in pediatric patients
    Angela T Wratney
    Division of Pediatric Critical Care Medicine, Duke University Medical Center, Box 3046, Durham, NC 27710, USA
    Respir Care 49:263-9. 2004
    ..These cases suggest that HFOV should be strongly considered for patients with severe acute chest syndrome that is refractory to conventional mechanical ventilation...
  44. ncbi request reprint Mechanically ventilated pediatric stem cell transplant recipients: effect of cord blood transplant and organ dysfunction on outcome
    Scott A Hagen
    Division of Pediatric Critical Care Medicine, Duke University Medical Center, Durham, NC, USA
    Pediatr Crit Care Med 4:206-13. 2003
    ..To compare survival of pediatric umbilical cord blood and bone marrow transplant recipients requiring admission to a pediatric intensive care unit for mechanical ventilation and to determine the effect of organ dysfunction on outcome...
  45. ncbi request reprint Respiratory controversies in the critical care setting. Part I
    Ira M Cheifetz
    Division of Pediatric Critical Care Medicine, Duke Childrens Hospital, Durham, North Carolina
    Respir Care 52:406-7. 2007