Research Topics
Species | Marc CaronSummaryAffiliation: Duke University Medical Center Country: USA Publications
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Publications
An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behaviorJean Martin Beaulieu
Department of Cell Biology, Center for Models of Human Disease, Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, North Carolina 27710, USA
Cell 122:261-73. 2005....- Norepinephrine transport-mediated gene expression in noradrenergic neurogenesisYao Fei Hu
Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226, USA
BMC Genomics 10:151. 2009..While the structure of NET und the regulation of NET function are well described, little is known about downstream target genes of norepinephrine (NE) transport... - The Akt-GSK-3 signaling cascade in the actions of dopamineJean Martin Beaulieu
Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
Trends Pharmacol Sci 28:166-72. 2007.... - Pharmacological characterization of membrane-expressed human trace amine-associated receptor 1 (TAAR1) by a bioluminescence resonance energy transfer cAMP biosensorLarry S Barak
Box 3287, Duke University, Durham, NC 27710
Mol Pharmacol 74:585-94. 2008.... - Approaches to identify monoamine transporter interacting proteinsGonzalo E Torres
Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
J Neurosci Methods 143:63-8. 2005 - Rapid alterations in corticostriatal ensemble coordination during acute dopamine-dependent motor dysfunctionRui M Costa
Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
Neuron 52:359-69. 2006..Thus, dopamine-related disorders like Parkinson's disease may not stem from changes in the overall levels of cortical activity, but from dysfunctional activity coordination in corticostriatal circuits... - Dopaminergic supersensitivity in G protein-coupled receptor kinase 6-deficient miceRaul R Gainetdinov
Howard Hughes Medical Institute Laboratories, Duke University Medical Center, Durham, NC 27710, USA
Neuron 38:291-303. 2003..The present study indicates that postsynaptic D2-like dopamine receptors are physiological targets for GRK6 and suggests that this regulatory mechanism contributes to central dopaminergic supersensitivity... - Identification of PSD-95 as a regulator of dopamine-mediated synaptic and behavioral plasticityWei Dong Yao
Howard Hughes Medical Institute Laboratories, Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
Neuron 41:625-38. 2004..Our findings uncover a previously unappreciated role of PSD-95 in psychostimulant action and identify a molecular and cellular mechanism shared between drug-related plasticity and learning... - Dopamine-independent locomotor actions of amphetamines in a novel acute mouse model of Parkinson diseaseTatyana D Sotnikova
Department of Cell Biology, Center for Models of Human Disease, Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, North Carolina, USA
PLoS Biol 3:e271. 2005..Identification of dopamine transporter- and dopamine-independent locomotor actions of amphetamines suggests a novel paradigm in the search for prospective anti-Parkinsonian drugs... - Dopamine transporter-dependent and -independent actions of trace amine beta-phenylethylamineTatyana D Sotnikova
Howard Hughes Medical Institute, Department of Cell Biology and Medicine, and Center for Models of Human Disease, Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, North Carolina 27710, USA
J Neurochem 91:362-73. 2004..The inhibitory action on hyperactivity and certain stereotypies induced by beta-PEA in DAT-KO mice indicate that targets other than the DAT are responsible for these effects... - Food reward in the absence of taste receptor signalingIvan E de Araujo
Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA
Neuron 57:930-41. 2008..Our findings suggest that calorie-rich nutrients can directly influence brain reward circuits that control food intake independently of palatability or functional taste transduction... - Aberrant responses in social interaction of dopamine transporter knockout miceRamona M Rodriguiz
Department of Psychiatry, Mouse Behavioral and Neuroendocrine Analysis Core Facility, Duke University Medical Center, Durham, NC 27710, USA
Behav Brain Res 148:185-98. 2004..These data suggest that KO mice may serve as a useful animal model for understanding not only how DA dysfunction contributes to social abnormalities, but also how behavioral inflexibility distorts their social responses... - The multiple LIM domain-containing adaptor protein Hic-5 synaptically colocalizes and interacts with the dopamine transporterAna M Carneiro
Howard Hughes Medical Institute, Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
J Neurosci 22:7045-54. 2002.... - Novelty seeking and stereotypic activation of behavior in mice with disruption of the Dat1 geneVladimir M Pogorelov
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
Neuropsychopharmacology 30:1818-31. 2005.... - Activity-dependent expression of ELAV/Hu RBPs and neuronal mRNAs in seizure and cocaine brainDhanrajan M Tiruchinapalli
Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA
J Neurochem 107:1529-43. 2008..Finally, our data suggest that HuR and HuD RBPs potentially interact directly with neuronal mRNAs important for differentiation and synaptic plasticity... - Sustained elevation of extracellular dopamine causes motor dysfunction and selective degeneration of striatal GABAergic neuronsMichel Cyr
Howard Hughes Medical Institute Laboratory, Department of Cell Biology, and Center for Models of Human Disease, Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, NC 27710, USA
Proc Natl Acad Sci U S A 100:11035-40. 2003..These findings provide in vivo evidence that, in addition to its proposed role in the degeneration of dopamine neurons, dopamine can also contribute to the selective death of its target neurons via a previously unappreciated mechanism... - Paradoxical striatal cellular signaling responses to psychostimulants in hyperactive miceJean Martin Beaulieu
Department of Cell Biology, Duke University Medical Center, Research Drive, Durham, NC 27710, USA
J Biol Chem 281:32072-80. 2006.... - Magnetic resonance imaging at microscopic resolution reveals subtle morphological changes in a mouse model of dopaminergic hyperfunctionMichel Cyr
Department of Cell Biology, Center for Models of Human Disease, Duke University Medical Center, Durham, NC 27710, USA
Neuroimage 26:83-90. 2005.... - Lithium antagonizes dopamine-dependent behaviors mediated by an AKT/glycogen synthase kinase 3 signaling cascadeJean-Martin Beaulieu
Howard Hughes Medical Institute, Department of Cell Biology and Center for Models of Human Disease, Institute of Genome Sciences and Policy, Duke University Medical Center, Durham, NC 27710, USA
Proc Natl Acad Sci U S A 101:5099-104. 2004.... - DDD mice, a novel acute mouse model of Parkinson's diseaseTatyana D Sotnikova
Department of Cell Biology and Center for Models of Human Disease, IGSP, Duke University Medical Center, Durham, North Carolina 27710, USA
Neurology 67:S12-7. 2006..This model is particularly promising as a tool for evaluating the efficacy of compounds that may induce movement independently of DA. The advantages and limitations of DDD mice in comparison to other rodent PD models are discussed... - Reduced D2-mediated signaling activity and trans-synaptic upregulation of D1 and D2 dopamine receptors in mice overexpressing the dopamine transporterValentina Ghisi
Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
Cell Signal 21:87-94. 2009..In sum, our study reveals that hypodopaminegia caused by up-regulation of DAT results in significant alterations at postsynaptic receptor function with most notable dysregulation at the level of D2 receptor signaling... - Local knockdown of genes in the brain using small interfering RNA: a phenotypic comparison with knockout animalsAli Salahpour
Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
Biol Psychiatry 61:65-9. 2007..This study sought to determine the efficiency of local small interfering RNA (siRNA) injections, comparing this approach with animals generated through classical gene targeting... - Desensitization of G protein-coupled receptors and neuronal functionsRaul R Gainetdinov
Howard Hughes Medical Institute Laboratories, Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
Annu Rev Neurosci 27:107-44. 2004..Furthermore, the utility of a pharmacological strategy aimed at targeting this GPCR desensitization machinery to regulate brain functions can be envisaged... - Dopamine: from pharmacology to molecular biology and backMarc G Caron
Duke University Medical Center, Durham, NC 27710, USA
Wien Klin Wochenschr 118:565-8. 2006 - Dopaminergic control of sleep-wake statesKafui Dzirasa
Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
J Neurosci 26:10577-89. 2006..We propose that psychosis and the sleep disturbances experienced by Parkinsonian patients result from dopamine-mediated disturbances of REM sleep... - Characterization of conditioned place preference to cocaine in congenic dopamine transporter knockout female miceIvan O Medvedev
Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
Psychopharmacology (Berl) 180:408-13. 2005..The dopamine transporter (DAT) is thought to play a major role in the rewarding effects of cocaine. Therefore, it is surprising that cocaine reveals conditioned effects in DAT knockout (DAT-KO) mice... - Monoamine transporter pharmacology and mutant miceRaul R Gainetdinov
Howard Hughes Medical Institute Laboratories, Dept of Cell Biology, Box 3287, Duke University Medical Center, Durham, NC 27710, USA
Trends Pharmacol Sci 23:367-73. 2002..In this review, we summarize recent insights into the pharmacology of psychotropic drugs using mice in which the genes encoding these transporters have been deleted... - Monoamine transporters: from genes to behaviorRaul R Gainetdinov
Howard Hughes Medical Institute Laboratories, Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
Annu Rev Pharmacol Toxicol 43:261-84. 2003..In the present review, we summarize recent advances in understanding the physiology and pharmacology of monoamine transporters gained in mice with targeted genetic deletion of DAT, SERT, and NET... - Spinal cord stimulation restores locomotion in animal models of Parkinson's diseaseRomulo Fuentes
Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA
Science 323:1578-82. 2009..We propose that dorsal column stimulation might become an efficient and less invasive alternative for treatment of Parkinson's disease in the future... - Persistent hyperdopaminergia decreases the peak frequency of hippocampal theta oscillations during quiet waking and REM sleepKafui Dzirasa
Department of Neurobiology, Duke University Medical Center, Durham, NC, USA
PLoS ONE 4:e5238. 2009..Thus, we propose that persistent hyperdopaminergia, together with secondary alterations in other neuromodulatory systems, results in lower frequency activity in neural systems responsible for various cognitive processes... - A beta-arrestin 2 signaling complex mediates lithium action on behaviorJean Martin Beaulieu
Department of Cell Biology, Duke University Medical Center, Durham, NC, USA
Cell 132:125-36. 2008..These results point toward a pharmacological approach to modulating GPCR function that affects the formation of beta-arrestin-mediated signaling complexes... - Hyperdopaminergia and NMDA receptor hypofunction disrupt neural phase signalingKafui Dzirasa
Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
J Neurosci 29:8215-24. 2009.... - Noradrenergic control of cortico-striato-thalamic and mesolimbic cross-structural synchronyKafui Dzirasa
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA
J Neurosci 30:6387-97. 2010.... - Beta-arrestin goes nuclearJean-Martin Beaulieu
Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
Cell 123:755-7. 2005..In this issue of Cell, Kang et al. (2005) provide evidence that beta-arrestin 1 moves to the nucleus in response to GPCR stimulation, where it regulates gene expression by facilitating histone acetylation at specific gene promoters... - Antagonism of dopamine D2 receptor/beta-arrestin 2 interaction is a common property of clinically effective antipsychoticsBernard Masri
Departments of Cell Biology, Medicine and Neurobiology, Duke University Medical Center, Durham, NC 27710, USA
Proc Natl Acad Sci U S A 105:13656-61. 2008..Thus, selective targeting of D2(L)R/beta-arrestin 2 interaction and related signaling pathways may provide new opportunities for antipsychotic development... - Differential mechanisms of morphine antinociceptive tolerance revealed in (beta)arrestin-2 knock-out miceLaura M Bohn
Howard Hughes Medical Institute Laboratories, Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
J Neurosci 22:10494-500. 2002.... - A beta-arrestin binding determinant common to the second intracellular loops of rhodopsin family G protein-coupled receptorsSébastien Marion
Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
J Biol Chem 281:2932-8. 2006.... - Plasma membrane monoamine transporters: structure, regulation and functionGonzalo E Torres
Howard Hughes Medical Institute, Department of Cell Biology, Duke University, Durham, North Carolina 27710, USA
Nat Rev Neurosci 4:13-25. 2003 - Center stage for the serotonin transporter: a gain-of-function polymorphism in persons with obsessive-compulsive disorderGonzalo E Torres
Department of Cell Biology and Howard Hughes Medical Institute, CARL Bldg, Rm. 487, Research Dr, Box 3287, Duke University Medical Center, Durham, North Carolina, USA
Mol Pharmacol 64:196-8. 2003 - Hypertension and impaired glycine handling in mice lacking the orphan transporter XT2Hui Quan
Department of Cell Biology, Howard Hughes Medical Institute Laboratories, Duke University Medical Center, Durham, North Carolina 27710, USA
Mol Cell Biol 24:4166-73. 2004..001), a level virtually identical to that of the wild-type controls. These data suggest that the XT2 orphan transporter is involved in glycine reabsorption and that the absence of this transporter is sufficient to cause hypertension... - Increased amphetamine-induced hyperactivity and reward in mice overexpressing the dopamine transporterAli Salahpour
Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
Proc Natl Acad Sci U S A 105:4405-10. 2008..2 and 0.5 mg/kg) than WT mice (2 mg/kg). These results suggest that overexpression of DAT leads to a marked increase in sensitivity to psychomotor and rewarding properties of amphetamine... - Role of GSK3 beta in behavioral abnormalities induced by serotonin deficiencyJean Martin Beaulieu
Department of Cell Biology, Mouse Behavioral and Neuroendocrine Analyses Core Facility, Duke University Medical Center, Durham, NC 27710, USA
Proc Natl Acad Sci U S A 105:1333-8. 2008..Targeting GSK3beta and related signaling events may afford therapeutic advantages for the management of certain 5-HT-related psychiatric conditions... - Genetic NMDA receptor deficiency disrupts acute and chronic effects of cocaine but not amphetamineAmy J Ramsey
Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
Neuropsychopharmacology 33:2701-14. 2008.... - Trace amine associated receptor 1 and movement controlTatyana D Sotnikova
Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
Parkinsonism Relat Disord 14:S99-102. 2008..These investigations may eventually bring novel approaches to the pharmacology of Parkinson's disease... - Tryptophan hydroxylase 2 genotype determines brain serotonin synthesis but not tissue content in C57Bl/6 and BALB/c congenic miceWilliam B Siesser
Department of Cell Biology, Duke University, Durham, NC 27710, USA
Neurosci Lett 481:6-11. 2010..These data demonstrate that the C1473G polymorphism determines differences in 5-HT synthesis rates among strains but only minimally affects 5-HT tissue levels... - Oligomerization and trafficking of the human dopamine transporter. Mutational analysis identifies critical domains important for the functional expression of the transporterGonzalo E Torres
Howard Hughes Medical Institute, Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
J Biol Chem 278:2731-9. 2003..Taken together, our results suggest that the assembly of DAT monomers plays a critical role in the expression and function of the transporter... - Phosphoinositide 3-kinase regulates beta2-adrenergic receptor endocytosis by AP-2 recruitment to the receptor/beta-arrestin complexSathyamangla V Naga Prasad
Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
J Cell Biol 158:563-75. 2002.... - Effect of torsinA on membrane proteins reveals a loss of function and a dominant-negative phenotype of the dystonia-associated DeltaE-torsinA mutantGonzalo E Torres
Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
Proc Natl Acad Sci U S A 101:15650-5. 2004..These properties may contribute to the autosomal dominant nature of the condition... - Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4Wei Chen
Howard Hughes Medical Institute, Departments of Medicine and Biochemistry, Duke University Medical Center, Durham, NC 27710, USA
Science 301:1391-4. 2003..These findings provide a previously unrecognized mechanism for receptor recruitment of beta-arrestin and demonstrate that Dvl plays an important role in the endocytosis of frizzled, as well as in promoting signaling... - N-terminal tyrosine modulation of the endocytic adaptor function of the beta-arrestinsSébastien Marion
Department of Cell Biology, Duke University, Durham, North Carolina 27710, USA
J Biol Chem 282:18937-44. 2007..Additionally, these naturally occurring variations in beta-arrestins may also differentially regulate the composition of the signaling complexes organized on the receptor... - Vmat2 heterozygous mutant mice display a depressive-like phenotypeMasato Fukui
Department of Psychiatry and Behavioral Sciences, Mouse Behavioral and Neuroendocrine Analysis Core Facility, Duke University Medical Center, Durham, North Carolina 27710, USA
J Neurosci 27:10520-9. 2007..Collectively, these findings suggest that Vmat2 heterozygotes display a depressive-like phenotype that is devoid of anxiety-like behavior... - The stability of the G protein-coupled receptor-beta-arrestin interaction determines the mechanism and functional consequence of ERK activationAkira Tohgo
Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
J Biol Chem 278:6258-67. 2003.... - Smoothened signaling in vertebrates is facilitated by a G protein-coupled receptor kinaseMelanie Philipp
Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
Mol Biol Cell 19:5478-89. 2008..Together, these data suggest that a GRK functions as a vertebrate kinase for Smoothened, promoting Hedgehog signal transduction during early development... - G Protein-coupled receptor kinases phosphorylate LRP6 in the Wnt pathwayMinyong Chen
Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
J Biol Chem 284:35040-8. 2009..Expression of GRK5 rescues the diminished beta-catenin and axin2 response caused by GRK5 depletion. Thus, our findings identify GRK5/6 as novel kinases for the single transmembrane receptor LRP6 during Wnt signaling... - Regulation of Akt signaling by D2 and D3 dopamine receptors in vivoJean Martin Beaulieu
Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
J Neurosci 27:881-5. 2007.... - Molecular biology, pharmacology and functional role of the plasma membrane dopamine transporterTatyana D Sotnikova
Dept. of Cell Biology, Center for Models of Human Disease, Duke University Medical Center, Durham, NC 27710, USA
CNS Neurol Disord Drug Targets 5:45-56. 2006..Significant new insights on these issues have been gained using mice with genetic deletion of DAT... - Beta-arrestin 2 regulates zebrafish development through the hedgehog signaling pathwayAlyson M Wilbanks
Department of Cell Biology, Center for Models of Human Disease, Institute for Genome Science and Policy, Duke University Medical Center, Durham, NC 27710, USA
Science 306:2264-7. 2004..These results suggest that a functional interaction between beta-arrestin 2 and Smoothened may be critical to regulate Hh signaling in zebrafish development... - Smoothened signal transduction is promoted by G protein-coupled receptor kinase 2Alison R Meloni
Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
Mol Cell Biol 26:7550-60. 2006..Together, these data suggest that GRK2 plays a positive role in Smoothened signaling, at least in part, through the promotion of an association between beta-arrestin 2 and Smoothened... - RNA editing induces variation in desensitization and trafficking of 5-hydroxytryptamine 2c receptor isoformsSébastien Marion
Department of Cell Biology and Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina 27710, USA
J Biol Chem 279:2945-54. 2004..Thus the ultimate physiological output of constitutively active receptors may be determined not only by their agonist-independent activity but also by their interactions with GRKs and betaarrestin... - Genetic and genomic approaches to reward and addictionAmy R Mohn
Department of Cell Biology, HHMI Laboratories, Duke University Medical Centre, Box 3287, CARL Building, Durham, NC 27710, USA
Neuropharmacology 47:101-10. 2004.... - Experimental genetic approaches to addictionAki Laakso
Howard Hughes Medical Institute Laboratories, Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
Neuron 36:213-28. 2002..The view that addiction represents a pathological state of reward provides an approach to identifying the factors that contribute to vulnerability, addiction, and relapse in genetic animal models... - Tryptophan hydroxylase-2 controls brain serotonin synthesisXiaodong Zhang
Howard Hughes Medical Institute Laboratory, Department of Cell Biology, and Center for Models of Human Disease, Institute for Genome Sciences and Policy, Box 3287, Duke University Medical Center, Durham, NC 27710, USA
Science 305:217. 2004..Our data provide direct evidence for a fundamental role of Tph2 in brain serotonin synthesis... - Conditional calcineurin knockout mice exhibit multiple abnormal behaviors related to schizophreniaTsuyoshi Miyakawa
Howard Hughes Medical Institute, The Picower Center for Learning and Memory and RIKEN Massachusetts Institute of Technology Neuroscience Research Center, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Proc Natl Acad Sci U S A 100:8987-92. 2003..Collectively, the abnormalities of CN mutant mice are strikingly similar to those described for schizophrenia. We propose that alterations affecting CN signaling could comprise a contributing factor in schizophrenia pathogenesis... - Effect of antidepressant drugs in mice lacking the norepinephrine transporterMarta Dziedzicka-Wasylewska
Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
Neuropsychopharmacology 31:2424-32. 2006.... - G protein-coupled receptor kinase regulates dopamine D3 receptor signaling by modulating the stability of a receptor-filamin-beta-arrestin complex. A case of autoreceptor regulationKyeong Man Kim
Department of Pharmacology, College of Pharmacy, Chonnam National University, Kwang Ju, Korea
J Biol Chem 280:12774-80. 2005..These findings provide a novel GRK-based mechanism for regulating D3R signaling potential and provide insight for interpreting D3R autoreceptor behavior... - Regulation of arrestin-3 phosphorylation by casein kinase IIYou Me Kim
Department of Microbiology and Immunology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
J Biol Chem 277:16837-46. 2002..Differences between the regulatory roles of arrestin-2 and -3 phosphorylation may contribute to the different cellular functions of these proteins in G protein-coupled receptor signaling and regulation... - Behavioral and neurochemical effects of wild-type and mutated human alpha-synuclein in transgenic miceEric K Richfield
Department of Pathology and Lab Medicine, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, New York 14642, USA
Exp Neurol 175:35-48. 2002..Expression of hm2alpha-SYN adversely affects the integrity of dopaminergic terminals and leads to age-related declines in motor coordination and dopaminergic markers... - Decreased ethanol preference and consumption in dopamine transporter female knock-out miceKaterina V Savelieva
Division of Pharmacology and Toxicology, Waggoner Center for Alcohol and Addiction Research, College of Pharmacy, University of Texas at Austin, USA
Alcohol Clin Exp Res 26:758-64. 2002..Complete deletion of DAT reduces ethanol preference in female mice; this may be due to a combination of the pharmacological actions of DAT deletion and alterations in fluid consumption and taste discrimination... - Behavioral responses to social stress in noradrenaline transporter knockout mice: effects on social behavior and depressionJozsef Haller
Institute of Experimental Medicine, Hungarian Academy of Science, Budapest, Hungary
Brain Res Bull 58:279-84. 2002..Tentatively, our data suggest that enhanced noradrenergic function does not prevent situation-specific social learning but impedes the generalization of depression to heterotypic circumstances... - Clozapine-, but not haloperidol-, induced increases in deltaFosB-like immunoreactivity are completely blocked in the striatum of mice lacking D3 dopamine receptorsGeorge S Robertson
Department of Psychiatry, Sir Charles Tupper Medical Building, 5850 College Street, Halifax, Nova Scotia B3H 1X5, Canada
Eur J Neurosci 20:3189-94. 2004.... - Identification of Drosophila neuropeptide receptors by G protein-coupled receptors-beta-arrestin2 interactionsErik C Johnson
Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA
J Biol Chem 278:52172-8. 2003..Together these observations demonstrate the beta-arrestin-green fluorescent protein translocation assay is an important tool in the repertoire of strategies for ligand identification of novel G protein-coupled receptors... - G protein-coupled receptor kinase/beta-arrestin systems and drugs of abuse: psychostimulant and opiate studies in knockout miceLaura M Bohn
Department of Pharmacology, The Ohio State University College of Medicine and Public Health, Columbus, OH 43210, USA
Neuromolecular Med 5:41-50. 2004..Therefore, the regulation of GPCRs may have bearing on the neuronal adaptations that underlie the reinforcing properties of drugs of abuse... - Dopamine enhances motor and neuropathological consequences of polyglutamine expanded huntingtinMichel Cyr
Neuroscience Research Group, University of Quebec at Trois Rivieres, C P 500, Trois Rivieres, Quebec G9A 5H7, Canada
FASEB J 20:2541-3. 2006..These findings indicate that dopamine contributes to the deleterious effects of mutated huntingtin on striatal function, and this is accompanied by enhanced formation of huntingtin aggregates... - MDMA "ecstasy" alters hyperactive and perseverative behaviors in dopamine transporter knockout miceSusan B Powell
Department of Psychiatry 0804, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
Psychopharmacology (Berl) 173:310-7. 2004..CONCLUSIONS: The effects of MDMA observed here demonstrate that the different aspects of the abnormal locomotor behavior exhibited by DAT (-/-) mice can be independently manipulated by pharmacological treatments... - Uptake and release of norepinephrine by serotonergic terminals in norepinephrine transporter knock-out mice: implications for the action of selective serotonin reuptake inhibitorsE Sylvester Vizi
Department of Pharmacology, Institute of Experimental Medicine, Hungarian Academy of Sciences, H 1450 Budapest, Hungary
J Neurosci 24:7888-94. 2004.... - A murine model of hyperdopaminergic state displays altered respiratory controlSandra G Vincent
Department of Physiology, Queen s University, Kingston, ON K7L 3N6, Canada
FASEB J 21:1463-71. 2007.... - Enhanced rewarding properties of morphine, but not cocaine, in beta(arrestin)-2 knock-out miceLaura M Bohn
Department of Pharmacology, The Ohio State University College of Medicine and Public Health, Columbus, Ohio 43210, USA
J Neurosci 23:10265-73. 2003..Thus, beta(arr2) appears to play a more important role in the dopaminergic effects mediated by morphine than those induced by cocaine... - Neuropathic pain activates the endogenous kappa opioid system in mouse spinal cord and induces opioid receptor toleranceMei Xu
Department of Pharmacology, University of Washington School of Medicine, Seattle, Washington 98195 7280, USA
J Neurosci 24:4576-84. 2004..Thus, endogenous dynorphin had both pronociceptive and antinociceptive actions after nerve injury and induced GRK3-mediated opioid tolerance... - The selective serotonin-2A receptor antagonist M100907 reverses behavioral deficits in dopamine transporter knockout miceAlasdair M Barr
Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA, USA
Neuropsychopharmacology 29:221-8. 2004.... - Prolonged kappa opioid receptor phosphorylation mediated by G-protein receptor kinase underlies sustained analgesic toleranceJay P McLaughlin
Department of Pharmacology, University of Washington School of Medicine, Seattle, WA 98195, USA
J Biol Chem 279:1810-8. 2004.... - Inhibition of the dopamine D1 receptor signaling by PSD-95Jingping Zhang
Department of Psychiatry, Harvard Medical School, New England Primate Research Center, Southborough, Massachusetts 01772, USA
J Biol Chem 282:15778-89. 2007..These studies demonstrate a role for a glutamatergic scaffold in dopamine receptor signaling and trafficking and identify a new potential target for the modulation of abnormal dopaminergic function... - G-protein receptor kinase 3 (GRK3) influences opioid analgesic tolerance but not opioid withdrawalGregory W Terman
Department of Anesthesiology, University of Washington School of Medicine, Seattle, WA 98195, USA
Br J Pharmacol 141:55-64. 2004..Fentanyl, a high efficacy opioid, more effectively produced GRK3-dependent effects than morphine, a low efficacy agonist... - Comparative studies of molecular mechanisms of dopamine D2 and D3 receptors for the activation of extracellular signal-regulated kinaseSunryeo Beom
Department of Pharmacology, College of Pharmacy, Chonnam National University, Kwang Ju, 500 757 Korea
J Biol Chem 279:28304-14. 2004....
Research Grants
- Akt/GSK-3 Signaling Cascade and the Actions of DopamineMarc G Caron; Fiscal Year: 2011....
- GENETIC ANALYSIS OF DOPAMINERGIC REWARD MECHANISMSMarc Caron; Fiscal Year: 2005..This should allow identification of genes involved in stable alterations of the CNS associated with chronic drug exposure. ..
- DOPAMINE RECEPTORS--CHARACTERIZATION AND REGULATIONMarc Caron; Fiscal Year: 2003....
- Dopamine Receptors: Characterization and RegulationMarc Caron; Fiscal Year: 2007..abstract_text> ..
- Akt/GSK-3 Signaling Cascade and the Actions of DopamineMarc Caron; Fiscal Year: 2007..abstract_text> ..
- Functional Variants of the Human TPH2 GeneMarc G Caron; Fiscal Year: 2011..Results from these experiments should provide potential genetic determinants for 5-HT-related disorders as well as useful animal models to explore the actions of and responsiveness to SSRI and test new therapeutic approaches. ..
- Functional Variants of the Human TPH2 GeneMarc Caron; Fiscal Year: 2009..Results from these experiments should provide potential genetic determinants for 5-HT-related disorders as well as useful animal models to explore the actions of and responsiveness to SSRI and test new therapeutic approaches. ..
- Functional Variants of the Human TPH2 GeneMarc G Caron; Fiscal Year: 2010..Results from these experiments should provide potential genetic determinants for 5-HT-related disorders as well as useful animal models to explore the actions of and responsiveness to SSRI and test new therapeutic approaches. ..
- Akt/GSK-3 Signaling Cascade and the Actions of DopamineMarc Caron; Fiscal Year: 2009..abstract_text> ..
- Functional Variants of the Human TPH2 GeneMarc Caron; Fiscal Year: 2009..Results from these experiments should provide potential genetic determinants for 5-HT-related disorders as well as useful animal models to explore the actions of and responsiveness to SSRI and test new therapeutic approaches. ..
- Drug abuse: Discovering ligands for pertinent GPCRsMarc Caron; Fiscal Year: 2007....
- DOPAMINE RECEPTORS--CHARACTERIZATION AND REGULATIONMarc Caron; Fiscal Year: 1993..This project constitutes an integral part of the overall long term objective of this laboratory to characterized at the molecular level the Various receptors for catecholamines...
- DOPAMINE RECEPTORS: CHARACTERIZATION & ENDOCRINE REGULATMarc Caron; Fiscal Year: 1991..This project constitutes an integral part of the overall long term objective of this laboratory to characterize at the molecular level the various receptors for catecholamines...