Marc Caron

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. ncbi request reprint An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior
    Jean Martin Beaulieu
    Department of Cell Biology, Center for Models of Human Disease, Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, North Carolina 27710, USA
    Cell 122:261-73. 2005
  2. pmc The effects of congenital brain serotonin deficiency on responses to chronic fluoxetine
    B D Sachs
    Department of Cell Biology, Duke University, Durham, NC 27710, USA
    Transl Psychiatry 3:e291. 2013
  3. pmc Norepinephrine transport-mediated gene expression in noradrenergic neurogenesis
    Yao Fei Hu
    Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    BMC Genomics 10:151. 2009
  4. ncbi request reprint Approaches to identify monoamine transporter interacting proteins
    Gonzalo E Torres
    Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    J Neurosci Methods 143:63-8. 2005
  5. pmc Pharmacological characterization of membrane-expressed human trace amine-associated receptor 1 (TAAR1) by a bioluminescence resonance energy transfer cAMP biosensor
    Larry S Barak
    Box 3287, Duke University, Durham, NC 27710
    Mol Pharmacol 74:585-94. 2008
  6. ncbi request reprint The Akt-GSK-3 signaling cascade in the actions of dopamine
    Jean Martin Beaulieu
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Trends Pharmacol Sci 28:166-72. 2007
  7. ncbi request reprint Rapid alterations in corticostriatal ensemble coordination during acute dopamine-dependent motor dysfunction
    Rui M Costa
    Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Neuron 52:359-69. 2006
  8. ncbi request reprint Dopaminergic supersensitivity in G protein-coupled receptor kinase 6-deficient mice
    Raul R Gainetdinov
    Howard Hughes Medical Institute Laboratories, Duke University Medical Center, Durham, NC 27710, USA
    Neuron 38:291-303. 2003
  9. ncbi request reprint Identification of PSD-95 as a regulator of dopamine-mediated synaptic and behavioral plasticity
    Wei Dong Yao
    Howard Hughes Medical Institute Laboratories, Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Neuron 41:625-38. 2004
  10. pmc Dopamine-independent locomotor actions of amphetamines in a novel acute mouse model of Parkinson disease
    Tatyana D Sotnikova
    Department of Cell Biology, Center for Models of Human Disease, Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, North Carolina, USA
    PLoS Biol 3:e271. 2005

Detail Information

Publications85

  1. ncbi request reprint An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior
    Jean Martin Beaulieu
    Department of Cell Biology, Center for Models of Human Disease, Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, North Carolina 27710, USA
    Cell 122:261-73. 2005
    ....
  2. pmc The effects of congenital brain serotonin deficiency on responses to chronic fluoxetine
    B D Sachs
    Department of Cell Biology, Duke University, Durham, NC 27710, USA
    Transl Psychiatry 3:e291. 2013
    ..Overall, these findings shed new light on the impact of 5-HT deficiency on responses to FLX and may have important implications for treatment selection in depression and anxiety disorders. ..
  3. pmc Norepinephrine transport-mediated gene expression in noradrenergic neurogenesis
    Yao Fei Hu
    Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    BMC Genomics 10:151. 2009
    ..While the structure of NET und the regulation of NET function are well described, little is known about downstream target genes of norepinephrine (NE) transport...
  4. ncbi request reprint Approaches to identify monoamine transporter interacting proteins
    Gonzalo E Torres
    Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    J Neurosci Methods 143:63-8. 2005
  5. pmc Pharmacological characterization of membrane-expressed human trace amine-associated receptor 1 (TAAR1) by a bioluminescence resonance energy transfer cAMP biosensor
    Larry S Barak
    Box 3287, Duke University, Durham, NC 27710
    Mol Pharmacol 74:585-94. 2008
    ....
  6. ncbi request reprint The Akt-GSK-3 signaling cascade in the actions of dopamine
    Jean Martin Beaulieu
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Trends Pharmacol Sci 28:166-72. 2007
    ....
  7. ncbi request reprint Rapid alterations in corticostriatal ensemble coordination during acute dopamine-dependent motor dysfunction
    Rui M Costa
    Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Neuron 52:359-69. 2006
    ..Thus, dopamine-related disorders like Parkinson's disease may not stem from changes in the overall levels of cortical activity, but from dysfunctional activity coordination in corticostriatal circuits...
  8. ncbi request reprint Dopaminergic supersensitivity in G protein-coupled receptor kinase 6-deficient mice
    Raul R Gainetdinov
    Howard Hughes Medical Institute Laboratories, Duke University Medical Center, Durham, NC 27710, USA
    Neuron 38:291-303. 2003
    ..The present study indicates that postsynaptic D2-like dopamine receptors are physiological targets for GRK6 and suggests that this regulatory mechanism contributes to central dopaminergic supersensitivity...
  9. ncbi request reprint Identification of PSD-95 as a regulator of dopamine-mediated synaptic and behavioral plasticity
    Wei Dong Yao
    Howard Hughes Medical Institute Laboratories, Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Neuron 41:625-38. 2004
    ..Our findings uncover a previously unappreciated role of PSD-95 in psychostimulant action and identify a molecular and cellular mechanism shared between drug-related plasticity and learning...
  10. pmc Dopamine-independent locomotor actions of amphetamines in a novel acute mouse model of Parkinson disease
    Tatyana D Sotnikova
    Department of Cell Biology, Center for Models of Human Disease, Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, North Carolina, USA
    PLoS Biol 3:e271. 2005
    ..Identification of dopamine transporter- and dopamine-independent locomotor actions of amphetamines suggests a novel paradigm in the search for prospective anti-Parkinsonian drugs...
  11. ncbi request reprint Dopamine transporter-dependent and -independent actions of trace amine beta-phenylethylamine
    Tatyana D Sotnikova
    Howard Hughes Medical Institute, Department of Cell Biology and Medicine, and Center for Models of Human Disease, Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurochem 91:362-73. 2004
    ..The inhibitory action on hyperactivity and certain stereotypies induced by beta-PEA in DAT-KO mice indicate that targets other than the DAT are responsible for these effects...
  12. pmc Sustained elevation of extracellular dopamine causes motor dysfunction and selective degeneration of striatal GABAergic neurons
    Michel Cyr
    Howard Hughes Medical Institute Laboratory, Department of Cell Biology, and Center for Models of Human Disease, Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 100:11035-40. 2003
    ..These findings provide in vivo evidence that, in addition to its proposed role in the degeneration of dopamine neurons, dopamine can also contribute to the selective death of its target neurons via a previously unappreciated mechanism...
  13. ncbi request reprint Aberrant responses in social interaction of dopamine transporter knockout mice
    Ramona M Rodriguiz
    Department of Psychiatry, Mouse Behavioral and Neuroendocrine Analysis Core Facility, Duke University Medical Center, Durham, NC 27710, USA
    Behav Brain Res 148:185-98. 2004
    ..These data suggest that KO mice may serve as a useful animal model for understanding not only how DA dysfunction contributes to social abnormalities, but also how behavioral inflexibility distorts their social responses...
  14. doi request reprint Food reward in the absence of taste receptor signaling
    Ivan E de Araujo
    Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA
    Neuron 57:930-41. 2008
    ..Our findings suggest that calorie-rich nutrients can directly influence brain reward circuits that control food intake independently of palatability or functional taste transduction...
  15. doi request reprint Activity-dependent expression of ELAV/Hu RBPs and neuronal mRNAs in seizure and cocaine brain
    Dhanrajan M Tiruchinapalli
    Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA
    J Neurochem 107:1529-43. 2008
    ..Finally, our data suggest that HuR and HuD RBPs potentially interact directly with neuronal mRNAs important for differentiation and synaptic plasticity...
  16. ncbi request reprint The multiple LIM domain-containing adaptor protein Hic-5 synaptically colocalizes and interacts with the dopamine transporter
    Ana M Carneiro
    Howard Hughes Medical Institute, Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurosci 22:7045-54. 2002
    ....
  17. ncbi request reprint Novelty seeking and stereotypic activation of behavior in mice with disruption of the Dat1 gene
    Vladimir M Pogorelov
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Neuropsychopharmacology 30:1818-31. 2005
    ....
  18. pmc Reduced D2-mediated signaling activity and trans-synaptic upregulation of D1 and D2 dopamine receptors in mice overexpressing the dopamine transporter
    Valentina Ghisi
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Cell Signal 21:87-94. 2009
    ..In sum, our study reveals that hypodopaminegia caused by up-regulation of DAT results in significant alterations at postsynaptic receptor function with most notable dysregulation at the level of D2 receptor signaling...
  19. pmc Lithium antagonizes dopamine-dependent behaviors mediated by an AKT/glycogen synthase kinase 3 signaling cascade
    Jean Martin Beaulieu
    Howard Hughes Medical Institute, Department of Cell Biology and Center for Models of Human Disease, Institute of Genome Sciences and Policy, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 101:5099-104. 2004
    ....
  20. ncbi request reprint Magnetic resonance imaging at microscopic resolution reveals subtle morphological changes in a mouse model of dopaminergic hyperfunction
    Michel Cyr
    Department of Cell Biology, Center for Models of Human Disease, Duke University Medical Center, Durham, NC 27710, USA
    Neuroimage 26:83-90. 2005
    ....
  21. ncbi request reprint DDD mice, a novel acute mouse model of Parkinson's disease
    Tatyana D Sotnikova
    Department of Cell Biology and Center for Models of Human Disease, IGSP, Duke University Medical Center, Durham, North Carolina 27710, USA
    Neurology 67:S12-7. 2006
    ..This model is particularly promising as a tool for evaluating the efficacy of compounds that may induce movement independently of DA. The advantages and limitations of DDD mice in comparison to other rodent PD models are discussed...
  22. ncbi request reprint Paradoxical striatal cellular signaling responses to psychostimulants in hyperactive mice
    Jean Martin Beaulieu
    Department of Cell Biology, Duke University Medical Center, Research Drive, Durham, NC 27710, USA
    J Biol Chem 281:32072-80. 2006
    ....
  23. pmc Spinal cord stimulation restores locomotion in animal models of Parkinson's disease
    Romulo Fuentes
    Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA
    Science 323:1578-82. 2009
    ..We propose that dorsal column stimulation might become an efficient and less invasive alternative for treatment of Parkinson's disease in the future...
  24. ncbi request reprint Desensitization of G protein-coupled receptors and neuronal functions
    Raul R Gainetdinov
    Howard Hughes Medical Institute Laboratories, Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Annu Rev Neurosci 27:107-44. 2004
    ..Furthermore, the utility of a pharmacological strategy aimed at targeting this GPCR desensitization machinery to regulate brain functions can be envisaged...
  25. ncbi request reprint Local knockdown of genes in the brain using small interfering RNA: a phenotypic comparison with knockout animals
    Ali Salahpour
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Biol Psychiatry 61:65-9. 2007
    ..This study sought to determine the efficiency of local small interfering RNA (siRNA) injections, comparing this approach with animals generated through classical gene targeting...
  26. ncbi request reprint Characterization of conditioned place preference to cocaine in congenic dopamine transporter knockout female mice
    Ivan O Medvedev
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Psychopharmacology (Berl) 180:408-13. 2005
    ..The dopamine transporter (DAT) is thought to play a major role in the rewarding effects of cocaine. Therefore, it is surprising that cocaine reveals conditioned effects in DAT knockout (DAT-KO) mice...
  27. ncbi request reprint Dopaminergic control of sleep-wake states
    Kafui Dzirasa
    Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurosci 26:10577-89. 2006
    ..We propose that psychosis and the sleep disturbances experienced by Parkinsonian patients result from dopamine-mediated disturbances of REM sleep...
  28. pmc Hyperdopaminergia and NMDA receptor hypofunction disrupt neural phase signaling
    Kafui Dzirasa
    Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurosci 29:8215-24. 2009
    ....
  29. ncbi request reprint Monoamine transporter pharmacology and mutant mice
    Raul R Gainetdinov
    Howard Hughes Medical Institute Laboratories, Dept of Cell Biology, Box 3287, Duke University Medical Center, Durham, NC 27710, USA
    Trends Pharmacol Sci 23:367-73. 2002
    ..In this review, we summarize recent insights into the pharmacology of psychotropic drugs using mice in which the genes encoding these transporters have been deleted...
  30. pmc Persistent hyperdopaminergia decreases the peak frequency of hippocampal theta oscillations during quiet waking and REM sleep
    Kafui Dzirasa
    Department of Neurobiology, Duke University Medical Center, Durham, NC, USA
    PLoS ONE 4:e5238. 2009
    ..Thus, we propose that persistent hyperdopaminergia, together with secondary alterations in other neuromodulatory systems, results in lower frequency activity in neural systems responsible for various cognitive processes...
  31. ncbi request reprint Monoamine transporters: from genes to behavior
    Raul R Gainetdinov
    Howard Hughes Medical Institute Laboratories, Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Annu Rev Pharmacol Toxicol 43:261-84. 2003
    ..In the present review, we summarize recent advances in understanding the physiology and pharmacology of monoamine transporters gained in mice with targeted genetic deletion of DAT, SERT, and NET...
  32. ncbi request reprint Dopamine: from pharmacology to molecular biology and back
    Marc G Caron
    Duke University Medical Center, Durham, NC 27710, USA
    Wien Klin Wochenschr 118:565-8. 2006
  33. pmc Noradrenergic control of cortico-striato-thalamic and mesolimbic cross-structural synchrony
    Kafui Dzirasa
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurosci 30:6387-97. 2010
    ....
  34. doi request reprint A beta-arrestin 2 signaling complex mediates lithium action on behavior
    Jean Martin Beaulieu
    Department of Cell Biology, Duke University Medical Center, Durham, NC, USA
    Cell 132:125-36. 2008
    ..These results point toward a pharmacological approach to modulating GPCR function that affects the formation of beta-arrestin-mediated signaling complexes...
  35. ncbi request reprint A beta-arrestin binding determinant common to the second intracellular loops of rhodopsin family G protein-coupled receptors
    Sébastien Marion
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 281:2932-8. 2006
    ....
  36. ncbi request reprint Beta-arrestin goes nuclear
    Jean Martin Beaulieu
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Cell 123:755-7. 2005
    ..In this issue of Cell, Kang et al. (2005) provide evidence that beta-arrestin 1 moves to the nucleus in response to GPCR stimulation, where it regulates gene expression by facilitating histone acetylation at specific gene promoters...
  37. pmc Hypertension and impaired glycine handling in mice lacking the orphan transporter XT2
    Hui Quan
    Department of Cell Biology, Howard Hughes Medical Institute Laboratories, Duke University Medical Center, Durham, North Carolina 27710, USA
    Mol Cell Biol 24:4166-73. 2004
    ..001), a level virtually identical to that of the wild-type controls. These data suggest that the XT2 orphan transporter is involved in glycine reabsorption and that the absence of this transporter is sufficient to cause hypertension...
  38. pmc Role of GSK3 beta in behavioral abnormalities induced by serotonin deficiency
    Jean Martin Beaulieu
    Department of Cell Biology, Mouse Behavioral and Neuroendocrine Analyses Core Facility, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 105:1333-8. 2008
    ..Targeting GSK3beta and related signaling events may afford therapeutic advantages for the management of certain 5-HT-related psychiatric conditions...
  39. pmc Antagonism of dopamine D2 receptor/beta-arrestin 2 interaction is a common property of clinically effective antipsychotics
    Bernard Masri
    Departments of Cell Biology, Medicine and Neurobiology, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 105:13656-61. 2008
    ..Thus, selective targeting of D2(L)R/beta-arrestin 2 interaction and related signaling pathways may provide new opportunities for antipsychotic development...
  40. ncbi request reprint Differential mechanisms of morphine antinociceptive tolerance revealed in (beta)arrestin-2 knock-out mice
    Laura M Bohn
    Howard Hughes Medical Institute Laboratories, Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurosci 22:10494-500. 2002
    ....
  41. pmc Increased amphetamine-induced hyperactivity and reward in mice overexpressing the dopamine transporter
    Ali Salahpour
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 105:4405-10. 2008
    ..2 and 0.5 mg/kg) than WT mice (2 mg/kg). These results suggest that overexpression of DAT leads to a marked increase in sensitivity to psychomotor and rewarding properties of amphetamine...
  42. ncbi request reprint Plasma membrane monoamine transporters: structure, regulation and function
    Gonzalo E Torres
    Howard Hughes Medical Institute, Department of Cell Biology, Duke University, Durham, North Carolina 27710, USA
    Nat Rev Neurosci 4:13-25. 2003
  43. ncbi request reprint Center stage for the serotonin transporter: a gain-of-function polymorphism in persons with obsessive-compulsive disorder
    Gonzalo E Torres
    Department of Cell Biology and Howard Hughes Medical Institute, CARL Bldg, RM 487, Research Dr, Box 3287, Duke University Medical Center, Durham, North Carolina, USA
    Mol Pharmacol 64:196-8. 2003
  44. ncbi request reprint Oligomerization and trafficking of the human dopamine transporter. Mutational analysis identifies critical domains important for the functional expression of the transporter
    Gonzalo E Torres
    Howard Hughes Medical Institute, Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 278:2731-9. 2003
    ..Taken together, our results suggest that the assembly of DAT monomers plays a critical role in the expression and function of the transporter...
  45. pmc Tryptophan hydroxylase 2 genotype determines brain serotonin synthesis but not tissue content in C57Bl/6 and BALB/c congenic mice
    William B Siesser
    Department of Cell Biology, Duke University, Durham, NC 27710, USA
    Neurosci Lett 481:6-11. 2010
    ..These data demonstrate that the C1473G polymorphism determines differences in 5-HT synthesis rates among strains but only minimally affects 5-HT tissue levels...
  46. doi request reprint Trace amine associated receptor 1 and movement control
    Tatyana D Sotnikova
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Parkinsonism Relat Disord 14:S99-102. 2008
    ..These investigations may eventually bring novel approaches to the pharmacology of Parkinson's disease...
  47. pmc Phosphoinositide 3-kinase regulates beta2-adrenergic receptor endocytosis by AP-2 recruitment to the receptor/beta-arrestin complex
    Sathyamangla V Naga Prasad
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    J Cell Biol 158:563-75. 2002
    ....
  48. ncbi request reprint Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4
    Wei Chen
    Howard Hughes Medical Institute, Departments of Medicine and Biochemistry, Duke University Medical Center, Durham, NC 27710, USA
    Science 301:1391-4. 2003
    ..These findings provide a previously unrecognized mechanism for receptor recruitment of beta-arrestin and demonstrate that Dvl plays an important role in the endocytosis of frizzled, as well as in promoting signaling...
  49. pmc Effect of torsinA on membrane proteins reveals a loss of function and a dominant-negative phenotype of the dystonia-associated DeltaE-torsinA mutant
    Gonzalo E Torres
    Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Proc Natl Acad Sci U S A 101:15650-5. 2004
    ..These properties may contribute to the autosomal dominant nature of the condition...
  50. doi request reprint Genetic NMDA receptor deficiency disrupts acute and chronic effects of cocaine but not amphetamine
    Amy J Ramsey
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Neuropsychopharmacology 33:2701-14. 2008
    ....
  51. ncbi request reprint N-terminal tyrosine modulation of the endocytic adaptor function of the beta-arrestins
    Sébastien Marion
    Department of Cell Biology, Duke University, Durham, North Carolina 27710, USA
    J Biol Chem 282:18937-44. 2007
    ..Additionally, these naturally occurring variations in beta-arrestins may also differentially regulate the composition of the signaling complexes organized on the receptor...
  52. pmc Vmat2 heterozygous mutant mice display a depressive-like phenotype
    Masato Fukui
    Department of Psychiatry and Behavioral Sciences, Mouse Behavioral and Neuroendocrine Analysis Core Facility, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurosci 27:10520-9. 2007
    ..Collectively, these findings suggest that Vmat2 heterozygotes display a depressive-like phenotype that is devoid of anxiety-like behavior...
  53. pmc G Protein-coupled receptor kinases phosphorylate LRP6 in the Wnt pathway
    Minyong Chen
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 284:35040-8. 2009
    ..Expression of GRK5 rescues the diminished beta-catenin and axin2 response caused by GRK5 depletion. Thus, our findings identify GRK5/6 as novel kinases for the single transmembrane receptor LRP6 during Wnt signaling...
  54. ncbi request reprint Regulation of Akt signaling by D2 and D3 dopamine receptors in vivo
    Jean Martin Beaulieu
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurosci 27:881-5. 2007
    ....
  55. pmc Smoothened signal transduction is promoted by G protein-coupled receptor kinase 2
    Alison R Meloni
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Mol Cell Biol 26:7550-60. 2006
    ..Together, these data suggest that GRK2 plays a positive role in Smoothened signaling, at least in part, through the promotion of an association between beta-arrestin 2 and Smoothened...
  56. ncbi request reprint Molecular biology, pharmacology and functional role of the plasma membrane dopamine transporter
    Tatyana D Sotnikova
    Dept of Cell Biology, Center for Models of Human Disease, Duke University Medical Center, Durham, NC 27710, USA
    CNS Neurol Disord Drug Targets 5:45-56. 2006
    ..Significant new insights on these issues have been gained using mice with genetic deletion of DAT...
  57. ncbi request reprint Beta-arrestin 2 regulates zebrafish development through the hedgehog signaling pathway
    Alyson M Wilbanks
    Department of Cell Biology, Center for Models of Human Disease, Institute for Genome Science and Policy, Duke University Medical Center, Durham, NC 27710, USA
    Science 306:2264-7. 2004
    ..These results suggest that a functional interaction between beta-arrestin 2 and Smoothened may be critical to regulate Hh signaling in zebrafish development...
  58. ncbi request reprint The stability of the G protein-coupled receptor-beta-arrestin interaction determines the mechanism and functional consequence of ERK activation
    Akira Tohgo
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 278:6258-67. 2003
    ....
  59. pmc Smoothened signaling in vertebrates is facilitated by a G protein-coupled receptor kinase
    Melanie Philipp
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Mol Biol Cell 19:5478-89. 2008
    ..Together, these data suggest that a GRK functions as a vertebrate kinase for Smoothened, promoting Hedgehog signal transduction during early development...
  60. ncbi request reprint Tryptophan hydroxylase-2 controls brain serotonin synthesis
    Xiaodong Zhang
    Howard Hughes Medical Institute Laboratory, Department of Cell Biology, and Center for Models of Human Disease, Institute for Genome Sciences and Policy, Box 3287, Duke University Medical Center, Durham, NC 27710, USA
    Science 305:217. 2004
    ..Our data provide direct evidence for a fundamental role of Tph2 in brain serotonin synthesis...
  61. ncbi request reprint Experimental genetic approaches to addiction
    Aki Laakso
    Howard Hughes Medical Institute Laboratories, Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Neuron 36:213-28. 2002
    ..The view that addiction represents a pathological state of reward provides an approach to identifying the factors that contribute to vulnerability, addiction, and relapse in genetic animal models...
  62. ncbi request reprint RNA editing induces variation in desensitization and trafficking of 5-hydroxytryptamine 2c receptor isoforms
    Sébastien Marion
    Department of Cell Biology and Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 279:2945-54. 2004
    ..Thus the ultimate physiological output of constitutively active receptors may be determined not only by their agonist-independent activity but also by their interactions with GRKs and betaarrestin...
  63. ncbi request reprint Genetic and genomic approaches to reward and addiction
    Amy R Mohn
    Department of Cell Biology, HHMI Laboratories, Duke University Medical Centre, Box 3287, CARL Building, Durham, NC 27710, USA
    Neuropharmacology 47:101-10. 2004
    ....
  64. ncbi request reprint Regulation of arrestin-3 phosphorylation by casein kinase II
    You Me Kim
    Department of Microbiology and Immunology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 277:16837-46. 2002
    ..Differences between the regulatory roles of arrestin-2 and -3 phosphorylation may contribute to the different cellular functions of these proteins in G protein-coupled receptor signaling and regulation...
  65. ncbi request reprint The selective serotonin-2A receptor antagonist M100907 reverses behavioral deficits in dopamine transporter knockout mice
    Alasdair M Barr
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA, USA
    Neuropsychopharmacology 29:221-8. 2004
    ....
  66. pmc Prolonged kappa opioid receptor phosphorylation mediated by G-protein receptor kinase underlies sustained analgesic tolerance
    Jay P McLaughlin
    Department of Pharmacology, University of Washington School of Medicine, Seattle, WA 98195, USA
    J Biol Chem 279:1810-8. 2004
    ....
  67. ncbi request reprint Identification of Drosophila neuropeptide receptors by G protein-coupled receptors-beta-arrestin2 interactions
    Erik C Johnson
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 278:52172-8. 2003
    ..Together these observations demonstrate the beta-arrestin-green fluorescent protein translocation assay is an important tool in the repertoire of strategies for ligand identification of novel G protein-coupled receptors...
  68. pmc Conditional calcineurin knockout mice exhibit multiple abnormal behaviors related to schizophrenia
    Tsuyoshi Miyakawa
    Howard Hughes Medical Institute, The Picower Center for Learning and Memory and RIKEN Massachusetts Institute of Technology Neuroscience Research Center, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 100:8987-92. 2003
    ..Collectively, the abnormalities of CN mutant mice are strikingly similar to those described for schizophrenia. We propose that alterations affecting CN signaling could comprise a contributing factor in schizophrenia pathogenesis...
  69. ncbi request reprint Trafficking of the vesicular acetylcholine transporter in SN56 cells: a dynamin-sensitive step and interaction with the AP-2 adaptor complex
    Jose Barbosa
    Laboratorio de Neurofarmacologia, Departamento de Farmacologia, ICB, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
    J Neurochem 82:1221-8. 2002
    ..These observations suggest that the di-leucine motif regulates sorting of VAChT from the soma plasma membrane through a clathrin dependent mechanism prior to the targeting of the transporter to varicosities...
  70. ncbi request reprint Behavioral responses to social stress in noradrenaline transporter knockout mice: effects on social behavior and depression
    Jozsef Haller
    Institute of Experimental Medicine, Hungarian Academy of Science, Budapest, Hungary
    Brain Res Bull 58:279-84. 2002
    ..Tentatively, our data suggest that enhanced noradrenergic function does not prevent situation-specific social learning but impedes the generalization of depression to heterotypic circumstances...
  71. ncbi request reprint Decreased ethanol preference and consumption in dopamine transporter female knock-out mice
    Katerina V Savelieva
    Division of Pharmacology and Toxicology, Waggoner Center for Alcohol and Addiction Research, College of Pharmacy, University of Texas at Austin, USA
    Alcohol Clin Exp Res 26:758-64. 2002
    ..One of the most important regulators of DA synaptic transmission is the DA transporter (DAT). We examined the effects of the genetic reduction or deletion of DAT on voluntary ethanol consumption and ethanol-induced sedation...
  72. ncbi request reprint Enhanced rewarding properties of morphine, but not cocaine, in beta(arrestin)-2 knock-out mice
    Laura M Bohn
    Department of Pharmacology, The Ohio State University College of Medicine and Public Health, Columbus, Ohio 43210, USA
    J Neurosci 23:10265-73. 2003
    ..Thus, beta(arr2) appears to play a more important role in the dopaminergic effects mediated by morphine than those induced by cocaine...
  73. ncbi request reprint Behavioral and neurochemical effects of wild-type and mutated human alpha-synuclein in transgenic mice
    Eric K Richfield
    Department of Pathology and Lab Medicine, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, New York 14642, USA
    Exp Neurol 175:35-48. 2002
    ..Expression of hm2alpha-SYN adversely affects the integrity of dopaminergic terminals and leads to age-related declines in motor coordination and dopaminergic markers...
  74. pmc Neuropathic pain activates the endogenous kappa opioid system in mouse spinal cord and induces opioid receptor tolerance
    Mei Xu
    Department of Pharmacology, University of Washington School of Medicine, Seattle, Washington 98195 7280, USA
    J Neurosci 24:4576-84. 2004
    ..Thus, endogenous dynorphin had both pronociceptive and antinociceptive actions after nerve injury and induced GRK3-mediated opioid tolerance...
  75. ncbi request reprint Effect of antidepressant drugs in mice lacking the norepinephrine transporter
    Marta Dziedzicka-Wasylewska
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
    Neuropsychopharmacology 31:2424-32. 2006
    ....
  76. ncbi request reprint Dopamine enhances motor and neuropathological consequences of polyglutamine expanded huntingtin
    Michel Cyr
    Neuroscience Research Group, University of Quebec at Trois Rivieres, C P 500, Trois Rivieres, Quebec G9A 5H7, Canada
    FASEB J 20:2541-3. 2006
    ..These findings indicate that dopamine contributes to the deleterious effects of mutated huntingtin on striatal function, and this is accompanied by enhanced formation of huntingtin aggregates...
  77. ncbi request reprint G protein-coupled receptor kinase regulates dopamine D3 receptor signaling by modulating the stability of a receptor-filamin-beta-arrestin complex. A case of autoreceptor regulation
    Kyeong Man Kim
    Department of Pharmacology, College of Pharmacy, Chonnam National University, Kwang Ju, Korea
    J Biol Chem 280:12774-80. 2005
    ..These findings provide a novel GRK-based mechanism for regulating D3R signaling potential and provide insight for interpreting D3R autoreceptor behavior...
  78. ncbi request reprint A murine model of hyperdopaminergic state displays altered respiratory control
    Sandra G Vincent
    Department of Physiology, Queen s University, Kingston, ON K7L 3N6, Canada
    FASEB J 21:1463-71. 2007
    ....
  79. pmc Inhibition of the dopamine D1 receptor signaling by PSD-95
    Jingping Zhang
    Department of Psychiatry, Harvard Medical School, New England Primate Research Center, Southborough, Massachusetts 01772, USA
    J Biol Chem 282:15778-89. 2007
    ..These studies demonstrate a role for a glutamatergic scaffold in dopamine receptor signaling and trafficking and identify a new potential target for the modulation of abnormal dopaminergic function...
  80. ncbi request reprint Clozapine-, but not haloperidol-, induced increases in deltaFosB-like immunoreactivity are completely blocked in the striatum of mice lacking D3 dopamine receptors
    George S Robertson
    Department of Psychiatry, Sir Charles Tupper Medical Building, 5850 College Street, Halifax, Nova Scotia B3H 1X5, Canada
    Eur J Neurosci 20:3189-94. 2004
    ....
  81. ncbi request reprint Uptake and release of norepinephrine by serotonergic terminals in norepinephrine transporter knock-out mice: implications for the action of selective serotonin reuptake inhibitors
    E Sylvester Vizi
    Department of Pharmacology, Institute of Experimental Medicine, Hungarian Academy of Sciences, H 1450 Budapest, Hungary
    J Neurosci 24:7888-94. 2004
    ....
  82. ncbi request reprint G protein-coupled receptor kinase/beta-arrestin systems and drugs of abuse: psychostimulant and opiate studies in knockout mice
    Laura M Bohn
    Department of Pharmacology, The Ohio State University College of Medicine and Public Health, Columbus, OH 43210, USA
    Neuromolecular Med 5:41-50. 2004
    ..Therefore, the regulation of GPCRs may have bearing on the neuronal adaptations that underlie the reinforcing properties of drugs of abuse...
  83. ncbi request reprint MDMA "ecstasy" alters hyperactive and perseverative behaviors in dopamine transporter knockout mice
    Susan B Powell
    Department of Psychiatry 0804, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Psychopharmacology (Berl) 173:310-7. 2004
    ..The hyperactivity of DAT (-/-) mice can be attenuated by psychostimulants and by serotonin uptake inhibitors, suggesting an important role for serotonin in the attenuation of locomotor hyperactivity in these mice...
  84. ncbi request reprint Comparative studies of molecular mechanisms of dopamine D2 and D3 receptors for the activation of extracellular signal-regulated kinase
    Sunryeo Beom
    Department of Pharmacology, College of Pharmacy, Chonnam National University, Kwang Ju, 500 757 Korea
    J Biol Chem 279:28304-14. 2004
    ....
  85. pmc G-protein receptor kinase 3 (GRK3) influences opioid analgesic tolerance but not opioid withdrawal
    Gregory W Terman
    Department of Anesthesiology, University of Washington School of Medicine, Seattle, WA 98195, USA
    Br J Pharmacol 141:55-64. 2004
    ..Fentanyl, a high efficacy opioid, more effectively produced GRK3-dependent effects than morphine, a low efficacy agonist...

Research Grants46

  1. Akt/GSK-3 Signaling Cascade and the Actions of Dopamine
    Marc G Caron; Fiscal Year: 2011
    ....
  2. GENETIC ANALYSIS OF DOPAMINERGIC REWARD MECHANISMS
    Marc Caron; Fiscal Year: 2005
    ..This should allow identification of genes involved in stable alterations of the CNS associated with chronic drug exposure. ..
  3. DOPAMINE RECEPTORS--CHARACTERIZATION AND REGULATION
    Marc Caron; Fiscal Year: 2003
    ....
  4. Dopamine Receptors: Characterization and Regulation
    Marc Caron; Fiscal Year: 2007
    ..abstract_text> ..
  5. Akt/GSK-3 Signaling Cascade and the Actions of Dopamine
    Marc Caron; Fiscal Year: 2007
    ..abstract_text> ..
  6. Functional Variants of the Human TPH2 Gene
    Marc G Caron; Fiscal Year: 2011
    ..Results from these experiments should provide potential genetic determinants for 5-HT-related disorders as well as useful animal models to explore the actions of and responsiveness to SSRI and test new therapeutic approaches. ..
  7. Functional Variants of the Human TPH2 Gene
    Marc Caron; Fiscal Year: 2009
    ..Results from these experiments should provide potential genetic determinants for 5-HT-related disorders as well as useful animal models to explore the actions of and responsiveness to SSRI and test new therapeutic approaches. ..
  8. Functional Variants of the Human TPH2 Gene
    Marc G Caron; Fiscal Year: 2010
    ..Results from these experiments should provide potential genetic determinants for 5-HT-related disorders as well as useful animal models to explore the actions of and responsiveness to SSRI and test new therapeutic approaches. ..
  9. Akt/GSK-3 Signaling Cascade and the Actions of Dopamine
    Marc Caron; Fiscal Year: 2009
    ..abstract_text> ..
  10. Functional Variants of the Human TPH2 Gene
    Marc Caron; Fiscal Year: 2009
    ..Results from these experiments should provide potential genetic determinants for 5-HT-related disorders as well as useful animal models to explore the actions of and responsiveness to SSRI and test new therapeutic approaches. ..
  11. Drug abuse: Discovering ligands for pertinent GPCRs
    Marc Caron; Fiscal Year: 2007
    ....
  12. DOPAMINE RECEPTORS--CHARACTERIZATION AND REGULATION
    Marc Caron; Fiscal Year: 1993
    ..This project constitutes an integral part of the overall long term objective of this laboratory to characterized at the molecular level the Various receptors for catecholamines...
  13. DOPAMINE RECEPTORS: CHARACTERIZATION & ENDOCRINE REGULAT
    Marc Caron; Fiscal Year: 1991
    ..This project constitutes an integral part of the overall long term objective of this laboratory to characterize at the molecular level the various receptors for catecholamines...