M E Cardenas

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. pmc Human protein phosphatase PP6 regulatory subunits provide Sit4-dependent and rapamycin-sensitive sap function in Saccharomyces cerevisiae
    Helena Morales-Johansson
    Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, USA
    PLoS ONE 4:e6331. 2009
  2. pmc The protein kinase Tor1 regulates adhesin gene expression in Candida albicans
    Robert J Bastidas
    Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, USA
    PLoS Pathog 5:e1000294. 2009
  3. pmc Rapamycin exerts antifungal activity in vitro and in vivo against Mucor circinelloides via FKBP12-dependent inhibition of Tor
    Robert J Bastidas
    Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, USA
    Eukaryot Cell 11:270-81. 2012
  4. pmc Conservation, duplication, and loss of the Tor signaling pathway in the fungal kingdom
    Cecelia A Shertz
    Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA
    BMC Genomics 11:510. 2010
  5. pmc The TOR signaling cascade regulates gene expression in response to nutrients
    M E Cardenas
    Departments of Genetics, Duke University Medical Center, Durham, North Carolina 27710 USA
    Genes Dev 13:3271-9. 1999
  6. pmc The TOR signal transduction cascade controls cellular differentiation in response to nutrients
    N S Cutler
    Department of Genetics, Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA
    Mol Biol Cell 12:4103-13. 2001
  7. pmc Cyclophilin A and Ess1 interact with and regulate silencing by the Sin3-Rpd3 histone deacetylase
    M Arevalo-Rodriguez
    Departments of Genetics, Pharmacology and Cancer Biology, Microbiology and Medicine, The Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA
    EMBO J 19:3739-49. 2000
  8. pmc Protein kinase activity and identification of a toxic effector domain of the target of rapamycin TOR proteins in yeast
    C M Alarcon
    Department of Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Mol Biol Cell 10:2531-46. 1999
  9. pmc Targets of immunophilin-immunosuppressant complexes are distinct highly conserved regions of calcineurin A
    M E Cardenas
    Department of Genetics, Duke University Medical Center, Durham, NC 27710, USA
    EMBO J 14:2772-83. 1995
  10. ncbi request reprint Calcineurin regulatory subunit is essential for virulence and mediates interactions with FKBP12-FK506 in Cryptococcus neoformans
    D S Fox
    Department of Genetics, 322 CARL Bldg, Box 3546, Duke University Medical Center, Research Drive, Durham, NC 27710, USA
    Mol Microbiol 39:835-49. 2001

Research Grants

  1. Function of the rapamycin targets: The TOR kinases
    MARIA CARDENAS CORONA; Fiscal Year: 2004
  2. Signaling mechanisms by the rapamycin target: Tor kinase
    MARIA CARDENAS CORONA; Fiscal Year: 2005
  3. Signaling mechanisms by the rapamycin target: Tor kinase
    MARIA CARDENAS CORONA; Fiscal Year: 2006
  4. Signaling mechanisms by the rapamycin target: Tor kinase
    MARIA CARDENAS CORONA; Fiscal Year: 2007
  5. Signaling mechanisms by the rapamycin target: Tor kinase
    MARIA CARDENAS CORONA; Fiscal Year: 2009

Collaborators

  • P Wang
  • G M Cox
  • X Wu
  • S Rospert
  • M Arevalo-Rodriguez
  • Y Xue
  • C S Hemenway
  • G Zenke
  • MARIA CARDENAS CORONA
  • J Heitman
  • Robert J Bastidas
  • Cecelia A Shertz
  • Joseph Heitman
  • M C Cruz
  • Helena Morales-Johansson
  • N S Cutler
  • J R Rohde
  • Soo Chan Lee
  • D S Fox
  • J Rohde
  • X Pan
  • M Del Poeta
  • J R Perfect
  • M C Lorenz
  • Wenjun Li
  • Rekha Puria
  • David L Brautigan
  • C M Alarcon
  • K J Dolinski
  • N R Movva
  • K Dolinski
  • D Zhu
  • J H McCusker
  • J Blankenship
  • A L Goldstein
  • H Ke
  • Y L Bennani
  • R A Sia
  • R Wenger
  • V F Quesniaux
  • J P Hirsch
  • T Harashima
  • T Breuder
  • C Scholz
  • R S Muir
  • F X Schmid

Detail Information

Publications24

  1. pmc Human protein phosphatase PP6 regulatory subunits provide Sit4-dependent and rapamycin-sensitive sap function in Saccharomyces cerevisiae
    Helena Morales-Johansson
    Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, USA
    PLoS ONE 4:e6331. 2009
    ..We hypothesize that the human Saps may play analogous roles in mTORC1-PP6 signaling events in metazoans...
  2. pmc The protein kinase Tor1 regulates adhesin gene expression in Candida albicans
    Robert J Bastidas
    Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, USA
    PLoS Pathog 5:e1000294. 2009
    ..Taken together, these results provide evidence that Tor1-mediated cellular adhesion might be broadly conserved among eukaryotic organisms...
  3. pmc Rapamycin exerts antifungal activity in vitro and in vivo against Mucor circinelloides via FKBP12-dependent inhibition of Tor
    Robert J Bastidas
    Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, USA
    Eukaryot Cell 11:270-81. 2012
    ....
  4. pmc Conservation, duplication, and loss of the Tor signaling pathway in the fungal kingdom
    Cecelia A Shertz
    Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA
    BMC Genomics 11:510. 2010
    ....
  5. pmc The TOR signaling cascade regulates gene expression in response to nutrients
    M E Cardenas
    Departments of Genetics, Duke University Medical Center, Durham, North Carolina 27710 USA
    Genes Dev 13:3271-9. 1999
    ....
  6. pmc The TOR signal transduction cascade controls cellular differentiation in response to nutrients
    N S Cutler
    Department of Genetics, Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA
    Mol Biol Cell 12:4103-13. 2001
    ..Filamentous differentiation of diverse fungi was also blocked by rapamycin, demonstrating that the Tor signaling cascade plays a conserved role in regulating filamentous differentiation in response to nutrients...
  7. pmc Cyclophilin A and Ess1 interact with and regulate silencing by the Sin3-Rpd3 histone deacetylase
    M Arevalo-Rodriguez
    Departments of Genetics, Pharmacology and Cancer Biology, Microbiology and Medicine, The Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA
    EMBO J 19:3739-49. 2000
    ..Our findings support a model in which Ess1 and cyclophilin A modulate the activity of the Sin3-Rpd3 complex, and excess histone deacetylation causes mitotic arrest in ess1 mutants...
  8. pmc Protein kinase activity and identification of a toxic effector domain of the target of rapamycin TOR proteins in yeast
    C M Alarcon
    Department of Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Mol Biol Cell 10:2531-46. 1999
    ....
  9. pmc Targets of immunophilin-immunosuppressant complexes are distinct highly conserved regions of calcineurin A
    M E Cardenas
    Department of Genetics, Duke University Medical Center, Durham, NC 27710, USA
    EMBO J 14:2772-83. 1995
    ..These studies identify cyclophilin A-CsA and FKBP12-FK506 binding targets as distinct, highly conserved regions of calcineurin A that overlap the binding domain for the calcineurin B regulatory subunit...
  10. ncbi request reprint Calcineurin regulatory subunit is essential for virulence and mediates interactions with FKBP12-FK506 in Cryptococcus neoformans
    D S Fox
    Department of Genetics, 322 CARL Bldg, Box 3546, Duke University Medical Center, Research Drive, Durham, NC 27710, USA
    Mol Microbiol 39:835-49. 2001
    ..In summary, our studies reveal a central role for calcineurin B in virulence and antifungal drug action in the human fungal pathogen C. neoformans...
  11. pmc FKBP12-rapamycin target TOR2 is a vacuolar protein with an associated phosphatidylinositol-4 kinase activity
    M E Cardenas
    Department of Genetics, Durham, NC 27710, USA
    EMBO J 14:5892-907. 1995
    ..These studies demonstrate that TOR2 is an essential, highly conserved component of a signal transduction pathway regulating cell cycle progression conserved from yeast to man...
  12. pmc Immunosuppressive and nonimmunosuppressive cyclosporine analogs are toxic to the opportunistic fungal pathogen Cryptococcus neoformans via cyclophilin-dependent inhibition of calcineurin
    M C Cruz
    Department of Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Antimicrob Agents Chemother 44:143-9. 2000
    ..neoformans via fungal cyclophilin A and calcineurin homologs. Our findings identify calcineurin as a novel antifungal drug target and suggest nonimmunosuppressive CsA analogs warrant investigation as antifungal agents...
  13. pmc Functions of FKBP12 and mitochondrial cyclophilin active site residues in vitro and in vivo in Saccharomyces cerevisiae
    K Dolinski
    Department of Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Mol Biol Cell 8:2267-80. 1997
    ....
  14. ncbi request reprint Calcineurin mutants render T lymphocytes resistant to cyclosporin A
    D Zhu
    Department of Genetics, Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina 27710, USA
    Mol Pharmacol 50:506-11. 1996
    ....
  15. pmc Rapamycin and less immunosuppressive analogs are toxic to Candida albicans and Cryptococcus neoformans via FKBP12-dependent inhibition of TOR
    M C Cruz
    Department of Genetics, The Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina 27710, USA
    Antimicrob Agents Chemother 45:3162-70. 2001
    ....
  16. pmc vph6 mutants of Saccharomyces cerevisiae require calcineurin for growth and are defective in vacuolar H(+)-ATPase assembly
    C S Hemenway
    Department of Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Genetics 141:833-44. 1995
    ..Taken together, our findings suggest calcineurin plays a general role in the regulation of cation transport and homeostasis...
  17. ncbi request reprint The TOR kinases link nutrient sensing to cell growth
    J Rohde
    Departments of Genetics, Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 276:9583-6. 2001
    ..Ongoing clinical studies address new clinical applications for rapamycin as an antiproliferative drug for chemotherapy and invasive cardiology...
  18. pmc CNS1 encodes an essential p60/Sti1 homolog in Saccharomyces cerevisiae that suppresses cyclophilin 40 mutations and interacts with Hsp90
    K J Dolinski
    Departments of Genetics, Pharmacology and Cancer Biology, and Medicine, Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina 27710, USA
    Mol Cell Biol 18:7344-52. 1998
    ....
  19. ncbi request reprint Nutrient signaling through TOR kinases controls gene expression and cellular differentiation in fungi
    J R Rohde
    Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA
    Curr Top Microbiol Immunol 279:53-72. 2004
    ..The antimicrobial properties of less immunosuppressive analogs of rapamycin hold promise for the development of an effective antifungal therapy...
  20. pmc Two cyclophilin A homologs with shared and distinct functions important for growth and virulence of Cryptococcus neoformans
    P Wang
    Departments of Genetics, Duke University Medical Center, Durham, NC 27710, USA
    EMBO Rep 2:511-8. 2001
    ..Cyclophilin A active site mutants restored growth of cpa1 cpa2 mutants at ambient but not at higher temperatures, suggesting that the prolyl isomerase activity of cyclophilin A has an in vivo function...
  21. pmc The G protein-coupled receptor gpr1 is a nutrient sensor that regulates pseudohyphal differentiation in Saccharomyces cerevisiae
    M C Lorenz
    Departments of Genetics, Pharmacology and Cancer Biology, Microbiology, and Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Genetics 154:609-22. 2000
    ..In summary, our studies reveal a novel G protein-coupled receptor senses nutrients and regulates the dimorphic transition to filamentous growth via a Galpha protein-cAMP-PKA signal transduction cascade...
  22. ncbi request reprint STT4 is an essential phosphatidylinositol 4-kinase that is a target of wortmannin in Saccharomyces cerevisiae
    N S Cutler
    Department of Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 272:27671-7. 1997
    ....
  23. pmc Calcineurin is essential in cyclosporin A- and FK506-sensitive yeast strains
    T Breuder
    Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710
    Proc Natl Acad Sci U S A 91:5372-6. 1994
    ..In yeast strains in which calcineurin is not essential, calcineurin inhibition or mutation of calcineurin confers hypersensitivity to LiCl or NaCl, suggesting that calcineurin regulates cation transport...

Research Grants6

  1. Function of the rapamycin targets: The TOR kinases
    MARIA CARDENAS CORONA; Fiscal Year: 2004
    ..abstract_text> ..
  2. Signaling mechanisms by the rapamycin target: Tor kinase
    MARIA CARDENAS CORONA; Fiscal Year: 2005
    ..abstract_text> ..
  3. Signaling mechanisms by the rapamycin target: Tor kinase
    MARIA CARDENAS CORONA; Fiscal Year: 2006
    ..abstract_text> ..
  4. Signaling mechanisms by the rapamycin target: Tor kinase
    MARIA CARDENAS CORONA; Fiscal Year: 2007
    ..abstract_text> ..
  5. Signaling mechanisms by the rapamycin target: Tor kinase
    MARIA CARDENAS CORONA; Fiscal Year: 2009
    ..abstract_text> ..