R Cabeza

..detection in VPC), although on different types of information (mnemonic vs. sensory)...

..Finally, we assess how well four different hypotheses of VPC function can explain findings in various domains and conclude that a bottom-up attention hypothesis provides the most complete and parsimonious account...

..In conclusion, the results suggest that activity in anterior MTL regions does not distinguish True from False, whereas activity in posterior MTL regions does...

..In sum, the study demonstrates the existence of false memory across languages, and provides information about the memory traces underlying veridical and illusory recognition...

..The photo paradigm provides a way of investigating the functional neuroanatomy of real-life episodic memory under rigorous experimental control...

..Taken together, the results indicate that both common and specific factors play an important role in cognitive aging...

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..In sum, the results provide evidence for the production-monitoring hypothesis and clarify the role of different brain regions typically activated in PET and functional magnetic resonance imaging (fMRI) studies of episodic retrieval...

..retrieval. Finally, the DAP hypothesis explains why VPC lesions yield a memory neglect syndrome: a deficit in spontaneously reporting relevant memory details but not in accessing the same details when guided by specific questions...

..Overall, the present results suggest that many of the activations attributed to specific cognitive processes, such as episodic memory, may actually reflect more general cognitive operations...

..The rapid development of innovative methods for eliciting personal memories in the scanner provides the opportunity to delve into the functional neuroanatomy of our personal past...

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..They may have a cognitive or neural origin, and they may reflect regional or network mechanisms. The HAROLD model is a cognitive neuroscience model that integrates ideas and findings from psychology and neuroscience of aging...

..Overall, the results demonstrate how direct cross-function comparisons clarify the generality and specificity of the functions of various brain regions...

..Taken together, our results clarify the contribution of different brain regions to stimulus- and process-specific episodic memory mechanisms...

..Additional tests show that it is unlikely that their free recall deficit can be explained by general mental imagery problems. In sum, the parietal lobe appears to have a critical role in recollection aspects of episodic memory...

..These results support theories of autobiographical memory that hypothesize co-activation of frontotemporal areas during recollection of episodes from the personal past...

..Taken together, the results clarify the neural mechanisms of context effects on face recognition...

..We sought to determine if the APOE epsilon4 allele influences both the functional activation and connectivity of the medial temporal lobes (MTLs) during successful memory encoding in young adults...

..Taken together, the results suggest that although the COMT val108/158met genotype has no effect on cognitive behavioral measures in healthy individuals, it is associated with differences in neural process underlying cognitive output...

..Taken together, the results demonstrate how rewarding social signals from a smiling face can enhance relational memory for face-name associations...

..Thus, the neural correlates of EE and SR are dissociable but interact in specific brain regions...

..Taken together, these findings demonstrate the validity, function, and generalizability of PASA, as well as its importance for the cognitive neuroscience of aging...

..Overall, our results show that direct cross-function comparisons are critical to understand the role of different brain regions in various cognitive functions...

..Whereas most fMRI studies of encoding have focused on activation increases, the present study indicates that activation decreases are also critical for successful learning of new information...

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..This result is the first demonstration that the integrity of specific white matter tracts is a mediator of age-related changes in cognitive performance...

..familiarity processes) and cognition (systematic vs. heuristic processes). In sum, using a novel photo-paradigm, this study provided the first evidence regarding the neural correlates of temporal-order for autobiographical events...

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..These findings highlight the functional connectivity of frontoparietal activation as a potential source of age-related decline in executive control...

..These results suggest that the amygdala and its connectivity with the MTL are critical to sustaining emotional memories over time, consistent with the consolidation hypothesis...

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..Thus, age-related differences in evaluating negatively valenced stimuli might reflect decreased perceptual processing of these stimuli, as well as the engagement of control processes that inhibit the response to negative emotion...

..The functional connectivity findings are consistent with a posterior-anterior shift with aging previously reported in several cognitive domains and linked to functional compensation...

..Taken together, the results help to clarify how age-related white matter decline impairs cognitive performance...

..Results suggest that greater bilateral frontal activity during encoding in aging are not just task-related, but may be associated with subsequent successful memory performance...

..Findings regarding prevention goal priming were not consistent with predictions. The data illustrate the centrality of self-regulation and personal goal pursuit within the multilayered process of social cognition...

..Recent advances are revealing new insights into the reactivation of latent emotional associations and the recollection of personal episodes from the remote past...

..These findings clarify the role of the amygdala and the medial temporal lobe memory regions in recollection and familiarity of emotional memory after lengthy retention intervals...

..Finally, only one region in the entire brain was associated with RM in general (i.e., for both semantic and perceptual ESA and RSA): the left hippocampus. This finding highlights the fundamental role of the hippocampus in RM...

..These results underscore the critical role of PFC in emotional evaluation and memory, and disentangle the effects of arousal and valence across PFC regions associated with different cognitive functions...

..These results provide direct evidence for the modulation hypothesis in humans and reveal a functional specialization within the MTL regarding the effects of emotion on memory formation...

..This result suggests that emotional information has privileged access to processing resources, possibly leading to better memory formation...

..The right hemi-aging and the HAROLD models are not incompatible. For example, the latter may apply to prefrontal regions and the former to other brain regions...

..The authors conclude that under conditions that equate the physical structure of individual displays, top-down attentional guidance can be at least as effective for older adults as for younger adults...

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..The results underscore the importance of investigating aging effects on both transient and sustained neural activity...

..The findings indicate dynamic recruitment of emotion-, memory-, and sensory-related brain regions during remembering and their dissociable contributions to phenomenological features of the memories...

..These Fronto-amygdalar Age-related Differences in Emotion (FADE) may reflect emotional regulation strategies mediated by frontal brain regions that dampen emotion-related activations in the amygdala...

..This novel paradigm reveals how brain regions implicated in emotion, memory retrieval, visuomotor imagery, and social cognition contribute to the recollection of specific plays in the mind of a sports fan...

..There are only a few studies, however, investigating potential mechanisms for the improvements in aerobic fitness. Our study suggests that greater aerobic fitness may be related to greater WM integrity in select brain regions...

..These findings indicate that participants' behavior reflected the combined effects of multiple MTL regions. More generally, our results show that parts of MTL can distinguish old from new independently of consciousness...

..In sum, the present study shows that when one focuses exclusively on high-confidence responses, the neural correlates of true and false memory are clearly different...

..These findings suggest that white matter integrity in prefrontal regions is one mechanism underlying the relation between individual differences in perceptual speed and episodic retrieval...

..These findings provide evidence that some PFC regions are engaged during many different memory tests. The findings are discussed in relation to theories about the functional contribution of the PFC regions and the architecture of memory...

..Hippocampal atrophy associated with aMCI may disrupt this brain network, and thereby interfere with recollection...

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..Taken together, the results suggest that FMF is an unintended consequence, or by-product, of elaborative semantic and visual encoding processes...

..This finding has important clinical implications because early Alzheimer's disease impairs both hippocampus and rhinal cortex...

..Implications of the present results for the classification of memory tasks with respect to systems and/or processes are discussed...

..They will help develop cognitive training methods and will provide an essential baseline for research on Alzheimer's Disease. ..

..The results will also contribute to the understanding of how social factors may contribute to geriatric depression. ..

..Taken together, the results of these studies will clarify the neural correlates of age-related deficits in RM and will have important implications for the promotion of health. ..

..Taken together, the results of these studies will clarify the neural correlates of age-related deficits in RM and will have important implications for the promotion of health. ..

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..The results will also contribute to the understanding of how social factors may contribute to geriatric depression. ..