David M Brizel

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. ncbi request reprint Phase III randomized trial of amifostine as a radioprotector in head and neck cancer
    D M Brizel
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    J Clin Oncol 18:3339-45. 2000
  2. ncbi request reprint Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma
    D M Brizel
    Department of Radiation Oncology, Duke University Comprehensive Cancer Center, Durham, North Carolina, 27710, USA
    Cancer Res 56:941-3. 1996
  3. ncbi request reprint Tumor hypoxia adversely affects the prognosis of carcinoma of the head and neck
    D M Brizel
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Int J Radiat Oncol Biol Phys 38:285-9. 1997
  4. ncbi request reprint Necessity for adjuvant neck dissection in setting of concurrent chemoradiation for advanced head-and-neck cancer
    David M Brizel
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Int J Radiat Oncol Biol Phys 58:1418-23. 2004
  5. doi request reprint Phase II study of palifermin and concurrent chemoradiation in head and neck squamous cell carcinoma
    David M Brizel
    Department of Radiation Oncology, Duke University, Durham, NC, USA
    J Clin Oncol 26:2489-96. 2008
  6. ncbi request reprint Pharmacologic approaches to radiation protection
    David M Brizel
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    J Clin Oncol 25:4084-9. 2007
  7. ncbi request reprint Does amifostine have a role in chemoradiation treatment?
    David M Brizel
    Department of Radiation Oncology at Duke University Medical Center, NC, USA
    Lancet Oncol 4:378-81. 2003
  8. ncbi request reprint Elevated tumor lactate concentrations predict for an increased risk of metastases in head-and-neck cancer
    D M Brizel
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Int J Radiat Oncol Biol Phys 51:349-53. 2001
  9. doi request reprint Prospective trial of synchronous bevacizumab, erlotinib, and concurrent chemoradiation in locally advanced head and neck cancer
    David S Yoo
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Clin Cancer Res 18:1404-14. 2012
  10. ncbi request reprint Assessment of the protective effect of amifostine on radiation-induced pulmonary toxicity
    Zeljko Vujaskovic
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Exp Lung Res 28:577-90. 2002

Detail Information

Publications53

  1. ncbi request reprint Phase III randomized trial of amifostine as a radioprotector in head and neck cancer
    D M Brizel
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    J Clin Oncol 18:3339-45. 2000
    ..This randomized trial evaluated whether amifostine could ameliorate these side effects without compromising the effectiveness of radiotherapy in these patients...
  2. ncbi request reprint Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma
    D M Brizel
    Department of Radiation Oncology, Duke University Comprehensive Cancer Center, Durham, North Carolina, 27710, USA
    Cancer Res 56:941-3. 1996
    ..Median pO2 was 7.5 mm Hg for metastasizing tumors versus 20 mm Hg for nonmetastasizing tumors (P=0.03). Potential mechanisms and implications for clinical trial design are discussed...
  3. ncbi request reprint Tumor hypoxia adversely affects the prognosis of carcinoma of the head and neck
    D M Brizel
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Int J Radiat Oncol Biol Phys 38:285-9. 1997
    ..This study was performed to evaluate the relationship between tumor hypoxia and DFS in patients with squamous carcinoma of the head and neck (SCCHN)...
  4. ncbi request reprint Necessity for adjuvant neck dissection in setting of concurrent chemoradiation for advanced head-and-neck cancer
    David M Brizel
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Int J Radiat Oncol Biol Phys 58:1418-23. 2004
    ..The necessity for postchemoradiation neck dissection is controversial. The intent of this report was to define the value of neck dissection in this patient population better...
  5. doi request reprint Phase II study of palifermin and concurrent chemoradiation in head and neck squamous cell carcinoma
    David M Brizel
    Department of Radiation Oncology, Duke University, Durham, NC, USA
    J Clin Oncol 26:2489-96. 2008
    ..This study assessed the efficacy and safety of palifermin in patients receiving concurrent chemoradiotherapy for advanced head and neck squamous cell carcinoma...
  6. ncbi request reprint Pharmacologic approaches to radiation protection
    David M Brizel
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    J Clin Oncol 25:4084-9. 2007
    ..Pharmacologic radioprotective strategies should be integrated with physical strategies such as intensity-modulated radiotherapy to realize their maximum clinical potential...
  7. ncbi request reprint Does amifostine have a role in chemoradiation treatment?
    David M Brizel
    Department of Radiation Oncology at Duke University Medical Center, NC, USA
    Lancet Oncol 4:378-81. 2003
    ....
  8. ncbi request reprint Elevated tumor lactate concentrations predict for an increased risk of metastases in head-and-neck cancer
    D M Brizel
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Int J Radiat Oncol Biol Phys 51:349-53. 2001
    ..We assessed the relationship between pretreatment tumor lactate concentrations and subsequent development of metastatic disease in patients with newly diagnosed head-and-neck cancer...
  9. doi request reprint Prospective trial of synchronous bevacizumab, erlotinib, and concurrent chemoradiation in locally advanced head and neck cancer
    David S Yoo
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Clin Cancer Res 18:1404-14. 2012
    ..We assessed the safety and efficacy of synchronous VEGF and epidermal growth factor receptor (EGFR) blockade with concurrent chemoradiation (CRT) in locally advanced head and neck cancer (HNC)...
  10. ncbi request reprint Assessment of the protective effect of amifostine on radiation-induced pulmonary toxicity
    Zeljko Vujaskovic
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Exp Lung Res 28:577-90. 2002
    ....
  11. ncbi request reprint Pretreatment anemia is correlated with the reduced effectiveness of radiation and concurrent chemotherapy in advanced head and neck cancer
    Robert G Prosnitz
    Department of Radiation Oncology, Box 3085, Duke University Medical Center, Durham, NC 27710, USA
    Int J Radiat Oncol Biol Phys 61:1087-95. 2005
    ..This study was performed to evaluate whether pretreatment Hgb less than 13 g/dL was correlated with treatment outcome in patients with advanced HNC treated with a uniform regimen of RT/CCT...
  12. ncbi request reprint The effect of darbepoetin alfa on growth, oxygenation and radioresponsiveness of a breast adenocarcinoma
    John P Kirkpatrick
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Radiat Res 165:192-201. 2006
    ..In this nonanemic animal model of mammary adenocarcinoma, darbepoetin alfa does not significantly alter tumor growth or radioresponsiveness, even though it improves oxygenation when administered at high doses...
  13. ncbi request reprint Relation between pO2, 31P magnetic resonance spectroscopy parameters and treatment outcome in patients with high-grade soft tissue sarcomas treated with thermoradiotherapy
    Mark W Dewhirst
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Int J Radiat Oncol Biol Phys 61:480-91. 2005
    ....
  14. ncbi request reprint The protective effect of recombinant human keratinocyte growth factor on radiation-induced pulmonary toxicity in rats
    Liguang Chen
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Int J Radiat Oncol Biol Phys 60:1520-9. 2004
    ..The purpose of this study was to determine whether rHuKGF prevents or ameliorates the severity of late lung damage from fractionated irradiation in a rat model...
  15. ncbi request reprint Recent progress in defining mechanisms and potential targets for prevention of normal tissue injury after radiation therapy
    Mitchell S Anscher
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Int J Radiat Oncol Biol Phys 62:255-9. 2005
    ..With the application of a better understanding of fundamental biology to clinical practice, new approaches to treating and preventing normal tissue injury can focus on correcting these disturbed molecular processes...
  16. doi request reprint Analysis of pretreatment FDG-PET SUV parameters in head-and-neck cancer: tumor SUVmean has superior prognostic value
    Kristin A Higgins
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Int J Radiat Oncol Biol Phys 82:548-53. 2012
    ..To evaluate the prognostic significance of different descriptive parameters in head-and-neck cancer patients undergoing pretreatment [F-18] fluoro-D-glucose-positron emission tomography (FDG-PET) imaging...
  17. ncbi request reprint Radioprotective effects of amifostine on acute and chronic esophageal injury in rodents
    Zeljko Vujaskovic
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Int J Radiat Oncol Biol Phys 69:534-40. 2007
    ..This study was performed to evaluate the protective benefit of amifostine against esophageal injury from fractionated radiation in a rodent model...
  18. ncbi request reprint Human recombinant erythropoietin significantly improves tumor oxygenation independent of its effects on hemoglobin
    Kimberly L Blackwell
    Division of Medical Oncology, Department of Medicine, Duke University Comprehensive Cancer Center, Erwin Road, Durham, NC 27710, USA
    Cancer Res 63:6162-5. 2003
    ..These data confirm that tumor oxygenation in nonanemic individuals may be improved through the administration of EPO, and this improvement appears to be independent of HgB effects...
  19. ncbi request reprint Tumor-dependent kinetics of partial pressure of oxygen fluctuations during air and oxygen breathing
    L Isabel Cardenas-Navia
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Cancer Res 64:6010-7. 2004
    ..Fluctuations of pO2 of the type reported herein are predicted to significantly affect radiotherapy response and could be a source for genetic instability, increased angiogenesis, and metastases...
  20. doi request reprint Development and clinical evaluation of a three-dimensional cone-beam computed tomography estimation method using a deformation field map
    Lei Ren
    Department of Radiation Oncology, Henry Ford Health System, Detroit, MI, USA
    Int J Radiat Oncol Biol Phys 82:1584-93. 2012
    ..To develop a three-dimensional (3D) cone-beam computed tomography (CBCT) estimation method using a deformation field map, and to evaluate and optimize the efficiency and accuracy of the method for use in the clinical setting...
  21. ncbi request reprint Preoperative radiotherapy and bevacizumab for angiosarcoma of the head and neck: two case studies
    Bridget F Koontz
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina, USA
    Head Neck 30:262-6. 2008
    ..Given the vascular nature of angiosarcoma and the need for better treatment of this disease, we investigated the concurrent use of bevacizumab with preoperative radiotherapy for head and neck angiosarcoma...
  22. ncbi request reprint Concurrent chemoradiotherapy for locally advanced, nonmetastatic, squamous carcinoma of the head and neck: consensus, controversy, and conundrum
    David M Brizel
    Department of Radiation Oncology and the Division of Otolaryngology, Duke University Medical Center, Durham, NC 27710, USA
    J Clin Oncol 24:2612-7. 2006
    ..Epidermal growth factor receptor blockade enhances the effectiveness of RT alone. Its role and that of angiogenic blockade in CRT are under investigation...
  23. ncbi request reprint Multiple etiologies of tumor hypoxia require multifaceted solutions
    Mark W Dewhirst
    Department of Radiation Oncology and Biomedical Engineering, Duke University, Durham, NC 27710, USA
    Clin Cancer Res 13:375-7. 2007
  24. ncbi request reprint Influence of intravenous amifostine on xerostomia, tumor control, and survival after radiotherapy for head-and- neck cancer: 2-year follow-up of a prospective, randomized, phase III trial
    Todd H Wasserman
    Department of Radiation Oncology, Washington University, St Louis, MO 63110 1046, USA
    Int J Radiat Oncol Biol Phys 63:985-90. 2005
    ....
  25. doi request reprint Induction chemotherapy: to use or not to use? That is the question
    David M Brizel
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Semin Radiat Oncol 19:11-6. 2009
    ..Induction chemotherapy followed by concurrent chemoradiation (sequential chemoradiation) is now under investigation. The rationale and evidence supporting the choice to use or not to use a sequential program are discussed...
  26. ncbi request reprint Effect of longitudinal oxygen gradients on effectiveness of manipulation of tumor oxygenation
    Kristian Erickson
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Cancer Res 63:4705-12. 2003
    ..Therefore, the tumor surface is refractory to improvement in pO(2) with this method. Additional refinements may be needed to improve pO(2) of analogous regions in larger tumors; mechanism-driven suggestions are provided...
  27. doi request reprint Dynamic contrast-enhanced MRI in head-and-neck cancer: the impact of region of interest selection on the intra- and interpatient variability of pharmacokinetic parameters
    Oana I Craciunescu
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Int J Radiat Oncol Biol Phys 82:e345-50. 2012
    ..This work evaluates the impact of tumor ROI selection on the assessment of intra- and interpatient variability...
  28. doi request reprint Paraganglioma of the head and neck: long-term local control with radiotherapy
    Junzo P Chino
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Am J Clin Oncol 32:304-7. 2009
    ..Due to their rarity and indolent clinical behavior, the optimal management for long-term control is unknown...
  29. ncbi request reprint How much radiation is the chemotherapy worth in advanced head and neck cancer?
    Mohit Kasibhatla
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Int J Radiat Oncol Biol Phys 68:1491-5. 2007
    ..To estimate the radiotherapeutic dose equivalence of chemoradiotherapy in head and neck cancer...
  30. ncbi request reprint Comprehensive Population-Averaged Arterial Input Function for Dynamic Contrast-Enhanced vMagnetic Resonance Imaging of Head and Neck Cancer
    Jennifer D Onxley
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina
    Int J Radiat Oncol Biol Phys 89:658-65. 2014
    ..To generate a population-averaged arterial input function (PA-AIF) for quantitative analysis of dynamic contrast-enhanced MRI data in head and neck cancer patients...
  31. pmc Radiation induces aerobic glycolysis through reactive oxygen species
    Jim Zhong
    School of Medicine, Duke University, Durham, USA
    Radiother Oncol 106:390-6. 2013
    ..Here we tested whether concurrent use of this drug with radiotherapy would reduce the switch to a glycolytic phenotype...
  32. pmc M6P/IGF2R loss of heterozygosity in head and neck cancer associated with poor patient prognosis
    Timothy A Jamieson
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC, USA
    BMC Cancer 3:4. 2003
    ..The purpose of this investigation was to determine if the M6P/IGF2R tumor suppressor gene is mutated in human head and neck cancer, and if allelic loss is associated with poor patient prognosis...
  33. ncbi request reprint The potential role of intrinsic hypoxia markers as prognostic variables in cancer
    Eui Jung Moon
    Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Antioxid Redox Signal 9:1237-94. 2007
    ..In conclusion, this review suggests the need for further studies with standardized methods to examine gene expression, as well as the use of multiple gene expressions...
  34. ncbi request reprint Thermochemoradiotherapy improves oxygenation in locally advanced breast cancer
    Ellen L Jones
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina, USA
    Clin Cancer Res 10:4287-93. 2004
    ....
  35. ncbi request reprint Controversies in the locoregional management of head and neck cancer
    David M Brizel
    Department of Radiation Oncology, Duke Cancer Institute, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Natl Compr Canc Netw 9:653-62. 2011
    ..Recent data support the use of surgery in the presence of a positive posttreatment PET, and observation in the setting of a negative posttreatment scan...
  36. ncbi request reprint Ultrasound guided pO2 measurement of breast cancer reoxygenation after neoadjuvant chemotherapy and hyperthermia treatment
    Z Vujaskovic
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Int J Hyperthermia 19:498-506. 2003
    ..The results of this preliminary study suggest that the combination of neoadjuvant chemotherapy and hyperthermia improves oxygenation in locally advanced breast tumours that are initially hypoxic...
  37. ncbi request reprint The treatment of high-grade soft tissue sarcomas with preoperative thermoradiotherapy
    L R Prosnitz
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Int J Radiat Oncol Biol Phys 45:941-9. 1999
    ..To explore the use of a novel program of preoperative radiation and hyperthermia in the management of high-grade soft tissue sarcomas (STS)...
  38. ncbi request reprint Review of methods used to study oxygen transport at the microcirculatory level
    M W Dewhirst
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Int J Cancer 90:237-55. 2000
    ....
  39. doi request reprint Contemporary radiotherapy in head and neck cancer: balancing chance for cure with risk for complication
    Alvin R Cabrera
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Surg Oncol Clin N Am 22:579-98. 2013
    ....
  40. doi request reprint FDG-PET assessment of the effect of head and neck radiotherapy on parotid gland glucose metabolism
    Michael C Roach
    School of Medicine, Duke University Medical Center, Duke University, Durham, NC 27710, USA
    Int J Radiat Oncol Biol Phys 82:321-6. 2012
    ..The goal of this retrospective study was to identify the radiation dose-response relationship of parotid gland glucose metabolism in patients with head and neck squamous cell carcinoma (HNSCC)...
  41. ncbi request reprint Interlaboratory variation in oxygen tension measurement by Eppendorf "Histograph" and comparison with hypoxic marker
    M Nozue
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, USA
    J Surg Oncol 66:30-8. 1997
    ..These results were also compared to the immunohistochemical staining of 2-nitromidazole adducts...
  42. ncbi request reprint The role of amifostine as a radioprotector
    T H Wasserman
    Department of Radiation Oncology, Washington University Medical Center, St. Louis, Missouri 63110, USA
    Oncology (Williston Park) 15:1349-54; discussion 1357-60. 2001
    ..This article will review the current understanding of the nature of toxicity resulting from radiation therapy and the benefits that can be derived from using protection to increase the tolerance of normal tissue to radiation damage...
  43. ncbi request reprint A phase II trial testing the thermal dose parameter CEM43 degrees T90 as a predictor of response in soft tissue sarcomas treated with pre-operative thermoradiotherapy
    P D Maguire
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Int J Hyperthermia 17:283-90. 2001
    ..Possible explanations for this outcome are discussed...
  44. ncbi request reprint Simultaneous administration of glucose and hyperoxic gas achieves greater improvement in tumor oxygenation than hyperoxic gas alone
    S A Snyder
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Int J Radiat Oncol Biol Phys 51:494-506. 2001
    ..However, some cell lines are not susceptible to the Crabtree effect, and the magnitude is dependent on baseline pO(2). Additional or alternative manipulations may be necessary to achieve more uniform improvement in pO(2)...
  45. pmc The mechanisms by which hyperbaric oxygen and carbogen improve tumour oxygenation
    D M Brizel
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Br J Cancer 72:1120-4. 1995
    ..Sympathetic-mediated vasoconstriction during hyperbaric carbogen caused it to be less effective than HBO. This mechanism also appeared to operate during normobaric carbogen breathing...
  46. ncbi request reprint Incidence and risk factors of significant carotid artery stenosis in asymptomatic survivors of head and neck cancer after radiotherapy
    Jennifer A Dorth
    Department of Radiation Oncology, Duke Cancer Institute, Durham, North Carolina
    Head Neck 36:215-9. 2014
    ..The incidence and risk factors of carotid artery stenosis in asymptomatic patients after head and neck radiation therapy (RT) are unknown...
  47. ncbi request reprint On-board patient positioning for head-and-neck IMRT: comparing digital tomosynthesis to kilovoltage radiography and cone-beam computed tomography
    Q Jackie Wu
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Int J Radiat Oncol Biol Phys 69:598-606. 2007
    ..This clinical study evaluated DTS as a daily imaging technique for patient positioning and compared the results with 3D CBCT and two-dimensional (2D) radiography...
  48. ncbi request reprint A mathematical model of tumor oxygen and glucose mass transport and metabolism with complex reaction kinetics
    John P Kirkpatrick
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Radiat Res 159:336-44. 2003
    ..This model demonstrates that hypoxia is quite sensitive to metabolic rate and geometric factors. It also predicts quantitatively the effects of inhibited oxygen metabolism and enhanced mass transfer on tumor oxygenation...
  49. doi request reprint The role of adaptive and functional imaging modalities in radiation therapy: approach and application from a radiation oncology perspective
    David S Yoo
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC, USA
    Semin Ultrasound CT MR 31:444-61. 2010
    ..At the same time, no imaging technique can address all the uncertainties inherent in cancer therapy. The application, interpretation, and limitations of various imaging modalities are discussed from a radiation oncology perspective...
  50. doi request reprint Head and neck cancer as a model for advances in imaging prognosis, early assessment, and posttherapy evaluation
    David M Brizel
    Duke University Cancer Institute, Durham, NC, 27710, USA
    Cancer J 17:159-65. 2011
    ....
  51. ncbi request reprint Radioprotection of lungs by amifostine is associated with reduction in profibrogenic cytokine activity
    Zeljko Vujaskovic
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Radiat Res 157:656-60. 2002
    ..Future studies are needed to determine whether administration of amifostine both during and after radiotherapy may further increase its radioprotective effect...
  52. ncbi request reprint Is there a role for selective neck dissection after chemoradiation for head and neck cancer?
    K Thomas Robbins
    J Am Coll Surg 199:913-6. 2004
  53. ncbi request reprint A Phase II trial of subcutaneous amifostine and radiation therapy in patients with head-and-neck cancer
    Pramila Rani Anne
    Thomas Jefferson University Hospital, Bodine Center for Cancer Research, Philadelphia, PA 19107, USA
    Int J Radiat Oncol Biol Phys 67:445-52. 2007
    ..Intravenous amifostine 200 mg/m2 reduces xerostomia in head-and-neck cancer patients. This Phase II study evaluated subcutaneous (s.c.) amifostine in a similar patient population...