Catherine Bowes Rickman

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. pmc Defining the human macula transcriptome and candidate retinal disease genes using EyeSAGE
    Catherine Bowes Rickman
    Department of Ophthalmology, Duke University Medical Center, Durham, NC 27710, USA
    Invest Ophthalmol Vis Sci 47:2305-16. 2006
  2. pmc Anti-amyloid therapy protects against retinal pigmented epithelium damage and vision loss in a model of age-related macular degeneration
    Jin Dong Ding
    Department of Ophthalmology, Duke Eye Center, Duke University, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 108:E279-87. 2011
  3. pmc Dry age-related macular degeneration: mechanisms, therapeutic targets, and imaging
    Catherine Bowes Rickman
    Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina
    Invest Ophthalmol Vis Sci 54:ORSF68-80. 2013
  4. pmc Oxidative stress-induced expression and modulation of Phosphatase of Regenerating Liver-1 (PRL-1) in mammalian retina
    Ling Yu
    Department of Ophthalmology, Duke University Medical Center, Durham, NC 27710, USA
    Biochim Biophys Acta 1773:1473-82. 2007
  5. ncbi request reprint The role of complement dysregulation in AMD mouse models
    Jin Dong Ding
    Department of Ophthalmology, Duke University Medical Center, 2351 Erwin Rd, 27710, Durham, NC, USA
    Adv Exp Med Biol 801:213-9. 2014
  6. ncbi request reprint Human RPE expression of cell survival factors
    Ping Yang
    Departments of Ophthalmology, Duke University Medical Center, Durham, NC 27710, USA
    Invest Ophthalmol Vis Sci 46:1755-64. 2005
  7. pmc Targeting age-related macular degeneration with Alzheimer's disease based immunotherapies: anti-amyloid-beta antibody attenuates pathologies in an age-related macular degeneration mouse model
    Jin Dong Ding
    Department of Ophthalmology, Duke University Medical Center, Albert Eye Research Institute, Room 5010, Box 3802, Erwin Road, Durham, NC 27710, USA
    Vision Res 48:339-45. 2008
  8. ncbi request reprint Recurrence of retinal pigment epithelial changes after macular translocation with 360 degrees peripheral retinectomy for geographic atrophy
    Mark T Cahill
    Department of Ophthalmology, Duke University Eye Center, Erwin Road, Durham, NC 27710, USA
    Arch Ophthalmol 123:935-8. 2005
  9. ncbi request reprint The fibroblast growth factor receptors, FGFR-1 and FGFR-2, mediate two independent signalling pathways in human retinal pigment epithelial cells
    Rita Rosenthal
    Augenklinik und Hochschulambulanz, Charite Universitatsmedizin, Berlin Campus Benjamin Franklin, Berlin, Germany
    Biochem Biophys Res Commun 337:241-7. 2005
  10. ncbi request reprint Insulin-like growth factor-1 contributes to neovascularization in age-related macular degeneration
    Rita Rosenthal
    Augenklinik und Augenpoliklinik, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    Biochem Biophys Res Commun 323:1203-8. 2004

Research Grants

  1. The APOE TR Mouse: A Model for Elucidating Pathogenic Mechanisms of AMD
    Catherine Bowes Rickman; Fiscal Year: 2009
  2. Murine Age-related Macular Degeneration: Model of Known Human Risk Factors
    Catherine Bowes Rickman; Fiscal Year: 2007
  3. CHARACTERIZATION OF GENES IN NORMAL AND AMD RETINAS
    Catherine Bowes Rickman; Fiscal Year: 2005
  4. CHARACTERIZATION OF GENES IN NORMAL AND AMD RETINAS
    Catherine Bowes Rickman; Fiscal Year: 2003
  5. CHARACTERIZATION OF GENES IN NORMAL AND AMD RETINAS
    Catherine Bowes Rickman; Fiscal Year: 2004
  6. CHARACTERIZATION OF GENES IN NORMAL AND AMD RETINAS
    Catherine Bowes Rickman; Fiscal Year: 2003
  7. CHARACTERIZATION OF GENES IN NORMAL AND AMD RETINAS
    Catherine Bowes Rickman; Fiscal Year: 2002
  8. CHARACTERIZATION OF GENES IN NORMAL AND AMD RETINAS
    Catherine Bowes Rickman; Fiscal Year: 2001
  9. The APOE TR Mouse: A Model for Elucidating Pathogenic Mechanisms of AMD
    Catherine Bowes Rickman; Fiscal Year: 2010

Collaborators

Detail Information

Publications11

  1. pmc Defining the human macula transcriptome and candidate retinal disease genes using EyeSAGE
    Catherine Bowes Rickman
    Department of Ophthalmology, Duke University Medical Center, Durham, NC 27710, USA
    Invest Ophthalmol Vis Sci 47:2305-16. 2006
    ....
  2. pmc Anti-amyloid therapy protects against retinal pigmented epithelium damage and vision loss in a model of age-related macular degeneration
    Jin Dong Ding
    Department of Ophthalmology, Duke Eye Center, Duke University, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 108:E279-87. 2011
    ..They also implicate Aβ in the pathogenesis of AMD and identify Aβ as a viable therapeutic target for its treatment...
  3. pmc Dry age-related macular degeneration: mechanisms, therapeutic targets, and imaging
    Catherine Bowes Rickman
    Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina
    Invest Ophthalmol Vis Sci 54:ORSF68-80. 2013
    ....
  4. pmc Oxidative stress-induced expression and modulation of Phosphatase of Regenerating Liver-1 (PRL-1) in mammalian retina
    Ling Yu
    Department of Ophthalmology, Duke University Medical Center, Durham, NC 27710, USA
    Biochim Biophys Acta 1773:1473-82. 2007
    ..These findings suggest that PRL-1 is a molecular component of the photoreceptor's response to oxidative stress acting upstream of the glutathione system...
  5. ncbi request reprint The role of complement dysregulation in AMD mouse models
    Jin Dong Ding
    Department of Ophthalmology, Duke University Medical Center, 2351 Erwin Rd, 27710, Durham, NC, USA
    Adv Exp Med Biol 801:213-9. 2014
    ..In addition, we have also generated humanized CFH mice expressing normal and risk variants of CFH. ..
  6. ncbi request reprint Human RPE expression of cell survival factors
    Ping Yang
    Departments of Ophthalmology, Duke University Medical Center, Durham, NC 27710, USA
    Invest Ophthalmol Vis Sci 46:1755-64. 2005
    ..To determine basal and tumor necrosis factor (TNF)-alpha-regulated expression of retinal pigment epithelial (RPE) cell survival factors and whether regulation is dependent on nuclear transcription factor (NF)-kappaB...
  7. pmc Targeting age-related macular degeneration with Alzheimer's disease based immunotherapies: anti-amyloid-beta antibody attenuates pathologies in an age-related macular degeneration mouse model
    Jin Dong Ding
    Department of Ophthalmology, Duke University Medical Center, Albert Eye Research Institute, Room 5010, Box 3802, Erwin Road, Durham, NC 27710, USA
    Vision Res 48:339-45. 2008
    ..These data support the hypothesis that Abeta is a therapeutic target for AMD...
  8. ncbi request reprint Recurrence of retinal pigment epithelial changes after macular translocation with 360 degrees peripheral retinectomy for geographic atrophy
    Mark T Cahill
    Department of Ophthalmology, Duke University Eye Center, Erwin Road, Durham, NC 27710, USA
    Arch Ophthalmol 123:935-8. 2005
    ..To assess the prevalence of recurrence of macular geographic atrophy (GA) of the retinal pigment epithelium (RPE) after macular translocation with 360 degrees retinectomy (MT360) in one institution...
  9. ncbi request reprint The fibroblast growth factor receptors, FGFR-1 and FGFR-2, mediate two independent signalling pathways in human retinal pigment epithelial cells
    Rita Rosenthal
    Augenklinik und Hochschulambulanz, Charite Universitatsmedizin, Berlin Campus Benjamin Franklin, Berlin, Germany
    Biochem Biophys Res Commun 337:241-7. 2005
    ..Our findings support the hypothesis that there are two different FGFR-1- and FGFR-2-dependent pathways that modulate the role of bFGF in induction of neovascularisation in AMD...
  10. ncbi request reprint Insulin-like growth factor-1 contributes to neovascularization in age-related macular degeneration
    Rita Rosenthal
    Augenklinik und Augenpoliklinik, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    Biochem Biophys Res Commun 323:1203-8. 2004
    ..Thus, in RPE cells IGF-1 stimulates the second messenger Ca(2+) and increases VEGF secretion which, in turn, induces neovascularization...
  11. ncbi request reprint Expression of the blue-light receptor cryptochrome in the human retina
    Carol L Thompson
    Department of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA
    Invest Ophthalmol Vis Sci 44:4515-21. 2003
    ..To analyze the patterns of expression of the cryptochromes, CRY1 and CRY2, in the human retina and to correlate expression of these putative blue-light receptors with nonvisual photoreceptor localization...

Research Grants10

  1. The APOE TR Mouse: A Model for Elucidating Pathogenic Mechanisms of AMD
    Catherine Bowes Rickman; Fiscal Year: 2009
    ..Validation of A as a novel therapeutic target in AMD could lead to a fundamental paradigm shift in the understanding and treatment of AMD. ..
  2. Murine Age-related Macular Degeneration: Model of Known Human Risk Factors
    Catherine Bowes Rickman; Fiscal Year: 2007
    ..Analysis of these animals will provide insight into the pathogenesis of AMD as well as a means to separate the relative contribution and degenerative effects of specific risk factors. ..
  3. CHARACTERIZATION OF GENES IN NORMAL AND AMD RETINAS
    Catherine Bowes Rickman; Fiscal Year: 2005
    ..Understanding normal foveal cone biology and its alteration in disease will provide the rationale for therapies to prolong photoreceptor survival in macular degeneration. ..
  4. CHARACTERIZATION OF GENES IN NORMAL AND AMD RETINAS
    Catherine Bowes Rickman; Fiscal Year: 2003
    ..Understanding normal foveal cone biology and its alteration in disease will provide the rationale for therapies to prolong photoreceptor survival in macular degeneration. ..
  5. CHARACTERIZATION OF GENES IN NORMAL AND AMD RETINAS
    Catherine Bowes Rickman; Fiscal Year: 2004
    ..Understanding normal foveal cone biology and its alteration in disease will provide the rationale for therapies to prolong photoreceptor survival in macular degeneration. ..
  6. CHARACTERIZATION OF GENES IN NORMAL AND AMD RETINAS
    Catherine Bowes Rickman; Fiscal Year: 2003
    ..Understanding normal foveal cone biology and its alteration in disease will provide the rationale for therapies to prolong photoreceptor survival in macular degeneration. ..
  7. CHARACTERIZATION OF GENES IN NORMAL AND AMD RETINAS
    Catherine Bowes Rickman; Fiscal Year: 2002
    ..Understanding normal foveal cone biology and its alteration in disease will provide the rationale for therapies to prolong photoreceptor survival in macular degeneration. ..
  8. CHARACTERIZATION OF GENES IN NORMAL AND AMD RETINAS
    Catherine Bowes Rickman; Fiscal Year: 2001
    ..Understanding normal foveal cone biology and its alteration in disease will provide the rationale for therapies to prolong photoreceptor survival in macular degeneration. ..
  9. The APOE TR Mouse: A Model for Elucidating Pathogenic Mechanisms of AMD
    Catherine Bowes Rickman; Fiscal Year: 2010
    ..Validation of A as a novel therapeutic target in AMD could lead to a fundamental paradigm shift in the understanding and treatment of AMD. ..