Catherine Bowes Rickman

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. pmc Defining the human macula transcriptome and candidate retinal disease genes using EyeSAGE
    Catherine Bowes Rickman
    Department of Ophthalmology, Duke University Medical Center, Durham, NC 27710, USA
    Invest Ophthalmol Vis Sci 47:2305-16. 2006
  2. pmc Anti-amyloid therapy protects against retinal pigmented epithelium damage and vision loss in a model of age-related macular degeneration
    Jin Dong Ding
    Department of Ophthalmology, Duke Eye Center, Duke University, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 108:E279-87. 2011
  3. pmc Expression of human complement factor H prevents age-related macular degeneration-like retina damage and kidney abnormalities in aged Cfh knockout mice
    Jin Dong Ding
    Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina
    Am J Pathol 185:29-42. 2015
  4. doi request reprint The role of complement dysregulation in AMD mouse models
    Jin Dong Ding
    Department of Ophthalmology, Duke University Medical Center, 2351 Erwin Rd, 27710, Durham, NC, USA
    Adv Exp Med Biol 801:213-9. 2014
  5. pmc Dry age-related macular degeneration: mechanisms, therapeutic targets, and imaging
    Catherine Bowes Rickman
    Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina
    Invest Ophthalmol Vis Sci 54:ORSF68-80. 2013
  6. pmc Oxidative stress-induced expression and modulation of Phosphatase of Regenerating Liver-1 (PRL-1) in mammalian retina
    Ling Yu
    Department of Ophthalmology, Duke University Medical Center, Durham, NC 27710, USA
    Biochim Biophys Acta 1773:1473-82. 2007
  7. pmc Regulation of age-related macular degeneration-like pathology by complement factor H
    Christopher B Toomey
    Department of Ophthalmology, Duke Eye Center, Duke University, Durham, NC 27710 Department of Cell Biology, Duke University, Durham, NC 27710
    Proc Natl Acad Sci U S A 112:E3040-9. 2015
  8. ncbi request reprint Human RPE expression of cell survival factors
    Ping Yang
    Departments of Ophthalmology, Duke University Medical Center, Durham, NC 27710, USA
    Invest Ophthalmol Vis Sci 46:1755-64. 2005
  9. pmc Targeting age-related macular degeneration with Alzheimer's disease based immunotherapies: anti-amyloid-beta antibody attenuates pathologies in an age-related macular degeneration mouse model
    Jin Dong Ding
    Department of Ophthalmology, Duke University Medical Center, Albert Eye Research Institute, Room 5010, Box 3802, Erwin Road, Durham, NC 27710, USA
    Vision Res 48:339-45. 2008
  10. ncbi request reprint Recurrence of retinal pigment epithelial changes after macular translocation with 360 degrees peripheral retinectomy for geographic atrophy
    Mark T Cahill
    Department of Ophthalmology, Duke University Eye Center, Erwin Road, Durham, NC 27710, USA
    Arch Ophthalmol 123:935-8. 2005

Research Grants

  1. CHARACTERIZATION OF GENES IN NORMAL AND AMD RETINAS
    Catherine Bowes Rickman; Fiscal Year: 2005
  2. Murine Age-related Macular Degeneration: Model of Known Human Risk Factors
    Catherine Bowes Rickman; Fiscal Year: 2007

Collaborators

Detail Information

Publications13

  1. pmc Defining the human macula transcriptome and candidate retinal disease genes using EyeSAGE
    Catherine Bowes Rickman
    Department of Ophthalmology, Duke University Medical Center, Durham, NC 27710, USA
    Invest Ophthalmol Vis Sci 47:2305-16. 2006
    ....
  2. pmc Anti-amyloid therapy protects against retinal pigmented epithelium damage and vision loss in a model of age-related macular degeneration
    Jin Dong Ding
    Department of Ophthalmology, Duke Eye Center, Duke University, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 108:E279-87. 2011
    ..They also implicate Aβ in the pathogenesis of AMD and identify Aβ as a viable therapeutic target for its treatment...
  3. pmc Expression of human complement factor H prevents age-related macular degeneration-like retina damage and kidney abnormalities in aged Cfh knockout mice
    Jin Dong Ding
    Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina
    Am J Pathol 185:29-42. 2015
    ..These humanized CFH mice present a valuable model for study of the molecular mechanisms of age-related macular degeneration and dense deposit disease and for testing therapeutic targets. ..
  4. doi request reprint The role of complement dysregulation in AMD mouse models
    Jin Dong Ding
    Department of Ophthalmology, Duke University Medical Center, 2351 Erwin Rd, 27710, Durham, NC, USA
    Adv Exp Med Biol 801:213-9. 2014
    ..In addition, we have also generated humanized CFH mice expressing normal and risk variants of CFH. ..
  5. pmc Dry age-related macular degeneration: mechanisms, therapeutic targets, and imaging
    Catherine Bowes Rickman
    Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina
    Invest Ophthalmol Vis Sci 54:ORSF68-80. 2013
    ....
  6. pmc Oxidative stress-induced expression and modulation of Phosphatase of Regenerating Liver-1 (PRL-1) in mammalian retina
    Ling Yu
    Department of Ophthalmology, Duke University Medical Center, Durham, NC 27710, USA
    Biochim Biophys Acta 1773:1473-82. 2007
    ..These findings suggest that PRL-1 is a molecular component of the photoreceptor's response to oxidative stress acting upstream of the glutathione system...
  7. pmc Regulation of age-related macular degeneration-like pathology by complement factor H
    Christopher B Toomey
    Department of Ophthalmology, Duke Eye Center, Duke University, Durham, NC 27710 Department of Cell Biology, Duke University, Durham, NC 27710
    Proc Natl Acad Sci U S A 112:E3040-9. 2015
    ..This new understanding of the complicated interactions of CFH in AMD-like pathology provides an improved foundation for the development of targeted therapies for AMD. ..
  8. ncbi request reprint Human RPE expression of cell survival factors
    Ping Yang
    Departments of Ophthalmology, Duke University Medical Center, Durham, NC 27710, USA
    Invest Ophthalmol Vis Sci 46:1755-64. 2005
    ..To determine basal and tumor necrosis factor (TNF)-alpha-regulated expression of retinal pigment epithelial (RPE) cell survival factors and whether regulation is dependent on nuclear transcription factor (NF)-kappaB...
  9. pmc Targeting age-related macular degeneration with Alzheimer's disease based immunotherapies: anti-amyloid-beta antibody attenuates pathologies in an age-related macular degeneration mouse model
    Jin Dong Ding
    Department of Ophthalmology, Duke University Medical Center, Albert Eye Research Institute, Room 5010, Box 3802, Erwin Road, Durham, NC 27710, USA
    Vision Res 48:339-45. 2008
    ..These data support the hypothesis that Abeta is a therapeutic target for AMD...
  10. ncbi request reprint Recurrence of retinal pigment epithelial changes after macular translocation with 360 degrees peripheral retinectomy for geographic atrophy
    Mark T Cahill
    Department of Ophthalmology, Duke University Eye Center, Erwin Road, Durham, NC 27710, USA
    Arch Ophthalmol 123:935-8. 2005
    ..To assess the prevalence of recurrence of macular geographic atrophy (GA) of the retinal pigment epithelium (RPE) after macular translocation with 360 degrees retinectomy (MT360) in one institution...
  11. ncbi request reprint The fibroblast growth factor receptors, FGFR-1 and FGFR-2, mediate two independent signalling pathways in human retinal pigment epithelial cells
    Rita Rosenthal
    Augenklinik und Hochschulambulanz, Charite Universitatsmedizin, Berlin Campus Benjamin Franklin, Berlin, Germany
    Biochem Biophys Res Commun 337:241-7. 2005
    ..Our findings support the hypothesis that there are two different FGFR-1- and FGFR-2-dependent pathways that modulate the role of bFGF in induction of neovascularisation in AMD...
  12. ncbi request reprint Insulin-like growth factor-1 contributes to neovascularization in age-related macular degeneration
    Rita Rosenthal
    Augenklinik und Augenpoliklinik, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    Biochem Biophys Res Commun 323:1203-8. 2004
    ..Thus, in RPE cells IGF-1 stimulates the second messenger Ca(2+) and increases VEGF secretion which, in turn, induces neovascularization...
  13. ncbi request reprint Expression of the blue-light receptor cryptochrome in the human retina
    Carol L Thompson
    Department of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA
    Invest Ophthalmol Vis Sci 44:4515-21. 2003
    ..To analyze the patterns of expression of the cryptochromes, CRY1 and CRY2, in the human retina and to correlate expression of these putative blue-light receptors with nonvisual photoreceptor localization...

Research Grants2

  1. CHARACTERIZATION OF GENES IN NORMAL AND AMD RETINAS
    Catherine Bowes Rickman; Fiscal Year: 2005
    ..Understanding normal foveal cone biology and its alteration in disease will provide the rationale for therapies to prolong photoreceptor survival in macular degeneration. ..
  2. Murine Age-related Macular Degeneration: Model of Known Human Risk Factors
    Catherine Bowes Rickman; Fiscal Year: 2007
    ..Analysis of these animals will provide insight into the pathogenesis of AMD as well as a means to separate the relative contribution and degenerative effects of specific risk factors. [unreadable] [unreadable] [unreadable]..