J A Blumenthal

..We sought to determine the course of cognitive change during the five years after CABG and the effect of perioperative decline on long-term cognitive function...

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..The aim of this study was to assess the efficacy of exercise and antidepressant medication in reducing depressive symptoms and improving cardiovascular biomarkers in depressed patients with coronary heart disease...

..Some evidence suggests that aerobic exercise may reduce depressive symptoms, but to our knowledge the effects of exercise on depression in patients with heart failure have not been evaluated...

..Methodological issues in the assessment and treatment of hypertension are discussed, along with possible mechanisms by which lifestyle modification may reduce elevated blood pressure...

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..However, methodological limitations of previous studies have raised questions about the value of exercise, and no study has compared the effects of exercise with standard anti-depressant medication in depressed cardiac patients...

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..To assess the prospective relationship between spiritual experiences and health in a sample of patients surviving an acute myocardial infarction (AMI) with depression or low social support...

..Despite the severity of pulmonary disease in this patient population, significant improvements in quality of life, but not somatic measures or survival to transplant, were achieved...

..Observational studies have shown that psychosocial factors are associated with increased risk for cardiovascular morbidity and mortality, but the effects of behavioral interventions on psychosocial and medical end points remain uncertain...

..Moreover, these findings suggest that the financial benefits that accrue from an appropriately targeted intervention may be substantial and immediate...

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..Lifestyle modifications have been recommended as the initial treatment strategy for lowering high blood pressure (BP). However, evidence for the efficacy of exercise and weight loss in the management of high BP remains controversial...

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..Randomized controlled trials are needed to determine the clinical effects of exercise in this population and to compare the effects of exercise with those of antidepressants...

..Despite clinically significant reductions in blood pressure, the DASH diet alone, without caloric restriction or exercise, resulted in minimal improvements in insulin sensitivity or lipids...

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..To date, however, no studies have examined the effects of a caregiver-assisted CST intervention in patients with COPD with less severe disease...

..These results suggest that emotional responsivity may represent an individual difference characteristic that is associated with an increased likelihood of exhibiting myocardial ischemia in both the laboratory and the real-world setting...

..However, the extent to which exercise training may reduce depressive symptoms in older patients with major depressive disorder (MDD) has not been systematically evaluated...

..We sought to assess whether depression is associated with an increased risk of mortality...

..In conclusion, combining aerobic exercise with the DASH diet and caloric restriction improves neurocognitive function among sedentary and overweight/obese individuals with prehypertension and hypertension...

..To determine the relative risk of myocardial ischemia triggered by specific emotions during daily life...

..Maintenance of regular aerobic exercise for an extended time interval is associated with greater cardiovascular benefits among older adults than has been reported previously...

..The purpose of our investigation was to determine the association between cognitive dysfunction and long-term quality of life after cardiac surgery...

..It also examines the relationship between change in depression and late mortality...

..07). Lung transplantation, like cardiac revascularization procedures, appears to be associated with cognitive decline in a subset of older patients, which could impact daily functioning posttransplant...

..27, P=0.08). ED was associated with greater CVD risk and impaired vascular endothelial function in depressed men. CVD risk factors may affect ED through impairment of vascular endothelial function...

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..Identified risk factors are largely limited to demographic characteristics. We hypothesized that POCD was associated with apolipoprotein E4 (APOE4) genotype and plasma biomarkers of brain injury and inflammation...

..Lower 24-hour BP load may be a pathway through which religiosity and cardiovascular health are related...

..CONCLUSION: These findings indicate that exercise, especially when combined with weight loss, reduces BP levels at rest and in situations that typically elevate BP such as intense physical activity and emotional distress...

..Although coping strategies are related to QOL in patients with ESLD, the extent to which specific native lung disease moderates this relationship is unknown...

..These data support the role of behavioural interventions in the treatment of patients with elevations in BP...

..Depression after myocardial infarction (MI) is associated with higher morbidity and mortality. Although antidepressants are effective in reducing depression, their use in patients with cardiovascular disease remains controversial...

..023). CONCLUSIONS: Impaired neurocognitive functioning may be relatively common in patients awaiting lung transplantation and is associated with ineffective pulmonary gas exchange and reduced exercise tolerance...

..These observations suggest that blunted nighttime BP dipping may contribute to increased cardiovascular disease risk in postmenopausal women...

..Interventions designed to reduce emotional distress could improve patient's perceived cognitive abilities following CABG...

..These findings suggest that psychosocial traits that have been linked to cardiovascular disease may be associated with more marked cardiovascular activation occurring in response to negative emotions experienced throughout the day...

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..However, there is a lack of consensus regarding the measurement of social support and its relation to depression...

..To compare the impact of network support and different types of perceived functional support on all-cause mortality or nonfatal reinfarction for patients with a recent acute myocardial infarction (AMI)...

..Reduced plasma volume may be one mechanism by which mental stress may increase the risk for acute coronary events...

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..0001). CONCLUSION: A brief, relatively inexpensive, telephone-based psychosocial intervention is an effective method for reducing distress and increasing health-related quality of life in patients awaiting lung transplantation...

..04) than their counterparts without a psychiatric diagnosis. CONCLUSIONS: Psychiatric comorbidity affects a significant portion of patients awaiting lung transplantation and is associated with decreased health-related quality of life...

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..Factors responsible for subtle postoperative cognitive dysfunction do not appear to be associated with clinically important renal effects...

..Moreover, the contributions of self-efficacy were domain specific. Interventions targeting both arthritis self-efficacy and self-efficacy for resisting eating may be helpful in this population...

..Smoking is neither preventive nor causative of cognitive decline after CABG surgery...

..This article addresses the Heart Failure and A Controlled Trial Investigating Outcomes of Exercise TraiNing (HF-ACTION) gated SPECT imaging (gSPECT) substudy baseline results...

..Discussion of practical issues regarding exercise, potential mechanisms for the beneficial effects of exercise, and recommendations for future research are provided...

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..Older adults (50-70 years old) were selected for this study because of the greater cardiac risk associated with low vagal cardiac control across this age range...

..Cardiac operations frequently are complicated by postoperative cognitive decline. Less common and less studied is postoperative cognitive decline after noncardiac surgery, so we determined its incidence, severity, and possible predictors...

..Factors accounting for these individual differences are poorly understood. The present study examined the relationship of vascular endothelial function to stress-induced hemodynamic responses...

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..The aim of this study is to examine ethnic differences in depressive symptoms and antidepressant treatment in a cohort of patients undergoing diagnostic coronary angiography...

..These results suggest that a slower rewarming rate with lower peak temperatures during CPB may be an important factor in the prevention of neurocognitive decline after hypothermic CPB...

..Depression is associated with an increased risk for mortality after acute myocardial infarction (MI). The purpose of this study was to determine whether low heart rate variability (HRV) mediates the effect of depression on mortality...

..1 +/- 1.2) and normal (27.3 +/- 0.6) geometries. The LV geometric pattern was found to be associated with exercise capacity in unmedicated, hypertensive patients, such that patients with concentric hypertrophy showed reduced capacity...

..Finally, the numerous changes outlined in this series of articles will demand that health psychologists extend and refine their theoretical models including the biopsychosocial model...

..These results suggest that RWT is an important determinant of the association between cardiac mass and exercise SBP response...

..05). These data suggest that the SNS may contribute to individual differences in nighttime BP dipping, and appears to account in part for blunted BP dipping in African Americans...

..Previous findings suggest that phobic anxiety may pose increased risk of cardiac mortality in medically healthy cohorts...

..We therefore investigated the relationship between IMT and age of first depressive episode in a sample of 202 adults (age range 40-81 years) with major depression (MDD)...

..We assessed the effects of aerobic exercise on neurocognitive function in a randomized controlled trial of patients with major depressive disorder (MDD)...

..Guidelines recommend that exercise training be considered for medically stable outpatients with heart failure. Previous studies have not had adequate statistical power to measure the effects of exercise training on clinical outcomes...

..Findings from previous studies of the effects of exercise training on patient-reported health status have been inconsistent...

..To evaluate gender-related differences in quality of life (QOL) and cognitive function 1 year after coronary artery bypass surgery (CABG) after adjusting for known baseline differences...

..To examine the relationship between N-terminal pro-brain natriuretic peptide (NT-proBNP) and exercise capacity in a large contemporary cohort of patients with chronic heart failure...

..7, (95% confidence interval 1.1 to 2.6, p = 0.011). In conclusion, reductions in the LVEF during mental stress are prospectively associated with adverse clinical outcomes...

..In this article, the authors review the evidence that depression is a risk factor for ischemic heart disease and examine the efficacy and safety of depression treatments in patients with ischemic heart disease...

..The purpose of this study was to assess whether depressive symptomatology was associated with vascular endothelial dysfunction in patients with coronary heart disease (CHD)...

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..The observed inverse association between higher level of depressive symptoms and ischemic activity needs to be further assessed in large samples...

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..Sympathetic nervous system activity and cardiovascular adrenergic receptor (AR) function were also examined...

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..To study the effect of donepezil in treating patients with cognitive decline following coronary artery bypass graft (CABG) surgery...

..Neuropsychological deficits are common among adults with MDD, particularly among those with CVRFs and potentially persons with subclinical vascular disease...

..This study aimed to investigate changes in depressive symptoms in hypertensive individuals participating in an exercise and weight loss intervention...

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..The purpose of this study was to assess the impact of changes in symptoms of depression over a 1-year period on subsequent clinical outcomes in heart failure (HF) patients...

..e., abnormal turbulence) to premature ventricular contractions (VPCs), and b) whether abnormal HR turbulence accounts for the effect of depression on increased mortality after AMI...

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..CONCLUSIONS: Hypothermic CPB does not provide additional central nervous system protection in adult cardiac surgical patients who were maintained at either 30 or 35 degrees C during CPB...

..The 6MWD is thus a useful measure of both urgency and utility among patients awaiting lung transplantation...

..Depression is especially common in cardiac patients, and there is growing evidence that depression is a risk factor for fatal and nonfatal events in CHD patients...

..We hypothesize that BLT offers comparable, if not superior, clinical outcomes to SLT in all patients independent of recipient age...

..quot; Baseline levels of self-reported anxiety and lift satisfaction were the best predictors of both patient dropout and treatment success or failure across all treatment conditions...

..We describe these issues and the controversies that merit continued investigation...

..This review summarizes the extant literature on the psychosocial factors in lung transplantation and highlights several innovative efforts to improve psychological outcomes in this challenging patient population...

..We sought to determine the impact of this postoperative cognitive dysfunction on quality of life (QOL) and to characterize the dysfunction from the patient's perspective...

..Interventions that increase IgM EndoCAb levels might improve cognitive function after cardiac surgery...

..Although lifestyle interventions are efficacious in lowering blood pressure, evidence that they have a beneficial effect on target organs has been lacking...

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..The study also will provide information regarding the relationship between vascular depression and various indices of vascular and neurocognitive function, and the extent to which these indices may be modifiable by treatment. ..

..The data generated from this study will have important clinical significance by determining the extent to which exercise may reduce depression and improve intermediate markers of CHD risk in vulnerable cardiac patients. ..

..If the intervention is successful, it may serve as a model for the delivery of home-based, cost-effective treatment for seriously ill patients unable to benefit from more traditional face-to-face psychotherapy. ..

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..The data generated from this study will have important clinical significance by determining the extent to which exercise may reduce depression and improve intermediate markers of CHD risk in vulnerable cardiac patients. ..

..This study will examine the effects of an enhanced coping skills training program for COPD patients and their caregivers, delivered by telephone, on patients' psychosocial and physical functioning and long-term survival. ..

..This study will examine the effects of a Stress Management Training program combined with exercise-based cardiac rehabilitation on cardiovascular biomarkers of risk and event-free survival in CHD patients. ..

..The data generated from this study will have important clinical significance by determining the extent to which exercise may reduce depression and improve intermediate markers of CHD risk in vulnerable cardiac patients. ..

..This study will examine the effects of an enhanced coping skills training program for COPD patients and their caregivers, delivered by telephone, on patients'psychosocial and physical functioning and long-term survival. ..

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..This study will examine the effects of a Stress Management Training program combined with exercise-based cardiac rehabilitation on cardiovascular biomarkers of risk and event-free survival in CHD patients. ..