Dan G Blazer

..The authors explored the hypothesis that the epsilon4 allele is a risk factor for depression among older persons with a low cholesterol level (a known risk factor for depression)...

..Elevated rates of MUDs among African Americans and Hispanics require research to elucidate risk factors and improve assessments of MUDs for different racial/ethnic groups...

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..Regardless of stimulants used, most female users were in the most severe or the physiological dependence group. These results lend support for subtyping dependence in the emerging DSM-V...

..We hypothesize that a multidisciplinary approach involving a vascular surgeon will minimize morbidity and improve patency of VRs...

..The recent resurgence in ecstasy use among adults underscores the need to monitor trends in its use...

..To examine the course of depressive symptoms in older patients with comorbid major depression and dysthymia...

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..We examine past-year substance use and substance use disorders (alcohol, 9 drug classes) among adult ED users. Prevalences of substance use and substance use disorders among ED nonusers are calculated for reference purposes...

..21%); children, females, and blacks had elevated odds of inpatient psychiatric treatment. Collectively, results add clinical evidence on treatment needs and diagnostic patterns for understudied diagnoses...

..To study substance use and psychiatric disorders among prescription opioid users, heroin users, and non-opioid drug users in a national sample of adults...

..To ascertain accuracy of self-reported height, weight (and hence body mass index) in African American and white women and men older than 70 years of age...

..The authors analyzed data from two follow-up intervals-1986-1987 to 1989-1990 (interval 1) and 1992-1993 to 1996-1997 (interval 2)-from a community-based cohort of 4,162 older adults to determine predictors of future antidepressant use...

..To address an urgent need for screening of substance use problems in medical settings, we examined substance-specific dependence criteria as potential brief screeners for the detection of patients with a substance use disorder (SUD)...

..The findings do not contradict the previous association of epsilon4 with Alzheimer's disease (AD) and other conditions. Such conditions continue to merit full attention...

..To determine whether some health behaviors of older people (e.g., obtaining cancer screens) have a limited and others (e.g., exercise) have a broad association with population-level health status 4 to 6 years later...

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..Our objective was to examine the association between neighborhood context and level of depressive symptomatology in older adults in a diverse geographic region of central North Carolina...

..To examine the psychometric properties of diagnostic criteria for prescription analgesic opioid use disorders (OUDs) and to identify background predictors of a latent continuum for OUD liability...

..In this study, we determined, controlling for reported income and functional status, if perceived inadequate basic needs predicted depressive symptoms...

..To estimate the prevalence, distribution, and correlates of drug use among middle aged and elderly persons in the United States and to compare with alcohol use in this age group...

..To determine whether the characteristics of the usual medical care providers of older antidepressant users changed between 1986 and 1997 with the introduction of selective serotonin reuptake inhibitors...

..While young racial/ethnic groups are the fastest growing population in the United States, data about substance-related disorders among adolescents of various racial/ethnic backgrounds are lacking...

..To explore the underlying structure of symptom presentation in older adults with major depression by identifying homogeneous clusters of individuals based on symptom profiles...

..quot; and health outcomes over time...

..To determine which symptoms of depression are most likely to increase the risk of mortality in a biracial sample of older adults...

..To estimate 1-year prevalence and correlates of alcohol abuse, dependence, and subthreshold dependence (diagnostic orphans) among middle-aged and elderly persons in the United States...

..Until such time as studies use truly representative samples and include younger ages, findings in this area must be treated with caution...

..We sought to determine whether, among older adults (>65 years), a perception that their basic needs are not being met increased mortality risk and whether this risk varied by race/ethnicity...

..We attempted to determine if self-reported shortness of breath (SoB) is associated with depressive symptoms at long-term (3-year) follow-up in a community sample of older (65+) adults...

..The aim of the study was to compare symptom expression in primarily middle-aged (<60) and older (60+) patients who were depressed and determine if symptom profiles differed by age...

..To examine prevalence of tobacco use and identify psychiatric symptoms and substance use correlates of tobacco use comparing adults 50-64 years of age with those 65+ years of age (N = 10,891)...

..This study examined national trends, patterns, correlates, and barriers to substance abuse treatment use by adolescents aged 12-17 years who met at least one of the past-year criteria for prescription opioid abuse or dependence (N=1788)...

..In addition, the APOE4 allele is associated with reduced allopregnanolone levels. Neurosteroids may be relevant to the neurobiology and therapeutics of AD...

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..To identify subtypes of nonmedical opioid users, gender variations in psychiatric disorders, and quality of life in a representative sample of adults...

..7 million in 2020. The authors provide a review of epidemiological findings for this understudied area of research by focusing on illicit drug use disorders and nonmedical use of prescription drugs among adults aged 50+ years...

..Our aim was to explore the latent traits of trajectories of limitations in mobility and instrumental activities of daily living (IADL) tasks in a sample of older adults diagnosed with major depression...

..Our objective is to review the outcomes associated with VR during PD using a large multicenter data source...

..This review of selected empirical studies describes religious and spiritual factors that have been examined in their association with the consequences of trauma. A comprehensive model is proposed to explain the complex interrelationship...

..To estimate the frequency, distribution, and correlates of nonprescription use of pain relievers by middle-aged and elderly persons in the United States...

..The authors studied demographic, clinical, social, and perceived health and well-being factors as predictors of partial remission in older patients treated for major depressive disorder (MDD)...

..The goal of this study was to determine whether the epsilon4 allele of apolipoprotein E is predictive of mortality in a community-based sample...

..To review the diagnosis and treatment of depressive disorders in long-term care settings...

..This cross-disciplinary discussion reveals insights that we believe physicians can use when confronting such issues with patients...

..Factors associated with the severity of posttraumatic stress were depression, functional impairment, subjective severity and number of traumatic events, and the level of resilience...

..Treatment options include antidepressants (alone or in combination) and psychotherapy...

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..60; p=0.002) across the three periods. Subthreshold depression may result in different outcomes in women, possibly mediating against mortality...

..This study focuses on the comorbidity between depression and diabetes, as well as depression and obesity, in a biracial community sample of older adults...

..Despite the burden of depression in late life, its origins present a paradox to investigators and clinicians alike...

..To determine whether metabolic syndrome is an independent predictor of decline in mobility in an elderly community sample...

..To present the prevalence and correlates of hallucinogen use disorders (HUDs: abuse or dependence) and subthreshold dependence...

..Further work is needed to determine the generalizability of this finding to the broader population, as well as its significance for clinical outcomes...

..7% of the time, while comparable agreement was found for only 12.3% of candidate decedents who did not have the required combination of information. Thus, an easy to apply algorithm facilitates accurate identification of NDI matches...

..Finally, I present evidence for the current therapies prescribed for depressed elders, ranging from medications to group therapy...

..Illicit methadone use among patients in maintenance programs is infrequent; however, a number of factors may increase risk of illicit use...

..Although a similar but muted nonsignificant association was found in older African Americans, the curves for the two groups were not significantly different. Further studies in older African Americans are needed...

..Policymakers will eventually need to confront the issue of the use of this and other markers in the pricing of long-term care insurance...

..To compare outcomes and the use of multimodality therapy in young and elderly people with pancreatic cancer undergoing surgical resection...

..Also included is a discussion of risk factors and outcomes of these disorders and a discussion of the implications of these epidemiologic findings for geriatric medicine...

..Individuals with comorbid PTSS and BPD demonstrate greater overall impairment and usage of health care resources...

..The link between spirituality and depressive symptoms is indirect. The relationship is mediated by optimism, volunteering, and social support. Findings present research and practice implications...

..The authors anticipated that BMI would predict depressive symptoms, and that this relationship would be greater among women, individuals of higher socioeconomic status (SES), and white subjects...

..Spirituality appears to be a psychosocial resource against depressive symptoms, although the results must be confirmed in longitudinal investigations...

..Our study focused on Center for Epidemiologic Studies' Depression Scale (CES-D) scores of pregnant black and white women...

..The authors examined racial differences in cognitive decline (CD) and the role of education and literacy in mediating this relationship...

..The authors examined the association between depressive symptoms and cognitive errors measured 3 years apart in a longitudinal sample of community-dwelling elderly persons...

..Finally, we suggest some future steps for clarifying this diagnostic confusion...

..The authors examined whether older adults respond comparably to two standard depression instruments rating symptoms by frequency/duration or degree of severity/"bother."..

..To determine whether self-reports of delayed care predict increased mortality and functional decline in community-dwelling elderly...