Research Topics
Species | John BeyerSummaryAffiliation: Duke University Medical Center Country: USA Publications
Research Grants
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Detail Information
Publications
An evidence-based medicine strategy for achieving remission in bipolar disorderJohn L Beyer
Duke Mood and Anxiety Disorder Clinic, Duke University Medical Center, Durham, NC 27710, USA
J Clin Psychiatry 69:31-7. 2008..The purpose of this article is to briefly summarize the clinical importance of remission in bipolar disorder and to review data on the effectiveness of available treatments for achieving and sustaining remission...- Medical comorbidity in a bipolar outpatient clinical populationJohn Beyer
Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA
Neuropsychopharmacology 30:401-4. 2005..In conclusion, comorbid medical illnesses are common in bipolar outpatients, increasing with age. HIV rates may be increased relative to population norms. Their presence compounds the severity of the illness at time of presentation... 
Hyperintense MRI lesions in bipolar disorder: A meta-analysis and reviewJohn L Beyer
Department of Psychiatry, Duke University Medical Center, Durham, North Carolina, USA
Int Rev Psychiatry 21:394-409. 2009..This study was conducted to use meta-analytic techniques to investigate the association of hyperintensities and bipolar illness and to evaluate the current state of the literature...- Patterns of pharmacotherapy and treatment response in elderly adults with bipolar disorderJohn L Beyer
Department of Psychiatry, Duke University Medical Center, Durham, NC, USA
Psychopharmacol Bull 41:102-14. 2008..This study assessed patterns of psychopharmacological treatment and treatment response in acutely ill, bipolar patients over the age of 60... - Volumetric brain imaging findings in mood disordersJohn L Beyer
Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA
Bipolar Disord 4:89-104. 2002..We review the findings for the various regions of the brain, and discuss the implications on the understanding of mood disorders. Directions for future research in volumetric imaging is then discussed... - Gray and white matter brain volumes in older adults with bipolar disorderJohn L Beyer
Duke University Medical Center, Department of Psychiatry and Behavioral Sciences, Neuropsychiatric Imaging Research Laboratory, USA
Int J Geriatr Psychiatry 24:1445-52. 2009..This study assessed the presence of gray matter volume, and the potential for regional volumetric differences in older adults with bipolar disorder... 
Stressful life events in older bipolar patientsJohn L Beyer
Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA
Int J Geriatr Psychiatry 23:1271-5. 2008..Few studies have examined SLE in older bipolar patients. We wanted to assess the impact of SLE in late life bipolar disorder..- Managing depression in geriatric populationsJohn L Beyer
Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA
Ann Clin Psychiatry 19:221-38. 2007..The last few years has witnessed an explosion in the research literature changing our understanding of this disease... - Prevalence of HIV infection in a general psychiatric outpatient populationJohn L Beyer
Duke University Medical Center, Department of Psychiatry, Durham, NC, USA
Psychosomatics 48:31-7. 2007..The major psychiatric diagnostic categories with a high prevalence of HIV infection were substance abuse disorders (5%), personality disorders (3.1%), bipolar disorders (2.6%), and posttraumatic stress disorder (2.1%)... - Volumetric brain imaging studies in the elderly with mood disordersJohn L Beyer
Curr Psychiatry Rep 8:18-24. 2006..This article reviews articles describing findings of volumetric analyses in elderly with unipolar depression and bipolar disorders, and compares and contrasts these findings with the larger volumetric research in affective disorders... - Cortical white matter microstructural abnormalities in bipolar disorderJohn L Beyer
Department of Psychiatry and Behavioral Science, Duke University Medical Center, Box 3519 DUMC, Durham, NC 27710, USA
Neuropsychopharmacology 30:2225-9. 2005..Further research is needed to better understand the interaction of microstructural changes and bipolar symptoms and whether these changes are specific to bipolar disorder... - Hippocampal volume measurement in older adults with bipolar disorderJohn L Beyer
Dept of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA
Am J Geriatr Psychiatry 12:613-20. 2004..Initial studies of mixed-aged bipolar subjects and controls have had conflicting findings, with most noting no difference; however this region has not been examined in older bipolar subjects... - Social support in elderly patients with bipolar disorderJohn L Beyer
Duke University Medical Center, Department of Psychiatry, Durham, NC 27710, USA
Bipolar Disord 5:22-7. 2003..Our purpose was to evaluate social support in older adults with bipolar disorder compared with peer controls and younger bipolar patients. In addition, we looked at the role of social support in the age of illness onset... - Caudate volume measurement in older adults with bipolar disorderJohn L Beyer
Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA
Int J Geriatr Psychiatry 19:109-14. 2004..No differences have been noted in initial studies of multi-aged bipolar subjects; however, this region has not been examined in older bipolar subjects... - The COMT Val158Met polymorphism and temporal lobe morphometry in healthy adultsWarren D Taylor
Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA
Psychiatry Res 155:173-7. 2007..5T brain MRI and genotyping. After controlling for demographics, Val158 allele homozygotes exhibited significantly smaller temporal lobe and hippocampal volumes, with a trend for smaller amygdala volumes... - Functional evidence implicating a novel TOR1A mutation in idiopathic, late-onset focal dystoniaNicole Calakos
Center for Translational Neuroscience, Box 2900, Research Dr, Duke University Medical Center, Durham, NC 27710, USA
J Med Genet 47:646-50. 2010..Because of the established role of the TOR1A gene in heritable generalised dystonia (DYT1), a potential genetic contribution of TOR1A to the more prevalent and diverse presentations of late onset, focal dystonia has been suggested... - Temporal lobe volume in bipolar disorder: relationship with diagnosis and antipsychotic medication useLindsay D Jones
The Neuropsychiatric Imaging Research Laboratory, Duke University, Durham, North Carolina, United States
J Affect Disord 114:50-7. 2009..We tested for differences in temporal lobe volume in bipolar disorder and the relationship between these volumes and psychotropic medication use... - Age-dependent reduction of amygdala volume in bipolar disorderTracy J Doty
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
Psychiatry Res 163:84-94. 2008..Differential aging effects in bipolar disorder may compromise amygdala integrity and contribute to mood dysregulation... - Methodology and preliminary results from the neurocognitive outcomes of depression in the elderly studyDavid C Steffens
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA
J Geriatr Psychiatry Neurol 17:202-11. 2004..These results are consistent with prior evidence linking depression and later dementia. Future studies are needed to examine neuroimaging and genetic, clinical, and social predictors of neurocognitive decline in depression... - Treatment of older adults with co-morbid personality disorder and depression: a dialectical behavior therapy approachThomas R Lynch
Cognitive Behavioral Research and Treatment Program, Department of Psychiatry and Behavioral Sciences, Duke University Medical Center Duke University, Box 3026, 2213 Elba Street, Durham, North Carolina 27710, USA
Int J Geriatr Psychiatry 22:131-43. 2007..It has also been demonstrated that personality disorders in older adults complicate treatment of other psychopathology, as well as result in heightened interpersonal disturbance and emotional distress... - Pharmacotherapy of bipolar disorder in old age: review and recommendationsRobert C Young
Payne Whitney, Westchester, and the Institute for Geriatric Psychiatry, Department of Psychiatry, Weill Medical College of Cornell University, 21 Bloomingdale Road, White Plains, New York 10605, USA
Am J Geriatr Psychiatry 12:342-57. 2004..Similarly, there are no systematic studies of the treatment of BP depression in elderly patients. The authors make suggestions for management and delineate priorities for research... - Medical comorbidity in bipolar disorder: re-prioritizing unmet needsRoger S McIntyre
Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
Curr Opin Psychiatry 20:406-16. 2007..The aim of this review is to synthesize results from extant investigations which report on the co-occurrence of bipolar disorder and medical comorbidity...
Research Grants
- BIPOLAR DISORDER IN LATE LIFEJohn Beyer; Fiscal Year: 2009..This research is unique and is likely to enhance our understanding of the phenomenology, course, outcome and relationship of MRI changes to the pathophysiology of bipolar disorder in late life. ..
- Acute and Continuation Treatment in Late Life ManiaJohn Beyer; Fiscal Year: 2007..The sites have a history of successful collaborative research, including demanding geriatric studies. ..