Elliott Bennett-Guerrero

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. doi request reprint A phase II multicenter double-blind placebo-controlled study of ethyl pyruvate in high-risk patients undergoing cardiac surgery with cardiopulmonary bypass
    Elliott Bennett-Guerrero
    Duke Clinical Research Institute, Duke University, Durham, NC 27710, USA
    J Cardiothorac Vasc Anesth 23:324-9. 2009
  2. ncbi request reprint Preoperative anti-PF4/heparin antibody level predicts adverse outcome after cardiac surgery
    Elliott Bennett-Guerrero
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    J Thorac Cardiovasc Surg 130:1567-72. 2005
  3. doi request reprint Variation in use of blood transfusion in coronary artery bypass graft surgery
    Elliott Bennett-Guerrero
    Division of Perioperative Clinical Research, Duke Clinical Research Institute, Duke University Medical Center, PO Box 3094, Durham, NC 27710, USA
    JAMA 304:1568-75. 2010
  4. ncbi request reprint A phase II, double-blind, placebo-controlled, ascending-dose study of Eritoran (E5564), a lipid A antagonist, in patients undergoing cardiac surgery with cardiopulmonary bypass
    Elliott Bennett-Guerrero
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    Anesth Analg 104:378-83. 2007
  5. doi request reprint Gentamicin-collagen sponge for infection prophylaxis in colorectal surgery
    Elliott Bennett-Guerrero
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27710, USA
    N Engl J Med 363:1038-49. 2010
  6. doi request reprint Effect of an implantable gentamicin-collagen sponge on sternal wound infections following cardiac surgery: a randomized trial
    Elliott Bennett-Guerrero
    Division of Perioperative Clinical Research, Duke Clinical Research Institute, Duke University Medical Center, PO Box 3094, Durham, NC 27710, USA
    JAMA 304:755-62. 2010
  7. doi request reprint A prospective, double-blind, randomized clinical feasibility trial of controlling the storage age of red blood cells for transfusion in cardiac surgical patients
    Elliott Bennett-Guerrero
    Department of Anesthesiology, Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27710, USA
    Transfusion 49:1375-83. 2009
  8. ncbi request reprint The role of endogenous kallikrein inhibition in perioperative transfusion and adverse outcome in cardiac surgical patients
    Catherine M N O'Malley
    Department of Anesthesiology, Columbia University College of Physicians and Surgeons, New York, NY, USA
    J Cardiothorac Vasc Anesth 21:23-7. 2007
  9. ncbi request reprint Preserved gastric tonometric variables in cardiac surgical patients administered intravenous perflubron emulsion
    Robert J Frumento
    Department of Anesthesiology, Columbia University College of Physicians and Surgeons, New York, New York 10032 3784, USA
    Anesth Analg 94:809-14, table of contents. 2002
  10. ncbi request reprint A head-to-head comparison of the in vitro coagulation effects of saline-based and balanced electrolyte crystalloid and colloid intravenous fluids
    Anthony M Roche
    Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Anesth Analg 102:1274-9. 2006

Research Grants

Detail Information

Publications42

  1. doi request reprint A phase II multicenter double-blind placebo-controlled study of ethyl pyruvate in high-risk patients undergoing cardiac surgery with cardiopulmonary bypass
    Elliott Bennett-Guerrero
    Duke Clinical Research Institute, Duke University, Durham, NC 27710, USA
    J Cardiothorac Vasc Anesth 23:324-9. 2009
    ..The purpose of this study was to assess the safety of EP administration to patients undergoing higher-risk cardiac surgery and to obtain preliminary efficacy data for the prevention of single and multisystem organ dysfunction...
  2. ncbi request reprint Preoperative anti-PF4/heparin antibody level predicts adverse outcome after cardiac surgery
    Elliott Bennett-Guerrero
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    J Thorac Cardiovasc Surg 130:1567-72. 2005
    ....
  3. doi request reprint Variation in use of blood transfusion in coronary artery bypass graft surgery
    Elliott Bennett-Guerrero
    Division of Perioperative Clinical Research, Duke Clinical Research Institute, Duke University Medical Center, PO Box 3094, Durham, NC 27710, USA
    JAMA 304:1568-75. 2010
    ..Perioperative blood transfusions are costly and have safety concerns. As a result, there have been multiple initiatives to reduce transfusion use. However, the degree to which perioperative transfusion rates vary among hospitals is unknown...
  4. ncbi request reprint A phase II, double-blind, placebo-controlled, ascending-dose study of Eritoran (E5564), a lipid A antagonist, in patients undergoing cardiac surgery with cardiopulmonary bypass
    Elliott Bennett-Guerrero
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    Anesth Analg 104:378-83. 2007
    ..In this study we assessed the safety of eritoran administration in patients undergoing cardiac surgery and obtained preliminary efficacy data for the prophylaxis of endotoxin-mediated surgical complications...
  5. doi request reprint Gentamicin-collagen sponge for infection prophylaxis in colorectal surgery
    Elliott Bennett-Guerrero
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27710, USA
    N Engl J Med 363:1038-49. 2010
    ..The gentamicin-collagen sponge, an implantable topical antibiotic agent, is approved for surgical implantation in 54 countries. Since 1985, more than 1 million patients have been treated with the sponges...
  6. doi request reprint Effect of an implantable gentamicin-collagen sponge on sternal wound infections following cardiac surgery: a randomized trial
    Elliott Bennett-Guerrero
    Division of Perioperative Clinical Research, Duke Clinical Research Institute, Duke University Medical Center, PO Box 3094, Durham, NC 27710, USA
    JAMA 304:755-62. 2010
    ..A large, 2-center, randomized trial in Sweden reported in 2005 that the sponge reduced surgical site infection by 50% in cardiac patients...
  7. doi request reprint A prospective, double-blind, randomized clinical feasibility trial of controlling the storage age of red blood cells for transfusion in cardiac surgical patients
    Elliott Bennett-Guerrero
    Department of Anesthesiology, Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27710, USA
    Transfusion 49:1375-83. 2009
    ..We studied the feasibility of two different schemes for categorizing and randomizing age of RBC units transfused in cardiac surgical patients...
  8. ncbi request reprint The role of endogenous kallikrein inhibition in perioperative transfusion and adverse outcome in cardiac surgical patients
    Catherine M N O'Malley
    Department of Anesthesiology, Columbia University College of Physicians and Surgeons, New York, NY, USA
    J Cardiothorac Vasc Anesth 21:23-7. 2007
    ..The goal of this study was to explore the relationship among endogenous plasma kallikrein inhibition (KI), perioperative bleeding, and adverse outcomes in cardiac surgery...
  9. ncbi request reprint Preserved gastric tonometric variables in cardiac surgical patients administered intravenous perflubron emulsion
    Robert J Frumento
    Department of Anesthesiology, Columbia University College of Physicians and Surgeons, New York, New York 10032 3784, USA
    Anesth Analg 94:809-14, table of contents. 2002
    ..007) shorter time to first bowel movement postoperatively (2.0 +/- 0.8 vs 5.4 +/- 1.6 days). Time to consumption of solid food was also shorter in the PFC group and almost achieved statistical significance (P = 0.056)...
  10. ncbi request reprint A head-to-head comparison of the in vitro coagulation effects of saline-based and balanced electrolyte crystalloid and colloid intravenous fluids
    Anthony M Roche
    Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Anesth Analg 102:1274-9. 2006
    ....
  11. pmc Impact of transfusion of autologous 7- versus 42-day-old AS-3 red blood cells on tissue oxygenation and the microcirculation in healthy volunteers
    Russell S Roberson
    Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Transfusion 52:2459-64. 2012
    ..Maximum storage duration is based on acceptable in vitro characteristics and 24-hour survival, but not RBC function. Relatively little is known about the impact of RBC storage duration on oxygenation and the microcirculation...
  12. ncbi request reprint The association between duration of storage of transfused red blood cells and morbidity and mortality after reoperative cardiac surgery
    Sukhjeewan Basran
    Department of Anesthesiology, College of Physicians and Surgeons of Columbia University, New York, USA
    Anesth Analg 103:15-20, table of contents. 2006
    ..The duration of storage of RBCs is associated with adverse outcome after repeat sternotomy for cardiac surgery. The clinical significance of this finding should be investigated in a large, randomized, blinded clinical trial...
  13. ncbi request reprint National survey regarding the management of an intraoperatively diagnosed patent foramen ovale during coronary artery bypass graft surgery
    Mikhail R Sukernik
    Department of Anesthesiology, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    J Cardiothorac Vasc Anesth 19:150-4. 2005
    ..This survey was designed to study potential differences in the management of intraoperatively diagnosed PFO...
  14. ncbi request reprint The association of complication type with mortality and prolonged stay after cardiac surgery with cardiopulmonary bypass
    Ian J Welsby
    Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Anesth Analg 94:1072-8. 2002
    ..05). Complications involving organs other than the heart appear to be more deleterious than cardiac complications alone, underscoring the need for strategies to reduce noncardiac complications...
  15. ncbi request reprint Intraoperative tachycardia and hypertension are independently associated with adverse outcome in noncardiac surgery of long duration
    David L Reich
    Department of Anesthesiology, Mount Sinai School of Medicine, New York, New York 10029, USA
    Anesth Analg 95:273-7, table of contents. 2002
    ..Thus, intraoperative tachycardia and hypertension were associated independently with adverse outcomes after major noncardiac surgery of long duration, over and above the risk imparted by underlying medical conditions...
  16. ncbi request reprint The kaolin-activated Thrombelastograph predicts bleeding after cardiac surgery
    Ian J Welsby
    Department of Anesthesiology, Division of Cardiothoracic Anesthesia and Critical Care Medicine, Duke University Medical Center, Durham, NC 27710, USA
    J Cardiothorac Vasc Anesth 20:531-5. 2006
    ....
  17. ncbi request reprint The incidental finding of a patent foramen ovale during cardiac surgery: should it always be repaired? A core review
    Mikhail R Sukernik
    Department of Anesthesiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA
    Anesth Analg 105:602-10. 2007
    ..The recent development of percutaneous methods of PFO closure provides a valuable backup for those cases when PFO is not closed and postoperative hypoxemia or other complications may be attributable to the uncorrected PFO...
  18. ncbi request reprint Differences in arterial and venous thromboelastography parameters: potential roles of shear stress and oxygen content
    Robert J Frumento
    Department of Anesthesiology, Columbia University College of Physicians and Surgeons, Columbia University, New York, NY 10032 3784, USA
    J Cardiothorac Vasc Anesth 16:551-4. 2002
    ..To investigate potential mechanisms for the differences in thromboelastography variables observed between arterial blood samples and venous blood samples...
  19. ncbi request reprint Thromboelastography maximum amplitude predicts postoperative thrombotic complications including myocardial infarction
    Douglas J McCrath
    Department of Anesthesiology, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Anesth Analg 100:1576-83. 2005
    ..A postoperative hypercoagulable state as determined by thromboelastography is associated with postoperative thrombotic complications, including MI, in a diverse group of surgical patients...
  20. ncbi request reprint A randomized, double-blind, placebo-controlled study assessing the anti-inflammatory effects of ketamine in cardiac surgical patients
    Cristian Bartoc
    Department of Anesthesiology, Columbia University College of Physicians and Surgeons, New York, NY 10032 3784, USA
    J Cardiothorac Vasc Anesth 20:217-22. 2006
    ..To determine whether ketamine administration affects markers of inflammation in cardiac surgery with cardiopulmonary bypass (CPB) and to investigate differences between 2 low-dose ketamine regimens...
  21. doi request reprint Efficacy and safety of pyridoxal 5'-phosphate (MC-1) in high-risk patients undergoing coronary artery bypass graft surgery: the MEND-CABG II randomized clinical trial
    John H Alexander
    Duke University Medical Center, Duke Clinical Research Institute, Durham, North Carolina 27715, USA
    JAMA 299:1777-87. 2008
    ..Phase 2 trial data suggest that MC-1 may reduce death or MI in high-risk patients undergoing CABG surgery...
  22. doi request reprint Hemodynamic impact of dexmedetomidine administration in 15,656 noncardiac surgical cases
    Rebecca Y Klinger
    Department of Anesthesiology, Duke University, Durham, NC 27710, USA
    J Clin Anesth 24:212-20. 2012
    ..To assess the hemodynamic impact of dexmedetomidine administration in a large cohort of patients undergoing routine noncardiac surgery...
  23. ncbi request reprint Effects of decreased preoperative endotoxin core antibody levels on long-term mortality after coronary artery bypass graft surgery
    Eugene W Moretti
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    Arch Surg 141:637-41; discussion 642. 2006
    ..Decreased preoperative levels of antiendotoxin core antibody (EndoCAb) in patients undergoing cardiac surgery with cardiopulmonary bypass are associated with increased long-term mortality...
  24. ncbi request reprint CASE 1--2004. Intraoperative diagnosis of a patent foramen ovale in a patient undergoing coronary artery bypass graft surgery
    Mikhail R Sukernik
    Department of Anesthesiology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    J Cardiothorac Vasc Anesth 18:101-6. 2004
  25. pmc Evolution of adverse changes in stored RBCs
    Elliott Bennett-Guerrero
    Department of Anesthesiology, Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 104:17063-8. 2007
    ....
  26. doi request reprint A randomized, double blind, placebo controlled clinical trial of the preoperative use of ketamine for reducing inflammation and pain after thoracic surgery
    Richard C D'Alonzo
    Department of Anesthesiology, Pitt Count Memorial Hospital, Greenville, NC 27858, USA
    J Anesth 25:672-8. 2011
    ..We hypothesized that patients who received ketamine during thoracic surgery would benefit from suppression of the inflammatory cascade, represented by lower interleukin (IL)-6 and C-reactive protein (CRP) plasma levels...
  27. ncbi request reprint Abnormal gastric tonometric variables and vasoconstrictor use after left ventricular assist device insertion
    Catherine M N O'Malley
    Department of Anesthesiology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Ann Thorac Surg 75:1886-91. 2003
    ..We sought to determine whether gastric tonometric variables deteriorate after left ventricular assist device insertion and to explore the association between abnormal gastric tonometric variables and vasoconstrictor use...
  28. doi request reprint Multinational institutional survey on patterns of intraoperative transesophageal echocardiography use in adult cardiac surgery
    Heather A Dobbs
    Division of Cardiothoracic Anesthesiology and Critical Care Medicine, Department of Anesthesiology, Duke University Medical Center, Durham, NC
    J Cardiothorac Vasc Anesth 28:54-63. 2014
    ..To assess institutional patterns of perioperative transesophageal echocardiography (TEE) usage...
  29. pmc Impact of red blood cell transfusion on global and regional measures of oxygenation
    Russell S Roberson
    Department of Anesthesiology, Duke University Medical Center, Durham, NC, USA
    Mt Sinai J Med 79:66-74. 2012
    ..This article will review fundamental aspects of oxygen delivery and extraction, and the effects of red blood cell transfusion on tissue oxygenation as well as the microcirculation...
  30. ncbi request reprint Pilot study of sternal plating for primary closure of the sternum in cardiac surgical patients
    Elliott Bennett-Guerrero
    From the Duke Clinical Research Institute, Duke University, Durham, NC USA Department of Anesthesiology and Division of Cardiothoracic Surgery, Duke University Medical Center, Durham, NC USA and Oklahoma Heart Institute, Hillcrest Medical Center, Tulsa, OK USA
    Innovations (Phila) 6:382-8. 2011
    ..The rapid sternal closure system (Talon) is approved for stabilization and fixation of the anterior chest wall. Anecdotal evidence suggests that use of the Talon may result in improved postoperative recovery...
  31. ncbi request reprint Calcium supplementation of saline-based colloids does not produce equivalent coagulation profiles to similarly balanced salt preparations
    Anthony M Roche
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    J Cardiothorac Vasc Anesth 20:807-11. 2006
    ..The primary objective of this study was to test the hypothesis that calcium alone does not account for the observed coagulation differences between saline-based and balanced electrolyte IV fluid preparations...
  32. ncbi request reprint Unplanned left ventricular assist device insertion after elective low-risk off-pump coronary artery revascularization
    Sumeet Goswami
    Department of Anesthesiology, Columbia University College of Physicians and Surgeons, New York, NY, USA
    J Cardiothorac Vasc Anesth 17:499-501. 2003
  33. doi request reprint Impact of heart failure on patients undergoing major noncardiac surgery
    Bradley G Hammill
    Center for Clinical and Genetic Economics, Duke Clinical Research Institute, Durham, North Carolina, USA
    Anesthesiology 108:559-67. 2008
    ..The authors evaluated short-term outcomes among patients with heart failure, coronary artery disease (CAD), or neither who underwent major noncardiac surgery...
  34. ncbi request reprint Stroke after cardiac surgery: a retrospective analysis of the effect of aprotinin dosing regimens
    Robert J Frumento
    Department of Anesthesiology, Columbia University College of Physicians and Surgeons, New York, New York 10032 3784, USA
    Ann Thorac Surg 75:479-83; discussion 483-4. 2003
    ..Therefore, we performed a retrospective study in cardiac surgery patients at high risk for developing stroke to determine the relative effects of FDA and HDA regimens on the incidence of postoperative stroke...
  35. ncbi request reprint Pro: robotically-assisted CABG is the optimal treatment for coronary artery disease
    Maxim V Bashkirov
    Department of Anesthesiology, Columbia University College of Physicians and Surgeons, New York, NY, USA
    J Cardiothorac Vasc Anesth 17:546-8. 2003
  36. ncbi request reprint Comparison of arterial systolic pressure variation with other clinical parameters to predict the response to fluid challenges during cardiac surgery
    Elliott Bennett-Guerrero
    Department of Anesthesiology, Columbia University College of Physicians and Surgeons, 630 W 168th Street PH5 505, New York, NY 10032, USA
    Mt Sinai J Med 69:96-100. 2002
    ..There is a relationship between SPV and SPVdown values and intravascular volume status. SPV and echocardiographic-derived values did not predict the response to a fluid bolus as well as values obtained from the pulmonary artery catheter...
  37. ncbi request reprint A randomized, double-blind comparison of lactated Ringer's solution and 0.9% NaCl during renal transplantation
    Catherine M N O'Malley
    Department of Anesthesia, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Anesth Analg 100:1518-24, table of contents. 2005
    ..004). NS did not adversely affect renal function. LR was associated with less hyperkalemia and acidosis compared with NS. LR may be a safe choice for IV fluid therapy in patients undergoing kidney transplantation...
  38. ncbi request reprint Low-dose endotoxin elicits variability in the inflammatory response in healthy volunteers
    Robert C M Stephens
    Institute of Child Health, London, UK
    J Endotoxin Res 11:207-12. 2005
    ..We conclude that low-dose endotoxin elicits inter-individual variability in inflammation and could be used to test factors that may affect the human response to endotoxin...
  39. ncbi request reprint Structure and function of lipopolysaccharides
    Clett Erridge
    Medical Microbiology, University of Edinburgh Medical School, Edinburgh, Scotland, EH8 9AG, UK
    Microbes Infect 4:837-51. 2002
    ..Consideration is given in this review to the relationship between structure and function of these lipopolysaccharides...
  40. ncbi request reprint Gastric hypercarbia and adverse outcome after cardiac surgery
    Minoo N Kavarana
    Division Cardiothoracic Surgery, Columbia University College of Physicians and Surgeons, 630 West 168 Street, New York, NY 10032, USA
    Intensive Care Med 29:742-8. 2003
    ..This study examined whether gastric PCO(2) values are associated with adverse outcome in cardiac surgical patients...
  41. ncbi request reprint Perioperative blood transfusion and blood conservation in cardiac surgery: the Society of Thoracic Surgeons and The Society of Cardiovascular Anesthesiologists clinical practice guideline
    Victor A Ferraris
    Ann Thorac Surg 83:S27-86. 2007
    ..Blood must be viewed as a scarce resource that carries risks and benefits. A careful review of available evidence can provide guidelines to allocate this valuable resource and improve patient outcomes...
  42. ncbi request reprint Hydroxyethyl starch in balanced electrolyte solution (Hextend)--pharmacokinetic and pharmacodynamic profiles in healthy volunteers
    Nicholas J Wilkes
    Centre for Anaesthesia, Royal Free and University College London School of Medicine, London, UK
    Anesth Analg 94:538-44; table of contents. 2002
    ..Some hemostatic indices showed moderate changes, and serum amylase demonstrated a temporary increase. Our study suggested that Hextend has pharmacokinetic and pharmacodynamic profiles that are similar to those of other HES...

Research Grants1

  1. Impact of Blood Storage Duration on Physiologic Measures: RECESS Ancillary Study
    CHRISTOPHER PUTNAM STOWELL; Fiscal Year: 2010
    ..The proposed ancillary study will provide important new information on whether longer storage duration of RBCs has a negative impact on tissue oxygenation and blood flow at the level of the microcirculation. ..