Research Topics
| Elliott Bennett-GuerreroSummaryAffiliation: Duke University Medical Center Country: USA Publications
Research Grants
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Detail Information
Publications
Variation in use of blood transfusion in coronary artery bypass graft surgeryElliott Bennett-Guerrero
Division of Perioperative Clinical Research, Duke Clinical Research Institute, Duke University Medical Center, PO Box 3094, Durham, NC 27710, USA
JAMA 304:1568-75. 2010..Perioperative blood transfusions are costly and have safety concerns. As a result, there have been multiple initiatives to reduce transfusion use. However, the degree to which perioperative transfusion rates vary among hospitals is unknown...- A prospective, double-blind, randomized clinical feasibility trial of controlling the storage age of red blood cells for transfusion in cardiac surgical patientsElliott Bennett-Guerrero
Department of Anesthesiology, Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27710, USA
Transfusion 49:1375-83. 2009..We studied the feasibility of two different schemes for categorizing and randomizing age of RBC units transfused in cardiac surgical patients... - Effect of an implantable gentamicin-collagen sponge on sternal wound infections following cardiac surgery: a randomized trialElliott Bennett-Guerrero
Division of Perioperative Clinical Research, Duke Clinical Research Institute, Duke University Medical Center, PO Box 3094, Durham, NC 27710, USA
JAMA 304:755-62. 2010..A large, 2-center, randomized trial in Sweden reported in 2005 that the sponge reduced surgical site infection by 50% in cardiac patients... 
A phase II, double-blind, placebo-controlled, ascending-dose study of Eritoran (E5564), a lipid A antagonist, in patients undergoing cardiac surgery with cardiopulmonary bypassElliott Bennett-Guerrero
Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
Anesth Analg 104:378-83. 2007..In this study we assessed the safety of eritoran administration in patients undergoing cardiac surgery and obtained preliminary efficacy data for the prophylaxis of endotoxin-mediated surgical complications...- A phase II multicenter double-blind placebo-controlled study of ethyl pyruvate in high-risk patients undergoing cardiac surgery with cardiopulmonary bypassElliott Bennett-Guerrero
Duke Clinical Research Institute, Duke University, Durham, NC 27710, USA
J Cardiothorac Vasc Anesth 23:324-9. 2009..The purpose of this study was to assess the safety of EP administration to patients undergoing higher-risk cardiac surgery and to obtain preliminary efficacy data for the prevention of single and multisystem organ dysfunction... - Preoperative anti-PF4/heparin antibody level predicts adverse outcome after cardiac surgeryElliott Bennett-Guerrero
Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
J Thorac Cardiovasc Surg 130:1567-72. 2005..We sought to determine the association between preoperative serum antibodies directed against platelet factor 4/heparin complexes and major complications (in-hospital death or length of stay >10 days) in adult cardiac surgical patients... - Gentamicin-collagen sponge for infection prophylaxis in colorectal surgeryElliott Bennett-Guerrero
Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27710, USA
N Engl J Med 363:1038-49. 2010..The gentamicin-collagen sponge, an implantable topical antibiotic agent, is approved for surgical implantation in 54 countries. Since 1985, more than 1 million patients have been treated with the sponges... - Preserved gastric tonometric variables in cardiac surgical patients administered intravenous perflubron emulsionRobert J Frumento
Department of Anesthesiology, Columbia University College of Physicians and Surgeons, New York, New York 10032 3784, USA
Anesth Analg 94:809-14, table of contents. 2002..056). IMPLICATIONS: This study suggests that the administration of perflubron emulsion prevents gastrointestinal tract ischemia in cardiac surgical patients and may preserve postoperative gastrointestinal tract function... - The role of endogenous kallikrein inhibition in perioperative transfusion and adverse outcome in cardiac surgical patientsRobert J Frumento
Department of Anesthesiology, Columbia University College of Physicians and Surgeons, New York, NY, USA
J Cardiothorac Vasc Anesth 21:23-7. 2007..The goal of this study was to explore the relationship among endogenous plasma kallikrein inhibition (KI), perioperative bleeding, and adverse outcomes in cardiac surgery... - A head-to-head comparison of the in vitro coagulation effects of saline-based and balanced electrolyte crystalloid and colloid intravenous fluidsAnthony M Roche
Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
Anesth Analg 102:1274-9. 2006.... 
Impact of transfusion of autologous 7- versus 42-day-old AS-3 red blood cells on tissue oxygenation and the microcirculation in healthy volunteersRussell S Roberson
Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
Transfusion 52:2459-64. 2012..Maximum storage duration is based on acceptable in vitro characteristics and 24-hour survival, but not RBC function. Relatively little is known about the impact of RBC storage duration on oxygenation and the microcirculation...- National survey regarding the management of an intraoperatively diagnosed patent foramen ovale during coronary artery bypass graft surgeryMikhail R Sukernik
Department of Anesthesiology, College of Physicians and Surgeons, Columbia University, New York, NY, USA
J Cardiothorac Vasc Anesth 19:150-4. 2005..This survey was designed to study potential differences in the management of intraoperatively diagnosed PFO... - The association between duration of storage of transfused red blood cells and morbidity and mortality after reoperative cardiac surgerySukhjeewan Basran
Department of Anesthesiology, College of Physicians and Surgeons of Columbia University, New York, USA
Anesth Analg 103:15-20, table of contents. 2006..The duration of storage of RBCs is associated with adverse outcome after repeat sternotomy for cardiac surgery. The clinical significance of this finding should be investigated in a large, randomized, blinded clinical trial... - The association of complication type with mortality and prolonged stay after cardiac surgery with cardiopulmonary bypassIan J Welsby
Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
Anesth Analg 94:1072-8. 2002..Strategies aimed at preventing damage to other organs during cardiac surgery need to be improved... - Intraoperative tachycardia and hypertension are independently associated with adverse outcome in noncardiac surgery of long durationDavid L Reich
Department of Anesthesiology, Mount Sinai School of Medicine, New York, New York 10029, USA
Anesth Analg 95:273-7, table of contents. 2002..These results imply that intraoperative tachycardia and hypertension may have independent effects on outcome over and above the risk imparted by underlying medical conditions... - The incidental finding of a patent foramen ovale during cardiac surgery: should it always be repaired? A core reviewMikhail R Sukernik
Department of Anesthesiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA
Anesth Analg 105:602-10. 2007..The recent development of percutaneous methods of PFO closure provides a valuable backup for those cases when PFO is not closed and postoperative hypoxemia or other complications may be attributable to the uncorrected PFO... - Differences in arterial and venous thromboelastography parameters: potential roles of shear stress and oxygen contentRobert J Frumento
Department of Anesthesiology, Columbia University College of Physicians and Surgeons, Columbia University, New York, NY 10032 3784, USA
J Cardiothorac Vasc Anesth 16:551-4. 2002..To investigate potential mechanisms for the differences in thromboelastography variables observed between arterial blood samples and venous blood samples... - The kaolin-activated Thrombelastograph predicts bleeding after cardiac surgeryIan J Welsby
Department of Anesthesiology, Division of Cardiothoracic Anesthesia and Critical Care Medicine, Duke University Medical Center, Durham, NC 27710, USA
J Cardiothorac Vasc Anesth 20:531-5. 2006.... - Thromboelastography maximum amplitude predicts postoperative thrombotic complications including myocardial infarctionDouglas J McCrath
Department of Anesthesiology, Columbia University College of Physicians and Surgeons, New York, NY, USA
Anesth Analg 100:1576-83. 2005..A postoperative hypercoagulable state as determined by thromboelastography is associated with postoperative thrombotic complications, including MI, in a diverse group of surgical patients... - A randomized, double-blind, placebo-controlled study assessing the anti-inflammatory effects of ketamine in cardiac surgical patientsCristian Bartoc
Department of Anesthesiology, Columbia University College of Physicians and Surgeons, New York, NY 10032-3784, USA
J Cardiothorac Vasc Anesth 20:217-22. 2006..05). CONCLUSION: Low-dose ketamine (0.5 mg/kg) attenuates increases in CRP, IL-6, and IL-10 while decreasing vasodilatation after CPB... - Hemodynamic impact of dexmedetomidine administration in 15,656 noncardiac surgical casesRebecca Y Klinger
Department of Anesthesiology, Duke University, Durham, NC 27710, USA
J Clin Anesth 24:212-20. 2012..To assess the hemodynamic impact of dexmedetomidine administration in a large cohort of patients undergoing routine noncardiac surgery... - Effects of decreased preoperative endotoxin core antibody levels on long-term mortality after coronary artery bypass graft surgeryEugene W Moretti
Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
Arch Surg 141:637-41; discussion 642. 2006..Decreased preoperative levels of antiendotoxin core antibody (EndoCAb) in patients undergoing cardiac surgery with cardiopulmonary bypass are associated with increased long-term mortality... - Evolution of adverse changes in stored RBCsElliott Bennett Guerrero
Department of Anesthesiology, Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27710, USA
Proc Natl Acad Sci U S A 104:17063-8. 2007.... - CASE 1--2004. Intraoperative diagnosis of a patent foramen ovale in a patient undergoing coronary artery bypass graft surgeryMikhail R Sukernik
Department of Anesthesiology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
J Cardiothorac Vasc Anesth 18:101-6. 2004 - A randomized, double blind, placebo controlled clinical trial of the preoperative use of ketamine for reducing inflammation and pain after thoracic surgeryRichard C D'Alonzo
Department of Anesthesiology, Pitt Count Memorial Hospital, Greenville, NC 27858, USA
J Anesth 25:672-8. 2011..We hypothesized that patients who received ketamine during thoracic surgery would benefit from suppression of the inflammatory cascade, represented by lower interleukin (IL)-6 and C-reactive protein (CRP) plasma levels... - Abnormal gastric tonometric variables and vasoconstrictor use after left ventricular assist device insertionCatherine M N O'Malley
Department of Anesthesiology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
Ann Thorac Surg 75:1886-91. 2003..We sought to determine whether gastric tonometric variables deteriorate after left ventricular assist device insertion and to explore the association between abnormal gastric tonometric variables and vasoconstrictor use... - Efficacy and safety of pyridoxal 5'-phosphate (MC-1) in high-risk patients undergoing coronary artery bypass graft surgery: the MEND-CABG II randomized clinical trialJohn H Alexander
Duke University Medical Center, Duke Clinical Research Institute, Durham, North Carolina 27715, USA
JAMA 299:1777-87. 2008..Phase 2 trial data suggest that MC-1 may reduce death or MI in high-risk patients undergoing CABG surgery... - Impact of red blood cell transfusion on global and regional measures of oxygenationRussell S Roberson
Department of Anesthesiology, Duke University Medical Center, Durham, NC, USA
Mt Sinai J Med 79:66-74. 2012..This article will review fundamental aspects of oxygen delivery and extraction, and the effects of red blood cell transfusion on tissue oxygenation as well as the microcirculation... - Pilot study of sternal plating for primary closure of the sternum in cardiac surgical patientsElliott Bennett-Guerrero
From the Duke Clinical Research Institute, Duke University, Durham, NC USA Department of Anesthesiology and Division of Cardiothoracic Surgery, Duke University Medical Center, Durham, NC USA and Oklahoma Heart Institute, Hillcrest Medical Center, Tulsa, OK USA
Innovations (Phila) 6:382-8. 2011..The rapid sternal closure system (Talon) is approved for stabilization and fixation of the anterior chest wall. Anecdotal evidence suggests that use of the Talon may result in improved postoperative recovery... - Unplanned left ventricular assist device insertion after elective low-risk off-pump coronary artery revascularizationSumeet Goswami
Department of Anesthesiology, Columbia University College of Physicians and Surgeons, New York, NY, USA
J Cardiothorac Vasc Anesth 17:499-501. 2003 - Calcium supplementation of saline-based colloids does not produce equivalent coagulation profiles to similarly balanced salt preparationsAnthony M Roche
Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
J Cardiothorac Vasc Anesth 20:807-11. 2006..The primary objective of this study was to test the hypothesis that calcium alone does not account for the observed coagulation differences between saline-based and balanced electrolyte IV fluid preparations... - Comparison of arterial systolic pressure variation with other clinical parameters to predict the response to fluid challenges during cardiac surgeryElliott Bennett-Guerrero
Department of Anesthesiology, Columbia University College of Physicians and Surgeons, 630 W. 168th Street (PH5-505, New York, NY 10032, USA
Mt Sinai J Med 69:96-100. 2002..There is a relationship between SPV and SPVdown values and intravascular volume status. SPV and echocardiographic-derived values did not predict the response to a fluid bolus as well as values obtained from the pulmonary artery catheter... - Stroke after cardiac surgery: a retrospective analysis of the effect of aprotinin dosing regimensRobert J Frumento
Department of Anesthesiology, Columbia University College of Physicians and Surgeons, New York, New York 10032 3784, USA
Ann Thorac Surg 75:479-83; discussion 483-4. 2003..Therefore, we performed a retrospective study in cardiac surgery patients at high risk for developing stroke to determine the relative effects of FDA and HDA regimens on the incidence of postoperative stroke... - Impact of heart failure on patients undergoing major noncardiac surgeryBradley G Hammill
Center for Clinical and Genetic Economics, Duke Clinical Research Institute, Durham, North Carolina, USA
Anesthesiology 108:559-67. 2008..The authors evaluated short-term outcomes among patients with heart failure, coronary artery disease (CAD), or neither who underwent major noncardiac surgery... - Pro: robotically-assisted CABG is the optimal treatment for coronary artery diseaseMaxim V Bashkirov
Department of Anesthesiology, Columbia University College of Physicians and Surgeons, New York, NY, USA
J Cardiothorac Vasc Anesth 17:546-8. 2003 - Low-dose endotoxin elicits variability in the inflammatory response in healthy volunteersRobert C M Stephens
Institute of Child Health, London, UK
J Endotoxin Res 11:207-12. 2005..We conclude that low-dose endotoxin elicits inter-individual variability in inflammation and could be used to test factors that may affect the human response to endotoxin... - A randomized, double-blind comparison of lactated Ringer's solution and 0.9% NaCl during renal transplantationCatherine M N O'Malley
Department of Anesthesia, Columbia University College of Physicians and Surgeons, New York, NY, USA
Anesth Analg 100:1518-24, table of contents. 2005..004). NS did not adversely affect renal function. LR was associated with less hyperkalemia and acidosis compared with NS. LR may be a safe choice for IV fluid therapy in patients undergoing kidney transplantation... - Gastric hypercarbia and adverse outcome after cardiac surgeryMinoo N Kavarana
Division Cardiothoracic Surgery, Columbia University College of Physicians and Surgeons, 630 West 168 Street, New York, NY 10032, USA
Intensive Care Med 29:742-8. 2003.... - Hydroxyethyl starch in balanced electrolyte solution (Hextend)--pharmacokinetic and pharmacodynamic profiles in healthy volunteersNicholas J Wilkes
Centre for Anaesthesia, Royal Free and University College London School of Medicine, London, UK
Anesth Analg 94:538-44; table of contents. 2002..This open-label volunteer study demonstrated that it has pharmacokinetic and pharmacodynamic profiles similar to those of established HES... - Structure and function of lipopolysaccharidesClett Erridge
Medical Microbiology, University of Edinburgh Medical School, Edinburgh, Scotland, EH8 9AG, UK
Microbes Infect 4:837-51. 2002..Consideration is given in this review to the relationship between structure and function of these lipopolysaccharides... - Perioperative blood transfusion and blood conservation in cardiac surgery: the Society of Thoracic Surgeons and The Society of Cardiovascular Anesthesiologists clinical practice guidelineVictor A Ferraris
Ann Thorac Surg 83:S27-86. 2007....
Research Grants
- Impact of Blood Storage Duration on Physiologic Measures: RECESS Ancillary StudyCHRISTOPHER PUTNAM STOWELL; Fiscal Year: 2010..The proposed ancillary study will provide important new information on whether longer storage duration of RBCs has a negative impact on tissue oxygenation and blood flow at the level of the microcirculation. ..