Daniel K Benjamin

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. ncbi request reprint Candida endocarditis: contemporary cases from the International Collaboration of Infectious Endocarditis Merged Database (ICE-mD)
    Daniel K Benjamin
    Department of Pediatrics, Duke University, Durham, NC, USA
    Scand J Infect Dis 36:453-5. 2004
  2. pmc Triazole use in the nursery: fluconazole, voriconazole, posaconazole, and ravuconazole
    Kevin Watt
    Duke University, Pediatrics, Duke Clinical Research Institute, P O Box 17969, Durham, NC 27715, USA
    Curr Drug Metab 14:193-202. 2013
  3. ncbi request reprint Empirical therapy for neonatal candidemia in very low birth weight infants
    Daniel K Benjamin
    Department of Pediatrics, Duke University, Durham, North Carolina, USA
    Pediatrics 112:543-7. 2003
  4. ncbi request reprint Latent class analysis: an illustrative application for education in the assessment of resident otoscopic skills
    Daniel K Benjamin
    Duke University Medical Center Department of Pediatrics, Duke Clinical Research Institute, Durham, NC 27715, USA
    Ambul Pediatr 4:13-7. 2004
  5. ncbi request reprint A blinded, randomized, multicenter study of an intravenous Staphylococcus aureus immune globulin
    D K Benjamin
    Duke University Department of Pediatrics, Durham, NC 27710, USA
    J Perinatol 26:290-5. 2006
  6. pmc Safety and transparency of pediatric drug trials
    Daniel K Benjamin
    Department of Pediatrics, Duke Clinical Research Institute, Duke University, Durham, North Carolina, USA
    Arch Pediatr Adolesc Med 163:1080-6. 2009
  7. ncbi request reprint Neonatal candidiasis among extremely low birth weight infants: risk factors, mortality rates, and neurodevelopmental outcomes at 18 to 22 months
    Daniel K Benjamin
    Department of Pediatrics, Duke Clinical Research Institute, Duke University, Durham, North Carolina, USA
    Pediatrics 117:84-92. 2006
  8. ncbi request reprint Growth patterns reflect response to antiretroviral therapy in HIV-positive infants: potential utility in resource-poor settings
    D K Benjamin
    Duke Clinical Research Institute, Durham, North Carolina 27715, USA
    AIDS Patient Care STDS 18:35-43. 2004
  9. pmc Safety of micafungin in infants: insights into optimal dosing
    Simon Ascher
    Duke University, Department of Pediatrics, 2400 Pratt St, Durham, NC 27715, USA
    Expert Opin Drug Saf 10:281-6. 2011
  10. pmc Safety and pharmacokinetics of repeat-dose micafungin in young infants
    D K Benjamin
    Department of Pediatrics and Duke Clinical Research Institute, Duke University, Durham, North Carolina, USA
    Clin Pharmacol Ther 87:93-9. 2010

Detail Information

Publications121 found, 100 shown here

  1. ncbi request reprint Candida endocarditis: contemporary cases from the International Collaboration of Infectious Endocarditis Merged Database (ICE-mD)
    Daniel K Benjamin
    Department of Pediatrics, Duke University, Durham, NC, USA
    Scand J Infect Dis 36:453-5. 2004
    ..We evaluated 16 patients with Candida IE nested within a cohort of 2,022 patients with IE. Prosthetic valve IE was more common in patients with Candida (50% vs 17%); mortality was 37% for patients with Candida...
  2. pmc Triazole use in the nursery: fluconazole, voriconazole, posaconazole, and ravuconazole
    Kevin Watt
    Duke University, Pediatrics, Duke Clinical Research Institute, P O Box 17969, Durham, NC 27715, USA
    Curr Drug Metab 14:193-202. 2013
    ..Related to this class, future research is needed in order to better assess dosing, safety, schedules and areas of use of these agents in infants admitted to the neonatal intensive care unit...
  3. ncbi request reprint Empirical therapy for neonatal candidemia in very low birth weight infants
    Daniel K Benjamin
    Department of Pediatrics, Duke University, Durham, North Carolina, USA
    Pediatrics 112:543-7. 2003
    ..Although guidelines for empirical therapy exist for patients with fever and neutropenia, these do not exist for neonates...
  4. ncbi request reprint Latent class analysis: an illustrative application for education in the assessment of resident otoscopic skills
    Daniel K Benjamin
    Duke University Medical Center Department of Pediatrics, Duke Clinical Research Institute, Durham, NC 27715, USA
    Ambul Pediatr 4:13-7. 2004
    ..This is one reason why the otoscopic examination is difficult to teach. Available techniques can assess diagnostic exams when there is no gold standard-one of these is latent class analysis...
  5. ncbi request reprint A blinded, randomized, multicenter study of an intravenous Staphylococcus aureus immune globulin
    D K Benjamin
    Duke University Department of Pediatrics, Durham, NC 27710, USA
    J Perinatol 26:290-5. 2006
    ..aureus infections are caused by capsular polysaccharide (CPS) types 5 and 8. Altastaph is a polyclonal investigational human immunoglobulin G (IgG) with high levels of opsonizing S. aureus CPS types 5 and 8 IgG...
  6. pmc Safety and transparency of pediatric drug trials
    Daniel K Benjamin
    Department of Pediatrics, Duke Clinical Research Institute, Duke University, Durham, North Carolina, USA
    Arch Pediatr Adolesc Med 163:1080-6. 2009
    ....
  7. ncbi request reprint Neonatal candidiasis among extremely low birth weight infants: risk factors, mortality rates, and neurodevelopmental outcomes at 18 to 22 months
    Daniel K Benjamin
    Department of Pediatrics, Duke Clinical Research Institute, Duke University, Durham, North Carolina, USA
    Pediatrics 117:84-92. 2006
    ..Neonatal candidiasis is associated with substantial morbidity and mortality rates. Neurodevelopmental follow-up data for a large multicenter cohort have not been reported...
  8. ncbi request reprint Growth patterns reflect response to antiretroviral therapy in HIV-positive infants: potential utility in resource-poor settings
    D K Benjamin
    Duke Clinical Research Institute, Durham, North Carolina 27715, USA
    AIDS Patient Care STDS 18:35-43. 2004
    ..The model was most pertinent to children 36 months of age or younger, and was conducted in children receiving monotherapy and dual therapy...
  9. pmc Safety of micafungin in infants: insights into optimal dosing
    Simon Ascher
    Duke University, Department of Pediatrics, 2400 Pratt St, Durham, NC 27715, USA
    Expert Opin Drug Saf 10:281-6. 2011
    ..Understanding micafungin safety in infants is particularly important because antifungals are most often used in premature infants with multiple underlying medical conditions in a critical care setting...
  10. pmc Safety and pharmacokinetics of repeat-dose micafungin in young infants
    D K Benjamin
    Department of Pediatrics and Duke Clinical Research Institute, Duke University, Durham, North Carolina, USA
    Clin Pharmacol Ther 87:93-9. 2010
    ..These data suggest that micafungin dosages of 7 and 10 mg/kg/day are well tolerated and provide exposure levels that have been shown (in animal models) to be adequate for central nervous system coverage...
  11. ncbi request reprint Growth as a part of the composite endpoint in paediatric antiretroviral clinical trials
    Daniel K Benjamin
    Department of Pediatrics, Duke University, Durham, NC, USA
    J Antimicrob Chemother 54:701-3. 2004
    ....
  12. ncbi request reprint Candida bloodstream infection in neonates
    Daniel K Benjamin
    Department of Pediatrics, Duke University, Durham, NC, USA
    Semin Perinatol 27:375-83. 2003
    ....
  13. pmc Peer-reviewed publication of clinical trials completed for pediatric exclusivity
    Daniel K Benjamin
    Office of Pediatric Therapeutics, Office of the Commissioner, US Food and Drug Administration, Rockville, MD, USA
    JAMA 296:1266-73. 2006
    ..As a result, there have been over 100 product labeling changes. The publication status of studies completed for pediatric exclusivity has not been evaluated...
  14. ncbi request reprint Neonatal candidemia and end-organ damage: a critical appraisal of the literature using meta-analytic techniques
    Daniel K Benjamin
    Department of Pediatrics, Duke University, Durham, North Carolina, USA
    Pediatrics 112:634-40. 2003
    ..We evaluated the current medical literature in an effort to critique the literature and to document the reported prevalences of end-organ damage after neonatal candidemia...
  15. pmc First, do no harm
    Daniel K Benjamin
    Department of Pediatrics, Duke University, Duke Clinical Research Institute, PO Box 17969, Durham, NC 27715, USA
    Pediatrics 121:831-2. 2008
  16. pmc Pediatric antihypertensive trial failures: analysis of end points and dose range
    Daniel K Benjamin
    Office of Pediatric Therapeutics, US Food and Drug Administration, Rockville, MD, USA
    Hypertension 51:834-40. 2008
    ..More importantly, our ability to combine data across trials allowed us to evaluate and potentially improve trial design...
  17. ncbi request reprint Integration of statistical theory and practical clinical expertise. Polymerase chain reaction testing of the HIV-exposed infant
    D K Benjamin
    Duke University Medical Center, Department of Pediatrics, Duke Clinical Research Institute, Durham, NC, USA
    Minerva Pediatr 54:105-11. 2002
    ..Any positive PCR test requires virologic confirmation and serologic follow-up...
  18. ncbi request reprint Infection in late preterm infants
    Daniel K Benjamin
    Department of Pediatrics, Duke Clinical Research Institute, Duke University, Durham, NC 27705, USA
    Clin Perinatol 33:871-82; abstract x. 2006
    ..This article discusses infections that might be seen in this population and gives options for diagnosis and treatment...
  19. pmc Neonatal candidiasis: epidemiology, risk factors, and clinical judgment
    Daniel K Benjamin
    Department of Pediatrics, Duke University, Duke Clinical Research Institute, 2400 Pratt St, Durham, NC 27705, USA
    Pediatrics 126:e865-73. 2010
    ..We quantified risk factors that predict infection in premature infants at high risk and compared clinical judgment with a prediction model of invasive candidiasis...
  20. pmc Center variation in patient age and weight at Fontan operation and impact on postoperative outcomes
    Michelle C Wallace
    Department of Pediatrics, Duke University School of Medicine, Durham, North Carolina 27715, USA
    Ann Thorac Surg 91:1445-52. 2011
    ..We evaluated variation in age, weight, and weight-for-age z-score at Fontan across institutions, and the impact of these variables on postoperative morbidity and mortality...
  21. pmc Group B streptococcal meningitis: cerebrospinal fluid parameters in the era of intrapartum antibiotic prophylaxis
    Annette K Ansong
    Department of Pediatrics, Duke University, Durham, North Carolina, USA
    Early Hum Dev 85:S5-7. 2009
    ..Describe cerebrospinal fluid parameters in infants with culture-proven Group B streptococcal meningitis in the era of intrapartum antibiotic prophylaxis...
  22. pmc Group B Streptococcus and Escherichia coli infections in the intensive care nursery in the era of intrapartum antibiotic prophylaxis
    Melissa S Bauserman
    School of Medicine, Division of Neonatal Perinatal Medicine, University of North Carolina, Chapel Hill, NC, USA
    Pediatr Infect Dis J 32:208-12. 2013
    ..Intrapartum antibiotic prophylaxis reduces early-onset SBIs caused by GBS. The effect of intrapartum antibiotic prophylaxis on late-onset SBIs caused by these organisms is unknown...
  23. pmc Early and late onset sepsis in late preterm infants
    Michael Cohen-Wolkowiez
    Department of Pediatrics, Duke University, Durham, NC 27715, USA
    Pediatr Infect Dis J 28:1052-6. 2009
    ..Early and late onset sepsis results in significant mortality in extremely preterm infants, but little is known about sepsis outcomes in late preterm infants...
  24. pmc Meningitis in preterm neonates: importance of cerebrospinal fluid parameters
    P Brian Smith
    Department of Pediatrics, Duke University, Durham, North Carolina 27710, USA
    Am J Perinatol 25:421-6. 2008
    ..Cerebrospinal fluid parameters used to diagnose meningitis in the absence of dependable cerebrospinal fluid cultures are unreliable. Caution should be employed when interpreting cerebrospinal fluid parameters in the premature neonate...
  25. pmc Use of the complete blood cell count in late-onset neonatal sepsis
    Christoph P Hornik
    Department of Pediatrics, Duke University, Durham, NC 27715, USA
    Pediatr Infect Dis J 31:803-7. 2012
    ..Diagnosis of late-onset sepsis can be challenging. The complete blood cell count and differential have been previously evaluated as diagnostic tools for late-onset sepsis in small, single-center reports...
  26. pmc Pharmacokinetics and safety of fluconazole in young infants supported with extracorporeal membrane oxygenation
    Kevin M Watt
    Duke University, Pediatrics, Duke Clinical Research Institute, P O Box 3499, Durham, NC 27710, USA
    Pediatr Infect Dis J 31:1042-7. 2012
    ..The ECMO circuit can alter drug pharmacokinetics; thus, standard fluconazole dosing in children on ECMO may result in suboptimal drug exposure. This study determined the pharmacokinetics of fluconazole in infants on ECMO...
  27. pmc Antifungal therapy and outcomes in infants with invasive Candida infections
    Simon B Ascher
    Department of Pediatrics, Duke University Medical Center, Durham, NC, USA
    Pediatr Infect Dis J 31:439-43. 2012
    ..Invasive candidiasis is a leading cause of mortality and morbidity in neonatal intensive care units. Treatment recommendations are limited by a lack of comparative outcomes data...
  28. pmc Traumatic lumbar punctures in neonates: test performance of the cerebrospinal fluid white blood cell count
    Rachel G Greenberg
    Department of Pediatrics, Duke University, Durham, NC, USA
    Pediatr Infect Dis J 27:1047-51. 2008
    ..The purpose of this study is to evaluate the diagnostic utility of adjusting CSF white blood cell counts based on CSF and peripheral red blood cell counts...
  29. pmc Adverse events associated with meropenem versus imipenem/cilastatin therapy in a large retrospective cohort of hospitalized infants
    Christoph P Hornik
    Duke Clinical Research Institute and Department of Pediatrics, Duke University, Durham, NC 27715, USA
    Pediatr Infect Dis J 32:748-53. 2013
    ..We compared the incidence of adverse events in hospitalized infants receiving meropenem versus imipenem/cilastatin...
  30. ncbi request reprint Predictive value of cerebrospinal fluid parameters in neonates with intraventricular drainage devices
    Robert W Lenfestey
    Department of Pediatrics, Duke University, Durham, North Carolina, USA
    J Neurosurg 107:209-12. 2007
    ..The goal of this study was to determine the normal ranges for cell count parameters in neonates with VP shunts and CSF reservoirs, as well as to determine the predictive value of CSF parameters as markers of infection...
  31. doi request reprint Staphylococcus aureus bacteremia among patients with health care-associated fever
    Martin E Stryjewski
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC, USA
    Am J Med 122:281-289.e2. 2009
    ..aureus bacteremia...
  32. pmc Population pharmacokinetics of piperacillin using scavenged samples from preterm infants
    Michael Cohen-Wolkowiez
    Department of Pediatrics, Duke University, Durham, North Carolina 27715, USA
    Ther Drug Monit 34:312-9. 2012
    ..We evaluated the population pharmacokinetics (PK) of piperacillin using targeted sparse sampling and scavenged samples obtained from preterm infants ‚ȧ 32 weeks of gestational age at birth and <120 postnatal days...
  33. pmc Empiric antifungal therapy and outcomes in extremely low birth weight infants with invasive candidiasis
    Rachel G Greenberg
    Department of Pediatrics, Duke University, Durham, NC, USA
    J Pediatr 161:264-9.e2. 2012
    ..To assess the impact of empiric antifungal therapy for invasive candidiasis on subsequent outcomes in premature infants...
  34. ncbi request reprint A meta-analysis of medical versus surgical therapy for Candida endocarditis
    William J Steinbach
    Division of Infectious Diseases, Department of Pediatrics, Duke University, Durham, NC 27710, USA
    J Infect 51:230-47. 2005
    ..The optimal management of Candida infective endocarditis (IE) is unknown...
  35. ncbi request reprint Venous thrombosis in patients with short- and long-term central venous catheter-associated Staphylococcus aureus bacteremia
    Anna Lisa Crowley
    Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC, USA
    Crit Care Med 36:385-90. 2008
    ....
  36. ncbi request reprint Mortality and neurodevelopmental outcome after Staphylococcus aureus bacteremia in infants
    Michael Cohen-Wolkowiez
    Department of Pediatrics, Duke University, Durham, NC, USA
    Pediatr Infect Dis J 26:1159-61. 2007
    ..Infants with methicillin-resistant S. aureus infection had a longer median duration of bacteremia (4.5 versus 1 day, P = 0.01), but no difference in length of hospital stay, mortality, or neurodevelopmental impairment...
  37. pmc Safety and effectiveness of meropenem in infants with suspected or complicated intra-abdominal infections
    Michael Cohen-Wolkowiez
    Department of Pediatrics, Duke University, Durham, North Carolina 27715, USA
    Clin Infect Dis 55:1495-502. 2012
    ..The purpose of this study was to determine the safety and effectiveness of meropenem in young infants with suspected or complicated intra-abdominal infections...
  38. pmc Candida virulence properties and adverse clinical outcomes in neonatal candidiasis
    Joseph M Bliss
    Department of Pediatrics, Women and Infants Hospital, Providence, RI, USA
    J Pediatr 161:441-447.e2. 2012
    ..To determine whether premature infants with invasive Candida infection caused by strains with increased virulence properties have worse clinical outcomes than those infected with less virulent strains...
  39. pmc Very late onset infections in the neonatal intensive care unit
    James L Wynn
    Department of Pediatrics, Duke University, Durham, NC, USA
    Early Hum Dev 88:217-25. 2012
    ..We sought to determine the risk factors, incidence, and mortality of very late onset bacterial infection (blood, urine, or cerebrospinal fluid culture positive occurring after day of life 120) in preterm infants...
  40. ncbi request reprint The association of third-generation cephalosporin use and invasive candidiasis in extremely low birth-weight infants
    C Michael Cotten
    Duke University Department of Pediatrics, Durham, North Carolina 27710, USA
    Pediatrics 118:717-22. 2006
    ..We evaluated the relationship between empirical antibiotic practices for extremely low birth-weight infants and center incidence of candidiasis...
  41. ncbi request reprint Successful medical treatment of cutaneous aspergillosis in a premature infant using liposomal amphotericin B, voriconazole and micafungin
    Roberto P Santos
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390 9063, USA
    Pediatr Infect Dis J 26:364-6. 2007
    ....
  42. pmc Prolonged duration of initial empirical antibiotic treatment is associated with increased rates of necrotizing enterocolitis and death for extremely low birth weight infants
    C Michael Cotten
    Department of Pediatrics, Duke University, Durham, NC 27710, USA
    Pediatrics 123:58-66. 2009
    ....
  43. ncbi request reprint Mortality following blood culture in premature infants: increased with Gram-negative bacteremia and candidemia, but not Gram-positive bacteremia
    Daniel K Benjamin
    Duke Clinical Research Institute, Durham, NC 27715, USA
    J Perinatol 24:175-80. 2004
    ..To describe survival following nosocomial bloodstream infections and quantify excess mortality associated with positive blood culture...
  44. pmc In vitro interactions between antifungals and immunosuppressants against Aspergillus fumigatus isolates from transplant and nontransplant patients
    William J Steinbach
    Division of Pediatric Infectious Diseases, Department of Pediatrics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Antimicrob Agents Chemother 48:4922-5. 2004
    ..We were not able to detect a difference in calcineurin inhibitor antifungal activity against isolates from transplant recipients and nontransplant patients...
  45. pmc Risk factors for invasive candidiasis in infants >1500 g birth weight
    Jan Hau Lee
    Department of Pediatrics, Duke University Medical Center, Durham, NC, USA
    Pediatr Infect Dis J 32:222-6. 2013
    ..We describe the incidence, risk factors and outcomes of invasive candidiasis in infants >1500 g birth weight...
  46. pmc Old and new: appropriate dosing for neonatal antifungal drugs in the nursery
    Jessica Ericson
    Duke University Medical Center, Durham, NC 27715, USA
    Early Hum Dev 89:S25-7. 2013
    ..The echinocandins are increasingly administered for invasive Candida infections, although higher doses are required in neonates than in older children and adults. ..
  47. ncbi request reprint Infections due to Aspergillus terreus: a multicenter retrospective analysis of 83 cases
    William J Steinbach
    Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA
    Clin Infect Dis 39:192-8. 2004
    ..29; 95% CI, 0.15-0.56). Voriconazole is likely to be a better treatment choice for A. terreus infection than is a polyene...
  48. pmc Use of the complete blood cell count in early-onset neonatal sepsis
    Christoph P Hornik
    Department of Pediatrics, Duke University, Durham, NC 27715, USA
    Pediatr Infect Dis J 31:799-802. 2012
    ..We evaluated the diagnostic accuracy of the complete blood cell count and differential in EOS in a large, multicenter population of neonates admitted to the neonatal intensive care unit...
  49. pmc Outcomes following candiduria in extremely low birth weight infants
    James L Wynn
    Department of Pediatrics, Duke University, Durham, NC 27715, USA
    Clin Infect Dis 54:331-9. 2012
    ..Candidiasis carries a significant risk of death or neurodevelopmental impairment (NDI) in extremely low birth weight infants (ELBW; <1000 g). We sought to determine the impact of candiduria in ELBW preterm infants...
  50. ncbi request reprint Use of vancomycin or first-generation cephalosporins for the treatment of hemodialysis-dependent patients with methicillin-susceptible Staphylococcus aureus bacteremia
    Martin E Stryjewski
    Duke Clinical Research Institute, Durham, North Carolina, USA
    Clin Infect Dis 44:190-6. 2007
    ..Clinical outcomes resulting from such a therapeutic strategy have not been well defined...
  51. pmc Comparison of costs, length of stay, and mortality associated with Candida glabrata and Candida albicans bloodstream infections
    Cassandra Moran
    Department of Pediatrics, Duke University School of Medicine, Durham, NC, USA
    Am J Infect Control 38:78-80. 2010
    ..04) and longer hospital stays (19.7 vs 14.5 days; P = .05) compared with early evidence of C albicans. Mortality was similar between the groups...
  52. pmc Therapeutic monitoring of voriconazole in children less than three years of age: a case report and summary of voriconazole concentrations for ten children
    Elizabeth H Doby
    Department of Pediatrics, University of Utah, Salt Lake City, UT, USA
    Pediatr Infect Dis J 31:632-5. 2012
    ..Trough concentrations were unpredictable based on dose, highlighting the need to follow values during therapy...
  53. pmc Population pharmacokinetics of metronidazole evaluated using scavenged samples from preterm infants
    Michael Cohen-Wolkowiez
    Department of Pediatrics, Duke University, Durham, North Carolina, USA
    Antimicrob Agents Chemother 56:1828-37. 2012
    ..Minimal-risk methods such as scavenged PK sampling provided meaningful information related to development of metronidazole PK models and dosing recommendations...
  54. ncbi request reprint Antifungal treatment in pediatric patients
    Theoklis E Zaoutis
    Department of Pediatrics, Division of Infectious Diseases, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Drug Resist Updat 8:235-45. 2005
    ....
  55. pmc Safety monitoring of drugs receiving pediatric marketing exclusivity
    P Brian Smith
    MHS, Duke University Medical Center, Box 3179, Durham, NC 27710, USA
    Pediatrics 122:e628-33. 2008
    ..We sought to describe the Pediatric Advisory Committee's recommendations made in response to safety reviews informed by data from the Food and Drug Administration Adverse Event Reporting System in 67 drugs granted exclusivity...
  56. pmc Safety of placebo controls in pediatric hypertension trials
    P Brian Smith
    Food and Drug Administration, Rockville, MD, USA
    Hypertension 51:829-33. 2008
    ..Short-term exposure to placebo in pediatric trials of antihypertensive medications appears to be safe...
  57. pmc Is an increased dwell time of a peripherally inserted catheter associated with an increased risk of bloodstream infection in infants?
    P Brian Smith
    Department of Pediatrics, Duke University, Durham, North Carolina 27715, USA
    Infect Control Hosp Epidemiol 29:749-53. 2008
    ..To estimate the risk of bloodstream infection associated with catheter dwell time in infants...
  58. pmc The economic returns of pediatric clinical trials of antihypertensive drugs
    Carissa M Baker-Smith
    Department of Pediatrics, Duke University Medical Center, Durham, NC, USA
    Am Heart J 156:682-8. 2008
    ..We sought to determine the cost of performing pediatric exclusivity trials within a single therapeutic area and the subsequent economic return to industry sponsors...
  59. ncbi request reprint Association between thrombosis and bloodstream infection in neonates with peripherally inserted catheters
    Courtney D Thornburg
    Department of Pediatrics, Duke University, Durham, NC, USA
    Thromb Res 122:782-5. 2008
    ..The primary objective of this study was to determine the association between catheter associated blood stream infection (CABSI) and catheter-related thrombosis in the Neonatal Intensive Care Unit...
  60. ncbi request reprint Delivery of glucose-6-phosphatase in a canine model for glycogen storage disease, type Ia, with adeno-associated virus (AAV) vectors
    R M Beaty
    Division of Medical Genetics, Duke University Medical Center, Durham, NC, USA
    Gene Ther 9:1015-22. 2002
    ..AAV vector administration in the canine model for GSD Ia resulted in sustained G6Pase expression and improvement in liver histology and in biochemical parameters...
  61. ncbi request reprint Anidulafungin: a new echinocandin for the treatment of fungal infections
    Michael Cohen-Wolkowiez
    Department of Pediatrics, Miami Children s Hospital, Florida, USA
    Drugs Today (Barc) 42:533-44. 2006
    ..In February 2006, the U.S. Food and Drug Administration approved the echinocandin anidulafungin for the treatment of patients with candidemia, peritonitis, intra-abdominal abscesses and esophageal candidiasis...
  62. pmc Innovative clinical trial design for pediatric therapeutics
    Matthew M Laughon
    School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Expert Rev Clin Pharmacol 4:643-52. 2011
    ....
  63. pmc Coagulase-negative staphylococcal infections in the neonatal intensive care unit
    Naomi Jean-Baptiste
    Duke Clinical Research Institute, Durham, North Carolina 27715, USA
    Infect Control Hosp Epidemiol 32:679-86. 2011
    ..Coagulase-negative staphylococci (CoNS) are the most commonly isolated pathogens in the neonatal intensive care unit (NICU). CoNS infections are associated with increased morbidity, including neurodevelopmental impairment...
  64. pmc Outcomes of catheter-associated infections in pediatric patients with short bowel syndrome
    Rachel G Greenberg
    Department of Pediatrics, Duke Clinical Research Institute, Duke University, Durham, NC, USA
    J Pediatr Gastroenterol Nutr 50:460-2. 2010
    ..We conducted a retrospective observational study in children with short bowel syndrome to compare outcomes of catheter-associated infections treated with catheter removal plus antibiotic therapy versus antibiotic therapy alone...
  65. ncbi request reprint Postconception age and other risk factors associated with mortality following Gram-negative rod bacteremia
    Daniel K Benjamin
    Duke Clinical Research Institute, Durham, NC 27715, USA
    J Perinatol 24:169-74. 2004
    ..Neonatal nosocomial Gram-negative rod bacteremia (GNR-b) is considered ominous...
  66. doi request reprint AAV vector-mediated reversal of hypoglycemia in canine and murine glycogen storage disease type Ia
    Dwight D Koeberl
    Division of Medical Genetics, Department of Pediatrics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Mol Ther 16:665-72. 2008
    ..These preclinical data demonstrated the efficacy of correcting hepatic G6Pase deficiency, and support the further preclinical development of AAV vector-mediated gene therapy for GSD-Ia...
  67. pmc Higher clearance of micafungin in neonates compared with adults: role of age-dependent micafungin serum binding
    Souzan B Yanni
    UNC Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, NC, USA
    Biopharm Drug Dispos 32:222-32. 2011
    ....
  68. ncbi request reprint Neonatal meningitis: what is the correlation among cerebrospinal fluid cultures, blood cultures, and cerebrospinal fluid parameters?
    Harmony P Garges
    Pediatrics, Duke University, Durham, North Carolina, USA
    Pediatrics 117:1094-100. 2006
    ..Abnormal cerebrospinal fluid (CSF) parameters are often used to predict neonatal meningitis and determine length and type of antibiotic therapy in neonates with a positive blood culture and negative CSF culture...
  69. pmc Economic return of clinical trials performed under the pediatric exclusivity program
    Jennifer S Li
    Department of Pediatrics, Duke Clinical Research Institute, Duke University, Durham, NC 27705, USA
    JAMA 297:480-8. 2007
    ..This critique has been a substantial part of congressional debate on the program, which is due to expire in 2007...
  70. ncbi request reprint A comparison of height and weight velocity as a part of the composite endpoint in pediatric HIV
    Daniel K Benjamin
    Duke Clinical Research Institute and the Department of Pediatrics, Duke University, Durham, North Carolina, USA
    AIDS 17:2331-6. 2003
    ..However, WAZ and height velocity (HAZ) have not been critically compared for their utility as part of the composite endpoint...
  71. pmc Pediatric antifungal agents
    Michael Cohen-Wolkowiez
    Department of Pediatrics, Duke University, Duke Clinical Research Institute, Durham, NC 27715, USA
    Curr Opin Infect Dis 22:553-8. 2009
    ..In the past decade, the antifungal armamentarium against invasive mycoses has expanded greatly. The purpose of the present report is to review the most recent literature addressing the use of antifungal agents in children...
  72. pmc Fluconazole dosing for the prevention or treatment of invasive candidiasis in young infants
    Kelly C Wade
    Department of Pediatrics, Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Pediatr Infect Dis J 28:717-23. 2009
    ..Fluconazole is increasingly used to prevent and treat invasive candidiasis in infants. Dosing guidance remains empiric and variable because limited pharmacokinetic data exist...
  73. pmc Total lymphocyte count and World Health Organization pediatric clinical stage as markers to assess need to initiate antiretroviral therapy among human immunodeficiency virus-infected children in Moshi, Northern Tanzania
    Opemipo O Johnson
    Department of Pediatrics, Duke University Medical Center, Durham, NC, USA
    Pediatr Infect Dis J 28:493-7. 2009
    ....
  74. pmc Fluconazole loading dose pharmacokinetics and safety in infants
    Lauren Piper
    Department of Pediatrics and Duke Clinical Research Institute, Duke University, Durham, NC, USA
    Pediatr Infect Dis J 30:375-8. 2011
    ..A loading dose of fluconazole is advised for older patients but has not been evaluated in infants. We sought to determine the pharmacokinetics and safety of a fluconazole loading dose in infants at risk for invasive fungal infection...
  75. pmc Candida albicans and non-albicans bloodstream infections in adult and pediatric patients: comparison of mortality and costs
    Cassandra Moran
    Duke Clinical Research Institute, Durham, NC 27715, USA
    Pediatr Infect Dis J 28:433-5. 2009
    ..7 vs. 20.7 days; P < 0.001) and higher inpatient costs ($133,871 vs. $56,725; P < 0.001) but lower mortality (28.3% vs. 43.5%; P < 0.001)...
  76. pmc Effect of methicillin-resistant Staphylococcus aureus colonization in the neonatal intensive care unit on total hospital cost
    Eric D Schultz
    Department of Pediatrics, Duke University Medical Center, Durham, North Carolina, USA
    Infect Control Hosp Epidemiol 30:383-5. 2009
    ..We determined the economic impact of isolating and cohorting MRSA-colonized neonates on total hospital cost at a 49-bed, level III-IV neonatal intensive care unit...
  77. pmc Population pharmacokinetics of fluconazole in young infants
    K C Wade
    Department of Pediatrics, Division of Neonatology, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Antimicrob Agents Chemother 52:4043-9. 2008
    ..This population PK model of fluconazole discriminated the impact of BGA, PNA, and creatinine on drug CL. Our data suggest that dosing in young infants will require adjustment for BGA and PNA to achieve targeted systemic drug exposures...
  78. ncbi request reprint Neonatal candidiasis: prophylaxis and treatment
    Kenneth F Tiffany
    Duke University, Department of Pediatrics, Durham, NC, USA
    Expert Opin Pharmacother 6:1647-55. 2005
    ..Systemic prophylaxis is currently not recommended for any neonatal population, and amphotericin B deoxycholate continues to be used as first-line therapy for the treatment of invasive disease...
  79. ncbi request reprint Invasive Candida infections in the neonate
    P Brian Smith
    Department of Pediatrics, Duke University, PO Box 17969, Durham, NC 27705, USA
    Drug Resist Updat 8:147-62. 2005
    ..In addition, diagnostic alternatives to traditional blood culture, experience with antifungal agents for prophylaxis and therapeutic options, including newer antifungal agents, will be presented...
  80. ncbi request reprint Risk factors for hematogenous complications of intravascular catheter-associated Staphylococcus aureus bacteremia
    Vance G Fowler
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Clin Infect Dis 40:695-703. 2005
    ..The role of both host and pathogen characteristics in hematogenous seeding following Staphylococcus aureus bacteremia is incompletely understood...
  81. pmc In vitro analyses, animal models, and 60 clinical cases of invasive Aspergillus terreus infection
    William J Steinbach
    Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA
    Antimicrob Agents Chemother 48:3217-25. 2004
  82. ncbi request reprint Rational testing of the HIV-exposed infant
    D K Benjamin
    Duke University Medical Center, Department of Pediatrics, Durham, North Carolina, USA
    Pediatrics 108:E3. 2001
    ..Given the low probability of disease in patients who have had 3 negative PCR tests, documentation of a negative ELISA may not be an appropriate use of medical resources...
  83. ncbi request reprint Value of an inhalational model of invasive aspergillosis
    William J Steinbach
    Division of Pediatric Infectious Diseases, Box 3499, Duke University Medical Center, Durham, NC 27710, USA
    Med Mycol 42:417-25. 2004
    ....
  84. ncbi request reprint Comparative safety of amphotericin B lipid complex and amphotericin B deoxycholate as aerosolized antifungal prophylaxis in lung-transplant recipients
    Richard H Drew
    Division of Infectious Diseases, Duke University Medical Center, Durham, NC 27710, USA
    Transplantation 77:232-7. 2004
    ..The incidence of invasive fungal infections in patients receiving aerosolized amphotericin B formulations as sole prophylaxis was determined...
  85. ncbi request reprint Pediatric residents' clinical diagnostic accuracy of otitis media
    William J Steinbach
    Division of General Pediatrics, Stanford University School of Medicine, Stanford, California, USA
    Pediatrics 109:993-8. 2002
    ..Pediatric resident physicians' clinical diagnostic accuracy of otitis media is unknown. We attempted to correlate the clinical examination of pediatric house staff with pediatric otolaryngologists and tympanometry...
  86. ncbi request reprint New antifungal agents under development in children and neonates
    William J Steinbach
    Department of Pediatrics, Division of Pediatric Infectious Diseases, Duke University, Durham, NC 27710, USA
    Curr Opin Infect Dis 18:484-9. 2005
    ..The larger body of data in adult patients is used for comparative purposes only in an attempt to understand pediatric implications...
  87. pmc Globalization of pediatric research: analysis of clinical trials completed for pediatric exclusivity
    Sara K Pasquali
    Duke University Medical Center, Department of Pediatrics, Division of Cardiology, PO Box 17969, Durham, NC 27715, USA
    Pediatrics 126:e687-92. 2010
    ..We evaluated the setting of published studies conducted under the US Pediatric Exclusivity Provision, which provides economic incentives to pharmaceutical companies to conduct drug studies with children...
  88. doi request reprint Obesity, inflammation, and asthma severity in childhood: data from the National Health and Nutrition Examination Survey 2001-2004
    Peter H Michelson
    Division of Pediatric Pulmonary and Sleep Medicine, Duke Children s Hospital, Durham, North Carolina 27710, USA
    Ann Allergy Asthma Immunol 103:381-5. 2009
    ..The prevalences of asthma and obesity in children have increased significantly during the past 2 decades. The basis for the relationship between pediatric asthma and obesity is not well established...
  89. ncbi request reprint Racial differences are seen in blood pressure response to fosinopril in hypertensive children
    Sharad Menon
    Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA
    Am Heart J 152:394-9. 2006
    ..It is well established that adult patients of different races show disparate response to angiotensin-converting enzyme (ACE) inhibitors, however no such studies have been performed in children...
  90. ncbi request reprint Disseminated Candida tropicalis in a patient with chronic mucocutaneous candidiasis
    Terry C Dixon
    Department of Pediatrics, the Division of Pediatric Infectious Diseases, Duke University, Durham, NC, USA
    South Med J 97:788-90. 2004
    ..The authors report a case of a 16-year-old with chronic mucocutaneous candidiasis who developed a fungemia with Candida tropicalis...
  91. pmc Calcineurin controls growth, morphology, and pathogenicity in Aspergillus fumigatus
    William J Steinbach
    Department of Pediatrics, Division of Pediatric Infectious Diseases, Box 3499, Duke University Medical Center, Durham, North Carolina 27710, USA
    Eukaryot Cell 5:1091-103. 2006
    ..Our findings reveal that calcineurin appears to play a globally conserved role in the virulence of several pathogenic fungi and yet plays specialized roles in each and can be an excellent target for therapeutic intervention...
  92. pmc Pharmacokinetics of an elevated dosage of micafungin in premature neonates
    P Brian Smith
    Department of Pediatrics and Duke Clinical Research Institute, Duke University, Durham, NC 27715, USA
    Pediatr Infect Dis J 28:412-5. 2009
    ..The primary objective of this study was to assess the safety and pharmacokinetics of an increased (15 mg/kg/d) dose of micafungin...
  93. ncbi request reprint Excess costs of hospital care associated with neonatal candidemia
    P Brian Smith
    Department of Pediatrics, 3179 Duke University Medical Center, Durham NC, 27710, USA
    Pediatr Infect Dis J 26:197-200. 2007
    ..Candida is an increasingly important nosocomial pathogen within intensive care nurseries. The purpose of this study was to determine the attributable cost of candidemia in neonates...
  94. ncbi request reprint Active or prior GB virus C infection does not protect against vertical transmission of HIV in coinfected women from Tanzania
    Amy C Weintrob
    Duke University Medical Center, Durham, North Carolina 27710, USA
    Clin Infect Dis 38:e46-8. 2004
    ..Neither active nor prior GBV-C infection was associated with a lower rate of HIV acquisition among infants. Thus, GBV-C does not appear to protect against perinatal HIV acquisition...
  95. ncbi request reprint Candidal mycetoma in the neonatal kidney
    D K Benjamin
    Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA
    Pediatrics 104:1126-9. 1999
    ..To determine the natural history of renal mycetoma (fungal balls) in the neonate...
  96. pmc Cough in pediatric patients receiving angiotensin-converting enzyme inhibitor therapy or angiotensin receptor blocker therapy in randomized controlled trials
    C M Baker-Smith
    Department of Pediatrics, Duke University, Durham, North Carolina, USA
    Clin Pharmacol Ther 87:668-71. 2010
    ..The incidence of cough in children receiving ACEis (reported cough, 3.2%) was similar to that in children receiving ARBs (reported cough, 1.8%) (P = 0.34). Reports of cough were lower in children than in adults...
  97. pmc Racial differences in blood pressure response to angiotensin-converting enzyme inhibitors in children: a meta-analysis
    J S Li
    Office of Pediatric Therapeutics, Office of the Commissioner, US Food and Drug Administration, Rockville, Maryland, USA
    Clin Pharmacol Ther 84:315-9. 2008
    ..This study evaluated the results of six trials of ACE inhibitors in children, using meta-analytic techniques to estimate the effect of race on blood pressure response...
  98. ncbi request reprint When to suspect fungal infection in neonates: A clinical comparison of Candida albicans and Candida parapsilosis fungemia with coagulase-negative staphylococcal bacteremia
    D K Benjamin
    Department of Pediatrics, Duke University, Medical Center, Durham, North Carolina 27710, USA
    Pediatrics 106:712-8. 2000
    ....
  99. ncbi request reprint Caspofungin for the treatment of azole resistant candidemia in a premature infant
    P B Smith
    Department of Pediatrics, Duke University, Durham, NC 27710, USA
    J Perinatol 27:127-9. 2007
    ..The infant's Candida isolate developed resistance to azoles during fluconazole administration and also suffered from severe hypercalcemia during the initiation of caspofungin therapy...
  100. ncbi request reprint Early, sustained efficacy of adeno-associated virus vector-mediated gene therapy in glycogen storage disease type Ia
    D D Koeberl
    Division of Medical Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Gene Ther 13:1281-9. 2006
    ..o. The development of efficacious AAV vector-mediated gene therapy could significantly reduce the impact of long-term complications in GSD-Ia, including hypoglycemia, hyperlipidemia and growth failure...
  101. pmc Daptomycin use in infants: report of two cases with peak and trough drug concentrations
    M Cohen-Wolkowiez
    Department of Pediatrics, Duke University, Durham, NC, USA
    J Perinatol 28:233-4. 2008
    ..7 and 16.3 mcg ml(-1), respectively. Even though the infants received higher doses than adults, their drug concentrations were comparable to those observed in adults treated with regular dosing of daptomycin...

Research Grants11

  1. Clinical Predictors of Antiretroviral Failure
    Daniel Benjamin; Fiscal Year: 2003
    ..abstract_text> ..
  2. Prevention of Invasive Candidiasis: PK, Safety, and Neurodevelopmental Outcomes
    Daniel K Benjamin; Fiscal Year: 2010
    ..The research will provide guidance as to the efficacy, safety, and neurodevelopmental outcomes related to fluconazole use. ..
  3. Prevention of Invasive Candidiasis: PK, Safety, and Neurodevelopmental Outcomes
    Daniel Benjamin; Fiscal Year: 2009
    ..The research will evaluate the efficacy, safety, and neurodevelopmental outcomes related to fluconazole use. ..
  4. Prevention of Invasive Candidiasis: PK, Safety, and Neurodevelopmental Outcomes
    Daniel Benjamin; Fiscal Year: 2009
    ..The research will provide guidance as to the efficacy, safety, and neurodevelopmental outcomes related to fluconazole use. ..
  5. Early Diagnosis of Neonatal Candidiasis
    Daniel Benjamin; Fiscal Year: 2007
    ..abstract_text> ..
  6. North Carolina Collaborative PPRU Network
    Daniel Benjamin; Fiscal Year: 2007
    ..6) To train physicians and pharmacologists in clinical and developmental pharmacology: the centerpiece will be a 3-year pediatric pharmacology fellowship. Drs. Brouwer and Lindley (UNC) will lead this program. ..
  7. Prevention of Invasive Candidiasis: PK, Safety, and Neurodevelopmental Outcomes
    Daniel K Benjamin; Fiscal Year: 2010
    ..The research will evaluate the efficacy, safety, and neurodevelopmental outcomes related to fluconazole use. ..