Research Topics
| Ines Batinic-HaberleSummaryAffiliation: Duke University Medical Center Country: USA Publications
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Detail Information
Publications
Diverse functions of cationic Mn(III) N-substituted pyridylporphyrins, recognized as SOD mimicsInes Batinic-Haberle
Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
Free Radic Biol Med 51:1035-53. 2011....- Lipophilicity is a critical parameter that dominates the efficacy of metalloporphyrins in blocking the development of morphine antinociceptive tolerance through peroxynitrite-mediated pathwaysInes Batinic-Haberle
Department of Radiation Oncology, Duke University Medical School, Durham, NC 27710, USA
Free Radic Biol Med 46:212-9. 2009.... - Design of Mn porphyrins for treating oxidative stress injuries and their redox-based regulation of cellular transcriptional activitiesInes Batinic-Haberle
Department of Radiation Oncology, Duke University Medical Center, 281b 285 MSRB I, Durham, NC 27710, USA
Amino Acids 42:95-113. 2012..Given the remarkable therapeutic potential of metalloporphyrins, future studies are warranted to further our understanding of in vivo action/s of Mn porphyrins, particularly with respect to their subcellular distribution... 
Tetrahydrobiopterin rapidly reduces the SOD mimic Mn(III) ortho-tetrakis(N-ethylpyridinium-2-yl)porphyrinInes Batinic-Haberle
Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
Free Radic Biol Med 37:367-74. 2004..The data are discussed with regard to the possible impact of the interaction of Mn(III)TE-2-PyP(5+) with BH(4) on endothelial cell proliferation and hence on tumor antiangiogenesis via inhibition of nitric oxide synthase...- Pure MnTBAP selectively scavenges peroxynitrite over superoxide: comparison of pure and commercial MnTBAP samples to MnTE-2-PyP in two models of oxidative stress injury, an SOD-specific Escherichia coli model and carrageenan-induced pleurisyInes Batinic-Haberle
Department of Radiation Oncology, Duke University Medical School, Durham, NC 27710, USA
Free Radic Biol Med 46:192-201. 2009..from O2.- pathways... - A combination of two antioxidants (an SOD mimic and ascorbate) produces a pro-oxidative effect forcing Escherichia coli to adapt via induction of oxyR regulonInes Batinic-Haberle
Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
Anticancer Agents Med Chem 11:329-40. 2011..As anticipated, when catalase was added into medium to remove H(2)O(2), E. coli did not respond with upregulation of its own antioxidant systems... - Superoxide dismutase mimics: chemistry, pharmacology, and therapeutic potentialInes Batinic-Haberle
Department of Radiation Oncology, Duke University Medical School, Durham, North Carolina 27710, USA
Antioxid Redox Signal 13:877-918. 2010..We here provide a comprehensive overview of the chemical properties and some in vivo effects observed with various classes of compounds with a special emphasis on porphyrin-based compounds... - High lipophilicity of meta Mn(III) N-alkylpyridylporphyrin-based superoxide dismutase mimics compensates for their lower antioxidant potency and makes them as effective as ortho analogues in protecting superoxide dismutase-deficient Escherichia coliIvan Kos
Department of Radiation Oncology, Duke University Medical School, Durham, North Carolina 27710, USA
J Med Chem 52:7868-72. 2009..coli. Thus meta isomers may be prospective therapeutics as are ortho porphyrins... - Bioavailability of metalloporphyrin-based SOD mimics is greatly influenced by a single charge residing on a Mn siteIvan Spasojevic
Department of Medicine, Duke University Medical School, Durham, NC 27710, USA
Free Radic Res 45:188-200. 2011..The work is in progress to understand how coupling of MnPs with ascorbate affects their mechanism of action, in particular with respect to cancer therapy... 
Methoxy-derivatization of alkyl chains increases the in vivo efficacy of cationic Mn porphyrins. Synthesis, characterization, SOD-like activity, and SOD-deficient E. coli study of meta Mn(III) N-methoxyalkylpyridylporphyrinsArtak G Tovmasyan
Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
Dalton Trans 40:4111-21. 2011....- Lipophilicity of potent porphyrin-based antioxidants: comparison of ortho and meta isomers of Mn(III) N-alkylpyridylporphyrinsIvan Kos
Department of Radiation Oncology, Duke University Medical School, Durham, NC 27710, USA
Free Radic Biol Med 47:72-8. 2009..Although meta isomers are only slightly less potent SOD mimics and antioxidants than their ortho analogues, their higher lipophilicity and smaller bulkiness may lead to a higher cellular uptake and overall similar effectiveness in vivo... - Cytotoxic effects of Mn(III) N-alkylpyridylporphyrins in the presence of cellular reductant, ascorbateXiaodong Ye
Department of Biomedical Engineering, Duke University, Durham, NC, USA
Free Radic Res 45:1289-306. 2011..The tumour oxidative stress was enhanced and its microvessel density reduced when mice were treated either with ascorbate or MnP/ascorbate; the trend towards tumour growth suppression was detected... - A small molecular weight catalytic metalloporphyrin antioxidant with superoxide dismutase (SOD) mimetic properties protects lungs from radiation-induced injuryZeljko Vujaskovic
Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
Free Radic Biol Med 33:857-63. 2002..In conclusion, the novel SOD mimetic, AEOL 10113, demonstrates a significant protective effect from radiation-induced lung injury... - Quality of potent Mn porphyrin-based SOD mimics and peroxynitrite scavengers for pre-clinical mechanistic/therapeutic purposesJulio S Reboucas
Department of Radiation Oncology, Duke University Medical School, Durham, NC 27710, USA
J Pharm Biomed Anal 48:1046-9. 2008.... - Early and late administration of MnTE-2-PyP5+ in mitigation and treatment of radiation-induced lung damageBenjamin Gauter-Fleckenstein
Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
Free Radic Biol Med 48:1034-43. 2010..The radioprotective effects are presumably mediated through its ability both to suppress oxidative stress and to decrease activation of key transcription factors and proangiogenic and profibrogenic cytokines... - Manganese porphyrins and related compounds as mimics of superoxide dismutaseInes Batinic-Haberle
Department of Biochemistry, Duke University Medical Center, Durham, North Carolina 27710, USA
Methods Enzymol 349:223-33. 2002 - A new SOD mimic, Mn(III) ortho N-butoxyethylpyridylporphyrin, combines superb potency and lipophilicity with low toxicityZrinka Rajic
Department of Radiation Oncology, Duke University Medical Center, NC 27710, USA
Free Radic Biol Med 52:1828-34. 2012..MnTnHep-2-PyP(5+) was already toxic at 5 μM, and MnTnHex-2-PyP(5+) became toxic at 30 μM. In a mouse toxicity study, MnTnBuOE-2-PyP(5+) was several-fold less toxic than either MnTnHex-2-PyP(5+) or MnTnHep-2-PyP(5+)... - Low molecular weight catalytic metalloporphyrin antioxidant AEOL 10150 protects lungs from fractionated radiationZahid N Rabbani
Department of Radiation Oncology, Durham Regional Hospital Duke University Medical Center, Durham, NC 27710, USA
Free Radic Res 41:1273-82. 2007..Administration of AEOL10150 at 5 mg/kg BID during and after RT results in a significant protective effect from long-term RT-induced lung injury. Low dose (2.5 mg/kg BID) delivery of AEOL10150 has no beneficial radioprotective effects... - Electrostatic contribution in the catalysis of O2*- dismutation by superoxide dismutase mimics. MnIIITE-2-PyP5+ versus MnIIIBr8T-2-PyP+Ivan Spasojevic
Department of Biochemistry, Duke University Medical Center, Durham, North Carolina 27710, USA
J Biol Chem 278:6831-7. 2003.... - Long-term administration of a small molecular weight catalytic metalloporphyrin antioxidant, AEOL 10150, protects lungs from radiation-induced injuryZahid N Rabbani
Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
Int J Radiat Oncol Biol Phys 67:573-80. 2007.... - An SOD mimic protects NADP+-dependent isocitrate dehydrogenase against oxidative inactivationInes Batinic-Haberle
Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
Free Radic Res 42:618-24. 2008..Statistically significant decrease of ICD activity was found in the hearts of diabetic rats. MnTM-2-PyP(5+) protected ICD in both models... - Pure manganese(III) 5,10,15,20-tetrakis(4-benzoic acid)porphyrin (MnTBAP) is not a superoxide dismutase mimic in aqueous systems: a case of structure-activity relationship as a watchdog mechanism in experimental therapeutics and biologyJulio S Reboucas
Department of Radiation Oncology, Duke University Medical School, Durham, NC 27710, USA
J Biol Inorg Chem 13:289-302. 2008.... - Impact of electrostatics in redox modulation of oxidative stress by Mn porphyrins: protection of SOD-deficient Escherichia coli via alternative mechanism where Mn porphyrin acts as a Mn carrierJulio S Reboucas
Department of Radiation Oncology, Duke University Medical School, Durham, NC 27710, USA
Free Radic Biol Med 45:201-10. 2008..We proposed herein the alternative mechanism where a labile Mn porphyrin [Mn(III)Br(8)TSPP](3-) is not an SOD mimic per se but carries Mn into the E. coli cell... - Comparison of two Mn porphyrin-based mimics of superoxide dismutase in pulmonary radioprotectionBenjamin Gauter-Fleckenstein
Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
Free Radic Biol Med 44:982-9. 2008..However, MnTE-2-PyP5+ at 6 mg/kg proved to be more effective in reducing expression of key molecular factors known to play an important role in radiation-induced lung injury... - Complementation of SOD-deficient Escherichia coli by manganese porphyrin mimics of superoxide dismutase activityAyako Okado-Matsumoto
Department of Biochemistry, Duke University Medical Center, Durham, NC 27710, USA
Free Radic Biol Med 37:401-10. 2004..The greater efficacy of the more lipophilic compounds was achieved at the cost of greater toxicity that became apparent when these compounds were applied at higher concentrations... - Mn porphyrin-based superoxide dismutase (SOD) mimic, MnIIITE-2-PyP5+, targets mouse heart mitochondriaIvan Spasojevic
Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
Free Radic Biol Med 42:1193-200. 2007.... - Antiangiogenic action of redox-modulating Mn(III) meso-tetrakis(N-ethylpyridinium-2-yl)porphyrin, MnTE-2-PyP(5+), via suppression of oxidative stress in a mouse model of breast tumorZahid N Rabbani
Department of Radiation Oncology, Duke University School of Medicine, Durham, NC 27710, USA
Free Radic Biol Med 47:992-1004. 2009..Mn porphyrins may be advantageous compared to other anti-cancer drugs, owing to their radioprotection of normal tissue and the ability to afford pain management in cancer patients via prevention of chronic morphine tolerance... - Determination of residual manganese in Mn porphyrin-based superoxide dismutase (SOD) and peroxynitrite reductase mimicsJulio S Reboucas
Department of Radiation Oncology, Duke University Medical School, Durham, NC 27710, USA
J Pharm Biomed Anal 50:1088-91. 2009..The overall procedure is simple, sensitive, specific, and amenable to adaptation. This quantification method has been routinely used by us for a large variety of water-soluble porphyrins... - 2-hydroxyglutarate production, but not dominant negative function, is conferred by glioma-derived NADP-dependent isocitrate dehydrogenase mutationsGenglin Jin
The Preston Robert Tisch Brain Tumor Center at Duke, Pediatric Brain Tumor Foundation Institute, and Department of Pathology, Duke University Medical Center, Durham, North Carolina, United States of America
PLoS ONE 6:e16812. 2011..Genetic evidence indicates that these mutations share a common gain of function, but it is unclear whether the shared function is dominant negative activity, neomorphic production of (R)-2-hydroxyglutarate (2HG), or both... - ErbB1/2 tyrosine kinase inhibitor mediates oxidative stress-induced apoptosis in inflammatory breast cancer cellsKatherine M Aird
Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA
Breast Cancer Res Treat 132:109-19. 2012..Taken together, these data demonstrate a novel mechanism of lapatinib-analog-induced apoptosis and indicate that resistant cells have increased antioxidant potential, which can be overcome by treatment with SOD modulators... - Proteomic analysis of radiation-induced changes in rat lung: Modulation by the superoxide dismutase mimetic MnTE-2-PyP(5+)Vasily A Yakovlev
Department of Radiation Oncology, Virginia Commonwealth University, Richmond, 23298, USA
Int J Radiat Oncol Biol Phys 78:547-54. 2010..To identify temporal changes in protein expression in the irradiated rat lung and generate putative mechanisms underlying the radioprotective effect of the manganese superoxide dismutase mimetic MnTE-2-PyP(5+)... - Neuroprotective efficacy from a lipophilic redox-modulating Mn(III) N-Hexylpyridylporphyrin, MnTnHex-2-PyP: rodent models of ischemic stroke and subarachnoid hemorrhageHuaxin Sheng
Multidisciplinary Neuroprotection Laboratories, Departments of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
J Pharmacol Exp Ther 338:906-16. 2011..This advance now allows consideration of MnPorphyrins for treatment of cerebrovascular disease... - Pharmacokinetics of the potent redox-modulating manganese porphyrin, MnTE-2-PyP(5+), in plasma and major organs of B6C3F1 miceIvan Spasojevic
Department of Medicine, Duke University Medical School, Durham, NC 27710, USA
Free Radic Biol Med 45:943-9. 2008..The calculated pharmacokinetic parameters will be used to design optimal dosing regimens in future preclinical studies utilizing this and similar compounds... - XIAP inhibition and generation of reactive oxygen species enhances TRAIL sensitivity in inflammatory breast cancer cellsJennifer L Allensworth
Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
Mol Cancer Ther 11:1518-27. 2012..Thus, ROS modulators represent a novel approach to enhance efficacy of TRAIL-based treatment protocols in IBC... - Long-term neuroprotection from a potent redox-modulating metalloporphyrin in the ratHuaxin Sheng
The Multidisciplinary Neuroprotection Laboratories, Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
Free Radic Biol Med 47:917-23. 2009..Pharmacologic modulation of postischemic oxidative stress is likely to require sustained intervention for enduring efficacy in improving neurologic and histologic outcome from a transient focal ischemic insult... - New approach to the activation of anti-cancer pro-drugs by metalloporphyrin-based cytochrome P450 mimics in all-aqueous biologically relevant systemIvan Spasojevic
Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
J Inorg Biochem 100:1897-902. 2006.... - Design, mechanism of action, bioavailability and therapeutic effects of mn porphyrin-based redox modulatorsArtak Tovmasyan
Department of Radiation Oncology, Duke University Medical Center, Durham, N C, USA
Med Princ Pract 22:103-30. 2013..Few of the most potent modulators of cellular redox-based pathways, MnTE2-PyP(5+), MnTDE-2-ImP(5+), MnTnHex-2-PyP(5+) and MnTnBuOE-2-PyP(5+), are under preclinical and clinical development... - Effect of lipophilicity of Mn (III) ortho N-alkylpyridyl- and diortho N, N'-diethylimidazolylporphyrins in two in-vitro models of oxygen and glucose deprivation-induced neuronal deathLisa Wise-Faberowski
Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
Free Radic Res 43:329-39. 2009..Such remarkable increase in efficacy parallels 5.7-orders of magnitude increase in lipophilicity of MnTnOct-2-PyP5+ (log P=-0.77) when compared to MnTE-2-PyP5+ (log POW=-6.43), POW being partition coefficient between n-octanol and water... - Oxidants, antioxidants and the ischemic brainDavid S Warner
Department of Anesthesiology, The Multidisciplinary Neuroprotection Laboratories, Duke University Medical Center, Durham, NC 27710, USA
J Exp Biol 207:3221-31. 2004..Because oxidative stress involves multiple post-ischemic cascades leading to cell death, effective prevention/treatment of ischemic brain injury is likely to require intervention at multiple effect sites... - Cryptococcus neoformans mitochondrial superoxide dismutase: an essential link between antioxidant function and high-temperature growthSteven S Giles
Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
Eukaryot Cell 4:46-54. 2005..These data suggest that the C. neoformans Sod2 is a major component of the antioxidant defense system in this human fungal pathogen and that adaptation to growth at elevated temperatures is also dependent on Sod2 activity... - Cellular redox modulator, ortho Mn(III) meso-tetrakis(N-n-hexylpyridinium-2-yl)porphyrin, MnTnHex-2-PyP(5+) in the treatment of brain tumorsStephen T Keir
Preston Robert Tisch Brain Tumor Center at Duke, Duke University, Durham, NC 27710, USA
Anticancer Agents Med Chem 11:202-12. 2011..Our findings suggest that the use of Mn porphyrin-based SOD mimics, and in particular lipophilic analogues such as MnTnHex-2-PyP(5+), is a promising approach for brain tumor therapy... - Mouse spinal cord compression injury is ameliorated by intrathecal cationic manganese(III) porphyrin catalytic antioxidant therapyHuaxin Sheng
Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
Neurosci Lett 366:220-5. 2004..However, efficacy was dependent upon route of administration suggesting that bioavailability is critical in defining efficacy... - Superoxide dismutase mimetic reduces hypoxia-induced O2*-, TGF-beta, and VEGF production by macrophagesIsabel L Jackson
Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
Free Radic Res 41:8-14. 2007.... - Influence of oxygen tension on interleukin 1-induced peroxynitrite formation and matrix turnover in articular cartilageJulie M Cernanec
Department of Surgery, Division of Orthopaedic Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
J Rheumatol 34:401-7. 2007..Cartilage is avascular and functions at reduced oxygen tension. We investigated whether oxygen tension influences the effects of interleukin 1 (IL-1) on peroxynitrite formation and cartilage matrix metabolism... - NADPH oxidase-mediated reactive oxygen species production activates hypoxia-inducible factor-1 (HIF-1) via the ERK pathway after hyperthermia treatmentEui Jung Moon
Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA
Proc Natl Acad Sci U S A 107:20477-82. 2010.... - A manganese porphyrin superoxide dismutase mimetic enhances tumor radioresponsivenessBenjamin J Moeller
Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
Int J Radiat Oncol Biol Phys 63:545-52. 2005.... - Mn porphyrins as novel molecular magnetic resonance imaging contrast agentsVladimir Mouraviev
1 Department of Urology Surgery, Duke University Medical Center, Durham, North Carolina
J Endourol 26:1420-4. 2012.... - IDH1 and IDH2 mutations in gliomasHai Yan
Department of Pathology, Pediatric Brain Tumor Foundation Institute, Duke University Medical Center, Durham, NC 27710, USA
N Engl J Med 360:765-73. 2009.... - Motor deficits are triggered by reperfusion-reoxygenation injury as diagnosed by MRI and by a mechanism involving oxidantsAlexander Drobyshevsky
Department of Pediatrics, NorthShore University Healthcare Research Institute, Evanston, Illinois 60201, USA
J Neurosci 32:5500-9. 2012..The etiological link between early injury and later motor deficits can thus be investigated by MRI, and allows us to distinguish between critical oxidative stress that causes motor deficits and noncritical oxidative stress that does not... - A no-laminectomy spinal cord compression injury model in miceHuaxin Sheng
Multidisciplinary Neuroprotection Laboratories, Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
J Neurotrauma 21:595-603. 2004..This model may be useful for study of spinal cord injury in genetically modified mice in the absence of anesthetic confounds while leaving the vertebral column intact...