Ines Batinic-Haberle

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. pmc A combination of two antioxidants (an SOD mimic and ascorbate) produces a pro-oxidative effect forcing Escherichia coli to adapt via induction of oxyR regulon
    Ines Batinic-Haberle
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Anticancer Agents Med Chem 11:329-40. 2011
  2. pmc Pure MnTBAP selectively scavenges peroxynitrite over superoxide: comparison of pure and commercial MnTBAP samples to MnTE-2-PyP in two models of oxidative stress injury, an SOD-specific Escherichia coli model and carrageenan-induced pleurisy
    Ines Batinic-Haberle
    Department of Radiation Oncology, Duke University Medical School, Durham, NC 27710, USA
    Free Radic Biol Med 46:192-201. 2009
  3. pmc Lipophilicity is a critical parameter that dominates the efficacy of metalloporphyrins in blocking the development of morphine antinociceptive tolerance through peroxynitrite-mediated pathways
    Ines Batinic-Haberle
    Department of Radiation Oncology, Duke University Medical School, Durham, NC 27710, USA
    Free Radic Biol Med 46:212-9. 2009
  4. pmc Design of Mn porphyrins for treating oxidative stress injuries and their redox-based regulation of cellular transcriptional activities
    Ines Batinic-Haberle
    Department of Radiation Oncology, Duke University Medical Center, 281b 285 MSRB I, Durham, NC 27710, USA
    Amino Acids 42:95-113. 2012
  5. pmc Superoxide dismutase mimics: chemistry, pharmacology, and therapeutic potential
    Ines Batinic-Haberle
    Department of Radiation Oncology, Duke University Medical School, Durham, North Carolina 27710, USA
    Antioxid Redox Signal 13:877-918. 2010
  6. pmc Diverse functions of cationic Mn(III) N-substituted pyridylporphyrins, recognized as SOD mimics
    Ines Batinic-Haberle
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Free Radic Biol Med 51:1035-53. 2011
  7. ncbi request reprint Tetrahydrobiopterin rapidly reduces the SOD mimic Mn(III) ortho-tetrakis(N-ethylpyridinium-2-yl)porphyrin
    Ines Batinic-Haberle
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Free Radic Biol Med 37:367-74. 2004
  8. pmc Comprehensive pharmacokinetic studies and oral bioavailability of two Mn porphyrin-based SOD mimics, MnTE-2-PyP5+ and MnTnHex-2-PyP5+
    Tin Weitner
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Free Radic Biol Med 58:73-80. 2013
  9. pmc High lipophilicity of meta Mn(III) N-alkylpyridylporphyrin-based superoxide dismutase mimics compensates for their lower antioxidant potency and makes them as effective as ortho analogues in protecting superoxide dismutase-deficient Escherichia coli
    Ivan Kos
    Department of Radiation Oncology, Duke University Medical School, Durham, North Carolina 27710, USA
    J Med Chem 52:7868-72. 2009
  10. pmc Bioavailability of metalloporphyrin-based SOD mimics is greatly influenced by a single charge residing on a Mn site
    Ivan Spasojevic
    Department of Medicine, Duke University Medical School, Durham, NC 27710, USA
    Free Radic Res 45:188-200. 2011

Collaborators

Detail Information

Publications58

  1. pmc A combination of two antioxidants (an SOD mimic and ascorbate) produces a pro-oxidative effect forcing Escherichia coli to adapt via induction of oxyR regulon
    Ines Batinic-Haberle
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Anticancer Agents Med Chem 11:329-40. 2011
    ..As anticipated, when catalase was added into medium to remove H(2)O(2), E. coli did not respond with upregulation of its own antioxidant systems...
  2. pmc Pure MnTBAP selectively scavenges peroxynitrite over superoxide: comparison of pure and commercial MnTBAP samples to MnTE-2-PyP in two models of oxidative stress injury, an SOD-specific Escherichia coli model and carrageenan-induced pleurisy
    Ines Batinic-Haberle
    Department of Radiation Oncology, Duke University Medical School, Durham, NC 27710, USA
    Free Radic Biol Med 46:192-201. 2009
    ..from O2.- pathways...
  3. pmc Lipophilicity is a critical parameter that dominates the efficacy of metalloporphyrins in blocking the development of morphine antinociceptive tolerance through peroxynitrite-mediated pathways
    Ines Batinic-Haberle
    Department of Radiation Oncology, Duke University Medical School, Durham, NC 27710, USA
    Free Radic Biol Med 46:212-9. 2009
    ....
  4. pmc Design of Mn porphyrins for treating oxidative stress injuries and their redox-based regulation of cellular transcriptional activities
    Ines Batinic-Haberle
    Department of Radiation Oncology, Duke University Medical Center, 281b 285 MSRB I, Durham, NC 27710, USA
    Amino Acids 42:95-113. 2012
    ..Given the remarkable therapeutic potential of metalloporphyrins, future studies are warranted to further our understanding of in vivo action/s of Mn porphyrins, particularly with respect to their subcellular distribution...
  5. pmc Superoxide dismutase mimics: chemistry, pharmacology, and therapeutic potential
    Ines Batinic-Haberle
    Department of Radiation Oncology, Duke University Medical School, Durham, North Carolina 27710, USA
    Antioxid Redox Signal 13:877-918. 2010
    ..We here provide a comprehensive overview of the chemical properties and some in vivo effects observed with various classes of compounds with a special emphasis on porphyrin-based compounds...
  6. pmc Diverse functions of cationic Mn(III) N-substituted pyridylporphyrins, recognized as SOD mimics
    Ines Batinic-Haberle
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Free Radic Biol Med 51:1035-53. 2011
    ....
  7. ncbi request reprint Tetrahydrobiopterin rapidly reduces the SOD mimic Mn(III) ortho-tetrakis(N-ethylpyridinium-2-yl)porphyrin
    Ines Batinic-Haberle
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Free Radic Biol Med 37:367-74. 2004
    ..The data are discussed with regard to the possible impact of the interaction of Mn(III)TE-2-PyP(5+) with BH(4) on endothelial cell proliferation and hence on tumor antiangiogenesis via inhibition of nitric oxide synthase...
  8. pmc Comprehensive pharmacokinetic studies and oral bioavailability of two Mn porphyrin-based SOD mimics, MnTE-2-PyP5+ and MnTnHex-2-PyP5+
    Tin Weitner
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Free Radic Biol Med 58:73-80. 2013
    ....
  9. pmc High lipophilicity of meta Mn(III) N-alkylpyridylporphyrin-based superoxide dismutase mimics compensates for their lower antioxidant potency and makes them as effective as ortho analogues in protecting superoxide dismutase-deficient Escherichia coli
    Ivan Kos
    Department of Radiation Oncology, Duke University Medical School, Durham, North Carolina 27710, USA
    J Med Chem 52:7868-72. 2009
    ..coli. Thus meta isomers may be prospective therapeutics as are ortho porphyrins...
  10. pmc Bioavailability of metalloporphyrin-based SOD mimics is greatly influenced by a single charge residing on a Mn site
    Ivan Spasojevic
    Department of Medicine, Duke University Medical School, Durham, NC 27710, USA
    Free Radic Res 45:188-200. 2011
    ..The work is in progress to understand how coupling of MnPs with ascorbate affects their mechanism of action, in particular with respect to cancer therapy...
  11. pmc Design, mechanism of action, bioavailability and therapeutic effects of mn porphyrin-based redox modulators
    Artak Tovmasyan
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Med Princ Pract 22:103-30. 2013
    ..Few of the most potent modulators of cellular redox-based pathways, MnTE2-PyP5+, MnTDE-2-ImP5+, MnTnHex-2-PyP5+ and MnTnBuOE-2-PyP5+, are under preclinical and clinical development...
  12. pmc Methoxy-derivatization of alkyl chains increases the in vivo efficacy of cationic Mn porphyrins. Synthesis, characterization, SOD-like activity, and SOD-deficient E. coli study of meta Mn(III) N-methoxyalkylpyridylporphyrins
    Artak G Tovmasyan
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Dalton Trans 40:4111-21. 2011
    ....
  13. pmc Differential coordination demands in Fe versus Mn water-soluble cationic metalloporphyrins translate into remarkably different aqueous redox chemistry and biology
    Artak Tovmasyan
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, United States
    Inorg Chem 52:5677-91. 2013
    ..Under the same experimental conditions, (OH)(H2O)FePs do not cause mouse arterial hypotension, whereas (H2O)2MnPs do, which greatly limits the application of Mn porphyrins in vivo...
  14. ncbi request reprint A small molecular weight catalytic metalloporphyrin antioxidant with superoxide dismutase (SOD) mimetic properties protects lungs from radiation-induced injury
    Zeljko Vujaskovic
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Free Radic Biol Med 33:857-63. 2002
    ..In conclusion, the novel SOD mimetic, AEOL 10113, demonstrates a significant protective effect from radiation-induced lung injury...
  15. pmc Lipophilicity of potent porphyrin-based antioxidants: comparison of ortho and meta isomers of Mn(III) N-alkylpyridylporphyrins
    Ivan Kos
    Department of Radiation Oncology, Duke University Medical School, Durham, NC 27710, USA
    Free Radic Biol Med 47:72-8. 2009
    ..Although meta isomers are only slightly less potent SOD mimics and antioxidants than their ortho analogues, their higher lipophilicity and smaller bulkiness may lead to a higher cellular uptake and overall similar effectiveness in vivo...
  16. pmc Long-term administration of a small molecular weight catalytic metalloporphyrin antioxidant, AEOL 10150, protects lungs from radiation-induced injury
    Zahid N Rabbani
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Int J Radiat Oncol Biol Phys 67:573-80. 2007
    ....
  17. pmc Cytotoxic effects of Mn(III) N-alkylpyridylporphyrins in the presence of cellular reductant, ascorbate
    Xiaodong Ye
    Department of Biomedical Engineering, Duke University, Durham, NC, USA
    Free Radic Res 45:1289-306. 2011
    ..The tumour oxidative stress was enhanced and its microvessel density reduced when mice were treated either with ascorbate or MnP/ascorbate; the trend towards tumour growth suppression was detected...
  18. pmc Quality of potent Mn porphyrin-based SOD mimics and peroxynitrite scavengers for pre-clinical mechanistic/therapeutic purposes
    Julio S Reboucas
    Department of Radiation Oncology, Duke University Medical School, Durham, NC 27710, USA
    J Pharm Biomed Anal 48:1046-9. 2008
    ....
  19. ncbi request reprint Low molecular weight catalytic metalloporphyrin antioxidant AEOL 10150 protects lungs from fractionated radiation
    Zahid N Rabbani
    Department of Radiation Oncology, Durham Regional Hospital Duke University Medical Center, Durham, NC 27710, USA
    Free Radic Res 41:1273-82. 2007
    ..Administration of AEOL10150 at 5 mg/kg BID during and after RT results in a significant protective effect from long-term RT-induced lung injury. Low dose (2.5 mg/kg BID) delivery of AEOL10150 has no beneficial radioprotective effects...
  20. ncbi request reprint Effects of a manganese (III) porphyrin catalytic antioxidant in a mouse closed head injury model
    Stephen B Leinenweber
    Department of Pediatrics, Duke University Medical Center, Durham NC 27710, USA
    Eur J Pharmacol 531:126-32. 2006
    ..Closed head injury altered performance in both tests. No statistically significant effect of MnTE-2-PyP5+ was observed. We conclude that single dose MnTE-2-PyP5+ does not alter outcome in this mouse closed head injury model...
  21. pmc Early and late administration of MnTE-2-PyP5+ in mitigation and treatment of radiation-induced lung damage
    Benjamin Gauter-Fleckenstein
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Free Radic Biol Med 48:1034-43. 2010
    ..The radioprotective effects are presumably mediated through its ability both to suppress oxidative stress and to decrease activation of key transcription factors and proangiogenic and profibrogenic cytokines...
  22. pmc A new SOD mimic, Mn(III) ortho N-butoxyethylpyridylporphyrin, combines superb potency and lipophilicity with low toxicity
    Zrinka Rajic
    Department of Radiation Oncology, Duke University Medical Center, NC 27710, USA
    Free Radic Biol Med 52:1828-34. 2012
    ..MnTnHep-2-PyP(5+) was already toxic at 5 μM, and MnTnHex-2-PyP(5+) became toxic at 30 μM. In a mouse toxicity study, MnTnBuOE-2-PyP(5+) was several-fold less toxic than either MnTnHex-2-PyP(5+) or MnTnHep-2-PyP(5+)...
  23. pmc An SOD mimic protects NADP+-dependent isocitrate dehydrogenase against oxidative inactivation
    Ines Batinic-Haberle
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Free Radic Res 42:618-24. 2008
    ..Statistically significant decrease of ICD activity was found in the hearts of diabetic rats. MnTM-2-PyP(5+) protected ICD in both models...
  24. ncbi request reprint Electrostatic contribution in the catalysis of O2*- dismutation by superoxide dismutase mimics. MnIIITE-2-PyP5+ versus MnIIIBr8T-2-PyP+
    Ivan Spasojevic
    Department of Biochemistry, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 278:6831-7. 2003
    ....
  25. ncbi request reprint Pure manganese(III) 5,10,15,20-tetrakis(4-benzoic acid)porphyrin (MnTBAP) is not a superoxide dismutase mimic in aqueous systems: a case of structure-activity relationship as a watchdog mechanism in experimental therapeutics and biology
    Julio S Reboucas
    Department of Radiation Oncology, Duke University Medical School, Durham, NC 27710, USA
    J Biol Inorg Chem 13:289-302. 2008
    ....
  26. pmc Impact of electrostatics in redox modulation of oxidative stress by Mn porphyrins: protection of SOD-deficient Escherichia coli via alternative mechanism where Mn porphyrin acts as a Mn carrier
    Julio S Reboucas
    Department of Radiation Oncology, Duke University Medical School, Durham, NC 27710, USA
    Free Radic Biol Med 45:201-10. 2008
    ..We proposed herein the alternative mechanism where a labile Mn porphyrin [Mn(III)Br(8)TSPP](3-) is not an SOD mimic per se but carries Mn into the E. coli cell...
  27. ncbi request reprint Manganese porphyrins and related compounds as mimics of superoxide dismutase
    Ines Batinic-Haberle
    Department of Biochemistry, Duke University Medical Center, Durham, North Carolina 27710, USA
    Methods Enzymol 349:223-33. 2002
  28. ncbi request reprint Complementation of SOD-deficient Escherichia coli by manganese porphyrin mimics of superoxide dismutase activity
    Ayako Okado-Matsumoto
    Department of Biochemistry, Duke University Medical Center, Durham, NC 27710, USA
    Free Radic Biol Med 37:401-10. 2004
    ..The greater efficacy of the more lipophilic compounds was achieved at the cost of greater toxicity that became apparent when these compounds were applied at higher concentrations...
  29. pmc Mn porphyrin-based superoxide dismutase (SOD) mimic, MnIIITE-2-PyP5+, targets mouse heart mitochondria
    Ivan Spasojevic
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Free Radic Biol Med 42:1193-200. 2007
    ....
  30. pmc 2-hydroxyglutarate production, but not dominant negative function, is conferred by glioma-derived NADP-dependent isocitrate dehydrogenase mutations
    Genglin Jin
    The Preston Robert Tisch Brain Tumor Center at Duke, Pediatric Brain Tumor Foundation Institute, and Department of Pathology, Duke University Medical Center, Durham, North Carolina, United States of America
    PLoS ONE 6:e16812. 2011
    ..Genetic evidence indicates that these mutations share a common gain of function, but it is unclear whether the shared function is dominant negative activity, neomorphic production of (R)-2-hydroxyglutarate (2HG), or both...
  31. pmc Antiangiogenic action of redox-modulating Mn(III) meso-tetrakis(N-ethylpyridinium-2-yl)porphyrin, MnTE-2-PyP(5+), via suppression of oxidative stress in a mouse model of breast tumor
    Zahid N Rabbani
    Department of Radiation Oncology, Duke University School of Medicine, Durham, NC 27710, USA
    Free Radic Biol Med 47:992-1004. 2009
    ..Mn porphyrins may be advantageous compared to other anti-cancer drugs, owing to their radioprotection of normal tissue and the ability to afford pain management in cancer patients via prevention of chronic morphine tolerance...
  32. pmc Determination of residual manganese in Mn porphyrin-based superoxide dismutase (SOD) and peroxynitrite reductase mimics
    Julio S Reboucas
    Department of Radiation Oncology, Duke University Medical School, Durham, NC 27710, USA
    J Pharm Biomed Anal 50:1088-91. 2009
    ..The overall procedure is simple, sensitive, specific, and amenable to adaptation. This quantification method has been routinely used by us for a large variety of water-soluble porphyrins...
  33. pmc Long-term neuroprotection from a potent redox-modulating metalloporphyrin in the rat
    Huaxin Sheng
    The Multidisciplinary Neuroprotection Laboratories, Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    Free Radic Biol Med 47:917-23. 2009
    ..Pharmacologic modulation of postischemic oxidative stress is likely to require sustained intervention for enduring efficacy in improving neurologic and histologic outcome from a transient focal ischemic insult...
  34. pmc ErbB1/2 tyrosine kinase inhibitor mediates oxidative stress-induced apoptosis in inflammatory breast cancer cells
    Katherine M Aird
    Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA
    Breast Cancer Res Treat 132:109-19. 2012
    ..Taken together, these data demonstrate a novel mechanism of lapatinib-analog-induced apoptosis and indicate that resistant cells have increased antioxidant potential, which can be overcome by treatment with SOD modulators...
  35. pmc Neuroprotective efficacy from a lipophilic redox-modulating Mn(III) N-Hexylpyridylporphyrin, MnTnHex-2-PyP: rodent models of ischemic stroke and subarachnoid hemorrhage
    Huaxin Sheng
    Multidisciplinary Neuroprotection Laboratories, Departments of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Pharmacol Exp Ther 338:906-16. 2011
    ..This advance now allows consideration of MnPorphyrins for treatment of cerebrovascular disease...
  36. pmc Proteomic analysis of radiation-induced changes in rat lung: Modulation by the superoxide dismutase mimetic MnTE-2-PyP(5+)
    Vasily A Yakovlev
    Department of Radiation Oncology, Virginia Commonwealth University, Richmond, 23298, USA
    Int J Radiat Oncol Biol Phys 78:547-54. 2010
    ..To identify temporal changes in protein expression in the irradiated rat lung and generate putative mechanisms underlying the radioprotective effect of the manganese superoxide dismutase mimetic MnTE-2-PyP(5+)...
  37. ncbi request reprint Thermodynamics, kinetics, and mechanism of the stepwise dissociation and formation of Tris(L-lysinehydroxamato)iron(III) in aqueous acid
    Joseph I Wirgau
    Department of Chemistry, Duke University, Box 90346, Durham, North Carolina 27708 0346, USA
    Inorg Chem 41:1464-73. 2002
    ..The reduction potential for tris(L-lysinehydroxamato)iron(III) is -214 mV (vs. NHE), and a comparison to other hydroxamic acid complexes of Fe(III) is made through a correlation between E(1/2) and pFe...
  38. pmc Pharmacokinetics of the potent redox-modulating manganese porphyrin, MnTE-2-PyP(5+), in plasma and major organs of B6C3F1 mice
    Ivan Spasojevic
    Department of Medicine, Duke University Medical School, Durham, NC 27710, USA
    Free Radic Biol Med 45:943-9. 2008
    ..The calculated pharmacokinetic parameters will be used to design optimal dosing regimens in future preclinical studies utilizing this and similar compounds...
  39. ncbi request reprint Effects of metalloporphyrin catalytic antioxidants in experimental brain ischemia
    Huaxin Sheng
    Department of Anesthesiology, Multidisciplinary Neuroprotection Laboratories, Duke University Medical Center, Durham, NC 27710, USA
    Free Radic Biol Med 33:947-61. 2002
    ..AEOL 10150 is an effective neuroprotective compound offering a wide therapeutic window with a large margin of safety against adverse behavioral side effects...
  40. ncbi request reprint Superoxide dismutase mimetic reduces hypoxia-induced O2*-, TGF-beta, and VEGF production by macrophages
    Isabel L Jackson
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Free Radic Res 41:8-14. 2007
    ....
  41. doi request reprint XIAP inhibition and generation of reactive oxygen species enhances TRAIL sensitivity in inflammatory breast cancer cells
    Jennifer L Allensworth
    Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Mol Cancer Ther 11:1518-27. 2012
    ..Thus, ROS modulators represent a novel approach to enhance efficacy of TRAIL-based treatment protocols in IBC...
  42. ncbi request reprint New approach to the activation of anti-cancer pro-drugs by metalloporphyrin-based cytochrome P450 mimics in all-aqueous biologically relevant system
    Ivan Spasojevic
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    J Inorg Biochem 100:1897-902. 2006
    ....
  43. pmc Comparison of two Mn porphyrin-based mimics of superoxide dismutase in pulmonary radioprotection
    Benjamin Gauter-Fleckenstein
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Free Radic Biol Med 44:982-9. 2008
    ..However, MnTE-2-PyP5+ at 6 mg/kg proved to be more effective in reducing expression of key molecular factors known to play an important role in radiation-induced lung injury...
  44. ncbi request reprint Oxidants, antioxidants and the ischemic brain
    David S Warner
    Department of Anesthesiology, The Multidisciplinary Neuroprotection Laboratories, Duke University Medical Center, Durham, NC 27710, USA
    J Exp Biol 207:3221-31. 2004
    ..Because oxidative stress involves multiple post-ischemic cascades leading to cell death, effective prevention/treatment of ischemic brain injury is likely to require intervention at multiple effect sites...
  45. ncbi request reprint Mouse spinal cord compression injury is ameliorated by intrathecal cationic manganese(III) porphyrin catalytic antioxidant therapy
    Huaxin Sheng
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    Neurosci Lett 366:220-5. 2004
    ..However, efficacy was dependent upon route of administration suggesting that bioavailability is critical in defining efficacy...
  46. pmc Effect of lipophilicity of Mn (III) ortho N-alkylpyridyl- and diortho N, N'-diethylimidazolylporphyrins in two in-vitro models of oxygen and glucose deprivation-induced neuronal death
    Lisa Wise-Faberowski
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    Free Radic Res 43:329-39. 2009
    ..Such remarkable increase in efficacy parallels 5.7-orders of magnitude increase in lipophilicity of MnTnOct-2-PyP5+ (log P=-0.77) when compared to MnTE-2-PyP5+ (log POW=-6.43), POW being partition coefficient between n-octanol and water...
  47. pmc Cellular redox modulator, ortho Mn(III) meso-tetrakis(N-n-hexylpyridinium-2-yl)porphyrin, MnTnHex-2-PyP(5+) in the treatment of brain tumors
    Stephen T Keir
    Preston Robert Tisch Brain Tumor Center at Duke, Duke University, Durham, NC 27710, USA
    Anticancer Agents Med Chem 11:202-12. 2011
    ..Our findings suggest that the use of Mn porphyrin-based SOD mimics, and in particular lipophilic analogues such as MnTnHex-2-PyP(5+), is a promising approach for brain tumor therapy...
  48. pmc Cryptococcus neoformans mitochondrial superoxide dismutase: an essential link between antioxidant function and high-temperature growth
    Steven S Giles
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Eukaryot Cell 4:46-54. 2005
    ..These data suggest that the C. neoformans Sod2 is a major component of the antioxidant defense system in this human fungal pathogen and that adaptation to growth at elevated temperatures is also dependent on Sod2 activity...
  49. ncbi request reprint A manganese porphyrin superoxide dismutase mimetic enhances tumor radioresponsiveness
    Benjamin J Moeller
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Int J Radiat Oncol Biol Phys 63:545-52. 2005
    ....
  50. pmc NADPH oxidase-mediated reactive oxygen species production activates hypoxia-inducible factor-1 (HIF-1) via the ERK pathway after hyperthermia treatment
    Eui Jung Moon
    Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 107:20477-82. 2010
    ....
  51. pmc Radiation induces aerobic glycolysis through reactive oxygen species
    Jim Zhong
    School of Medicine, Duke University, Durham, USA
    Radiother Oncol 106:390-6. 2013
    ..Here we tested whether concurrent use of this drug with radiotherapy would reduce the switch to a glycolytic phenotype...
  52. ncbi request reprint Influence of oxygen tension on interleukin 1-induced peroxynitrite formation and matrix turnover in articular cartilage
    Julie M Cernanec
    Department of Surgery, Division of Orthopaedic Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Rheumatol 34:401-7. 2007
    ..Cartilage is avascular and functions at reduced oxygen tension. We investigated whether oxygen tension influences the effects of interleukin 1 (IL-1) on peroxynitrite formation and cartilage matrix metabolism...
  53. pmc Mn porphyrins as novel molecular magnetic resonance imaging contrast agents
    Vladimir Mouraviev
    Department of Urology Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Endourol 26:1420-4. 2012
    ..Strong paramagnetic MRI contrast properties and affinity for cancer cells suggest their potential application as novel diagnostic imaging agents...
  54. doi request reprint Mn porphyrin in combination with ascorbate acts as a pro-oxidant and mediates caspase-independent cancer cell death
    Myron K Evans
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA
    Free Radic Biol Med 68:302-14. 2014
    ..The catalysis of ascorbate oxidation by an optimized metal-based catalyst (such as MnP) carries a large therapeutic potential as an anticancer agent by itself or in combination with other modalities such as radio- and chemotherapy. ..
  55. pmc IDH1 and IDH2 mutations in gliomas
    Hai Yan
    Department of Pathology, Pediatric Brain Tumor Foundation Institute, Duke University Medical Center, Durham, NC 27710, USA
    N Engl J Med 360:765-73. 2009
    ....
  56. pmc Motor deficits are triggered by reperfusion-reoxygenation injury as diagnosed by MRI and by a mechanism involving oxidants
    Alexander Drobyshevsky
    Department of Pediatrics, NorthShore University Healthcare Research Institute, Evanston, Illinois 60201, USA
    J Neurosci 32:5500-9. 2012
    ..The etiological link between early injury and later motor deficits can thus be investigated by MRI, and allows us to distinguish between critical oxidative stress that causes motor deficits and noncritical oxidative stress that does not...
  57. ncbi request reprint A no-laminectomy spinal cord compression injury model in mice
    Huaxin Sheng
    Multidisciplinary Neuroprotection Laboratories, Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurotrauma 21:595-603. 2004
    ..This model may be useful for study of spinal cord injury in genetically modified mice in the absence of anesthetic confounds while leaving the vertebral column intact...