Research Topics
| John A BartlettSummaryAffiliation: Duke University Medical Center Country: USA Publications
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Detail Information
Publications
An updated systematic overview of triple combination therapy in antiretroviral-naive HIV-infected adultsJohn A Bartlett
Duke University Medical Center, Durham, North Carolina 27710, USA
AIDS 20:2051-64. 2006..To compare the effectiveness of three drug combination antiretroviral therapy (ART) in treatment-naive HIV-infected persons, and identify the predictors of responses...- Minimizing resistance consequences after virologic failure on initial combination therapy: a systematic overviewJohn A Bartlett
AIDS Research and Treatment Center, Duke University Medical Center, Durham, NC, USA
J Acquir Immune Defic Syndr 41:323-31. 2006..To identify optimal first-line therapies based on the rate of virologic success (VS) and the preservation of future treatment options in antiretroviral therapy (ART)-naive subjects... 
Successes, challenges, and limitations of current antiretroviral therapy in low-income and middle-income countriesJohn A Bartlett
Division of Infectious Diseases and International Health, Duke University Medical Center, Durham, NC, USA
Lancet Infect Dis 9:637-49. 2009..There is also a need for more randomised controlled studies to identify the long-term outcomes, cost-effectiveness of ART, and use of virological monitoring in LMICs...
Invasive bacterial and fungal infections among hospitalized HIV-infected and HIV-uninfected children and infants in northern TanzaniaJohn A Crump
Division of Infectious Diseases and International Health, Department of Medicine, Duke University Medical Center, Durham, NC, USA
Trop Med Int Health 16:830-7. 2011..To describe the contribution of paediatric HIV and of HIV co-infections to admissions to a hospital in Moshi, Tanzania, using contemporary laboratory methods...- Characteristics of HIV voluntary counseling and testing clients before and during care and treatment scale-up in Moshi, TanzaniaMeghan M Shorter
Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
J Acquir Immune Defic Syndr 52:648-54. 2009..We evaluated changes in characteristics of clients presenting for voluntary counseling and testing (VCT) before and during care and treatment center (CTC) scale-up activities in Moshi, Tanzania, between November 2003 and December 2007... - Decreasing CD4+ T-cell count during suppressed or low-level viraemia in patients with HIV infectionAlbert M L Anderson
Department of Medicine, Division of Infectious Diseases, Duke University Medical Centre, Durham, NC, USA
Antivir Ther 12:1041-8. 2007..Suboptimal improvement in CD4+ T-cell count is not uncommon in HIV-infected patients with suppressed plasma HIV RNA levels, and a decrease in CD4+ T-cell count in patients with suppressed or low-level viraemia has been observed... - Predicting virologic failure among HIV-1-infected children receiving antiretroviral therapy in Tanzania: a cross-sectional studySusan D Emmett
Duke University Medical Center, Durham, North Carolina, USA
J Acquir Immune Defic Syndr 54:368-75. 2010.... - Lopinavir/ritonavir monotherapy after virologic failure of first-line antiretroviral therapy in resource-limited settingsJohn A Bartlett
Duke University Medical Center, Durham, NC 27710, USA
AIDS 26:1345-54. 2012..To evaluate virologic response rates of lopinavir/ritonavir (LPV/r) monotherapy as second-line antiretroviral treatment (ART) among adults in resource-limited settings (RLSs)... - Changing antiretroviral therapy in the setting of virologic relapse: review of the current literatureAlbert M L Anderson
Duke University Medical Center, Durham, NC 27710, USA
Curr HIV/AIDS Rep 3:79-85. 2006..In general, a lower switch threshold is recommended for patients during relapse on first or second line regimens... - Comparative efficacy of nucleoside/nucleotide reverse transcriptase inhibitors in combination with efavirenz: results of a systematic overviewJohn A Bartlett
Duke University Medical Center, Durham, North Carolina 27710, USA
HIV Clin Trials 8:221-6. 2007..However, the nucleoside/nucleotide reverse transcriptase inhibitor (NRTI) components may also affect efficacy... - Gender differences in the risk of HIV infection among persons reporting abstinence, monogamy, and multiple sexual partners in northern TanzaniaKeren Z Landman
Duke University Medical Center, Durham, North Carolina, USA
PLoS ONE 3:e3075. 2008..We examined the association between the number of sexual partners and the risk of HIV seropositivity among men and women presenting for HIV voluntary counseling and testing (VCT) in northern Tanzania... - Brucellosis among hospitalized febrile patients in northern TanzaniaAndrew J Bouley
Division of Infectious Diseases and International Health, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
Am J Trop Med Hyg 87:1105-11. 2012..Brucellosis is an underdiagnosed and untreated cause of febrile disease among hospitalized adult and pediatric patients in northern Tanzania... - Bacteremic disseminated tuberculosis in sub-saharan Africa: a prospective cohort studyJohn A Crump
Division of Infectious Diseases and International Health, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
Clin Infect Dis 55:242-50. 2012.... - Effect of trimethoprim-sulfamethoxazole prophylaxis on antimicrobial resistance of fecal Escherichia coli in HIV-infected patients in TanzaniaSusan C Morpeth
Division of Infectious Diseases and International Health, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
J Acquir Immune Defic Syndr 47:585-91. 2008..Trimethoprim-sulfamethoxazole (SXT) reduces morbidity and mortality among HIV-infected persons in Africa, but its impact on antimicrobial resistance is of concern... - Antiretroviral treatment literacy among HIV voluntary counseling and testing clients in Moshi, Tanzania, 2003 to 2005Keren Z Landman
Division of Infectious Diseases and International Health, Duke University Medical Center, Durham, North Carolina 27710, USA
J Int Assoc Physicians AIDS Care (Chic) 6:24-6. 2007..Previous HIV testing was protective against low antiretroviral treatment literacy. These results support refocusing HIV education efforts and increasing synergy between HIV prevention and treatment programs... - Persistent antiretroviral activity of nucleoside analogues after prolonged zidovudine and lamivudine therapy as demonstrated by rapid loss of activity after discontinuationJoseph J Eron
AIDS Clinical Research Unit, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
J Acquir Immune Defic Syndr 37:1581-3. 2004..Nucleoside analogue reverse transcriptase inhibitors may have continued ARV activity despite long durations of partially suppressive therapy and the presence of resistant HIV-1... - Naïve T cells are maintained in the periphery during the first 3 months of acute HIV-1 infection: implications for analysis of thymus functionGregory D Sempowski
Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
J Clin Immunol 25:462-72. 2005.... - Long-term results of initial therapy with abacavir and Lamivudine combined with Efavirenz, Amprenavir/Ritonavir, or StavudineJohn A Bartlett
Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
J Acquir Immune Defic Syndr 43:284-92. 2006..To compare alternative class-sparing antiretroviral regimens in treatment-naive subjects... - A cost-effectiveness analysis of alternative HIV retesting strategies in sub-saharan AfricaRichard C Waters
Duke Global Health Institute, Duke University, Durham, NC 27701, USA
J Acquir Immune Defic Syndr 56:443-52. 2011..Guidelines in sub-Saharan Africa on when HIV-seronegative persons should retest range from never to annually for lower-risk populations and from annually to every 3 months for high-risk populations... - Chikungunya and dengue fever among hospitalized febrile patients in northern TanzaniaJulian T Hertz
Division of Infectious Diseases and International Health, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA
Am J Trop Med Hyg 86:171-7. 2012..5, P = 0.007). CHIKV infection is an important but unrecognized cause of febrile illness in northern Tanzania. DENV or other closely related flaviviruses are likely also circulating... - Detection of minor drug-resistant populations by parallel allele-specific sequencingFangping Cai
Duke Human Vaccine Institute, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
Nat Methods 4:123-5. 2007..This assay may serve as a useful tool to study drug resistance in HIV and other infectious agents... - Leptospirosis among hospitalized febrile patients in northern TanzaniaHolly M Biggs
Department of Medicine and Department of Pathology, Duke University Medical Center, Durham, NC, USA
Am J Trop Med Hyg 85:275-81. 2011..001). Among those with confirmed leptospirosis, the predominant reactive serogroups were Mini and Australis. Leptospirosis is a major yet underdiagnosed cause of febrile illness in northern Tanzania, where it appears to be endemic... - Changes in CD4+ T-cell differentiation phenotype during structured treatment interruption in patients with chronic HIV-1 infectionThomas H Alexander
Duke University Medical Center, Durham, NC 27705, USA
J Acquir Immune Defic Syndr 34:475-81. 2003..These results suggest that interruptions should be avoided whenever possible in patients on HAART with high plasma HIV-1 RNA set-points... - Predicting CD4 lymphocyte count <200 cells/mm(3) in an HIV type 1-infected African populationSusan C Morpeth
Duke University Medical Center, Durham, North Carolina, 27710, Kilimanjaro Christian Medical Centre, Moshi, Tanzania
AIDS Res Hum Retroviruses 23:1230-6. 2007.... - Q fever, spotted fever group, and typhus group rickettsioses among hospitalized febrile patients in northern TanzaniaMalavika Prabhu
Department of Medicine, Division of Infectious Diseases and International Health, Duke University Medical Center, Duke University, Durham, North Carolina 27710, USA
Clin Infect Dis 53:e8-15. 2011.... - Invasive disease caused by nontuberculous mycobacteria, TanzaniaJohn A Crump
Division of Infectious Diseases and International Health, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
Emerg Infect Dis 15:53-5. 2009..avium complex sequevar MAC-D. Invasive NTM disease is present in HIV-infected patients in sub-Saharan Africa... - Invasive bacterial and fungal infections among hospitalized HIV-infected and HIV-uninfected adults and adolescents in northern TanzaniaJohn A Crump
Division of Infectious Diseases and International Health, Department ofMedicine, Duke University Medical Center, Box 102359, Durham, NC 27710, USA
Clin Infect Dis 52:341-8. 2011..few studies describe patterns of human immunodeficiency virus (HIV) co-infections in African hospitals in the antiretroviral therapy (ART) era... - Fixed dose combination abacavir/lamivudine in the treatment of HIV-1 infectionAlbert M L Anderson
Division of Infectious Diseases, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
Expert Rev Anti Infect Ther 3:871-83. 2005..Fixed dose combination abacavir/lamivudine should be considered as a viable treatment option for HIV-infected patients, particularly for those who have otherwise limited nucleoside reverse transcriptase inhibitor choices... - Addition of cyclophosphamide to antiretroviral therapy does not diminish the cellular reservoir in HIV-infected personsJohn A Bartlett
Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
AIDS Res Hum Retroviruses 18:535-43. 2002..We conclude that the addition of CTX to ART did not diminish the cellular reservoir in HIV-infected persons... - Predictors of proteinuria and renal failure among women with HIV infectionLynda Anne Szczech
Division of Nephrology, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
Kidney Int 61:195-202. 2002..This study examines the risk factors for proteinuria and renal failure in a large cohort of HIV-infected women not selected for the presence of renal disease... - Establishment of haematological and immunological reference values for healthy Tanzanian children in Kilimanjaro RegionAnn M Buchanan
Division of Pediatric Infectious Diseases, Department of Pediatrics, Duke University Medical Center, Durham, NC, USA
Trop Med Int Health 15:1011-21. 2010..To determine the normal haematological and immunological reference intervals for healthy Tanzanian children... - A prospective clinical and pathological examination of injection site reactions with the HIV-1 fusion inhibitor enfuvirtideSarah A Myers
Duke University Medical Center, Durham, NC, USA
Antivir Ther 11:935-9. 2006..Pathology was indistinguishable between ENF, vehicle and normal tissue in Cohort II patients. CONCLUSION: These results suggest that injection technique, injection volume and peptide may influence ISR to ENF... - Cost-effectiveness of free HIV voluntary counseling and testing through a community-based AIDS service organization in Northern TanzaniaNathan M Thielman
Division of Infectious Diseases and International Health, Duke University Medical Center, Box 3867, Durham, NC 27701, USA
Am J Public Health 96:114-9. 2006..72, $5.40, and $4.72, respectively. CONCLUSIONS: The provision of free VCT enhances both the number of clients testing per day and its cost-effectiveness in resource-limited settings... - Obstacles and proposed solutions to effective antiretroviral therapy in resource-limited settingsJohn A Bartlett
Department of Medicine, Duke University Medical Center, USA
J Int Assoc Physicians AIDS Care (Chic) 8:253-68. 2009..An understanding of these obstacles and suggested methods to overcome them must be addressed by global policy makers before universal ART access can be achieved... - Generic and branded drugs for the treatment of people living with HIV/AIDSJohn A Bartlett
Division of Infectious Disease and International Health, Duke University Medical Center, Durham, North Carolina 27710, USA
J Int Assoc Physicians AIDS Care (Chic) 6:15-23. 2007..Generic drugs have the potential to cause harm if rigorous standards for their use are not followed, but those that are qualified offer great promise in the treatment of HIV/AIDS... - HIV infection: treatment outcomes in older and younger adultsMelissa Fair Wellons
School of Medicine, Department of Medicine, Center for Study of Aging and Human Development, Duke University Medical Center, Durham, North Carolina 27705, USA
J Am Geriatr Soc 50:603-7. 2002..Older patients were less likely to interrupt ART, which suggests better adherence and/or tolerance and may explain the higher rate of HIV RNA suppression... - Evaluation of a dried blood spot HIV-1 RNA program for early infant diagnosis and viral load monitoring at rural and remote healthcare facilitiesSarah M Lofgren
Department of Medicine, Division of Infectious Diseases and International Health, Duke University Medical Center, Durham, North Carolina, USA
AIDS 23:2459-66. 2009..To assess technical and operational performance of a dried blood spot (DBS)-based HIV-1 RNA service for remote healthcare facilities in a low-income country... - Emergence of drug-resistant HIV-1 variants in patients undergoing structured treatment interruptionsBecky Schweighardt
Gladstone Institute of Virology and Immunology, University of California, San Francisco, CA, USA
AIDS 16:2342-4. 2002..We concluded that the repeated abrupt termination and resumption of certain antiretroviral drug regimens during STI therapy may lead to the development of drug resistance in chronically HIV-infected individuals... - Early intensification with abacavir in subjects at high risk for incomplete viral suppressionJohn A Bartlett
Antivir Ther 8:361-3. 2003 - Short-term safety and antiretroviral activity of T-1249, a second-generation fusion inhibitor of HIVJoseph J Eron
Division of Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
J Infect Dis 189:1075-83. 2004..43 to -0.05 log(10) copies/mL) for the lowest dose to -1.96 log(10) copies/mL (95% CI, -2.02 to -1.37 copies/mL) for the highest dose. These results indicate that T-1249 is a potent new therapeutic agent for HIV-1 infection... - Antiretroviral rounds. A communication conundrumKeith Henry
AIDS Clin Care 17:115-6. 2005 - Safety and immunogenicity of a polyvalent peptide C4-V3 HIV vaccine in conjunction with IL-12Beverly E Sha
Department of Medicine, Section of Infectious Diseases, Rush Medical College, Chicago, IL, USA
AIDS 18:1203-6. 2004..Three responders had received IL-12, suggesting a possible adjuvant effect of Il-12. Transient mild injection site reactions (7.9) and systemic symptoms (3/9) occurred... - Pharmacogenetics of nevirapine-associated hepatotoxicity: an Adult AIDS Clinical Trials Group collaborationDavid W Haas
Microbiology and Immunology, Center for Human Genetics Research, Vanderbilt University School of Medicine, Nashville, Tennessee 37203, USA
Clin Infect Dis 43:783-6. 2006..Among participants in a randomized study in South Africa (FTC-302), MDR1 3435C-->T was significantly associated with decreased risk of hepatotoxicity (risk ratio, 0.30; P=.016)... - A randomized study of antiviral medication switch at lower- versus higher-switch thresholds: AIDS Clinical Trials Group Study A5115Sharon A Riddler
Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
Antivir Ther 12:531-41. 2007..Clinical stability has been observed with continued antiretroviral therapy (ART) in the setting of partial virological suppression. The optimal time to switch treatment in patients with low but detectable HIV-1 RNA is not known... - Severe hepatotoxicity associated with nevirapine use in HIV-infected subjectsIan Sanne
Clinical HIV Research Unit, University of the Witwatersrand, Johannesburg, South Africa
J Infect Dis 191:825-9. 2005..The use of nevirapine in female patients with a low BMI should be discouraged... - Predictors of incomplete adherence, virologic failure, and antiviral drug resistance among HIV-infected adults receiving antiretroviral therapy in TanzaniaHabib O Ramadhani
Kilimanjaro Christian Medical Centre, Tumaini University, Moshi, Tanzania
Clin Infect Dis 45:1492-8. 2007..Access to antiretroviral therapy is rapidly expanding in sub-Saharan Africa. Identifying the predictors of incomplete adherence, virologic failure, and antiviral drug resistance is essential to achieving long-term success... - Definition of proteinuria among women with HIV infectionLynda Anne Szczech
Kidney Int 65:1519. 2004