Alexandra Badea

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. pmc Quantitative mouse brain phenotyping based on single and multispectral MR protocols
    Alexandra Badea
    Center for InVivo Microscopy, Box 3302, Duke University Medical Center, Durham, NC 27710, USA
    Neuroimage 63:1633-45. 2012
  2. pmc Remote sites of structural atrophy predict later amyloid formation in a mouse model of Alzheimer's disease
    Alexandra Badea
    Center for In Vivo Microscopy, Duke University Medical Center, Durham, NC, USA
    Neuroimage 50:416-27. 2010
  3. pmc Waxholm space: an image-based reference for coordinating mouse brain research
    G Allan Johnson
    Duke Center for In Vivo Microscopy, Radiology, Duke University Medical Center, Durham, NC 27710, USA
    Neuroimage 53:365-72. 2010
  4. pmc High-throughput morphologic phenotyping of the mouse brain with magnetic resonance histology
    G Allan Johnson
    Center for In Vivo Microscopy, Box 3302, Duke University Medical Center, Durham, NC 27710, USA
    Neuroimage 37:82-9. 2007
  5. ncbi request reprint Automated segmentation of neuroanatomical structures in multispectral MR microscopy of the mouse brain
    Anjum A Ali
    Center for In Vivo Microscopy, Box 3302, Duke University Medical Center, Durham, NC 27710, USA
    Neuroimage 27:425-35. 2005
  6. pmc Genetic dissection of the mouse CNS using magnetic resonance microscopy
    Alexandra Badea
    Center for In Vivo Microscopy, Department of Radiology, Duke University Medical Center, Durham, North Carolina, USA
    Curr Opin Neurol 22:379-86. 2009
  7. pmc A quantitative magnetic resonance histology atlas of postnatal rat brain development with regional estimates of growth and variability
    Evan Calabrese
    Center for In Vivo Microscopy, Department of Radiology, Box 3302 Duke University Medical Center, Durham, NC 27710, USA
    Neuroimage 71:196-206. 2013
  8. pmc Quantitative neuromorphometry using magnetic resonance histology
    G Allan Johnson
    Duke Center for In Vivo Microscopy, Durham, NC27710, USA
    Toxicol Pathol 39:85-91. 2011
  9. pmc Small animal imaging with magnetic resonance microscopy
    Bastiaan Driehuys
    Department of Radiology, Center for In Vivo Microscopy, Duke University Medical Center, Durham, NC 27710, USA
    ILAR J 49:35-53. 2008
  10. pmc Neuroanatomical phenotypes in the reeler mouse
    Alexandra Badea
    Center for In Vivo Microscopy, Box 3302, Duke University Medical Center, Durham, NC 27710, USA
    Neuroimage 34:1363-74. 2007

Detail Information

Publications13

  1. pmc Quantitative mouse brain phenotyping based on single and multispectral MR protocols
    Alexandra Badea
    Center for InVivo Microscopy, Box 3302, Duke University Medical Center, Durham, NC 27710, USA
    Neuroimage 63:1633-45. 2012
    ..g. fMRI and molecular imaging. This is the first demonstration that multiple MR imaging modalities combined with multivariate segmentation methods lead to significant improvements in anatomical segmentation in the mouse brain...
  2. pmc Remote sites of structural atrophy predict later amyloid formation in a mouse model of Alzheimer's disease
    Alexandra Badea
    Center for In Vivo Microscopy, Duke University Medical Center, Durham, NC, USA
    Neuroimage 50:416-27. 2010
    ..Our work provides proof-of-principle that MR microscopy can expand our view of AD by offering a complete and unbiased examination of volumetric changes that guide us in revisiting the canonical neuropathology...
  3. pmc Waxholm space: an image-based reference for coordinating mouse brain research
    G Allan Johnson
    Duke Center for In Vivo Microscopy, Radiology, Duke University Medical Center, Durham, NC 27710, USA
    Neuroimage 53:365-72. 2010
    ..All the data is available for download via the web...
  4. pmc High-throughput morphologic phenotyping of the mouse brain with magnetic resonance histology
    G Allan Johnson
    Center for In Vivo Microscopy, Box 3302, Duke University Medical Center, Durham, NC 27710, USA
    Neuroimage 37:82-9. 2007
    ..These collection and acquisition methods are now available to the neuroscience community as a standard web-deliverable service...
  5. ncbi request reprint Automated segmentation of neuroanatomical structures in multispectral MR microscopy of the mouse brain
    Anjum A Ali
    Center for In Vivo Microscopy, Box 3302, Duke University Medical Center, Durham, NC 27710, USA
    Neuroimage 27:425-35. 2005
    ..Results achieved in the mouse brain are comparable with those achieved in human brain studies using similar techniques. The segmentation algorithm shows excellent potential for routine morphological phenotyping of mouse models...
  6. pmc Genetic dissection of the mouse CNS using magnetic resonance microscopy
    Alexandra Badea
    Center for In Vivo Microscopy, Department of Radiology, Duke University Medical Center, Durham, North Carolina, USA
    Curr Opin Neurol 22:379-86. 2009
    ..Sophisticated mouse models will be critical in converting correlations into mechanisms and in determining genetic and epigenetic causes of differences in disease susceptibility...
  7. pmc A quantitative magnetic resonance histology atlas of postnatal rat brain development with regional estimates of growth and variability
    Evan Calabrese
    Center for In Vivo Microscopy, Department of Radiology, Box 3302 Duke University Medical Center, Durham, NC 27710, USA
    Neuroimage 71:196-206. 2013
    ..The atlas was used to establish a timeline of morphometric changes and variability throughout neurodevelopment and represents a quantitative database of rat neurodevelopment for characterizing rat models of human neurologic disease...
  8. pmc Quantitative neuromorphometry using magnetic resonance histology
    G Allan Johnson
    Duke Center for In Vivo Microscopy, Durham, NC27710, USA
    Toxicol Pathol 39:85-91. 2011
    ..MRH will not replace more traditional methods, but it promises enormous value in choosing particular areas and times for more traditional sectioning and assessment...
  9. pmc Small animal imaging with magnetic resonance microscopy
    Bastiaan Driehuys
    Department of Radiology, Center for In Vivo Microscopy, Duke University Medical Center, Durham, NC 27710, USA
    ILAR J 49:35-53. 2008
    ..The ability of MRM to provide a detailed functional and anatomical picture in rats and mice, and to track this picture over time, makes it a promising platform with broad applications in biomedical research...
  10. pmc Neuroanatomical phenotypes in the reeler mouse
    Alexandra Badea
    Center for In Vivo Microscopy, Box 3302, Duke University Medical Center, Durham, NC 27710, USA
    Neuroimage 34:1363-74. 2007
    ..Our results suggest that structural features of Reln(rl/rl) brain most closely phenocopy those of patients with Norman-Roberts lissencephaly...
  11. ncbi request reprint Magnetic resonance microscopy
    Alexandra Badea
    Center for In Vivo Microscopy, Department of Radiology, Duke University Medical Center, Durham, NC, USA
    Stud Health Technol Inform 185:153-84. 2013
    ..MRM, alone or in combination with other imaging modalities, will increase the knowledge of fundamental biological processes, help understanding the genetic basis of human diseases, and test pharmacological interventions...
  12. pmc A multidimensional magnetic resonance histology atlas of the Wistar rat brain
    G Allan Johnson
    Center for In Vivo Microscopy, Department of Radiology, Duke University Medical Center, Durham, NC 27710, USA
    Neuroimage 62:1848-56. 2012
    ....
  13. pmc Registration-based segmentation of murine 4D cardiac micro-CT data using symmetric normalization
    Darin Clark
    Center for In Vivo Microscopy, Duke University Medical Center, Durham, NC 27710, USA
    Phys Med Biol 57:6125-45. 2012
    ..76% or more due to systematic label propagation errors around atrioventricular valves; however, execution of the pipeline was 80% faster than performing analogous manual segmentation of each phase...