Richard Auten

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. ncbi request reprint Anti-neutrophil chemokine preserves alveolar development in hyperoxia-exposed newborn rats
    R L Auten
    Division of Neonatal Medicine, Department of Pediatrics, Neonatal Perinatal Research Institute, Durham, North Carolina 27710, USA
    Am J Physiol Lung Cell Mol Physiol 281:L336-44. 2001
  2. doi request reprint S-nitrosothiol transport via PEPT2 mediates biological effects of nitric oxide gas exposure in macrophages
    Mulugu V Brahmajothi
    Division of Neonatal Medicine, Department of Pediatrics, Duke University Medical Center, Duke University, Durham, NC 27710, USA
    Am J Respir Cell Mol Biol 48:230-9. 2013
  3. pmc Maternal diesel inhalation increases airway hyperreactivity in ozone-exposed offspring
    Richard L Auten
    Departments of Pediatrics, Duke University, Durham, NC 27710, USA
    Am J Respir Cell Mol Biol 46:454-60. 2012
  4. pmc Maternal exposure to particulate matter increases postnatal ozone-induced airway hyperreactivity in juvenile mice
    Richard L Auten
    Neonatal Medicine, Department of Pediatrics, Duke University, Durham, North Carolina, USA
    Am J Respir Crit Care Med 180:1218-26. 2009
  5. pmc Hyperoxia impairs postnatal alveolar epithelial development via NADPH oxidase in newborn mice
    Richard L Auten
    Division of Neonatology, Department of Pediatrics, Duke University Medical Center, Neonatal Perinatal Research Institute, Durham, North Carolina 27710, USA
    Am J Physiol Lung Cell Mol Physiol 297:L134-42. 2009
  6. pmc Inhaled ethyl nitrite prevents hyperoxia-impaired postnatal alveolar development in newborn rats
    Richard L Auten
    Division of Neonatal Medicine, Department of Pediatrics, Neonatal Perinatal Research Institute, University Medical Center, Durham, North Carolina 27710, USA
    Am J Respir Crit Care Med 176:291-9. 2007
  7. pmc Transgenic extracellular superoxide dismutase protects postnatal alveolar epithelial proliferation and development during hyperoxia
    Richard L Auten
    Neonatal Perinatal Research Institute, Department of Pediatrics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Physiol Lung Cell Mol Physiol 290:L32-40. 2006
  8. ncbi request reprint Nonpeptide CXCR2 antagonist prevents neutrophil accumulation in hyperoxia-exposed newborn rats
    R L Auten
    Department of Pediatrics, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Pharmacol Exp Ther 299:90-5. 2001
  9. ncbi request reprint Blocking leukocyte influx and function to prevent chronic lung disease of prematurity
    Richard L Auten
    Neonatal Perinatal Research Institute, Division of Neonatal Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Pediatr Pulmonol 35:335-41. 2003
  10. ncbi request reprint Antimacrophage chemokine treatment prevents neutrophil and macrophage influx in hyperoxia-exposed newborn rat lung
    Michael A Vozzelli
    Department of Pediatrics, Division of Neonatal Medicine, Neonatal Perinatal Research Institute, Durham, NC 27710, USA
    Am J Physiol Lung Cell Mol Physiol 286:L488-93. 2004

Research Grants

  1. Chemokine Blockade to Preserve Lung Development
    Richard Auten; Fiscal Year: 2005

Collaborators

Detail Information

Publications24

  1. ncbi request reprint Anti-neutrophil chemokine preserves alveolar development in hyperoxia-exposed newborn rats
    R L Auten
    Division of Neonatal Medicine, Department of Pediatrics, Neonatal Perinatal Research Institute, Durham, North Carolina 27710, USA
    Am J Physiol Lung Cell Mol Physiol 281:L336-44. 2001
    ..Blockade of neutrophil influx in newborns may avert early lung injury and avoid alveolar developmental arrest that contributes to bronchopulmonary dysplasia...
  2. doi request reprint S-nitrosothiol transport via PEPT2 mediates biological effects of nitric oxide gas exposure in macrophages
    Mulugu V Brahmajothi
    Division of Neonatal Medicine, Department of Pediatrics, Duke University Medical Center, Duke University, Durham, NC 27710, USA
    Am J Respir Cell Mol Biol 48:230-9. 2013
    ..The NO gas treatment of alveolar macrophages increased SNO uptake, the activation of sGC, F-actin polymerization, and phagocytosis, and inhibited NF-κB activation, in a manner dependent on SNO transport via PEPT2, as well as via LAT...
  3. pmc Maternal diesel inhalation increases airway hyperreactivity in ozone-exposed offspring
    Richard L Auten
    Departments of Pediatrics, Duke University, Durham, NC 27710, USA
    Am J Respir Cell Mol Biol 46:454-60. 2012
    ..We conclude that maternal inhalation of DE in pregnancy provokes a fetal inflammatory response that, combined with postnatal ozone exposure, impairs alveolar development, and causes a more severe and long-lasting AHR to ozone exposure...
  4. pmc Maternal exposure to particulate matter increases postnatal ozone-induced airway hyperreactivity in juvenile mice
    Richard L Auten
    Neonatal Medicine, Department of Pediatrics, Duke University, Durham, North Carolina, USA
    Am J Respir Crit Care Med 180:1218-26. 2009
    ..Epidemiologic studies implicate air pollutant exposure during pregnancy as a risk factor for wheezing in offspring. Ozone exposure is linked to exacerbations of wheezing in children...
  5. pmc Hyperoxia impairs postnatal alveolar epithelial development via NADPH oxidase in newborn mice
    Richard L Auten
    Division of Neonatology, Department of Pediatrics, Duke University Medical Center, Neonatal Perinatal Research Institute, Durham, North Carolina 27710, USA
    Am J Physiol Lung Cell Mol Physiol 297:L134-42. 2009
    ....
  6. pmc Inhaled ethyl nitrite prevents hyperoxia-impaired postnatal alveolar development in newborn rats
    Richard L Auten
    Division of Neonatal Medicine, Department of Pediatrics, Neonatal Perinatal Research Institute, University Medical Center, Durham, North Carolina 27710, USA
    Am J Respir Crit Care Med 176:291-9. 2007
    ..Because S-nitrosylation is a key pathway mediating many NO biological effects, treatment with inhaled ENO may better protect postnatal lung development from oxidative stress than NO...
  7. pmc Transgenic extracellular superoxide dismutase protects postnatal alveolar epithelial proliferation and development during hyperoxia
    Richard L Auten
    Neonatal Perinatal Research Institute, Department of Pediatrics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Physiol Lung Cell Mol Physiol 290:L32-40. 2006
    ..Reducing the 95% O2-induced impairment of epithelial proliferation at a critical window of lung development was associated with protection against DNA damage and preservation of apical T1alpha expression at P3...
  8. ncbi request reprint Nonpeptide CXCR2 antagonist prevents neutrophil accumulation in hyperoxia-exposed newborn rats
    R L Auten
    Department of Pediatrics, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Pharmacol Exp Ther 299:90-5. 2001
    ..SB-265610 reduced the antiapoptotic effect of CINC-1 to the levels of those untreated with CINC-1. A selective CXCR2 antagonist may be useful in diseases where neutrophil-mediated exacerbation is present...
  9. ncbi request reprint Blocking leukocyte influx and function to prevent chronic lung disease of prematurity
    Richard L Auten
    Neonatal Perinatal Research Institute, Division of Neonatal Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Pediatr Pulmonol 35:335-41. 2003
    ..Examination of the inflammatory pathways that initiate and propagate lung injury and subsequent abnormal development points to promising new strategies that may one day be tailored to individual patients...
  10. ncbi request reprint Antimacrophage chemokine treatment prevents neutrophil and macrophage influx in hyperoxia-exposed newborn rat lung
    Michael A Vozzelli
    Department of Pediatrics, Division of Neonatal Medicine, Neonatal Perinatal Research Institute, Durham, NC 27710, USA
    Am J Physiol Lung Cell Mol Physiol 286:L488-93. 2004
    ..Tissue carbonyls, a measure of protein oxidation, were decreased in anti-MCP-1-treated pups. Anti-MCP-1 treatment prevented neutrophil influx and reduced protein oxidation in hyperoxia-exposed newborn rats...
  11. ncbi request reprint Blocking neutrophil influx reduces DNA damage in hyperoxia-exposed newborn rat lung
    Richard L Auten
    Neonatal Perinatal Research Institute, Division of Neonatal Medicine, Department of Pediatrics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Respir Cell Mol Biol 26:391-7. 2002
    ..Effects of 95% O2 on TUNEL are not primarily due to apoptosis in this model. Neutrophil-mediated oxidative DNA damage may contribute to abnormal lung development in newborns subjected to significant oxidative stress...
  12. pmc Biochemical effects of ozone on asthma during postnatal development
    Richard L Auten
    Department of Pediatrics Neonatal Medicine, Duke University, DUMC Box 3373, Durham, NC 27710, USA
    Biochim Biophys Acta 1810:1114-9. 2011
    ..Ozone exposure during early life has the potential to contribute to the development of asthma as well as to exacerbate underlying allergic asthma...
  13. ncbi request reprint Extracellular superoxide dismutase protects lung development in hyperoxia-exposed newborn mice
    Mohamed N Ahmed
    Departments of Pediatrics, Medicine, Anesthesiology, Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Respir Crit Care Med 167:400-5. 2003
    ..After 7 days 95% O2 + 14 days 60% O2, lung inflammation measured as myeloperoxidase activity was reduced to control levels in all treatment groups...
  14. pmc Airway smooth muscle relaxation is impaired in mice lacking the p47phox subunit of NAD(P)H oxidase
    Pasquale Chitano
    Dept of Pediatrics and Neonatal Perinatal Research Institute, Duke Univ Medical Center, Rm 302, Bell Bldg, Box 2994, Durham, NC 27710, USA
    Am J Physiol Lung Cell Mol Physiol 294:L139-48. 2008
    ..Most importantly, we report the first evidence that the p47phox subunit of NAD(P)H oxidase plays a role in ASM relaxation...
  15. pmc Pharmacologically augmented S-nitrosylated hemoglobin improves recovery from murine subarachnoid hemorrhage
    Huaxin Sheng
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    Stroke 42:471-6. 2011
    ..This study tested the hypothesis that enhancement of S-nitrosylated hemoglobin by ethyl nitrite inhalation improves outcome after experimental subarachnoid hemorrhage (SAH)...
  16. doi request reprint Oxygen toxicity and reactive oxygen species: the devil is in the details
    Richard L Auten
    Department of Pediatrics, Duke Medical Center, Durham, NC 27710, USA
    Pediatr Res 66:121-7. 2009
    ....
  17. pmc Protection from lipopolysaccharide-induced lung injury by augmentation of airway S-nitrosothiols
    Harvey E Marshall
    Department of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Respir Crit Care Med 180:11-8. 2009
    ..Ethyl nitrite (ENO) is a gas with chemical properties favoring SNO formation. Augmentation of airway SNO by inhaled ENO treatment may decrease lung inflammation and subsequent injury by inhibiting activation of the airway epithelium...
  18. ncbi request reprint Discordant extracellular superoxide dismutase expression and activity in neonatal hyperoxic lung
    Lisa B Mamo
    Department of Pediatrics, Duke University Medical Center, Durham, North Carolina, USA
    Am J Respir Crit Care Med 170:313-8. 2004
    ..These data provide the first direct evidence that EC-SOD is itself a target of nitration in hyperoxia, and offer a plausible explanation for low EC-SOD activity despite its increased secretion by O(2)-exposed neonatal lung...
  19. pmc The role of Scgb1a1+ Clara cells in the long-term maintenance and repair of lung airway, but not alveolar, epithelium
    Emma L Rawlins
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Cell Stem Cell 4:525-34. 2009
    ..Rather, our results support a model in which the trachea, bronchioles, and alveoli are maintained by distinct populations of epithelial progenitor cells...
  20. pmc Mast cells mediate hyperoxia-induced airway hyper-reactivity in newborn rats
    Eric D Schultz
    Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA
    Pediatr Res 68:70-4. 2010
    ..Imatinib treatment completely blocked mast cell accumulation in tracheal/hilar airway tissues. Hyperoxia-induced AHR in neonatal rats is mediated, at least in part, via the mast cell...
  21. pmc Pulmonary alveolar epithelial uptake of S-nitrosothiols is regulated by L-type amino acid transporter
    Olivia M Granillo
    School of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Physiol Lung Cell Mol Physiol 295:L38-43. 2008
    ..This was unaffected by PEPT2 inhibition. We conclude that RSNOs (thionitrites, S-nitrosothiols) and NO enter alveolar epithelial cells predominantly by S-nitrosation of L-Cys, which is then imported through LAT...
  22. ncbi request reprint CXCR2 blockade reduces radical formation in hyperoxia-exposed newborn rat lung
    Lingjie Liao
    Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
    Pediatr Res 60:299-303. 2006
    ..Taken together with our previous studies, the present findings show that blocking neutrophil influx protects alveolar development and improves lung function in part by preventing reactive oxygen/nitrogen species accumulation...
  23. ncbi request reprint Early inhaled nitric oxide therapy in premature newborns with respiratory failure
    John P Kinsella
    Pediatric Heart Lung Center, University of Colorado School of Medicine, and Children s Hospital, Denver, USA
    N Engl J Med 355:354-64. 2006
    ..The safety and efficacy of early, low-dose, prolonged therapy with inhaled nitric oxide in premature newborns with respiratory failure are uncertain...
  24. ncbi request reprint Opposing effects of 60% oxygen and neutrophil influx on alveologenesis in the neonatal rat
    Man Yi
    Lung Biology Programme, The Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8, Canada
    Am J Respir Crit Care Med 170:1188-96. 2004
    ..These data suggest that exposure of the neonatal lung to moderate hyperoxia may enhance postnatal lung growth, provided postnatal pulmonary inflammation is suppressed...

Research Grants4

  1. Chemokine Blockade to Preserve Lung Development
    Richard Auten; Fiscal Year: 2005
    ..Aim 3 will determine whether blockade of leukocyte function can safely preserve normal alveolar development during recovery from severe oxidant stress. ..