Genomes and Genes
Affiliation: Duke University Medical Center
- Electrostatic and lipid anchor contributions to the interaction of transducin with membranes: mechanistic implications for activation and translocationMickey Kosloff
Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA
J Biol Chem 283:31197-207. 2008..In a broader view, this work exemplifies how the activity-dependent association and dissociation of a G protein can change both the affinity for membranes and the range of allowed orientations, thereby modulating G protein function...
- The outer segment serves as a default destination for the trafficking of membrane proteins in photoreceptorsSheila A Baker
Albert Eye Research Institute, Duke University Medical Center, Durham, NC 27710, USA
J Cell Biol 183:485-98. 2008..This also implies that every protein residing outside the outer segment must have a means to avoid this "default" trafficking flow...
- Integrating energy calculations with functional assays to decipher the specificity of G protein-RGS protein interactionsMickey Kosloff
Duke Eye Center, Duke University Medical Center, Durham, North Carolina, USA
Nat Struct Mol Biol 18:846-53. 2011..Finally, we show that our approach can be extended to analyze interaction specificity across other large protein families...
- RGS9 knockout causes a short delay in light responses of ON-bipolar cellsRolf Herrmann
Albert Eye Research Institute, Duke University, Durham, North Carolina, United States of America
PLoS ONE 6:e27573. 2011..This result is inconsistent with a slowdown of response propagation in ON-bipolar cells caused by the R9AP knockout, further arguing against the postsynaptic nature of the delayed b-wave phenotype in RGS9 and R9AP knockout mice...
- A single valine residue plays an essential role in peripherin/rds targeting to photoreceptor outer segmentsRaquel Y Salinas
Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina, United States of America
PLoS ONE 8:e54292. 2013..This valine is conserved in all species and its mutation is sufficient to completely abrogate the targeting of full-length peripherin in mouse rods...
- Photoreceptor signaling: supporting vision across a wide range of light intensitiesVadim Y Arshavsky
Departments of Ophthalmology and Pharmacology, Duke University, Durham, North Carolina 27710, USA
J Biol Chem 287:1620-6. 2012....
- Vision: the retinoid cycle in DrosophilaVadim Y Arshavsky
Duke University Eye Center, Durham, NC 27710, USA
Curr Biol 20:R96-8. 2010..New studies indicate that this pathway is present in Drosophila and is vital for maintaining both the amount of visual pigment and photoreceptor health in light-exposed flies...
- Proteome Map of the Photoreceptor CellVadim Arshavsky; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..