Vadim Arshavsky

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. pmc Electrostatic and lipid anchor contributions to the interaction of transducin with membranes: mechanistic implications for activation and translocation
    Mickey Kosloff
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA
    J Biol Chem 283:31197-207. 2008
  2. pmc The outer segment serves as a default destination for the trafficking of membrane proteins in photoreceptors
    Sheila A Baker
    Albert Eye Research Institute, Duke University Medical Center, Durham, NC 27710, USA
    J Cell Biol 183:485-98. 2008
  3. pmc Integrating energy calculations with functional assays to decipher the specificity of G protein-RGS protein interactions
    Mickey Kosloff
    Duke Eye Center, Duke University Medical Center, Durham, North Carolina, USA
    Nat Struct Mol Biol 18:846-53. 2011
  4. pmc RGS9 knockout causes a short delay in light responses of ON-bipolar cells
    Rolf Herrmann
    Albert Eye Research Institute, Duke University, Durham, North Carolina, United States of America
    PLoS ONE 6:e27573. 2011
  5. pmc A single valine residue plays an essential role in peripherin/rds targeting to photoreceptor outer segments
    Raquel Y Salinas
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina, United States of America
    PLoS ONE 8:e54292. 2013
  6. pmc Photoreceptor signaling: supporting vision across a wide range of light intensities
    Vadim Y Arshavsky
    Departments of Ophthalmology and Pharmacology, Duke University, Durham, North Carolina 27710, USA
    J Biol Chem 287:1620-6. 2012
  7. doi Vision: the retinoid cycle in Drosophila
    Vadim Y Arshavsky
    Duke University Eye Center, Durham, NC 27710, USA
    Curr Biol 20:R96-8. 2010

Research Grants

Collaborators

  • Mickey Kosloff
  • Emil Alexov
  • Sheila A Baker
  • Raquel Y Salinas
  • Rolf Herrmann
  • Sidney M Gospe
  • Bowa Lee
  • Peter Yoo
  • Barry E Knox
  • Nikolai P Skiba
  • Mohammad Haeri

Detail Information

Publications7

  1. pmc Electrostatic and lipid anchor contributions to the interaction of transducin with membranes: mechanistic implications for activation and translocation
    Mickey Kosloff
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA
    J Biol Chem 283:31197-207. 2008
    ..In a broader view, this work exemplifies how the activity-dependent association and dissociation of a G protein can change both the affinity for membranes and the range of allowed orientations, thereby modulating G protein function...
  2. pmc The outer segment serves as a default destination for the trafficking of membrane proteins in photoreceptors
    Sheila A Baker
    Albert Eye Research Institute, Duke University Medical Center, Durham, NC 27710, USA
    J Cell Biol 183:485-98. 2008
    ..This also implies that every protein residing outside the outer segment must have a means to avoid this "default" trafficking flow...
  3. pmc Integrating energy calculations with functional assays to decipher the specificity of G protein-RGS protein interactions
    Mickey Kosloff
    Duke Eye Center, Duke University Medical Center, Durham, North Carolina, USA
    Nat Struct Mol Biol 18:846-53. 2011
    ..Finally, we show that our approach can be extended to analyze interaction specificity across other large protein families...
  4. pmc RGS9 knockout causes a short delay in light responses of ON-bipolar cells
    Rolf Herrmann
    Albert Eye Research Institute, Duke University, Durham, North Carolina, United States of America
    PLoS ONE 6:e27573. 2011
    ..This result is inconsistent with a slowdown of response propagation in ON-bipolar cells caused by the R9AP knockout, further arguing against the postsynaptic nature of the delayed b-wave phenotype in RGS9 and R9AP knockout mice...
  5. pmc A single valine residue plays an essential role in peripherin/rds targeting to photoreceptor outer segments
    Raquel Y Salinas
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina, United States of America
    PLoS ONE 8:e54292. 2013
    ..This valine is conserved in all species and its mutation is sufficient to completely abrogate the targeting of full-length peripherin in mouse rods...
  6. pmc Photoreceptor signaling: supporting vision across a wide range of light intensities
    Vadim Y Arshavsky
    Departments of Ophthalmology and Pharmacology, Duke University, Durham, North Carolina 27710, USA
    J Biol Chem 287:1620-6. 2012
    ....
  7. doi Vision: the retinoid cycle in Drosophila
    Vadim Y Arshavsky
    Duke University Eye Center, Durham, NC 27710, USA
    Curr Biol 20:R96-8. 2010
    ..New studies indicate that this pathway is present in Drosophila and is vital for maintaining both the amount of visual pigment and photoreceptor health in light-exposed flies...

Research Grants30

  1. GTPASE ACTIVATING COMPLEX FROM ROD PHOTORECEPTORS
    Vadim Arshavsky; Fiscal Year: 2006
    ..This work is relevant to understanding of how biochemical pathways responsible for ensuring normal photoreceptor activity may be affected in various inherited eye diseases. ..
  2. TRANSDUCIN GTPASE AND PHOTORECEPTOR LIGHT ADAPTATION
    Vadim Arshavsky; Fiscal Year: 1999
    ..The experiments outlined in this application are relevant to understanding the intricate feedback controls that regulate photoreceptor activity, controls that may be perturbed in several inherited diseases. ..
  3. GTPASE ACTIVATING COMPLEX FROM ROD PHOTORECEPTORS
    Vadim Arshavsky; Fiscal Year: 2005
    ..This work is relevant to understanding of how biochemical pathways responsible for ensuring normal photoreceptor activity may be affected in various inherited eye diseases. ..
  4. TRANSDUCIN GTPASE AND PHOTORECEPTOR LIGHT ADAPTATION
    Vadim Arshavsky; Fiscal Year: 2000
    ..The experiments outlined in this application are relevant to understanding the intricate feedback controls that regulate photoreceptor activity, controls that may be perturbed in several inherited diseases. ..
  5. Transducin movement and photoreceptor light adaptation
    Vadim Arshavsky; Fiscal Year: 2007
    ..The proposed experiments are relevant to understanding the molecular and cellular mechanisms that regulate normal photoreceptor activity, mechanisms that may be perturbed in several degenerative retinal diseases. ..
  6. Transducin movement and photoreceptor light adaptation
    Vadim Arshavsky; Fiscal Year: 2006
    ..The proposed experiments are relevant to understanding the molecular and cellular mechanisms that regulate normal photoreceptor activity, mechanisms that may be perturbed in several degenerative retinal diseases. ..
  7. GTPASE ACTIVATING COMPLEX FROM ROD PHOTORECEPTORS
    Vadim Arshavsky; Fiscal Year: 2007
    ..This work is relevant to understanding of how biochemical pathways responsible for ensuring normal photoreceptor activity may be affected in various inherited eye diseases. ..
  8. Protein Translocation and Photoreceptor Light Adaptation
    Vadim Arshavsky; Fiscal Year: 2009
    ....
  9. GTPASE ACTIVATING COMPLEX FROM ROD PHOTORECEPTORS
    Vadim Arshavsky; Fiscal Year: 2009
    ..This work is relevant to understanding of how biochemical pathways responsible for ensuring normal photoreceptor activity may be affected in various inherited eye diseases. ..
  10. Protein Translocation and Photoreceptor Light Adaptation
    Vadim Y Arshavsky; Fiscal Year: 2010
    ....
  11. Delivery of signaling and structural proteins to photoreceptor outer segment
    Vadim Y Arshavsky; Fiscal Year: 2010
    ..Elucidating these mechanisms is essential for developing strategies for disease prevention and future therapeutic interventions. ..
  12. GTPASE ACTIVATING COMPLEX FROM ROD PHOTORECEPTORS
    Vadim Arshavsky; Fiscal Year: 2000
    ..The work is also relevant to understanding of how biochemical pathways responsible for ensuring normal duration of the photoresponse may be affected in various inherited eye diseases. ..
  13. TRANSDUCIN GTPASE AND PHOTORECEPTOR LIGHT ADAPTATION
    Vadim Arshavsky; Fiscal Year: 2001
    ..The experiments outlined in this application are relevant to understanding the intricate feedback controls that regulate photoreceptor activity, controls that may be perturbed in several inherited diseases. ..
  14. GTPASE ACTIVATING COMPLEX FROM ROD PHOTORECEPTORS
    Vadim Arshavsky; Fiscal Year: 2001
    ..The work is also relevant to understanding of how biochemical pathways responsible for ensuring normal duration of the photoresponse may be affected in various inherited eye diseases. ..
  15. TRANSDUCIN GTPASE AND PHOTORECEPTOR LIGHT ADAPTATION
    Vadim Arshavsky; Fiscal Year: 2002
    ..The experiments outlined in this application are relevant to understanding the intricate feedback controls that regulate photoreceptor activity, controls that may be perturbed in several inherited diseases. ..
  16. GTPASE ACTIVATING COMPLEX FROM ROD PHOTORECEPTORS
    Vadim Arshavsky; Fiscal Year: 2002
    ..The work is also relevant to understanding of how biochemical pathways responsible for ensuring normal duration of the photoresponse may be affected in various inherited eye diseases. ..
  17. Transducin movement and photoreceptor light adaptation
    Vadim Arshavsky; Fiscal Year: 2003
    ..The proposed experiments are relevant to understanding the molecular and cellular mechanisms that regulate normal photoreceptor activity, mechanisms that may be perturbed in several degenerative retinal diseases. ..
  18. GTPASE ACTIVATING COMPLEX FROM ROD PHOTORECEPTORS
    Vadim Arshavsky; Fiscal Year: 2003
    ..The work is also relevant to understanding of how biochemical pathways responsible for ensuring normal duration of the photoresponse may be affected in various inherited eye diseases. ..
  19. Proteome Map of the Photoreceptor Cell
    Vadim Arshavsky; Fiscal Year: 2007
    ....
  20. GTPASE ACTIVATING COMPLEX FROM ROD PHOTORECEPTORS
    Vadim Arshavsky; Fiscal Year: 2005
    ..This work is relevant to understanding of how biochemical pathways responsible for ensuring normal photoreceptor activity may be affected in various inherited eye diseases. ..
  21. GTPASE ACTIVATING COMPLEX FROM ROD PHOTORECEPTORS
    Vadim Arshavsky; Fiscal Year: 2004
    ..The work is also relevant to understanding of how biochemical pathways responsible for ensuring normal duration of the photoresponse may be affected in various inherited eye diseases. ..