Kevin J Anstrom

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. pmc Suspected acute exacerbation of idiopathic pulmonary fibrosis as an outcome measure in clinical trials
    Harold R Collard
    University of California San Francisco, San Francisco, CA, USA
    Respir Res 14:73. 2013
  2. doi request reprint Long-term clinical outcomes following coronary stenting
    Kevin J Anstrom
    Department of Biostatistics, Duke Clinical Research Institute, Durham, NC 27715, USA
    Arch Intern Med 168:1647-55. 2008
  3. doi request reprint Six-month follow-up of patients with in-hospital thrombocytopenia during heparin-based anticoagulation (from the Complications After Thrombocytopenia Caused by Heparin [CATCH] registry)
    Renato D Lopes
    Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina, USA
    Am J Cardiol 104:1285-91. 2009
  4. doi request reprint Short- and long-term outcomes of coronary stenting in women versus men: results from the National Cardiovascular Data Registry Centers for Medicare & Medicaid services cohort
    Monique L Anderson
    7022 N Pavilion DUMC, PO Box 17969, Durham, NC 27715, USA
    Circulation 126:2190-9. 2012
  5. doi request reprint Long-term clinical and economic analysis of the Endeavor zotarolimus-eluting stent versus the cypher sirolimus-eluting stent: 3-year results from the ENDEAVOR III trial (Randomized Controlled Trial of the Medtronic Endeavor Drug [ABT-578] Eluting Coronary
    Eric L Eisenstein
    Duke Clinical Research Institute, Durham, North Carolina 27705, USA
    JACC Cardiovasc Interv 2:1199-207. 2009
  6. doi request reprint Evaluating the impact of public health notification: Duke clopidogrel experience
    Eric L Eisenstein
    Duke Clinical Research Institute and Duke Translational Medicine Institute, Duke University Medical Center, Durham, NC, USA
    Circ Cardiovasc Qual Outcomes 5:767-74. 2012
  7. pmc Clinical effectiveness of coronary stents in elderly persons: results from 262,700 Medicare patients in the American College of Cardiology-National Cardiovascular Data Registry
    Pamela S Douglas
    Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina, USA
    J Am Coll Cardiol 53:1629-41. 2009
  8. ncbi request reprint Long-term costs and resource use in elderly participants with congestive heart failure in the Cardiovascular Health Study
    Lawrence Liao
    Duke Clinical Research Institute, Durham, NC, USA
    Am Heart J 153:245-52. 2007
  9. doi request reprint Long-term clinical and economic analysis of the Endeavor drug-eluting stent versus the Driver bare-metal stent: 4-year results from the ENDEAVOR II trial (Randomized Controlled Trial to Evaluate the Safety and Efficacy of the Medtronic AVE ABT-578 Eluting
    Eric L Eisenstein
    Duke Clinical Research Institute, Durham, North Carolina 27705, USA
    JACC Cardiovasc Interv 2:1178-87. 2009
  10. ncbi request reprint Cost-effectiveness of imatinib versus interferon-alpha plus low-dose cytarabine for patients with newly diagnosed chronic-phase chronic myeloid leukemia
    Shelby D Reed
    Center for Clinical and Genetic Economics, Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina, USA
    Cancer 101:2574-83. 2004

Research Grants

Collaborators

Detail Information

Publications86

  1. pmc Suspected acute exacerbation of idiopathic pulmonary fibrosis as an outcome measure in clinical trials
    Harold R Collard
    University of California San Francisco, San Francisco, CA, USA
    Respir Res 14:73. 2013
    ..Acute exacerbation of idiopathic pulmonary fibrosis has become an important outcome measure in clinical trials. This study aimed to explore the concept of suspected acute exacerbation as an outcome measure...
  2. doi request reprint Long-term clinical outcomes following coronary stenting
    Kevin J Anstrom
    Department of Biostatistics, Duke Clinical Research Institute, Durham, NC 27715, USA
    Arch Intern Med 168:1647-55. 2008
    ..The objective of this study was to compare the long-term clinical outcomes of patients receiving DES vs BMS in a clinical practice setting...
  3. doi request reprint Six-month follow-up of patients with in-hospital thrombocytopenia during heparin-based anticoagulation (from the Complications After Thrombocytopenia Caused by Heparin [CATCH] registry)
    Renato D Lopes
    Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina, USA
    Am J Cardiol 104:1285-91. 2009
    ..98, p = 0.03). In conclusion, the 6-month mortality rate among heparin-treated patients with thrombocytopenia is high, although the risk independently related to thrombocytopenia appears to be restricted to the acute hospital phase...
  4. doi request reprint Short- and long-term outcomes of coronary stenting in women versus men: results from the National Cardiovascular Data Registry Centers for Medicare & Medicaid services cohort
    Monique L Anderson
    7022 N Pavilion DUMC, PO Box 17969, Durham, NC 27715, USA
    Circulation 126:2190-9. 2012
    ..Conflicting evidence exists on sex-based outcomes after coronary stenting...
  5. doi request reprint Long-term clinical and economic analysis of the Endeavor zotarolimus-eluting stent versus the cypher sirolimus-eluting stent: 3-year results from the ENDEAVOR III trial (Randomized Controlled Trial of the Medtronic Endeavor Drug [ABT-578] Eluting Coronary
    Eric L Eisenstein
    Duke Clinical Research Institute, Durham, North Carolina 27705, USA
    JACC Cardiovasc Interv 2:1199-207. 2009
    ....
  6. doi request reprint Evaluating the impact of public health notification: Duke clopidogrel experience
    Eric L Eisenstein
    Duke Clinical Research Institute and Duke Translational Medicine Institute, Duke University Medical Center, Durham, NC, USA
    Circ Cardiovasc Qual Outcomes 5:767-74. 2012
    ..We evaluated whether public health interventions were associated with changes in patient-reported clopidogrel use among DES patients...
  7. pmc Clinical effectiveness of coronary stents in elderly persons: results from 262,700 Medicare patients in the American College of Cardiology-National Cardiovascular Data Registry
    Pamela S Douglas
    Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina, USA
    J Am Coll Cardiol 53:1629-41. 2009
    ..The aim of this study was to compare outcomes in older individuals receiving drug-eluting stents (DES) and bare-metal stents (BMS)...
  8. ncbi request reprint Long-term costs and resource use in elderly participants with congestive heart failure in the Cardiovascular Health Study
    Lawrence Liao
    Duke Clinical Research Institute, Durham, NC, USA
    Am Heart J 153:245-52. 2007
    ..In a prospective, longitudinal cohort of community-dwelling elderly from 4 regions, we examined the long-term costs and resource use of elderly patients with HF...
  9. doi request reprint Long-term clinical and economic analysis of the Endeavor drug-eluting stent versus the Driver bare-metal stent: 4-year results from the ENDEAVOR II trial (Randomized Controlled Trial to Evaluate the Safety and Efficacy of the Medtronic AVE ABT-578 Eluting
    Eric L Eisenstein
    Duke Clinical Research Institute, Durham, North Carolina 27705, USA
    JACC Cardiovasc Interv 2:1178-87. 2009
    ..This study was designed to evaluate long-term clinical and economic outcomes for subjects receiving Endeavor drug-eluting versus Driver bare-metal stents (both Medtronic CardioVascular, Santa Rosa, California)...
  10. ncbi request reprint Cost-effectiveness of imatinib versus interferon-alpha plus low-dose cytarabine for patients with newly diagnosed chronic-phase chronic myeloid leukemia
    Shelby D Reed
    Center for Clinical and Genetic Economics, Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina, USA
    Cancer 101:2574-83. 2004
    ..In the current study, the authors estimated the incremental cost-effectiveness of imatinib versus interferon-alpha plus low-dose cytarabine (IFN+LDAC) as first-line therapy for these patients...
  11. ncbi request reprint Economic assessment of thrombocytopenia: CATCH Registry
    Eric L Eisenstein
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27705, USA
    J Med Syst 34:379-86. 2010
    ..001); and (group 3) (difference, $27,077; 95% CI, $22,901-$31,252; P<.001). However, in our adjusted model, longer lengths-of-stay and greater use of blood transfusions accounted for most incremental in-hospital cost differences...
  12. doi request reprint Comparative effectiveness of drug-eluting versus bare-metal stents in elderly patients undergoing revascularization of chronic total coronary occlusions: results from the National Cardiovascular Data Registry, 2005-2008
    Manesh R Patel
    Department of Medicine, Division of Cardiology, Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27710, USA
    JACC Cardiovasc Interv 5:1054-61. 2012
    ..This study sought to investigate the long-term effectiveness of drug-eluting stents (DES) versus bare-metal stents (BMS)...
  13. doi request reprint Clopidogrel use and clinical events after drug-eluting stent implantation: findings from the HealthCore Integrated Research Database
    John L Petersen
    Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC, USA
    Am Heart J 159:462-470.e1. 2010
    ..Relationships between long-term use and level of dual antiplatelet therapy and outcomes after drug-eluting stent implantation are not well established...
  14. ncbi request reprint Use of surgery in patients with native valve infective endocarditis: results from the International Collaboration on Endocarditis Merged Database
    Christopher H Cabell
    Duke University Medical Center, Durham, NC, USA
    Am Heart J 150:1092-8. 2005
    ..The aim of the study was to characterize patients with native valve IE relative to surgery and to determine if patients who benefit from an early surgical intervention can be identified...
  15. pmc Survival of patients receiving a primary prevention implantable cardioverter-defibrillator in clinical practice vs clinical trials
    Sana M Al-Khatib
    Duke Clinical Research Institute, PO Box 17969, Durham, NC 27715, USA
    JAMA 309:55-62. 2013
    ..Whether the survival of patients who received an ICD in primary prevention clinical trials differs from that of trial-eligible patients receiving a primary prevention ICD in clinical practice is unknown...
  16. doi request reprint Characteristics and long-term outcomes of percutaneous revascularization of unprotected left main coronary artery stenosis in the United States: a report from the National Cardiovascular Data Registry, 2004 to 2008
    J Matthew Brennan
    Department of Medicine, Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina 27705, USA
    J Am Coll Cardiol 59:648-54. 2012
    ..This study sought to assess percutaneous coronary intervention (PCI) for unprotected left main coronary artery (ULMCA) stenosis in routine U.S. clinical practice...
  17. doi request reprint Re-evaluating the volume-outcome relationship in hemodialysis patients
    Eric L Eisenstein
    Duke Clinical Research Institute, 2400 Pratt Street, Room 0311, Durham, NC 27705, USA
    Health Policy 88:317-25. 2008
    ..We sought to determine whether dialysis patient mortality rates are associated with differences in dialysis facility size, and whether this relationship differs among higher risk diabetic and lower-risk non-diabetic patients...
  18. ncbi request reprint Pancreatic beta-cell function as a predictor of cardiovascular outcomes and costs: findings from the Cardiovascular Health Study
    Lesley H Curtis
    Center for Clinical and Genetic Economics, Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC 27715, USA
    Curr Med Res Opin 24:41-50. 2008
    ..To explore relationships between beta-cell function and incident cardiovascular events, death, and medical costs among elderly individuals...
  19. ncbi request reprint The use and effect of surgical therapy for prosthetic valve infective endocarditis: a propensity analysis of a multicenter, international cohort
    Andrew Wang
    Department of Medicine, Duke University Medical Center, Durham, NC, USA
    Am Heart J 150:1086-91. 2005
    ....
  20. ncbi request reprint Clinical and economic implications of the Multicenter Automatic Defibrillator Implantation Trial-II
    Sana M Al-Khatib
    Duke Clinical Research Institute, Durham, North Carolina 27715, USA
    Ann Intern Med 142:593-600. 2005
    ..3 or less...
  21. pmc Quality of life after late invasive therapy for occluded arteries
    Daniel B Mark
    Outcomes Research Group, Duke Clinical Research Institute, and the Department of Medicine, Duke University Medical Center, Durham, NC, USA
    N Engl J Med 360:774-83. 2009
    ..We evaluated the quality-of-life and economic outcomes associated with the use of this strategy...
  22. doi request reprint Linking the National Cardiovascular Data Registry CathPCI Registry with Medicare claims data: validation of a longitudinal cohort of elderly patients undergoing cardiac catheterization
    J Matthew Brennan
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27705, USA
    Circ Cardiovasc Qual Outcomes 5:134-40. 2012
    ..The degree to which this linked cohort is representative of the overall CathPCI Registry and CMS PCI populations is unknown...
  23. ncbi request reprint Clopidogrel use and long-term clinical outcomes after drug-eluting stent implantation
    Eric L Eisenstein
    Department of Medicine, Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27710, USA
    JAMA 297:159-68. 2007
    ..Recent studies of drug-eluting intracoronary stents suggest that current antiplatelet regimens may not be sufficient to prevent late stent thrombosis...
  24. ncbi request reprint Outcomes of second revascularization procedures after stent implantation
    Richard P Konstance
    Department of Medicine, Duke University Medical Center, Durham, NC, USA
    J Med Syst 32:177-86. 2008
    ..Further studies are needed to determine the optimum application for CABG vs. DES as a second or third revascularization procedure...
  25. doi request reprint Contribution of bleeding and thromboembolic events to in-hospital mortality among patients with thrombocytopenia treated with heparin
    E Marc Jolicoeur
    Duke Clinical Research Institute, Durham, North Carolina, USA
    Am J Cardiol 104:292-7. 2009
    ..77, 95% confidence interval 1.67 to 4.61, respectively). In conclusion, medical management should be directed mainly at the prevention of thromboembolic complications, while additionally considering the risk for bleeding...
  26. ncbi request reprint Decision support for evidence-based pharmacotherapy detects adherence problems but does not impact medication use
    Janese M Willis
    Duke University Medical Center, Durham, NC, USA
    Stud Health Technol Inform 183:116-25. 2013
    ....
  27. pmc Assessing the economic attractiveness of coronary artery revascularization in chronic kidney disease patients
    Eric L Eisenstein
    Duke University Medical Center, Durham, NC 27715, USA
    J Med Syst 33:287-97. 2009
    ..Medical therapy was an economically attractive strategy vs. CABG surgery or PCI for three-vessel CAD patients with CKD, two-vessel CAD patients without CKD, and all single-vessel CAD patients...
  28. doi request reprint Incidence and prevalence of heart failure in elderly persons, 1994-2003
    Lesley H Curtis
    Center for Clinical and Genetic Economics, Duke Clinical Research Institute, Durham, NC 27715, USA
    Arch Intern Med 168:418-24. 2008
    ..We sought to estimate the annual incidence and prevalence of heart failure and associated survival in elderly persons from January 1, 1994, through December 31, 2003...
  29. ncbi request reprint Costs for heart failure with normal vs reduced ejection fraction
    Lawrence Liao
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27710, USA
    Arch Intern Med 166:112-8. 2006
    ..However, there are few data regarding the costs of HF with normal EF. In a prospective, population-based cohort of elderly participants, we compared the costs and resource use of patients with HF and normal and reduced EF...
  30. doi request reprint Association between mortality and persistent use of beta blockers and angiotensin-converting enzyme inhibitors in patients with left ventricular systolic dysfunction and coronary artery disease
    Nancy M Allen LaPointe
    Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina, USA
    Am J Cardiol 103:1518-24. 2009
    ..We were unable to demonstrate a statistically significant association between persistent ACEI/ARB use and survival...
  31. pmc Quality of life with defibrillator therapy or amiodarone in heart failure
    Daniel B Mark
    Outcomes Research Group, Duke University Medical Center, Durham, NC, USA
    N Engl J Med 359:999-1008. 2008
    ..However, whether this increased longevity is accompanied by deterioration in the quality of life is unclear...
  32. ncbi request reprint Updated estimates of survival and cost effectiveness for imatinib versus interferon-alpha plus low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukaemia
    Shelby D Reed
    Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina 27715, USA
    Pharmacoeconomics 26:435-46. 2008
    ..For trials in which participants are followed beyond the main study period to assess long-term outcomes, economic evaluations conducted using short-term data should be systematically updated to reflect new information...
  33. pmc Quality of life and economic outcomes with surgical ventricular reconstruction in ischemic heart failure: results from the Surgical Treatment for Ischemic Heart Failure trial
    Daniel B Mark
    Outcomes Research Group, Duke University Medical Center, Durham, NC, USA
    Am Heart J 157:837-44, 844.e1-3. 2009
    ..The impact of SVR on quality of life (QOL) and medical costs is unknown...
  34. ncbi request reprint Clinical and economic results from a randomized trial of clinical decision support in a rural health network
    Eric L Eisenstein
    Division of Clinical Informatics, Department of Community and Family Medicine, Duke University Medical Center, Durham, NC, USA
    Stud Health Technol Inform 164:77-81. 2011
    ..Replication studies evaluate technologies in usual use settings...
  35. doi request reprint Mortality benefits from implantable cardioverter-defibrillator therapy are not restricted to patients with remote myocardial infarction: an analysis from the Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT)
    Jonathan P Piccini
    Division of Cardiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Heart Rhythm 8:393-400. 2011
    ....
  36. doi request reprint A randomized trial of population-based clinical decision support to manage health and resource use for medicaid beneficiaries
    David F Lobach
    Division of Clinical Informatics, Department of Community and Family Medicine, Duke University Medical Center, Durham, NC, USA
    J Med Syst 37:9922. 2013
    ..Health IT interventions must be carefully evaluated to ensure that the resultant outcomes are aligned with expectations as interventions can have differing effects on clinical and economic outcomes...
  37. doi request reprint Nonfatal myocardial infarction and long-term outcomes in coronary artery disease
    Eric L Eisenstein
    Duke Clinical Research Institute, Outcomes, Durham, NC 27705, USA
    Am Heart J 163:95-103. 2012
    ..We sought to estimate the long-term clinical implications of nonfatal MI occurring within the first 3 and 6 months after initial cardiac catheterization...
  38. doi request reprint Do income level and race influence survival in patients receiving hemodialysis?
    Eric L Eisenstein
    Duke Clinical Research Institute, Durham, NC 27715, USA
    Am J Med 122:170-80. 2009
    ..We sought to determine whether these differences persist and whether the effect of income-area on mortality is different for African Americans versus patients of other races...
  39. doi request reprint Cost effectiveness of ixabepilone plus capecitabine for metastatic breast cancer progressing after anthracycline and taxane treatment
    Shelby D Reed
    Center for Clinical and Genetic Economics and Outcomes Research and Assessment Group, Duke Clinical Research Institute, PO Box 17969, Durham, NC 27715, USA
    J Clin Oncol 27:2185-91. 2009
    ....
  40. pmc Pattern and predictors of the initiation of biologic agents for the treatment of rheumatoid arthritis in the United States: an analysis using a large observational data bank
    Esi Morgan Dewitt
    Department of Pediatrics, Division of Rheumatology, Duke University Medical Center, Durham, North Carolina, USA
    Clin Ther 31:1871-80; discussion 1858. 2009
    ..The aim of this study was to identify factors associated with the initiation of biologic agents for the treatment of rheumatoid arthritis (RA) in a large US observational cohort...
  41. ncbi request reprint Costs of the metabolic syndrome in elderly individuals: findings from the Cardiovascular Health Study
    Lesley H Curtis
    Center for Clinical and Genetic Economics, Duke Clinical Research Institute, P O Box 17969, Durham, NC 27715, USA
    Diabetes Care 30:2553-8. 2007
    ..Little is known about how the metabolic syndrome and its individual components translate into long-term medical costs...
  42. ncbi request reprint Conducting economic evaluations alongside multinational clinical trials: toward a research consensus
    Shelby D Reed
    Center for Clinical and Genetic Economics, Duke University Medical Centre, Durham, NC, USA
    Am Heart J 149:434-43. 2005
    ..Delineation of the various approaches to multinational economic evaluation may assist researchers, peer reviewers, journal editors, and decision makers in evaluating the strengths and limitations of particular studies...
  43. doi request reprint Use of beta-blockers in patients with an implantable cardioverter defibrillator
    Nancy M Allen LaPointe
    School of Medicine, Duke University, Duke Clinical Research Institute, Durham, NC 27705, USA
    Ann Pharmacother 43:1189-96. 2009
    ..beta-Blockers are also indicated in most patients who have an indication for an ICD; however, their use in this population is not well described. Some clinicians may be unaware of the recommendation for beta-blockers in this population...
  44. ncbi request reprint Usefulness of myocardial viability or ischemia in predicting long-term survival for patients with severe left ventricular dysfunction undergoing revascularization
    Lawrence Liao
    Department of Medicine, Division of Cardiology, Duke University Medical Center, Durham, NC 27710, USA
    Am J Cardiol 93:1275-9. 2004
    ..At a mean follow-up of 27 months, patients with viable myocardium who underwent revascularization had a significant survival advantage over all other patients (2-year survival 83.5% vs 57.2%, p = 0.0037)...
  45. ncbi request reprint Staphylococcus aureus endocarditis: a consequence of medical progress
    Vance G Fowler
    Duke University Medical Center, Durham, NC 27710, USA
    JAMA 293:3012-21. 2005
    ..The global significance of infective endocarditis (IE) caused by Staphylococcus aureus is unknown...
  46. ncbi request reprint Cost-effectiveness of defibrillator therapy or amiodarone in chronic stable heart failure: results from the Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT)
    Daniel B Mark
    Outcomes Research Group, Duke Clinical Research Institute, PO Box 17969, Durham, NC 27715, USA
    Circulation 114:135-42. 2006
    ..We examined long-term economic implications of these results...
  47. doi request reprint Long-term economic outcomes associated with intensive versus moderate lipid-lowering therapy in coronary artery disease: results from the Treating to New Targets (TNT) Trial
    Daniel B Mark
    Outcomes Research Group, Duke Clinical Research Institute, Durham, NC 27715, USA
    Am Heart J 156:698-705. 2008
    ....
  48. doi request reprint Optimal timing of implantable cardioverter-defibrillator implantation after myocardial infarction: a decision analysis
    Jonathan P Piccini
    Duke Clinical Research Institute and the Duke University School of Medicine, Durham, North Carolina 27705, USA
    J Cardiovasc Electrophysiol 21:791-8. 2010
    ..The optimal timing of implantable cardioverter defibrillator (ICD) placement for the primary prevention of sudden cardiac death after myocardial infarction (MI) remains unknown...
  49. pmc A generalized estimator of the attributable benefit of an optimal treatment regime
    Jason Brinkley
    Department of Biostatistics, East Carolina University, Greenville, North Carolina 27834, USA
    Biometrics 66:512-22. 2010
    ..The patients may be treated with either medical therapy alone or a combination of medical therapy and percutaneous coronary intervention without a general consensus on which is the best treatment for individual patients...
  50. ncbi request reprint Population-based clinical decision support: a clinical and economic evaluation
    Eric L Eisenstein
    Duke University Medical Center, Durham, NC, USA
    Stud Health Technol Inform 180:343-7. 2012
    ....
  51. ncbi request reprint Racial/ethnic variation in perceptions of medical information sources in Durham County, North Carolina
    Jason E Williams
    Center for Clinical and Genetic Economics, Duke Clinical Research Institute, Duke University, Durham, NC, USA
    N C Med J 68:391-8. 2007
    ..We examined the independent effect of race/ethnicity on perceptions of the usefulness of different sources of health information...
  52. ncbi request reprint Using inverse probability-weighted estimators in comparative effectiveness analyses with observational databases
    Lesley H Curtis
    Duke Clinical Research Institute, and Departments of Medicine, Duke University School of Medicine, Durham, North Carolina, USA
    Med Care 45:S103-7. 2007
    ..Finally, we offer detailed guidance about how to implement the estimators in comparative effectiveness analyses...
  53. ncbi request reprint Importance of echocardiography in patients with severe nonischemic heart failure: the second Prospective Randomized Amlodipine Survival Evaluation (PRAISE-2) echocardiographic study
    Christopher H Cabell
    Duke University School of Medicine, Durham, NC, USA
    Am Heart J 147:151-7. 2004
    ....
  54. doi request reprint Incidence and prognostic significance of thrombocytopenia in patients treated with prolonged heparin therapy
    Gustavo B F Oliveira
    Duke Clinical Research Institute, Duke University Medical Center, 2400 Pratt St, Durham, NC 27705, USA
    Arch Intern Med 168:94-102. 2008
    ..Despite widespread heparin use in clinical practice, the associated development of thrombocytopenia is an underrecognized and undertreated complication...
  55. doi request reprint Percutaneous coronary intervention and drug-eluting stent use among patients ≥85 years of age in the United States
    Tracy Y Wang
    Duke Clinical Research Institute, Durham, North Carolina 27705, USA
    J Am Coll Cardiol 59:105-12. 2012
    ..This study assessed the comparative effectiveness of drug-eluting stents (DES) versus bare-metal stents (BMS) among patients ≥85 years of age...
  56. pmc Diuretic strategies in patients with acute decompensated heart failure
    G Michael Felker
    Duke University School of Medicine and Duke Heart Center, Durham, NC, USA
    N Engl J Med 364:797-805. 2011
    ..Loop diuretics are an essential component of therapy for patients with acute decompensated heart failure, but there are few prospective data to guide their use...
  57. ncbi request reprint Development, deployment and usability of a point-of-care decision support system for chronic disease management using the recently-approved HL7 decision support service standard
    David F Lobach
    Division of Clinical Informatics, Department of Community and Family Medicine, Duke University, Durham, NC, USA
    Stud Health Technol Inform 129:861-5. 2007
    ..Use of the Decision Support Service standard provides a portable and scalable approach to clinical decision support that could facilitate the more extensive use of decision support systems...
  58. doi request reprint A prospective multicenter study of competency metrics and educational interventions in the learning of bronchoscopy among new pulmonary fellows
    Momen M Wahidi
    Division of Pulmonary, Allergy and Critical Care Medicine, Duke University Medical Center, Box 3683, Durham, NC 27710, USA
    Chest 137:1040-9. 2010
    ..Our study aimed to establish bronchoscopy competency metrics based on performance and enhanced learning with educational interventions...
  59. pmc Comparative evaluation of Etest and sensititre yeastone panels against the Clinical and Laboratory Standards Institute M27-A2 reference broth microdilution method for testing Candida susceptibility to seven antifungal agents
    Barbara D Alexander
    Division of Infectious Diseases and International Health, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Clin Microbiol 45:698-706. 2007
    ..However, further evaluation of their performance for determining the MICs of azoles, particularly for C. glabrata, is warranted...
  60. doi request reprint Economic analysis of endovascular repair versus surveillance for patients with small abdominal aortic aneurysms
    Eric L Eisenstein
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC Electronic address
    J Vasc Surg 58:302-10. 2013
    ..We evaluated resource use, medical cost, and quality of life outcomes associated with the PIVOTAL treatment strategies...
  61. doi request reprint Embedding a randomized clinical trial into an ongoing registry infrastructure: Unique opportunities for efficiency in design of the Study of Access site For Enhancement of Percutaneous Coronary Intervention for Women (SAFE-PCI for Women)
    Connie N Hess
    Duke Clinical Research Institute, Durham, NC
    Am Heart J 166:421-428.e1. 2013
    ..Secondary end points include procedure duration, contrast volume, radiation dose, quality of life, and a composite of 30-day death, vascular complication, or unplanned revascularization. ..
  62. doi request reprint TransRadial Education and Therapeutics (TREAT): shifting the balance of safety and efficacy of antithrombotic agents in percutaneous coronary intervention: a report from the Cardiac Safety Research Consortium
    Connie N Hess
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC, USA
    Am Heart J 165:344-53.e1. 2013
    ..This article summarizes the content and proceedings of these sessions...
  63. doi request reprint Patient-focused intervention to improve long-term adherence to evidence-based medications: a randomized trial
    Sara Bristol Calvert
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC, USA
    Am Heart J 163:657-65.e1. 2012
    ..Nonadherence to cardiovascular medications is a significant public health problem. This randomized study evaluated the effect on medication adherence of linking hospital and community pharmacists...
  64. doi request reprint Comparative effectiveness of beta-blockers in elderly patients with heart failure
    Judith M Kramer
    Department of Medicine, Duke Clinical Research Institute, Durham, NC 27715, USA
    Arch Intern Med 168:2422-8; discussion 2428-32. 2008
    ..We compared the effectiveness of EBBBs vs non-EBBBs on survival...
  65. pmc Quality of life effects of automatic external defibrillators in the home: results from the Home Automatic External Defibrillator Trial (HAT)
    Daniel B Mark
    Outcomes Research Group, Duke Clinical Research Institute PO Box 17969 Durham, NC 27715, USA
    Am Heart J 159:627-634.e7. 2010
    ..Quality of life (QOL) outcomes for both the patient and spouse/companion were secondary end points...
  66. doi request reprint Challenges in enrollment of minority, pediatric, and geriatric patients in emergency and acute care clinical research
    Seth W Glickman
    Division of Emergency Medicine, Department of Surgery, Duke Clinical Research Institute, Duke University Medical Center, Durham, NC, USA
    Ann Emerg Med 51:775-780.e3. 2008
    ..The objective of this study is to assess how emergency clinical care and research processes, informed consent, and patient demographic factors (age, sex, and ethnicity/race) affect enrollment and consent in clinical research in the ED...
  67. ncbi request reprint Implementation of a statewide system for coronary reperfusion for ST-segment elevation myocardial infarction
    James G Jollis
    Department of Cardiology, Duke University, Durham, North Carolina, USA
    JAMA 298:2371-80. 2007
    ..Despite 2 decades of evidence demonstrating benefits from prompt coronary reperfusion, registries continue to show that many patients with ST-segment elevation myocardial infarction (STEMI) are treated too slowly or not at all...
  68. ncbi request reprint The insurance effect on prescription drug expenditures among the elderly: findings from the 1997 Medical Expenditure Panel Survey
    Lesley H Curtis
    Center for Clinical and Genetic Economics, Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina, USA
    Med Care 42:439-46. 2004
    ..Despite continuing debate over a prescription drug benefit for the Medicare program, there has been relatively little research estimating the potential cost of providing such a benefit...
  69. ncbi request reprint Perceived racial/ethnic bias in healthcare in Durham County, North Carolina: a comparison of community and national samples
    Joelle Y Friedman
    Center for Clinical and Genetic Economics, Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27715, USA
    N C Med J 66:267-75. 2005
    ..We sought to compare findings of a national survey of perceptions of racial/ethnic discrimination in healthcare to those of a community survey, with emphasis on the perceptions of Latinos...
  70. ncbi request reprint Survival after coronary revascularization, with and without mitral valve surgery, in patients with ischemic mitral regurgitation
    Benjamin H Trichon
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC, USA
    Circulation 108:II103-10. 2003
    ....
  71. ncbi request reprint Outpatient use of anticoagulants, rate-controlling drugs, and antiarrhythmic drugs for atrial fibrillation
    Nancy M Allen LaPointe
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27715, USA
    Am Heart J 154:893-8. 2007
    ..We explored the use of anticoagulants, rate-controlling drugs, and antiarrhythmic drugs in patients with AF during the 4 years surrounding publication of these guidelines...
  72. ncbi request reprint A randomized clinical trial of clinical decision support in a rural community health network serving lower income individuals: study design and baseline characteristics
    Eric L Eisenstein
    Duke Clinical Research Institute, Durham, NC, USA
    Stud Health Technol Inform 143:220-6. 2009
    ..We propose to achieve these improvements by implementing system-to-system integration via a telehealth network with an asynchronous clinical decision support system for health care providers...
  73. ncbi request reprint Effects of skeletal morbidities on longitudinal patient-reported outcomes and survival in patients with metastatic prostate cancer
    Venita Depuy
    Center for Clinical and Genetic Economics, Duke Clinical Research Institute, Duke University Medical Center, P O Box 17969, Durham, NC 27715, USA
    Support Care Cancer 15:869-76. 2007
    ..We sought to quantify the longitudinal effects on patient-reported outcomes of skeletal-related events (SREs) and to ascertain the declines in health-related quality of life (HRQOL) and pain experienced by patients who experienced SREs...
  74. ncbi request reprint National evaluation of adherence to beta-blocker therapy for 1 year after acute myocardial infarction in patients with commercial health insurance
    Judith M Kramer
    Duke Center for Education and Research on Therapeutics, Duke University Medical Center, Durham, NC 27715, USA
    Am Heart J 152:454.e1-8. 2006
    ..We sought to examine long-term beta-blocker adherence over the first year after myocardial infarction in patients with commercial health insurance and prescription drug benefits...
  75. doi request reprint A global ranking approach to end points in trials of mechanical circulatory support devices
    G Michael Felker
    Duke Clinical Research Institute, Durham, NC 27705, USA
    J Card Fail 14:368-72. 2008
    ..The ideal composite end point for studies of MCSDs is uncertain...
  76. ncbi request reprint Long-term survival estimates for imatinib versus interferon-alpha plus low-dose cytarabine for patients with newly diagnosed chronic-phase chronic myeloid leukemia
    Kevin J Anstrom
    Center for Clinical and Genetic Economics, Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina, USA
    Cancer 101:2584-92. 2004
    ..The authors estimated survival among patients with chronic myeloid leukemia for a cost-effectiveness analysis of imatinib versus interferon-alpha plus low-dose cytarabine (IFN+LDAC)...
  77. ncbi request reprint Obesity and long-term clinical and economic outcomes in coronary artery disease patients
    Eric L Eisenstein
    The Outcomes Research and Assessment Group, The Duke Clinical Research Institute, Durham, North Carolina 27715, USA
    Obes Res 10:83-91. 2002
    ..We assessed the impact of increasing body mass index (BMI) on 10-year outcomes for ACS patients...
  78. ncbi request reprint Native valve endocarditis due to coagulase-negative staphylococci: report of 99 episodes from the International Collaboration on Endocarditis Merged Database
    Vivian H Chu
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Clin Infect Dis 39:1527-30. 2004
    ..These results emphasize the importance of CoNS as a cause of NVE and the potential for serious complications with this infection...
  79. pmc Patient receipt and understanding of written information provided with isotretinoin and estrogen prescriptions
    Nancy M Allen LaPointe
    Duke Center for Education and Research on Therapeutics, Duke Clinical Research Institute, Durham, NC 27715, USA
    J Gen Intern Med 22:98-101. 2007
    ..Medication guides (MG) and mandatory patient package inserts (MPPI) are required with some prescription medications...
  80. doi request reprint Central hair loss in African American women: incidence and potential risk factors
    Elise A Olsen
    Duke University Medical Center, Durham, NC, USA
    J Am Acad Dermatol 64:245-52. 2011
    ..Although central scalp hair loss is a common problem in African American women, data on etiology or incidence are limited...
  81. ncbi request reprint Influence of the Angioplasty Revascularization Investigation National Heart, Lung, and Blood Institute Diabetic Clinical Alert on practice patterns: results from the National Cardiovascular Network Database
    Darren K McGuire
    University of Texas Southwestern Medical Center, Dallas, Tex, USA
    Circulation 107:1864-70. 2003
    ..quot; The influence of the BARI findings and of the Clinical Alert on practice patterns is unknown...
  82. ncbi request reprint Costs and outcomes among hemodialysis-dependent patients with methicillin-resistant or methicillin-susceptible Staphylococcus aureus bacteremia
    Shelby D Reed
    Center for Clinical and Genetic Economics, USA
    Infect Control Hosp Epidemiol 26:175-83. 2005
    ..We compared costs and outcomes of methicillin resistance in patients with S. aureus bacteremia and a single chronic condition...
  83. ncbi request reprint Identification, diagnosis and treatment of heparin-induced thrombocytopenia and thrombosis: a registry of prolonged heparin use and thrombocytopenia among hospitalized patients with and without cardiovascular disease. The Complication After Thrombocytopen
    E Magnus Ohman
    Division of Cardiology, Division of Hematology, and School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599 7075, USA
    J Thromb Thrombolysis 19:11-9. 2005
    ..Both HIT and HITT are associated with high morbidity and mortality and represent substantial worldwide public health concerns...
  84. pmc Sildenafil improves walk distance in idiopathic pulmonary fibrosis
    Harold R Collard
    David Geffen School of Medicine at UCLA, 37 131 Center for Health Sciences, Los Angeles, CA 90095, USA
    Chest 131:897-9. 2007
    ..Sildenafil is a promising and well-tolerated therapeutic agent for use in patients with IPF and pulmonary hypertension, and should be studied in a large, well-controlled trial...
  85. ncbi request reprint Trends in operator and hospital procedure volume and outcomes for percutaneous transluminal coronary angioplasty, 1996 to 2001
    Susan M Kansagra
    Harvard Medical School, Boston, Massachusetts, USA
    Am J Cardiol 99:339-43. 2007
    ..There were outcome differences within subpopulations of operators in classes 2 and 4, which suggest possibilities for alternative volume classification guidelines...
  86. ncbi request reprint Outcomes of early extubation after bypass surgery in the elderly
    Ulrich Guller
    Department of Surgery, University of Alabama School of Medicine, Birmingham, Alabama, USA
    Ann Thorac Surg 77:781-8. 2004
    ..The goal of the present investigation was to evaluate whether early extubation can be performed safely in elderly CABG patients in community practice...

Research Grants3

  1. Idiopathic Pulmonary Fibrosis Clinical Research Network
    KEVIN ANSTROM; Fiscal Year: 2007
    ..End of Abstract) ..