Julio Aliberti

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. ncbi request reprint Host persistence: exploitation of anti-inflammatory pathways by Toxoplasma gondii
    Julio Aliberti
    Department of Immunology, Duke University Medical Center, Durham, North Carolina 27705, USA
    Nat Rev Immunol 5:162-70. 2005
  2. ncbi request reprint Anti-inflammatory pathways as a host evasion mechanism for pathogens
    Julio Aliberti
    Department of Immunology, Duke University Medical Center, Durham, NC 27705, USA
    Prostaglandins Leukot Essent Fatty Acids 73:283-8. 2005
  3. ncbi request reprint Cutting edge: dendritic cells are essential for in vivo IL-12 production and development of resistance against Toxoplasma gondii infection in mice
    Cheng hu Liu
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 177:31-5. 2006
  4. ncbi request reprint Anti-inflammatory actions of lipoxin A4 and aspirin-triggered lipoxin are SOCS-2 dependent
    Fabiana S Machado
    Department of Immunology, Duke University Medical Center, Durham, North Carolina 27705, USA
    Nat Med 12:330-4. 2006
  5. ncbi request reprint Turning it on and off: regulation of dendritic cell function in Toxoplasma gondii infection
    Julio Aliberti
    Department of Immunology, Duke University School of Medicine, Durham, NC, USA
    Immunol Rev 201:26-34. 2004
  6. ncbi request reprint Impact of lipoxin-mediated regulation on immune response to infectious disease
    Fabiana S Machado
    Division of Molecular Immunology, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Immunol Res 35:209-18. 2006
  7. pmc Host control of Mycobacterium tuberculosis is regulated by 5-lipoxygenase-dependent lipoxin production
    Andre Bafica
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA
    J Clin Invest 115:1601-6. 2005
  8. ncbi request reprint Cutting edge: identification of c-Rel-dependent and -independent pathways of IL-12 production during infectious and inflammatory stimuli
    Nicola Mason
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Immunol 168:2590-4. 2002
  9. ncbi request reprint Induction and regulation of IL-12-dependent host resistance to Toxoplasma gondii
    Alan Sher
    National Institutes of Health, Bethesda, MD 20892 8003, USA
    Immunol Res 27:521-8. 2003
  10. ncbi request reprint Cutting edge: MyD88 is required for resistance to Toxoplasma gondii infection and regulates parasite-induced IL-12 production by dendritic cells
    Charles A Scanga
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 168:5997-6001. 2002

Collaborators

Detail Information

Publications21

  1. ncbi request reprint Host persistence: exploitation of anti-inflammatory pathways by Toxoplasma gondii
    Julio Aliberti
    Department of Immunology, Duke University Medical Center, Durham, North Carolina 27705, USA
    Nat Rev Immunol 5:162-70. 2005
    ....
  2. ncbi request reprint Anti-inflammatory pathways as a host evasion mechanism for pathogens
    Julio Aliberti
    Department of Immunology, Duke University Medical Center, Durham, NC 27705, USA
    Prostaglandins Leukot Essent Fatty Acids 73:283-8. 2005
    ....
  3. ncbi request reprint Cutting edge: dendritic cells are essential for in vivo IL-12 production and development of resistance against Toxoplasma gondii infection in mice
    Cheng hu Liu
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 177:31-5. 2006
    ..Taken together, the results presented in this study indicate that DCs constitute the major IL-12-producing cell population in vivo during T. gondii infection...
  4. ncbi request reprint Anti-inflammatory actions of lipoxin A4 and aspirin-triggered lipoxin are SOCS-2 dependent
    Fabiana S Machado
    Department of Immunology, Duke University Medical Center, Durham, North Carolina 27705, USA
    Nat Med 12:330-4. 2006
    ..We also show that SOCS-2 is a crucial intracellular mediator of the anti-inflammatory actions of aspirin-induced lipoxins in vivo...
  5. ncbi request reprint Turning it on and off: regulation of dendritic cell function in Toxoplasma gondii infection
    Julio Aliberti
    Department of Immunology, Duke University School of Medicine, Durham, NC, USA
    Immunol Rev 201:26-34. 2004
    ..In addition, we discuss recent findings concerning the pathways responsible for endogenous regulation of DC IL-12 production during T. gondii infection...
  6. ncbi request reprint Impact of lipoxin-mediated regulation on immune response to infectious disease
    Fabiana S Machado
    Division of Molecular Immunology, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Immunol Res 35:209-18. 2006
    ....
  7. pmc Host control of Mycobacterium tuberculosis is regulated by 5-lipoxygenase-dependent lipoxin production
    Andre Bafica
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA
    J Clin Invest 115:1601-6. 2005
    ..tuberculosis...
  8. ncbi request reprint Cutting edge: identification of c-Rel-dependent and -independent pathways of IL-12 production during infectious and inflammatory stimuli
    Nicola Mason
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Immunol 168:2590-4. 2002
    ..Together these studies reveal the presence of c-Rel-dependent pathways critical for IL-12p40 production in response to inflammatory stimuli and demonstrate a novel c-Rel-independent pathway of IL-12p40 production during toxoplasmosis...
  9. ncbi request reprint Induction and regulation of IL-12-dependent host resistance to Toxoplasma gondii
    Alan Sher
    National Institutes of Health, Bethesda, MD 20892 8003, USA
    Immunol Res 27:521-8. 2003
    ..In addition, we present an overview of our studies investigating the mechanisms by which the IFN-gamma produced as a consequence of IL-12 stimulation controls intracellular replication of the parasite in host cells...
  10. ncbi request reprint Cutting edge: MyD88 is required for resistance to Toxoplasma gondii infection and regulates parasite-induced IL-12 production by dendritic cells
    Charles A Scanga
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 168:5997-6001. 2002
    ..Taken together, these data suggest that the induction of IL-12 by T. gondii depends on a unique mechanism involving both MyD88 and G protein-coupled signaling pathways...
  11. pmc Parasite-induced lipoxin A4 is an endogenous regulator of IL-12 production and immunopathology in Toxoplasma gondii infection
    Julio Aliberti
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, Bethesda, MD 20892, USA
    J Exp Med 196:1253-62. 2002
    ..Together, these findings demonstrate a new pathway involving the induction of host LXs for the in vivo regulation of proinflammatory responses during microbial infection...
  12. pmc Exogenous pathogen and plant 15-lipoxygenase initiate endogenous lipoxin A4 biosynthesis
    Gerard L Bannenberg
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 199:515-23. 2004
    ....
  13. ncbi request reprint The IFN-inducible GTPase LRG47 (Irgm1) negatively regulates TLR4-triggered proinflammatory cytokine production and prevents endotoxemia
    Andre Bafica
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 179:5514-22. 2007
    ..Thus, our findings reveal a new host-protective function for this GTPase in the response to pathogenic encounter...
  14. ncbi request reprint Role of G-protein-coupled signaling in the induction and regulation of dendritic cell function by Toxoplasma gondii
    Julio Aliberti
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Microbes Infect 4:991-7. 2002
    ..Recent data on the inductive and regulatory pathways involved and their role in governing host resistance to parasite infection in vivo will be discussed...
  15. ncbi request reprint Mice deficient in LRG-47 display enhanced susceptibility to Trypanosoma cruzi infection associated with defective hemopoiesis and intracellular control of parasite growth
    Helton C Santiago
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 175:8165-72. 2005
    ..Together, these data establish that LRG-47 can influence pathogen control by simultaneously regulating macrophage-microbicidal activity and hemopoietic function...
  16. ncbi request reprint Th1-like cytokine induction by heat-killed Brucella abortus is dependent on triggering of TLR9
    Li Yun Huang
    Division of Hematology, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    J Immunol 175:3964-70. 2005
    ..These cytokines are important in protection against viruses and bacteria, and their induction enhances HKBA as a potential carrier for vaccines...
  17. ncbi request reprint Molecular mimicry of a CCR5 binding-domain in the microbial activation of dendritic cells
    Julio Aliberti
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Nat Immunol 4:485-90. 2003
    ..The ability to generate this strong protective response may benefit parasite transmission by preventing the protozoan from overwhelming its intermediate hosts...
  18. ncbi request reprint Inhibition of HIV-1 infection by a CCR5-binding cyclophilin from Toxoplasma gondii
    Hana Golding
    Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bldg 29A, Rm 1A21, 8800 Rockville Pike, Bethesda, MD, 20892, USA
    Blood 102:3280-6. 2003
    ..These data support the further development of C-18 derivatives as HIV-1 inhibitors for preventing HIV-1 transmission and for postexposure prophylaxis...
  19. pmc Stereochemical assignment, antiinflammatory properties, and receptor for the omega-3 lipid mediator resolvin E1
    Makoto Arita
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 201:713-22. 2005
    ..These results demonstrate novel counterregulatory responses in inflammation initiated via RvE1 receptor activation that provide the first evidence for EPA-derived potent endogenous agonists of antiinflammation...
  20. ncbi request reprint Structural determinants of the anti-HIV activity of a CCR5 antagonist derived from Toxoplasma gondii
    Felix Yarovinsky
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Biol Chem 279:53635-42. 2004
    ..These findings shed light on the structural basis of the molecular mimicry of the chemokine function by a pathogen-derived protein and provide a basis for further modification of C-18 into an antiviral agent...
  21. doi request reprint Role of lipoxin in the modulation of immune response during infection
    Fabiana S Machado
    Division of Molecular Immunology, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Int Immunopharmacol 8:1316-9. 2008
    ..gondii and Mycobacterium tuberculosis. Here, we review the pro-resolution pathways triggered by LXA that are responsible for control of pro-inflammatory response during chronic disease...