Research Topics
Species | Julio AlibertiSummaryAffiliation: Duke University Medical Center Country: USA Publications
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Detail Information
Publications
Host persistence: exploitation of anti-inflammatory pathways by Toxoplasma gondiiJulio Aliberti
Department of Immunology, Duke University Medical Center, Durham, North Carolina 27705, USA
Nat Rev Immunol 5:162-70. 2005....- Anti-inflammatory pathways as a host evasion mechanism for pathogensJulio Aliberti
Department of Immunology, Duke University Medical Center, Durham, NC 27705, USA
Prostaglandins Leukot Essent Fatty Acids 73:283-8. 2005.... - Cutting edge: dendritic cells are essential for in vivo IL-12 production and development of resistance against Toxoplasma gondii infection in miceCheng hu Liu
Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
J Immunol 177:31-5. 2006..Taken together, the results presented in this study indicate that DCs constitute the major IL-12-producing cell population in vivo during T. gondii infection... - Anti-inflammatory actions of lipoxin A4 and aspirin-triggered lipoxin are SOCS-2 dependentFabiana S Machado
Department of Immunology, Duke University Medical Center, Durham, North Carolina 27705, USA
Nat Med 12:330-4. 2006..We also show that SOCS-2 is a crucial intracellular mediator of the anti-inflammatory actions of aspirin-induced lipoxins in vivo... - Turning it on and off: regulation of dendritic cell function in Toxoplasma gondii infectionJulio Aliberti
Department of Immunology, Duke University School of Medicine, Durham, NC, USA
Immunol Rev 201:26-34. 2004..In addition, we discuss recent findings concerning the pathways responsible for endogenous regulation of DC IL-12 production during T. gondii infection... - Impact of lipoxin-mediated regulation on immune response to infectious diseaseFabiana S Machado
Division of Molecular Immunology, Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH, USA
Immunol Res 35:209-18. 2006.... - Host control of Mycobacterium tuberculosis is regulated by 5-lipoxygenase-dependent lipoxin productionAndre Bafica
Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA
J Clin Invest 115:1601-6. 2005..tuberculosis... - Cutting edge: identification of c-Rel-dependent and -independent pathways of IL-12 production during infectious and inflammatory stimuliNicola Mason
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
J Immunol 168:2590-4. 2002..Together these studies reveal the presence of c-Rel-dependent pathways critical for IL-12p40 production in response to inflammatory stimuli and demonstrate a novel c-Rel-independent pathway of IL-12p40 production during toxoplasmosis... - Induction and regulation of IL-12-dependent host resistance to Toxoplasma gondiiAlan Sher
National Institutes of Health, Bethesda, MD 20892 8003, USA
Immunol Res 27:521-8. 2003..In addition, we present an overview of our studies investigating the mechanisms by which the IFN-gamma produced as a consequence of IL-12 stimulation controls intracellular replication of the parasite in host cells... - Cutting edge: MyD88 is required for resistance to Toxoplasma gondii infection and regulates parasite-induced IL-12 production by dendritic cellsCharles A Scanga
Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 168:5997-6001. 2002..Taken together, these data suggest that the induction of IL-12 by T. gondii depends on a unique mechanism involving both MyD88 and G protein-coupled signaling pathways... - Parasite-induced lipoxin A4 is an endogenous regulator of IL-12 production and immunopathology in Toxoplasma gondii infectionJulio Aliberti
Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, Bethesda, MD 20892, USA
J Exp Med 196:1253-62. 2002..Together, these findings demonstrate a new pathway involving the induction of host LXs for the in vivo regulation of proinflammatory responses during microbial infection... - Exogenous pathogen and plant 15-lipoxygenase initiate endogenous lipoxin A4 biosynthesisGerard L Bannenberg
Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA
J Exp Med 199:515-23. 2004.... - The IFN-inducible GTPase LRG47 (Irgm1) negatively regulates TLR4-triggered proinflammatory cytokine production and prevents endotoxemiaAndre Bafica
Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 179:5514-22. 2007..Thus, our findings reveal a new host-protective function for this GTPase in the response to pathogenic encounter... - Role of G-protein-coupled signaling in the induction and regulation of dendritic cell function by Toxoplasma gondiiJulio Aliberti
Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
Microbes Infect 4:991-7. 2002..Recent data on the inductive and regulatory pathways involved and their role in governing host resistance to parasite infection in vivo will be discussed... - Mice deficient in LRG-47 display enhanced susceptibility to Trypanosoma cruzi infection associated with defective hemopoiesis and intracellular control of parasite growthHelton C Santiago
Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 175:8165-72. 2005..Together, these data establish that LRG-47 can influence pathogen control by simultaneously regulating macrophage-microbicidal activity and hemopoietic function... - Th1-like cytokine induction by heat-killed Brucella abortus is dependent on triggering of TLR9Li Yun Huang
Division of Hematology, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
J Immunol 175:3964-70. 2005..These cytokines are important in protection against viruses and bacteria, and their induction enhances HKBA as a potential carrier for vaccines... - Molecular mimicry of a CCR5 binding-domain in the microbial activation of dendritic cellsJulio Aliberti
Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Nat Immunol 4:485-90. 2003..The ability to generate this strong protective response may benefit parasite transmission by preventing the protozoan from overwhelming its intermediate hosts... - Inhibition of HIV-1 infection by a CCR5-binding cyclophilin from Toxoplasma gondiiHana Golding
Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bldg 29A, Rm 1A21, 8800 Rockville Pike, Bethesda, MD, 20892, USA
Blood 102:3280-6. 2003..These data support the further development of C-18 derivatives as HIV-1 inhibitors for preventing HIV-1 transmission and for postexposure prophylaxis... - Stereochemical assignment, antiinflammatory properties, and receptor for the omega-3 lipid mediator resolvin E1Makoto Arita
Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
J Exp Med 201:713-22. 2005..These results demonstrate novel counterregulatory responses in inflammation initiated via RvE1 receptor activation that provide the first evidence for EPA-derived potent endogenous agonists of antiinflammation... - Structural determinants of the anti-HIV activity of a CCR5 antagonist derived from Toxoplasma gondiiFelix Yarovinsky
Immunobiology Section, Laboratory of Parasitic Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Biol Chem 279:53635-42. 2004..These findings shed light on the structural basis of the molecular mimicry of the chemokine function by a pathogen-derived protein and provide a basis for further modification of C-18 into an antiviral agent... - Role of lipoxin in the modulation of immune response during infectionFabiana S Machado
Division of Molecular Immunology, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
Int Immunopharmacol 8:1316-9. 2008..gondii and Mycobacterium tuberculosis. Here, we review the pro-resolution pathways triggered by LXA that are responsible for control of pro-inflammatory response during chronic disease...