Karen P Alexander

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. ncbi request reprint Evolution in cardiovascular care for elderly patients with non-ST-segment elevation acute coronary syndromes: results from the CRUSADE National Quality Improvement Initiative
    Karen P Alexander
    Duke Clinical Research Institute and Division of Cardiology, Duke University Medical Center, Durham, North Carolina 27715, USA
    J Am Coll Cardiol 46:1479-87. 2005
  2. ncbi request reprint Acute coronary care in the elderly, part II: ST-segment-elevation myocardial infarction: a scientific statement for healthcare professionals from the American Heart Association Council on Clinical Cardiology: in collaboration with the Society of Geriatric
    Karen P Alexander
    Duke University Medical Center, USA
    Circulation 115:2570-89. 2007
  3. doi request reprint Antithrombotic strategy in non-ST-segment elevation myocardial infarction patients undergoing percutaneous coronary intervention: insights from the ACTION (Acute Coronary Treatment and Intervention Outcomes Network) Registry
    Renato D Lopes
    Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina, USA
    JACC Cardiovasc Interv 3:669-77. 2010
  4. ncbi request reprint Acute coronary care in the elderly, part I: Non-ST-segment-elevation acute coronary syndromes: a scientific statement for healthcare professionals from the American Heart Association Council on Clinical Cardiology: in collaboration with the Society of Ger
    Karen P Alexander
    Duke University Medical Center, USA
    Circulation 115:2549-69. 2007
  5. ncbi request reprint Atrial fibrillation and acute myocardial infarction: antithrombotic therapy and outcomes
    Renato D Lopes
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC, USA
    Am J Med 125:897-905. 2012
  6. pmc Polyvascular disease and long-term cardiovascular outcomes in older patients with non-ST-segment-elevation myocardial infarction
    Sumeet Subherwal
    Duke University Medical Center, Durham, NC, USA
    Circ Cardiovasc Qual Outcomes 5:541-9. 2012
  7. ncbi request reprint Sex differences in major bleeding with glycoprotein IIb/IIIa inhibitors: results from the CRUSADE (Can Rapid risk stratification of Unstable angina patients Suppress ADverse outcomes with Early implementation of the ACC/AHA guidelines) initiative
    Karen P Alexander
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27715, USA
    Circulation 114:1380-7. 2006
  8. ncbi request reprint Do patients treated at academic hospitals have better longitudinal outcomes after admission for non-ST-elevation myocardial infarction?
    Emily O'Brien
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC Electronic address
    Am Heart J 167:762-9. 2014
  9. doi request reprint Long-term outcomes after invasive management for older patients with non-ST-segment elevation myocardial infarction
    Matthew T Roe
    Duke Clinical Research Institute, Durham, NC 27705, USA
    Circ Cardiovasc Qual Outcomes 6:323-32. 2013
  10. doi request reprint Safety and effectiveness of antithrombotic strategies in older adult patients with atrial fibrillation and non-ST elevation myocardial infarction
    Emil L Fosbol
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27705, USA
    Am Heart J 163:720-8. 2012

Detail Information

Publications69

  1. ncbi request reprint Evolution in cardiovascular care for elderly patients with non-ST-segment elevation acute coronary syndromes: results from the CRUSADE National Quality Improvement Initiative
    Karen P Alexander
    Duke Clinical Research Institute and Division of Cardiology, Duke University Medical Center, Durham, North Carolina 27715, USA
    J Am Coll Cardiol 46:1479-87. 2005
    ..This study evaluated the impact of age on care and outcomes for non-ST-segment elevation acute coronary syndromes (NSTE ACS)...
  2. ncbi request reprint Acute coronary care in the elderly, part II: ST-segment-elevation myocardial infarction: a scientific statement for healthcare professionals from the American Heart Association Council on Clinical Cardiology: in collaboration with the Society of Geriatric
    Karen P Alexander
    Duke University Medical Center, USA
    Circulation 115:2570-89. 2007
    ....
  3. doi request reprint Antithrombotic strategy in non-ST-segment elevation myocardial infarction patients undergoing percutaneous coronary intervention: insights from the ACTION (Acute Coronary Treatment and Intervention Outcomes Network) Registry
    Renato D Lopes
    Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina, USA
    JACC Cardiovasc Interv 3:669-77. 2010
    ..The aim of this study was to examine the use of and outcomes associated with antithrombotic strategies in patients with non-ST-segment elevation myocardial infarction (NSTEMI) who undergo percutaneous coronary intervention (PCI)...
  4. ncbi request reprint Acute coronary care in the elderly, part I: Non-ST-segment-elevation acute coronary syndromes: a scientific statement for healthcare professionals from the American Heart Association Council on Clinical Cardiology: in collaboration with the Society of Ger
    Karen P Alexander
    Duke University Medical Center, USA
    Circulation 115:2549-69. 2007
    ..Reasons include limited trial data to guide the care of older adults and uncertainty about benefits and risks, particularly with newer medications or invasive treatments and in the setting of advanced age or complex health status...
  5. ncbi request reprint Atrial fibrillation and acute myocardial infarction: antithrombotic therapy and outcomes
    Renato D Lopes
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC, USA
    Am J Med 125:897-905. 2012
    ..Atrial fibrillation guidelines recommend long-term use of warfarin according to a patient's predicted risk of stroke. After acute myocardial infarction, however, combining warfarin and antiplatelet medications poses challenges...
  6. pmc Polyvascular disease and long-term cardiovascular outcomes in older patients with non-ST-segment-elevation myocardial infarction
    Sumeet Subherwal
    Duke University Medical Center, Durham, NC, USA
    Circ Cardiovasc Qual Outcomes 5:541-9. 2012
    ..The impact of polyvascular disease (peripheral arterial disease [PAD] and cerebrovascular disease [CVD]) on long-term cardiovascular outcomes among older patients with acute myocardial infarction has not been well studied...
  7. ncbi request reprint Sex differences in major bleeding with glycoprotein IIb/IIIa inhibitors: results from the CRUSADE (Can Rapid risk stratification of Unstable angina patients Suppress ADverse outcomes with Early implementation of the ACC/AHA guidelines) initiative
    Karen P Alexander
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27715, USA
    Circulation 114:1380-7. 2006
    ..The contribution of dosing to the observed sex-related differences in bleeding is unknown...
  8. ncbi request reprint Do patients treated at academic hospitals have better longitudinal outcomes after admission for non-ST-elevation myocardial infarction?
    Emily O'Brien
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC Electronic address
    Am Heart J 167:762-9. 2014
    ....
  9. doi request reprint Long-term outcomes after invasive management for older patients with non-ST-segment elevation myocardial infarction
    Matthew T Roe
    Duke Clinical Research Institute, Durham, NC 27705, USA
    Circ Cardiovasc Qual Outcomes 6:323-32. 2013
    ....
  10. doi request reprint Safety and effectiveness of antithrombotic strategies in older adult patients with atrial fibrillation and non-ST elevation myocardial infarction
    Emil L Fosbol
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27705, USA
    Am Heart J 163:720-8. 2012
    ..We aimed to study the comparative safety and effectiveness of various antithrombotic treatment strategies among older adults with non-ST elevation myocardial infarction (NSTEMI) and atrial fibrillation (AF)...
  11. doi request reprint Unfractionated heparin dosing and risk of major bleeding in non-ST-segment elevation acute coronary syndromes
    Chiara Melloni
    Division of Cardiology and Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27705, USA
    Am Heart J 156:209-15. 2008
    ..Unfractionated heparin (UFH) is a mainstay of treatment for patients with non-ST-segment elevation acute coronary syndromes (NSTE ACS), but the practice of weight-adjusted bolus and infusion dosing has not been carefully evaluated...
  12. doi request reprint Age and persistent use of cardiovascular medication after acute coronary syndrome: results from medication applied and sustained over time
    Robin C Ali
    Department of Community and Family Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Am Geriatr Soc 57:1990-6. 2009
    ..To describe the persistent use of evidence-based cardiovascular medications (EBCMs) 3 months after discharge from an acute coronary syndrome (ACS) event and patient-reported reasons for nonpersistence across age groups...
  13. doi request reprint Long-term outcomes among older patients with non-ST-segment elevation myocardial infarction complicated by cardiogenic shock
    Akshay Bagai
    Duke Clinical Research Institute, Durham, NC 27705, USA
    Am Heart J 166:298-305. 2013
    ....
  14. pmc Antithrombotic therapy for atrial fibrillation and coronary artery disease in older patients
    Connie N Hess
    Duke Clinical Research Institute, Durham, NC 27705, USA
    Am Heart J 164:607-15. 2012
    ..Balancing safe and effective use of aspirin, clopidogrel, and warfarin in this population is important...
  15. doi request reprint Incorporation of bleeding as an element of the composite end point in clinical trials of antithrombotic therapies in patients with non-ST-segment elevation acute coronary syndrome: validity, pitfalls, and future approaches
    Sumeet Subherwal
    Duke Clinical Research Institute, Durham, NC 27705, USA
    Am Heart J 165:644-54, 654.e1. 2013
    ..We describe alternative statistical approaches for concurrent assessment of the safety and efficacy of antithrombotic therapies used to treat patients with NSTE ACS...
  16. doi request reprint Cockcroft-Gault versus modification of diet in renal disease: importance of glomerular filtration rate formula for classification of chronic kidney disease in patients with non-ST-segment elevation acute coronary syndromes
    Chiara Melloni
    Division of Cardiology and Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina 27705, USA
    J Am Coll Cardiol 51:991-6. 2008
    ..Our purpose was to compare formulae for estimating glomerular filtration rate (GFR) in non-ST-segment elevation acute coronary syndromes (NSTE ACS) patients...
  17. doi request reprint Implications and reasons for the lack of use of reperfusion therapy in patients with ST-segment elevation myocardial infarction: findings from the CRUSADE initiative
    Shahyar Michael Gharacholou
    Duke Clinical Research Institute, Durham, NC, USA
    Am Heart J 159:757-63. 2010
    ..However, many STEMI patients in contemporary practice still do not receive any form of reperfusion therapy...
  18. pmc The association of in-hospital major bleeding with short-, intermediate-, and long-term mortality among older patients with non-ST-segment elevation myocardial infarction
    Renato D Lopes
    Duke Clinical Research Institute, Box 3850, 2400 Pratt Street, Room 0311, Terrace Level, Durham, NC 27705, USA
    Eur Heart J 33:2044-53. 2012
    ..Their association with long-term outcomes is less clear. This study examines mortality associated with in-hospital bleeding during NSTEMI over time intervals starting from hospital discharge and extending past 3 years...
  19. doi request reprint In-hospital major bleeding during ST-elevation and non-ST-elevation myocardial infarction care: derivation and validation of a model from the ACTION Registry®-GWTG™
    Robin Mathews
    Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina, USA
    Am J Cardiol 107:1136-43. 2011
    ....
  20. ncbi request reprint Excess heparin dosing among fibrinolytic-treated patients with ST-segment elevation myocardial infarction
    Tracy Y Wang
    Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina 27705, USA
    Am J Med 121:805-10. 2008
    ....
  21. doi request reprint Medical records and quality of care in acute coronary syndromes: results from CRUSADE
    Shannon M Dunlay
    Department of Medicine, Duke University Medical Center, Durham, NC, USA
    Arch Intern Med 168:1692-8. 2008
    ..Patient medical records are important means of communication among health care providers. Limited evaluation has been performed of the quality of the medical records or its association with health care processes or outcomes...
  22. doi request reprint Patterns and prognostic implications of low high-density lipoprotein levels in patients with non-ST-segment elevation acute coronary syndromes
    Matthew T Roe
    Department of Medicine, Division of Cardiovascular Medicine, Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27705, USA
    Eur Heart J 29:2480-8. 2008
    ..We sought to determine the prevalence and prognostic significance of low HDL cholesterol levels in patients with non-ST-segment elevation acute coronary syndromes (NSTE ACS)...
  23. doi request reprint Predicting long-term mortality in older patients after non-ST-segment elevation myocardial infarction: the CRUSADE long-term mortality model and risk score
    Matthew T Roe
    Duke Clinical Research Institute, Durham, NC, USA
    Am Heart J 162:875-883.e1. 2011
    ..We sought to develop a long-term mortality risk prediction model and a simplified risk score for use in older patients with non-ST-segment elevation myocardial infarction (NSTEMI)...
  24. doi request reprint Outcomes in elderly patients with acute coronary syndromes randomized to enoxaparin vs. unfractionated heparin: results from the SYNERGY trial
    Renato D Lopes
    Duke Clinical Research Institute, Box 3850, 2400 Pratt Street, Room 311, Terrace Level, Durham, NC 27705, USA
    Eur Heart J 29:1827-33. 2008
    ..The SYNERGY database was used to study the influence of age on treatment outcomes with enoxaparin vs. unfractionated heparin (UFH) in patients with high-risk NSTE ACS...
  25. doi request reprint Transfusion practice and outcomes in non-ST-segment elevation acute coronary syndromes
    Karen P Alexander
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27715, USA
    Am Heart J 155:1047-53. 2008
    ..To describe the association between transfusion and outcomes as a function of nadir hematocrit (HCT) in patients with non-ST-segment elevation acute coronary syndromes (NSTE ACS)...
  26. doi request reprint Advanced age, antithrombotic strategy, and bleeding in non-ST-segment elevation acute coronary syndromes: results from the ACUITY (Acute Catheterization and Urgent Intervention Triage Strategy) trial
    Renato D Lopes
    Duke University Medical Center, Durham, North Carolina, USA
    J Am Coll Cardiol 53:1021-30. 2009
    ....
  27. doi request reprint Prognostic value of troponins in patients with non-ST-segment elevation acute coronary syndromes and chronic kidney disease
    Chiara Melloni
    Division of Cardiology and Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina, USA
    Clin Cardiol 31:125-9. 2008
    ..The prognostic value of cardiac troponins (cTn) in patients with non-ST-segment elevation acute coronary syndromes (NSTE ACS) and chronic kidney disease (CKD) is debated...
  28. ncbi request reprint Comparison of baseline characteristics, treatment patterns, and in-hospital outcomes of Asian versus non-Asian white Americans with non-ST-segment elevation acute coronary syndromes from the CRUSADE quality improvement initiative
    Tracy Y Wang
    Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina, USA
    Am J Cardiol 100:391-6. 2007
    ..Further investigation is needed to explore the potential for ethnic variability in antithrombotic susceptibility...
  29. doi request reprint Antiplatelet therapy use after discharge among acute myocardial infarction patients with in-hospital bleeding
    Tracy Y Wang
    Duke Clinical Research Institute, 2400 Pratt St, Room 0311, Terrace Level, Durham, NC 27705, USA
    Circulation 118:2139-45. 2008
    ..Although the mechanism underlying this association is unclear, a potential explanation is that withholding antiplatelet therapies long beyond resolution of the bleeding event may contribute to recurrent events...
  30. doi request reprint Use of early clopidogrel by reperfusion strategy among patients presenting with ST-segment elevation myocardial infarction
    Chiara Melloni
    Division of Cardiology and Duke Clinical Research Institute, Duke University Medical Center, 2400 Pratt St, Durham, NC 27705, USA
    Circ Cardiovasc Qual Outcomes 4:603-9. 2011
    ..The 2007 update of the ACC/AHA guidelines for STEMI patients recommended addition of clopidogrel to aspirin regardless of reperfusion strategy, with a bolus dose in patients <75 years of age...
  31. ncbi request reprint Enoxaparin dosing and associated risk of in-hospital bleeding and death in patients with non ST-segment elevation acute coronary syndromes
    Nancy M Allen LaPointe
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27705, USA
    Arch Intern Med 167:1539-44. 2007
    ..The extent to which bleeding risk is attributable to excess dosing of enoxaparin is unclear...
  32. doi request reprint Impact of anemia on physical function and survival among patients with coronary artery disease
    Uptal D Patel
    Division of Nephrology, Duke University Medical Center, Duke Clinical Research Institute, Durham, NC 27710, USA
    Clin Cardiol 31:546-50. 2008
    ..Although anemia at the time of discharge has been associated with poor functional status and survival, its impact over time is not clear...
  33. doi request reprint Lipid-lowering intensification and low-density lipoprotein cholesterol achievement from hospital admission to 1-year follow-up after an acute coronary syndrome event: results from the Medications ApplIed aNd SusTAINed Over Time (MAINTAIN) registry
    Chiara Melloni
    Duke Clinical Research Institute and Division of Cardiology, Duke University Medical Center, Durham, NC 27705, USA
    Am Heart J 160:1121-9, 1129.e1. 2010
    ....
  34. doi request reprint Association between patient beliefs and medication adherence following hospitalization for acute coronary syndrome
    Nancy M Allen LaPointe
    Division of Clinical Pharmacology, Duke Clinical Research Institute, Duke University Medical Center, Durham, NC, USA
    Am Heart J 161:855-63. 2011
    ....
  35. ncbi request reprint Predictors of early discontinuation of evidence-based medicine after acute coronary syndrome
    Chiara Melloni
    Division of Cardiology and Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina, USA
    Am J Cardiol 104:175-81. 2009
    ..Patient education, better prescription drug coverage, and reminder strategies may improve use of EBMs at 3 months after discharge from ACS admission...
  36. ncbi request reprint The implications of blood transfusions for patients with non-ST-segment elevation acute coronary syndromes: results from the CRUSADE National Quality Improvement Initiative
    Xin Yang
    Division of Cardiology and Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina 27715, USA
    J Am Coll Cardiol 46:1490-5. 2005
    ....
  37. pmc Modifiable factors associated with failure to attain low-density lipoprotein cholesterol goal at 6 months after acute myocardial infarction
    Seth S Martin
    Department of Medicine, Duke University Medical Center, Durham, NC, USA
    Am Heart J 165:26-33.e3. 2013
    ..We sought to illuminate patient and provider characteristics associated with LDL-C goal nonattainment after AMI...
  38. doi request reprint Admission international normalized ratio levels, early treatment strategies, and major bleeding risk among non-ST-segment-elevation myocardial infarction patients on home warfarin therapy: insights from the National Cardiovascular Data Registry
    Sumeet Subherwal
    Duke University, 2500 Pratt St, Durham, NC 27715, USA
    Circulation 125:1414-23. 2012
    ..Yet, little is known about contemporary treatment patterns and bleeding risks in this population...
  39. ncbi request reprint Management of hyperlipidemia in older adults
    Karen P Alexander
    Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina 27715, USA
    J Cardiovasc Pharmacol Ther 14:49-58. 2009
    ..Reconsidering evidence around, use of statins as well as ways to optimize the prescription of statins and adherence in appropriately selected older adults is warranted...
  40. doi request reprint Changes in beliefs about medications during long-term care for ischemic heart disease
    Nancy M Allen LaPointe
    Division of Clinical Pharmacology and Duke Clinical Research Institute, Duke University Medical Center, Durham NC, USA
    Am Heart J 159:561-9. 2010
    ..Changes in these beliefs during long-term care have not previously been studied and were evaluated for purposes of this analysis...
  41. doi request reprint Cardiovascular research in the elderly: challenges, opportunities, and impact
    Robert M Califf
    Duke Clinical Research Institute, Box 17969, Durham, NC 27715, USA
    Postgrad Med 112:6-11. 2002
    ..Therefore, although treatments must continue to be applied to individuals based on their preferences, the evidence for these treatments must not summarily discriminate on the basis of age...
  42. ncbi request reprint Excess dosing of antiplatelet and antithrombin agents in the treatment of non-ST-segment elevation acute coronary syndromes
    Karen P Alexander
    Duke University Medical Center, Duke Clinical Research Institute, Durham, NC 27715, USA
    JAMA 294:3108-16. 2005
    ..Effective medical care assumes delivery of evidence-based medicines to appropriate patients with doses comparable to those studied...
  43. pmc Randomized trial of targeted performance feedback to facilitate quality improvement in acute myocardial infarction care
    Karen P Alexander
    Duke Clinical Research Institute, Durham, NC 27710, USA
    Circ Cardiovasc Qual Outcomes 4:129-35. 2011
    ..Efforts to improve quality of care for patients with acute myocardial infarction (AMI) are a national priority. To date, there have been few studies that have prospectively evaluated hospital quality improvement (QI) interventions...
  44. pmc Changes in glycoprotein IIb/IIIa inhibitor excess dosing with site-specific safety feedback in the Can Rapid risk stratification of Unstable angina patients Suppress ADverse outcomes with Early implementation of the ACC/AHA guidelines (CRUSADE) initiative
    Daniel W Mudrick
    Duke Clinical Research Institute and Division of Cardiology, Duke University Medical Center, Durham, NC 27715, USA
    Am Heart J 160:1072-8. 2010
    ..The impact of GP IIb/IIIa dosing feedback on safety and major bleeding is unknown...
  45. pmc Patterns of anticoagulation following bioprosthetic valve implantation: observations from ANSWER
    J Matthew Brennan
    The Duke Clinical Research Institute, Durham, NC 27715, USA
    J Heart Valve Dis 21:78-87. 2012
    ..However, strong evidence supporting this recommendation is lacking, making process variation likely...
  46. doi request reprint Dissociation between hospital performance of the smoking cessation counseling quality metric and cessation outcomes after myocardial infarction
    Gordon R Reeves
    Department of Internal Medicine, Duke Clinical Research Institute, Durham, NC 27705, USA
    Arch Intern Med 168:2111-7. 2008
    ..Yet, the association between hospitals' performance of this quality measure and subsequent tobacco cessation rates has not been established...
  47. doi request reprint Transitional care after hospitalization for acute stroke or myocardial infarction: a systematic review
    Janet Prvu Bettger
    Duke University School of Nursing, Duke Evidence Based Practice Center, Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC 27710, USA
    Ann Intern Med 157:407-16. 2012
    ..Transitional care is a time-limited service to prevent discontinuous care and adverse outcomes, including rehospitalization...
  48. ncbi request reprint International variation in invasive care of the elderly with acute coronary syndromes
    Karen P Alexander
    Outcomes Research and Assessment Group, Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27710, USA
    Eur Heart J 27:1558-64. 2006
    ..To explore variations in invasive care of the elderly with acute coronary syndromes across international practice...
  49. ncbi request reprint Treatment of non-ST-elevation acute coronary syndrome in the elderly: current practice and future opportunities
    Karen P Alexander
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27710, USA
    Am J Geriatr Cardiol 15:42-9. 2006
    ..Increased awareness of the beneficial impact of therapies on outcomes in the elderly, along with vigilance for adverse events, should enable care to move from the state of uncertainty to opportunity in this high-risk population...
  50. ncbi request reprint Statins for the primary prevention of cardiovascular events in older adults: a review of the evidence
    Robin Ali
    Division of Geriatric Medicine, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Geriatr Pharmacother 5:52-63. 2007
    ..Although statins have been demonstrated to be beneficial for secondary prevention in the elderly, their use for primary prevention has not been well described...
  51. pmc Preoperative anxiety as a predictor of mortality and major morbidity in patients aged >70 years undergoing cardiac surgery
    Judson B Williams
    Division of Cardiovascular and Thoracic Surgery, Department of Surgery, Duke University Medical Center, Durham, NC, USA
    Am J Cardiol 111:137-42. 2013
    ..3 to 20.2; p = 0.02). In conclusion, although high levels of anxiety were present in few patients anticipating cardiac surgery, this conferred a strong and independent heightened risk of mortality or major morbidity...
  52. ncbi request reprint Reperfusion strategies for acute myocardial infarction in the elderly: benefits and risks
    Rajendra H Mehta
    Duke Clinical Research Institute and Duke University Medical Center, Durham, North Carolina 27710, USA
    J Am Coll Cardiol 45:471-8. 2005
    ..Clearly targeted large-scale clinical trials are needed to evaluate the relative merits of available reperfusion strategies as well as newer antithrombotic adjunctive therapies in the elderly with STEMI...
  53. doi request reprint Age and outcomes in ST-segment elevation myocardial infarction treated with primary percutaneous coronary intervention: findings from the APEX-AMI trial
    S Michael Gharacholou
    Division of Cardiology, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA
    Arch Intern Med 171:559-67. 2011
    ....
  54. ncbi request reprint Long-term adherence with cardiovascular drug regimens
    Sonali P Kulkarni
    Duke Clinical Research Institute, Durham, NC, USA
    Am Heart J 151:185-91. 2006
    ..An increasing number of medications are prescribed for patients with coronary artery disease, but poor adherence may limit realization of their benefits...
  55. ncbi request reprint Multicenter experience in revascularization of very elderly patients
    Eric D Peterson
    The Outcomes Research and Assessment Group, The Duke Clinical Research Institute, Durham, NC 27715, USA
    Am Heart J 148:486-92. 2004
    ..We pooled the largest PCI and CABG clinical registries in the United States to better understand revascularization procedure use, risks and outcomes in patients aged > or =75 years...
  56. doi request reprint Antiplatelet therapy in older adults with non-ST-segment elevation acute coronary syndrome: considering risks and benefits
    Renato D Lopes
    Duke University Medical Center, 2400 Pratt Street, Terrace Level, Durham, NC 27705, USA
    Am J Cardiol 104:16C-21C. 2009
    ..However, given their complexity, it is important to further consider the application of existing and new therapies and strategies of care in "real-world" settings...
  57. ncbi request reprint Issues with care in the elderly patient presenting with acute ischemia
    S Michael Gharacholou
    Duke University Medical Center, Durham, NC 27710, USA
    Curr Heart Fail Rep 3:51-6. 2006
  58. ncbi request reprint Associations of gender and etiology with outcomes in heart failure with systolic dysfunction: a pooled analysis of 5 randomized control trials
    Camille G Frazier
    Division of Cardiovascular Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Am Coll Cardiol 49:1450-8. 2007
    ..This study sought to explore the gender-related differences in etiology and outcomes in chronic heart failure (HF) patients from 5 randomized trials...
  59. ncbi request reprint Identifying frailty in hospitalized older adults with significant coronary artery disease
    Jama L Purser
    Division of Geriatrics, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Am Geriatr Soc 54:1674-81. 2006
    ....
  60. doi request reprint Profile of chronic and recurrent angina pectoris in a referral population
    Karen P Alexander
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC, USA
    Am J Cardiol 102:1301-6. 2008
    ..001). In conclusion, patients with chronic and recurrent AP represent unique populations in whom AP continues to negatively impact quality of life despite contemporary care...
  61. ncbi request reprint Postmenopausal hormone use in women with acute coronary syndromes
    Elizabeth Parsons
    Duke University School of Medicine, Durham, North Carolina, USA
    J Womens Health (Larchmt) 13:863-71. 2004
    ..Recent trials reveal no benefit and possible harm from chronic hormone replacement therapy (HRT). Less is known about intermediate-term outcomes associated with HRT use in the setting of acute coronary syndromes (ACS)...
  62. ncbi request reprint Issues with care in the elderly patient presenting with acute ischemia
    S Michael Gharacholou
    Duke University Medical Center, Box 3411, Durham, NC 27710, USA
    Curr Cardiol Rep 7:270-5. 2005
    ..This review addresses clinically important issues in the care of elderly patients with acute ischemia and highlights recent studies that provide new insight into this complex area of cardiovascular care...
  63. ncbi request reprint Effect of cardiac rehabilitation on functional outcomes after coronary revascularization
    Sara K Pasquali
    Outcomes Research and Assessment Group, Duke Clinical Research Institute, Durham, NC, USA
    Am Heart J 145:445-51. 2003
    ..The main objective of this study was to evaluate the impact of CR in a diverse contemporary population on patient functional outcomes...
  64. ncbi request reprint Pulse pressure and vascular risk in the elderly: associations and clinical implications
    Rajesh V Swaminathan
    Duke University Medical Center and Duke Clinical Research Institute, Durham, NC 27710, USA
    Am J Geriatr Cardiol 15:226-32; quiz 133-4. 2006
    ..The authors review the mechanisms that contribute to pulse pressure and the association between pulse pressure, vascular risk factors, and outcomes...
  65. ncbi request reprint Use of evidence-based medicine for acute coronary syndromes in the elderly and very elderly: insights from the Sibrafiban vs aspirin to Yield Maximum Protection from ischemic Heart events postacute cOroNary sYndromes trials
    Cheuk Kit Wong
    Cardiology, Dunedin School of Medicine, Otago University, Dunedin, New Zealand
    Am Heart J 154:313-21. 2007
    ..Evidence-based medications (EBM) are underused in older patients despite potentially larger absolute benefits. Little is known about factors influencing prescribing in the elderly with acute coronary syndromes...
  66. doi request reprint The influence of age on health status outcomes after acute myocardial infarction
    P Michael Ho
    Medical Service, Denver VA Medical Center, Denver, CO, USA
    Am Heart J 155:855-61. 2008
    ..Older age is a risk factor for higher mortality after acute myocardial infarction (AMI), but the association with health status outcomes is largely unexplored...
  67. ncbi request reprint Characteristics, management, and outcomes of 5,557 patients age > or =90 years with acute coronary syndromes: results from the CRUSADE Initiative
    Adam H Skolnick
    Cardiovascular Division, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    J Am Coll Cardiol 49:1790-7. 2007
    ..The goal of this work was to explore the treatment and outcomes of patients with non-ST-segment elevation acute coronary syndromes (NSTE-ACS) age > or =90 years...
  68. ncbi request reprint Evidence-based care for all patients
    Karen P Alexander
    Am J Med 114:333-5. 2003
  69. ncbi request reprint Heart failure and the elderly: disease diversity, data, and delivery of care
    Karen P Alexander
    Am Heart J 146:194-6. 2003