Sana M Al-Khatib

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. pmc Assessment of the quality of existing patient educational tools focused on sudden cardiac arrest: a systematic evaluation by the Sudden Cardiac Arrest Thought Leadership Alliance
    Garrett Hazelton
    Department of Psychiatric Medicine, East Carolina University, Greenville, NC, USA
    Patient Prefer Adherence 7:361-8. 2013
  2. doi request reprint Outcomes of apixaban vs. warfarin by type and duration of atrial fibrillation: results from the ARISTOTLE trial
    Sana M Al-Khatib
    Duke Clinical Research Institute, Duke University Medical Center, PO Box 17969, Durham, NC 27715, USA
    Eur Heart J 34:2464-71. 2013
  3. ncbi request reprint Rate versus rhythm control and outcomes in patients with atrial fibrillation and chronic kidney disease: data from the GUSTO-III Trial
    Eric S Williams
    Division of Cardiology, University of Washington Medical Center, Seattle, WA, USA
    Cardiol J 20:439-46. 2013
  4. doi request reprint Performance measures to promote quality improvement in sudden cardiac arrest prevention and treatment
    Sana M Al-Khatib
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27715, USA
    Am Heart J 165:862-8. 2013
  5. pmc Follow-up of patients with new cardiovascular implantable electronic devices: are experts' recommendations implemented in routine clinical practice?
    Sana M Al-Khatib
    Duke Clinical Research Institute, Department of Medicine, Duke University School of Medicine, Durham, NC 27715, USA
    Circ Arrhythm Electrophysiol 6:108-16. 2013
  6. pmc Survival of patients receiving a primary prevention implantable cardioverter-defibrillator in clinical practice vs clinical trials
    Sana M Al-Khatib
    Duke Clinical Research Institute, PO Box 17969, Durham, NC 27715, USA
    JAMA 309:55-62. 2013
  7. pmc Trends in use of implantable cardioverter-defibrillator therapy among patients hospitalized for heart failure: have the previously observed sex and racial disparities changed over time?
    Sana M Al-Khatib
    MHS, Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC 27715, USA
    Circulation 125:1094-101. 2012
  8. ncbi request reprint Preventing tomorrow's sudden cardiac death today: dissemination of effective therapies for sudden cardiac death prevention
    Sana M Al-Khatib
    The Duke Clinical Research Institute, Durham, NC 27715, USA
    Am Heart J 156:613-22. 2008
  9. doi request reprint Promise of factor Xa inhibition in atrial fibrillation
    Sana M Al-Khatib
    Division of Cardiology, Department of Medicine, Duke Clinical Research Institute and Duke University, 2400 Pratt Street, PO Box 17969, Durham, NC 27705, USA
    Curr Cardiol Rep 14:70-8. 2012
  10. doi request reprint New directions in clinical outcomes assessment : VIth International Symposium on Interventional Electrophysiology in the Management of Cardiac Arrhythmias
    Sana M Al-Khatib
    Duke Clinical Research Institute, Duke University Medical Center, P O Box 17969, Durham, NC, 27715, USA
    J Interv Card Electrophysiol 32:221-6. 2011

Research Grants

Detail Information

Publications89

  1. pmc Assessment of the quality of existing patient educational tools focused on sudden cardiac arrest: a systematic evaluation by the Sudden Cardiac Arrest Thought Leadership Alliance
    Garrett Hazelton
    Department of Psychiatric Medicine, East Carolina University, Greenville, NC, USA
    Patient Prefer Adherence 7:361-8. 2013
    ..We hypothesized that this review would identify gaps in areas of information for the enhancement of patient education and decision-making materials...
  2. doi request reprint Outcomes of apixaban vs. warfarin by type and duration of atrial fibrillation: results from the ARISTOTLE trial
    Sana M Al-Khatib
    Duke Clinical Research Institute, Duke University Medical Center, PO Box 17969, Durham, NC 27715, USA
    Eur Heart J 34:2464-71. 2013
    ..It is uncertain whether the benefit from apixaban varies by type and duration of atrial fibrillation (AF)...
  3. ncbi request reprint Rate versus rhythm control and outcomes in patients with atrial fibrillation and chronic kidney disease: data from the GUSTO-III Trial
    Eric S Williams
    Division of Cardiology, University of Washington Medical Center, Seattle, WA, USA
    Cardiol J 20:439-46. 2013
    ..Atrial fibrillation (AF) and chronic kidney disease (CKD) have both been shown to portend worse outcomes after acute myocardial infarction (MI); however, the benefit of a rhythm control strategy in patients with CKD post-MI is unclear...
  4. doi request reprint Performance measures to promote quality improvement in sudden cardiac arrest prevention and treatment
    Sana M Al-Khatib
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27715, USA
    Am Heart J 165:862-8. 2013
    ..In this article, we review the burden of SCA and highlight the need to develop performance measures related to the prevention and treatment of SCA...
  5. pmc Follow-up of patients with new cardiovascular implantable electronic devices: are experts' recommendations implemented in routine clinical practice?
    Sana M Al-Khatib
    Duke Clinical Research Institute, Department of Medicine, Duke University School of Medicine, Durham, NC 27715, USA
    Circ Arrhythm Electrophysiol 6:108-16. 2013
    ..A 2008 expert consensus statement outlined the minimum frequency of follow-up of patients with cardiovascular implantable electronic devices (CIEDs)...
  6. pmc Survival of patients receiving a primary prevention implantable cardioverter-defibrillator in clinical practice vs clinical trials
    Sana M Al-Khatib
    Duke Clinical Research Institute, PO Box 17969, Durham, NC 27715, USA
    JAMA 309:55-62. 2013
    ..Whether the survival of patients who received an ICD in primary prevention clinical trials differs from that of trial-eligible patients receiving a primary prevention ICD in clinical practice is unknown...
  7. pmc Trends in use of implantable cardioverter-defibrillator therapy among patients hospitalized for heart failure: have the previously observed sex and racial disparities changed over time?
    Sana M Al-Khatib
    MHS, Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC 27715, USA
    Circulation 125:1094-101. 2012
    ..The degree to which the overall use of ICD therapy and disparities in use have changed is unclear...
  8. ncbi request reprint Preventing tomorrow's sudden cardiac death today: dissemination of effective therapies for sudden cardiac death prevention
    Sana M Al-Khatib
    The Duke Clinical Research Institute, Durham, NC 27715, USA
    Am Heart J 156:613-22. 2008
    ..Although the meeting was funded by industry participants, this article summarizing the presentations and discussions that occurred at the meeting presents the expert opinion of the authors...
  9. doi request reprint Promise of factor Xa inhibition in atrial fibrillation
    Sana M Al-Khatib
    Division of Cardiology, Department of Medicine, Duke Clinical Research Institute and Duke University, 2400 Pratt Street, PO Box 17969, Durham, NC 27705, USA
    Curr Cardiol Rep 14:70-8. 2012
    ....
  10. doi request reprint New directions in clinical outcomes assessment : VIth International Symposium on Interventional Electrophysiology in the Management of Cardiac Arrhythmias
    Sana M Al-Khatib
    Duke Clinical Research Institute, Duke University Medical Center, P O Box 17969, Durham, NC, 27715, USA
    J Interv Card Electrophysiol 32:221-6. 2011
    ..If prudently developed and executed, these new directions in assessing clinical outcomes have great potential to inform, and thereby improve the care of patients receiving electrophysiologic interventions...
  11. doi request reprint Do physicians' attitudes toward implantable cardioverter defibrillator therapy vary by patient age, gender, or race?
    Sana M Al-Khatib
    Duke Cardiovascular Center for Education and Research on Therapeutics, Duke Clinical Research Institute, Durham, NC, USA
    Ann Noninvasive Electrocardiol 16:77-84. 2011
    ..We assessed whether physicians' recommendation for ICD therapy varies as a function of patient age, gender, race, and physician's specialty...
  12. pmc Non-evidence-based ICD implantations in the United States
    Sana M Al-Khatib
    Duke Clinical Research Institute, PO Box 17969, Durham, NC 27715, USA
    JAMA 305:43-9. 2011
    ....
  13. doi request reprint Developing the Safety of Atrial Fibrillation Ablation Registry Initiative (SAFARI) as a collaborative pan-stakeholder critical path registry model: a Cardiac Safety Research Consortium "Incubator" Think Tank
    Sana M Al-Khatib
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27715, USA
    Am Heart J 160:619-26. 2010
    ....
  14. ncbi request reprint Remote monitoring of implantable cardioverter defibrillators versus quarterly device interrogations in clinic: results from a randomized pilot clinical trial
    Sana M Al-Khatib
    Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Cardiovasc Electrophysiol 21:545-50. 2010
    ..We sought to determine whether remote monitoring of ICDs improves patient outcomes compared with quarterly device interrogations in clinic...
  15. pmc Patient and implanting physician factors associated with mortality and complications after implantable cardioverter-defibrillator implantation, 2002-2005
    Sana M Al-Khatib
    Duke Clinical Research Institute, Department of Medicine, Duke University School of Medicine, Durham, NC 27715, USA
    Circ Arrhythm Electrophysiol 1:240-9. 2008
    ..We examined patient and implanting physician factors associated with outcomes of ICD therapy in Medicare beneficiaries from 2002 through 2005...
  16. ncbi request reprint Planning the Safety of Atrial Fibrillation Ablation Registry Initiative (SAFARI) as a Collaborative Pan-Stakeholder Critical Path Registry Model: a Cardiac Safety Research Consortium "Incubator" Think Tank
    Sana M Al-Khatib
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27715, USA
    Am Heart J 159:17-24. 2010
    ..The meeting took place on April 27 to 28, 2009, at the US Food and Drug Administration headquarters in Silver Spring, MD. This article summarizes the issues and directions presented and discussed at the meeting...
  17. doi request reprint Implantable cardioverter defibrillator therapy in patients with prior coronary revascularization in the Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT)
    Sana M Al-Khatib
    Duke Clinical Research Institute, Durham, North Carolina 27705, USA
    J Cardiovasc Electrophysiol 19:1059-65. 2008
    ....
  18. ncbi request reprint Preventing tomorrow's sudden cardiac death today: part I: Current data on risk stratification for sudden cardiac death
    Sana M Al-Khatib
    The Duke Clinical Research Institute, Durham, NC 27715, USA
    Am Heart J 153:941-50. 2007
    ..This article summarizes the presentations and discussions that occurred at that meeting...
  19. ncbi request reprint Observations on the transition from intermittent to permanent atrial fibrillation
    S M Al-Khatib
    Divisions of Clinical Pharmacology and Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Am Heart J 140:142-5. 2000
    ....
  20. ncbi request reprint Sustained ventricular arrhythmias among patients with acute coronary syndromes with no ST-segment elevation: incidence, predictors, and outcomes
    Sana M Al-Khatib
    Duke Clinical Research Institute, Durham, NC 27715, USA
    Circulation 106:309-12. 2002
    ..We studied the incidence, predictors, and outcomes of sustained ventricular arrhythmias in 4 large randomized trials of such patients...
  21. ncbi request reprint Outpatient prescribing of antiarrhythmic drugs from 1995 to 2000
    Sana M Al-Khatib
    Duke Center for Education and Research on Therapeutics CERTs at the Duke Clinical Research Institute, Durham, North Carolina 27715, USA
    Am J Cardiol 91:91-4. 2003
  22. ncbi request reprint Sustained ventricular arrhythmias and mortality among patients with acute myocardial infarction: results from the GUSTO-III trial
    Sana M Al-Khatib
    Duke Clinical Research Institute, Durham, NC 27715, USA
    Am Heart J 145:515-21. 2003
    ..We studied the incidence, timing, and outcomes of such arrhythmias in the international Global Utilization of Streptokinase and TPA (alteplase) for Occluded Coronary Arteries (GUSTO)-III trial...
  23. ncbi request reprint What clinicians should know about the QT interval
    Sana M Al-Khatib
    Duke Center for Education and Research on Therapeutics, Duke Clinical Research Institute, Durham, NC 27715, USA
    JAMA 289:2120-7. 2003
    ..Of the several factors implicated in causing QT interval prolongation and torsades de pointes, errors in the use of medications that may prolong this interval deserve special attention...
  24. ncbi request reprint Patterns of management of atrial fibrillation complicating coronary artery bypass grafting: Results from the PRoject of Ex-vivo Vein graft ENgineering via Transfection IV (PREVENT-IV) Trial
    Sana M Al-Khatib
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC, USA
    Am Heart J 158:792-8. 2009
    ..Current practice related to the management of atrial fibrillation (AF) complicating coronary artery bypass grafting (CABG) is uncertain...
  25. ncbi request reprint Is rhythm control superior to rate control in patients with atrial fibrillation and congestive heart failure?
    Sana M Al-Khatib
    Duke Clinical Research Institute, 2400 Pratt Street, PO Box 17969, Durham, NC 27715, USA
    Am J Cardiol 94:797-800. 2004
    ..After adjusting for differences in baseline characteristics and medications, no significant difference in mortality was found between the 2 groups...
  26. ncbi request reprint Incidence and predictors of sudden cardiac death in patients with diastolic heart failure
    Sana M Al-Khatib
    Duke Clinical Research Institute, Durham, North Carolina, USA
    J Cardiovasc Electrophysiol 18:1231-5. 2007
    ..We conducted this study to examine the incidence and predictors of sudden cardiac death (SCD) in patients with isolated diastolic heart failure...
  27. pmc A survey of health care practitioners' knowledge of the QT interval
    Sana M Al-Khatib
    Duke Center for Education and Research on Therapeutics, Duke Clinical Research Institute, Durham, NC 27715, USA
    J Gen Intern Med 20:392-6. 2005
    ..To assess health care practitioners' ability to correctly measure the QT interval, and to identify factors and medications that may increase the risk of QT-interval prolongation and torsades de pointes...
  28. ncbi request reprint Implantable cardioverter defibrillators and cardiac resynchronization therapy in patients with left ventricular dysfunction: randomized trial evidence through 2004
    Sana M Al-Khatib
    The Duke Clinical Research Institute, Durham, NC 27715, USA
    Am Heart J 149:1020-34. 2005
    ..This document summarizes the evidence reviewed at that meeting and the discussions of that evidence...
  29. ncbi request reprint The relation between patients' outcomes and the volume of cardioverter-defibrillator implantation procedures performed by physicians treating Medicare beneficiaries
    Sana M Al-Khatib
    Duke Clinical Research Institute, Durham, North Carolina 22715, USA
    J Am Coll Cardiol 46:1536-40. 2005
    ..The purpose of this study is to determine if implantable cardioverter-defibrillator (ICD) implantation should be limited to physicians with high procedural volume...
  30. pmc Outcomes associated with warfarin use in older patients with heart failure and atrial fibrillation and a cardiovascular implantable electronic device: findings from the ADHERE registry linked to Medicare claims
    Paul L Hess
    Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC, USA
    Clin Cardiol 35:649-57. 2012
    ..Warfarin use and associated outcomes in patients with heart failure and atrial fibrillation and a cardiovascular implantable electronic device have not been described previously...
  31. ncbi request reprint Incidence, predictors, and outcomes of high-degree atrioventricular block complicating acute myocardial infarction treated with thrombolytic therapy
    Trip J Meine
    Division of Cardiology, Department of Medicine, Duke University, Durham, NC 27715, USA
    Am Heart J 149:670-4. 2005
    ..We sought to delineate predictors of AVB and determine long-term mortality of patients developing AVB in the setting of ST-segment elevation MI (STEMI) treated with thrombolytic therapy...
  32. doi request reprint QRS duration, bundle-branch block morphology, and outcomes among older patients with heart failure receiving cardiac resynchronization therapy
    Pamela N Peterson
    Division of Cardiology, Department of Medicine, Denver Health Medical Center, Denver, CO 80204, USA
    JAMA 310:617-26. 2013
    ..The benefits of cardiac resynchronization therapy (CRT) in clinical trials were greater among patients with left bundle-branch block (LBBB) or longer QRS duration...
  33. doi request reprint Rhythm versus rate control in the contemporary management of atrial fibrillation in-hospital
    Nancy M Allen LaPointe
    Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina, USA
    Am J Cardiol 101:1134-41. 2008
    ..Some observations, such as greater use of the rate-control strategy with increasing age, were consistent with recommendations, but others, such as lower use of warfarin in the rate-control group, were not...
  34. pmc Association between prophylactic implantable cardioverter-defibrillators and survival in patients with left ventricular ejection fraction between 30% and 35%
    Sana M Al-Khatib
    Duke Clinical Research Institute, Department of Medicine, Duke University Medical Center, Durham, North Carolina3Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, North Carolina
    JAMA 311:2209-15. 2014
    ..Because a large number of ICDs in the United States are implanted in such patients, it is important to study survival associated with this therapy...
  35. ncbi request reprint Preventing tomorrow's sudden cardiac death today: part II: Translating sudden cardiac death risk assessment strategies into practice and policy
    Gillian D Sanders
    Duke Clinical Research Institute, Duke Medical Center, Durham, NC 27715, USA
    Am Heart J 153:951-9. 2007
    ....
  36. ncbi request reprint Is rhythm-control superior to rate-control in patients with atrial fibrillation and diastolic heart failure?
    Melissa H Kong
    Duke Clinical Research Institute, Durham, NC, USA
    Ann Noninvasive Electrocardiol 15:209-17. 2010
    ..We aimed to determine whether patients with AF and heart failure with preserved ejection fraction (EF) survive longer with rhythm versus rate-control strategy...
  37. doi request reprint Educational videos to reduce racial disparities in ICD therapy via innovative designs (VIVID): a randomized clinical trial
    Kevin L Thomas
    Duke Clinical Research Institute, Durham, NC 27710, USA
    Am Heart J 166:157-63. 2013
    ..We conducted a pilot study to assess the feasibility of testing this hypothesis in a randomized trial...
  38. doi request reprint Predictors of mortality in patients with chronic kidney disease and an implantable defibrillator: an EPGEN substudy
    Eric S Williams
    Division of Cardiology, Duke University Medical Center, Durham, NC 27710, USA
    Europace 13:1717-22. 2011
    ..Clinical trials of the implantable cardioverter-defibrillator (ICD) have demonstrated a survival benefit over medical therapy for the prevention of sudden cardiac death, but its benefit in patients with concomitant CKD is unclear...
  39. ncbi request reprint Reperfusion ventricular arrhythmia 'bursts' in TIMI 3 flow restoration with primary angioplasty for anterior ST-elevation myocardial infarction: a more precise definition of reperfusion arrhythmias
    Mohamed Majidi
    Duke Clinical Research Institute, 508 Fulton Street, Room A3012, Durham, NC 27705, USA
    Europace 10:988-97. 2008
    ....
  40. ncbi request reprint Predictors of sudden cardiac death change with time after myocardial infarction: results from the VALIANT trial
    Jonathan P Piccini
    Division of Cardiology, Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27705, USA
    Eur Heart J 31:211-21. 2010
    ..To determine whether predictors of sudden cardiac death (SCD) vary with time after myocardial infarction (MI)...
  41. doi request reprint Apixaban for reduction in stroke and other ThromboemboLic events in atrial fibrillation (ARISTOTLE) trial: design and rationale
    Renato D Lopes
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC, USA
    Am Heart J 159:331-9. 2010
    ....
  42. doi request reprint Efficacy and safety of apixaban compared with warfarin according to patient risk of stroke and of bleeding in atrial fibrillation: a secondary analysis of a randomised controlled trial
    Renato D Lopes
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27705, USA
    Lancet 380:1749-58. 2012
    ..We assessed in this trial's participants how results differed according to patients' CHADS(2), CHA(2)DS(2)VASc, and HAS-BLED scores, used to predict the risk of stroke and bleeding...
  43. ncbi request reprint Amiodarone use after acute myocardial infarction complicated by heart failure and/or left ventricular dysfunction may be associated with excess mortality
    Kevin L Thomas
    Duke Clinical Research Institute, Duke University Medical Center, Durham NC 27710, USA
    Am Heart J 155:87-93. 2008
    ....
  44. ncbi request reprint Warfarin use and outcomes in patients with atrial fibrillation complicating acute coronary syndromes
    Renato D Lopes
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC, USA
    Am J Med 123:134-40. 2010
    ....
  45. ncbi request reprint Clinical effectiveness of implantable cardioverter-defibrillators among medicare beneficiaries with heart failure
    Adrian F Hernandez
    Duke Clinical Research Institute, Department of Medicine, Duke University School of Medicine, Durham, NC, USA
    Circ Heart Fail 3:7-13. 2010
    ..The clinical effectiveness of implantable cardioverter-defibrillators (ICDs) in older patients with heart failure has not been established, and older patients have been underrepresented in previous studies...
  46. ncbi request reprint Clinical and economic implications of the Multicenter Automatic Defibrillator Implantation Trial-II
    Sana M Al-Khatib
    Duke Clinical Research Institute, Durham, North Carolina 27715, USA
    Ann Intern Med 142:593-600. 2005
    ..3 or less...
  47. doi request reprint Race and gender variation in the QT interval and its association with mortality in patients with coronary artery disease: results from the Duke Databank for Cardiovascular Disease (DDCD)
    Eric S Williams
    Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC, USA
    Am Heart J 164:434-41. 2012
    ..In several studies, prolongation of the corrected QT (QTc) interval has been associated with an increased risk of cardiac events. However, data on race and gender variation in the QTc and its associated risk of death are lacking...
  48. ncbi request reprint Sex and racial differences in the use of implantable cardioverter-defibrillators among patients hospitalized with heart failure
    Adrian F Hernandez
    Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina 27715, USA
    JAMA 298:1525-32. 2007
    ..The influence of sex and race on ICD use among eligible patients is unknown...
  49. ncbi request reprint Optimal timing of implantable cardioverter-defibrillator implantation after myocardial infarction: a decision analysis
    Jonathan P Piccini
    Duke Clinical Research Institute and the Duke University School of Medicine, Durham, North Carolina 27705, USA
    J Cardiovasc Electrophysiol 21:791-8. 2010
    ..The optimal timing of implantable cardioverter defibrillator (ICD) placement for the primary prevention of sudden cardiac death after myocardial infarction (MI) remains unknown...
  50. ncbi request reprint Quality of care for sudden cardiac arrest: Proposed steps to improve the translation of evidence into practice
    Zubin J Eapen
    Duke Clinical Research Institute, Durham, NC 27715, USA
    Am Heart J 162:222-31. 2011
    ..This article summarizes the discussions held at this meeting...
  51. ncbi request reprint Racial disparity in the utilization of implantable-cardioverter defibrillators among patients with prior myocardial infarction and an ejection fraction of <or=35%
    Kevin L Thomas
    Duke University Medical Center, Durham, North Carolina, USA
    Am J Cardiol 100:924-9. 2007
    ..62, 95% confidence interval 0.50 to 0.75, p<0.001). In conclusion, among patients at an increased risk for sudden cardiac death, blacks were significantly less likely to receive ICDs than whites...
  52. doi request reprint Pulmonary vein isolation for the maintenance of sinus rhythm in patients with atrial fibrillation: a meta-analysis of randomized, controlled trials
    Jonathan P Piccini
    Division of Cardiology, Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27715, USA
    Circ Arrhythm Electrophysiol 2:626-33. 2009
    ..The efficacy and safety of pulmonary vein isolation (PVI) compared with medical therapy remain in question...
  53. doi request reprint Extent of and reasons for nonuse of implantable cardioverter defibrillator devices in clinical practice among eligible patients with left ventricular systolic dysfunction
    Nancy M Allen LaPointe
    Duke University Medical Center, Duke Clinical Research Institute, Durham, NC 27705, USA
    Circ Cardiovasc Qual Outcomes 4:146-51. 2011
    ..The extent and documented reasons for nonuse of ICDs among patients with left ventricular systolic dysfunction are unknown...
  54. ncbi request reprint Use of implantable cardioverter-defibrillators for primary prevention in older patients: a systematic literature review and meta-analysis
    Melissa H Kong
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC, USA
    Cardiol J 18:503-14. 2011
    ..We evaluate the published data on ICD efficacy at reducing all-cause mortality in patients ≥ 65 years and in patients ≥ 75 years...
  55. doi request reprint Surgical Maze procedure as a treatment for atrial fibrillation: a meta-analysis of randomized controlled trials
    Melissa H Kong
    Duke University Medical Center, Durham, NC 27710, USA
    Cardiovasc Ther 28:311-26. 2010
    ..Large RCTs defining rates of freedom from AF without AADs postprocedure, are still needed to evaluate outcomes and determine the appropriate role for surgical Maze procedures in the management of AF...
  56. doi request reprint Single-photon emission computed tomography myocardial perfusion imaging and the risk of sudden cardiac death in patients with coronary disease and left ventricular ejection fraction>35%
    Jonathan P Piccini
    Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Am Coll Cardiol 56:206-14. 2010
    ....
  57. ncbi request reprint Mortality benefits from implantable cardioverter-defibrillator therapy are not restricted to patients with remote myocardial infarction: an analysis from the Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT)
    Jonathan P Piccini
    Division of Cardiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Heart Rhythm 8:393-400. 2011
    ....
  58. ncbi request reprint Atrial fibrillation management strategies and early mortality after myocardial infarction: results from the Valsartan in Acute Myocardial Infarction (VALIANT) Trial
    Kent R Nilsson
    Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Heart 96:838-42. 2010
    ..This study compared a rate control strategy to an anti-arrhythmic-based rhythm control strategy for the treatment of AF following myocardial infarction...
  59. ncbi request reprint Implantable cardioverter-defibrillators for primary prevention of sudden cardiac death in CKD: a meta-analysis of patient-level data from 3 randomized trials
    Patrick H Pun
    Duke Clinical Research Institute, Durham, NC Electronic address
    Am J Kidney Dis 64:32-9. 2014
    ..The benefit of a primary prevention implantable cardioverter-defibrillator (ICD) among patients with chronic kidney disease is uncertain...
  60. pmc Survival benefit of primary prevention implantable cardioverter-defibrillator therapy after myocardial infarction: does time to implant matter? A meta-analysis using patient-level data from 4 clinical trials
    Paul L Hess
    Duke Clinical Research Institute, Durham, North Carolina 27715, USA
    Heart Rhythm 10:828-35. 2013
    ..Whether there is an optimal time to place an implantable cardioverter-defibrillator (ICD) more than 40 days after myocardial infarction (MI) in guideline-eligible patients is unknown...
  61. pmc Follow-up of patients with new cardiovascular implantable electronic devices: is adherence to the experts' recommendations associated with improved outcomes?
    Paul L Hess
    Duke Clinical Research Institute, Durham, North Carolina 27715, USA
    Heart Rhythm 10:1127-33. 2013
    ..A 2008 expert consensus statement recommended an in-person follow-up visit between 2 and 12 weeks after the placement of a new cardiovascular implantable electronic device (CIED)...
  62. doi request reprint Adherence and persistence in the use of warfarin after hospital discharge among patients with heart failure and atrial fibrillation
    Zubin J Eapen
    Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina Department of Medicine, Duke University School of Medicine, Durham, North Carolina Electronic address
    J Card Fail 20:23-30. 2014
    ..Postdischarge adherence and long-term persistence in the use of warfarin among patients with heart failure and atrial fibrillation without contraindications have not been fully described...
  63. pmc Systematic review of the incidence of sudden cardiac death in the United States
    Melissa H Kong
    Duke Clinical Research Institute, Durham, North Carolina, USA
    J Am Coll Cardiol 57:794-801. 2011
    ..S. population...
  64. ncbi request reprint Cost-effectiveness of defibrillator therapy or amiodarone in chronic stable heart failure: results from the Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT)
    Daniel B Mark
    Outcomes Research Group, Duke Clinical Research Institute, PO Box 17969, Durham, NC 27715, USA
    Circulation 114:135-42. 2006
    ..We examined long-term economic implications of these results...
  65. doi request reprint Is heart failure guideline adherence being underestimated? The impact of therapeutic contraindications
    Brett D Atwater
    Division of Cardiology, Duke University Medical Center, Durham, NC, USA
    Am Heart J 164:750-755.e1. 2012
    ..Several studies based on claims data have reported underutilization of evidence-based heart failure (HF) therapies. The degree to which these estimates fail to account for therapeutic contraindications is unclear...
  66. ncbi request reprint Sex differences in the use of implantable cardioverter-defibrillators for primary and secondary prevention of sudden cardiac death
    Lesley H Curtis
    Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina 27715, USA
    JAMA 298:1517-24. 2007
    ..Previous studies of sex differences in the use of implantable cardioverter-defibrillators (ICDs) predate recent expansions in Medicare coverage and did not provide patient follow-up over multiple years...
  67. ncbi request reprint Knowledge deficits related to the QT interval could affect patient safety
    Nancy M Allen LaPointe
    Duke CERTs Centers for Education and Research on Therapeutics at the Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27715, USA
    Ann Noninvasive Electrocardiol 8:157-60. 2003
    ..S. Food and Drug Administration. This led us to assess the health care practitioners' knowledge of the QT interval and medications that may prolong it...
  68. pmc Age differences in the use of implantable cardioverter-defibrillators among older patients hospitalized with heart failure
    Paul L Hess
    Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC 27715, USA
    J Cardiovasc Electrophysiol 24:664-71. 2013
    ..Practice guidelines recommend the use of ICDs in patients with heart failure (HF) and a left ventricular ejection fraction (LVEF) of ≤ 35% in the absence of contraindications...
  69. ncbi request reprint Usefulness of the Duke Sudden Cardiac Death risk score for predicting sudden cardiac death in patients with angiographic (>75% narrowing) coronary artery disease
    Brett D Atwater
    Duke Clinical Research Institute, Durham, NC, USA
    Am J Cardiol 104:1624-30. 2009
    ....
  70. pmc Addressing disparities in sudden cardiac arrest care and the underutilization of effective therapies
    Melissa H Kong
    Duke Clinical Research Institute, Durham, NC, USA
    Am Heart J 160:605-18. 2010
    ..This article summarizes the discussions that occurred at the meeting...
  71. doi request reprint Single-photon emission computed tomography myocardial perfusion defects are associated with an increased risk of all-cause death, cardiovascular death, and sudden cardiac death
    Jonathan P Piccini
    Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Circ Cardiovasc Imaging 1:180-8. 2008
    ..However, it is unknown whether single-photon emission computed tomography myocardial perfusion imaging can identify patients at increased risk of sudden cardiac death (SCD)...
  72. doi request reprint Sustained ventricular tachycardia and ventricular fibrillation complicating non-ST-segment-elevation acute coronary syndromes
    Jonathan P Piccini
    Division of Cardiology, Duke Clinical Research Institute, Duke University Medical Center, PO Box 17969, Durham, NC 27705, USA
    Circulation 126:41-9. 2012
    ..However, the incidence and prognosis of sustained ventricular tachycardia/ventricular fibrillation (VT/VF) in contemporary non-ST-segment-elevation (NSTE) ACS populations are not well described...
  73. doi request reprint Cost-effectiveness of implantable cardioverter defibrillators in patients >or=65 years of age
    Gillian D Sanders
    Duke Clinical Research Institute, Duke University, Durham, NC, USA
    Am Heart J 160:122-31. 2010
    ..We sought to examine the cost-effectiveness of ICD therapy in at-risk patients >or=65 years old...
  74. pmc Relation between time from myocardial infarction to enrolment and patient outcomes in the Multicenter UnSustained Tachycardia Trial
    Sana M Al-Khatib
    1 Duke Clinical Research Institute, PO Box 17969, Durham, NC 27715, USA
    Europace 12:1112-8. 2010
    ..We sought to assess the relation between time from myocardial infarction (MI) to enrolment and patient outcomes and to examine the association between these outcomes and implantable cardioverter defibrillator (ICD) therapy...
  75. doi request reprint Use of beta-blockers in patients with an implantable cardioverter defibrillator
    Nancy M Allen LaPointe
    School of Medicine, Duke University, Duke Clinical Research Institute, Durham, NC 27705, USA
    Ann Pharmacother 43:1189-96. 2009
    ..beta-Blockers are also indicated in most patients who have an indication for an ICD; however, their use in this population is not well described. Some clinicians may be unaware of the recommendation for beta-blockers in this population...
  76. doi request reprint Hospital variation and characteristics of implantable cardioverter-defibrillator use in patients with heart failure: data from the GWTG-HF (Get With The Guidelines-Heart Failure) registry
    Bimal Shah
    Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Am Coll Cardiol 53:416-22. 2009
    ..The aim of this study was to describe hospital variation and factors associated with adherence to guidelines for implantable cardioverter-defibrillator (ICD) therapy...
  77. ncbi request reprint Prescription of QT-prolonging drugs in a cohort of about 5 million outpatients
    Lesley H Curtis
    Center for Clinical and Genetic Economics, Duke University Medical Center, Durham, North Carolina 27510, USA
    Am J Med 114:135-41. 2003
    ..Large pharmaceutical claims databases are useful for detecting potentially harmful prescribing behaviors, but better clinical evidence on medication safety is needed before such a system can be implemented fully...
  78. doi request reprint Evaluation of a new heparin agent in percutaneous coronary intervention: results of the phase 2 evaluation of M118 IN pErcutaNeous Coronary intErvention (EMINENCE) Trial
    Sunil V Rao
    Duke Clinical Research Institute, Durham, NC, USA
    Circulation 121:1713-21. 2010
    ..We performed a phase 2 randomized trial to evaluate the safety and feasibility of M118 in the setting of elective percutaneous coronary intervention...
  79. doi request reprint An evaluation of patient self-testing competency of prothrombin time for managing anticoagulation: pre-randomization results of VA Cooperative Study #481--The Home INR Study (THINRS)
    Rowena J Dolor
    Center for Health Services Research in Primary Care, VA Medical Center, Durham, NC, USA
    J Thromb Thrombolysis 30:263-75. 2010
    ..Successful home monitoring of PT with a PST device required adequate levels of cognition and manual dexterity. Training a caregiver modestly increased the proportion of patients who can perform PST...
  80. ncbi request reprint Amiodarone versus implantable cardioverter defibrillator for asymptomatic nonsustained ventricular tachycardia in nonischemic dilated cardiomyopathy
    Peter J Cawley
    Division of Cardiology and Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27715, USA
    Am Heart J 147:790-1. 2004
  81. doi request reprint Reperfusion ventricular arrhythmia 'bursts' predict larger infarct size despite TIMI 3 flow restoration with primary angioplasty for anterior ST-elevation myocardial infarction
    Mohamed Majidi
    eECG Core Laboratory, Duke Clinical Research Institute, 508 Fulton Street, Durham, NC 27705, USA
    Eur Heart J 30:757-64. 2009
    ..Well-characterized reperfusion VAs may provide a novel biomarker of reperfusion injury...
  82. doi request reprint Combined heart failure device diagnostics identify patients at higher risk of subsequent heart failure hospitalizations: results from PARTNERS HF (Program to Access and Review Trending Information and Evaluate Correlation to Symptoms in Patients With Hear
    David J Whellan
    Department of Medicine, Jefferson Medical College, 925 Chestnut Street, Philadelphia, PA 19107, USA
    J Am Coll Cardiol 55:1803-10. 2010
    ..We sought to determine the utility of combined heart failure (HF) device diagnostic information to predict clinical deterioration of HF in patients with systolic left ventricular dysfunction...
  83. pmc Chronic kidney disease is associated with increased risk of sudden cardiac death among patients with coronary artery disease
    Patrick H Pun
    Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA
    Kidney Int 76:652-8. 2009
    ..Additional studies are needed to better characterize the mechanisms by which reduced kidney function increases this risk...
  84. ncbi request reprint Improving the quality of care for women with cardiovascular disease: report of a DCRI Think Tank, March 8 to 9, 2007
    Jeffrey S Berger
    Duke Clinical Research Institute and the Division of Cardiovascular Medicine, Duke University, Durham, NC 27715, USA
    Am Heart J 156:816-25, 825.e1. 2008
    ..Nevertheless, little attention has focused on improving the quality of healthcare in women compared with other areas of cardiovascular medicine...
  85. doi request reprint Effect of home testing of international normalized ratio on clinical events
    David B Matchar
    Health Services Research Field Program, Veterans Affairs Medical Center, Durham, NC, USA
    N Engl J Med 363:1608-20. 2010
    ..As compared with venous plasma testing, point-of-care INR measuring devices allow greater testing frequency and patient involvement and may improve clinical outcomes...
  86. ncbi request reprint Efficacy and safety of sustained-release propafenone (propafenone SR) for patients with atrial fibrillation
    Edward L C Pritchett
    Duke University Medical Center, Durham, North Carolina, USA
    Am J Cardiol 92:941-6. 2003
    ..Adverse effects leading to withdrawal were higher in the propafenone SR 425-mg twice daily group than in any other group. Thus, propafenone SR has important and statistically significant antiarrhythmic effects in patients with AF...
  87. ncbi request reprint Azimilide dihydrochloride
    Mark Carlson
    Case Western Reserve University, Department of Medicine, University Hospitals of Cleveland, Cleveland, OH 44106, USA
    Expert Rev Cardiovasc Ther 3:387-91. 2005
    ..Clinical trials have utilized once-daily dosing. These trials have tested the use of the drug for patients with supraventricular and ventricular arrhythmias...
  88. ncbi request reprint Atrial overdrive pacing and incidence of heart failure-related adverse events in permanently paced patients
    Andreas Schuchert
    Medical Clinic, Friedrich Ebert Hospital, Friesenstrasse 11, D 24531 Neumünster, Germany
    J Interv Card Electrophysiol 19:55-60. 2007
    ..However, the maintenance of a heart rate incessantly faster than spontaneous could induce left ventricular (LV) dysfunction and promote heart failure (HF) on the long term...
  89. ncbi request reprint Biphasic versus monophasic shock waveform for conversion of atrial fibrillation: the results of an international randomized, double-blind multicenter trial
    Richard L Page
    Division of Cardiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9047, USA
    J Am Coll Cardiol 39:1956-63. 2002
    ..This study compared a biphasic waveform with a conventional monophasic waveform for cardioversion of atrial fibrillation (AF)...

Research Grants2

  1. ICD Therapy in Patients with Congestive Heart Failure
    Sana Al Khatib; Fiscal Year: 2009
    ..When completed, this project will provide novel evidence about the use of primary prevention ICDs that will support improved efficiency and effectiveness of this therapy at a national level. ..
  2. ICD Therapy in Patients with Congestive Heart Failure
    Sana M Al Khatib; Fiscal Year: 2010
    ..When completed, this project will provide novel evidence about the use of primary prevention ICDs that will support improved efficiency and effectiveness of this therapy at a national level. ..