Igor Akushevich

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. ncbi request reprint Health-based population forecasting: effects of smoking on mortality and fertility
    Igor Akushevich
    Center for Demographic Studies, Duke University, Durham, NC 27708 0408, USA
    Risk Anal 27:467-82. 2007
  2. pmc Trade-off in the effects of the apolipoprotein E polymorphism on the ages at onset of CVD and cancer influences human lifespan
    Alexander M Kulminski
    Center for Population Health and Aging, Duke University, Durham, NC 27708, USA
    Aging Cell 10:533-41. 2011
  3. pmc Time trends of incidence of age-associated diseases in the US elderly population: Medicare-based analysis
    Igor Akushevich
    Center for Population Health and Aging, Duke University, Durham, NC 27708, USA
    Age Ageing 42:494-500. 2013
  4. pmc Accelerated accumulation of health deficits as a characteristic of aging
    Alexander Kulminski
    Center for Population Health and Aging, Duke University Population Research Institute, Trent Drive, Box 90408, Durham, NC 27708, USA
    Exp Gerontol 42:963-70. 2007
  5. pmc Genetic model for longitudinal studies of aging, health, and longevity and its potential application to incomplete data
    Konstantin G Arbeev
    Center for Population Health and Aging, Duke University, Trent Hall, Room 002, Box 90408, Durham, NC 27708 0408, USA
    J Theor Biol 258:103-11. 2009
  6. pmc Exceptional survivors have lower age trajectories of blood glucose: lessons from longitudinal data
    Anatoli I Yashin
    Center for Population Health and Aging, Duke University, Durham, NC 27708 0408, USA
    Biogerontology 11:257-65. 2010
  7. pmc Medical cost trajectories and onsets of cancer and noncancer diseases in US elderly population
    Igor Akushevich
    Center for Population Health and Aging, Duke University, Durham, NC 27708, USA
    Comput Math Methods Med 2011:857892. 2011
  8. pmc Maintaining physiological state for exceptional survival: What is the normal level of blood glucose and does it change with age?
    Anatoli I Yashin
    Center for Population Health and Aging, Duke University, Durham, NC 27708 0408, USA
    Mech Ageing Dev 130:611-8. 2009
  9. pmc Age trajectories of physiological indices in relation to healthy life course
    Konstantin G Arbeev
    Centre for Population Health and Aging, Duke University, Department of Sociology, Durham, NC 27708 0408, USA
    Mech Ageing Dev 132:93-102. 2011
  10. pmc Age patterns of incidence of geriatric disease in the U.S. elderly population: Medicare-based analysis
    Igor Akushevich
    Center for Population Health and Aging, Duke University, Durham, North Carolina 27708, USA
    J Am Geriatr Soc 60:323-7. 2012

Detail Information

Publications33

  1. ncbi request reprint Health-based population forecasting: effects of smoking on mortality and fertility
    Igor Akushevich
    Center for Demographic Studies, Duke University, Durham, NC 27708 0408, USA
    Risk Anal 27:467-82. 2007
    ..The generalization of the model to account for multiple risk factors (e.g., the simultaneous effects of alcohol consumption, obesity, and smoking) and effects on medical expenditures are discussed...
  2. pmc Trade-off in the effects of the apolipoprotein E polymorphism on the ages at onset of CVD and cancer influences human lifespan
    Alexander M Kulminski
    Center for Population Health and Aging, Duke University, Durham, NC 27708, USA
    Aging Cell 10:533-41. 2011
    ..Deeper insights into biological mechanisms mediating gene action are critical for understanding the genetic regulation of a healthy lifespan and for personalizing medical care...
  3. pmc Time trends of incidence of age-associated diseases in the US elderly population: Medicare-based analysis
    Igor Akushevich
    Center for Population Health and Aging, Duke University, Durham, NC 27708, USA
    Age Ageing 42:494-500. 2013
    ....
  4. pmc Accelerated accumulation of health deficits as a characteristic of aging
    Alexander Kulminski
    Center for Population Health and Aging, Duke University Population Research Institute, Trent Drive, Box 90408, Durham, NC 27708, USA
    Exp Gerontol 42:963-70. 2007
    ..Longitudinal analysis provides strong evidence that the cumulative index of health/well-being deficits can characterize aging-associated processes in humans and predict death better than chronological age during short-term periods...
  5. pmc Genetic model for longitudinal studies of aging, health, and longevity and its potential application to incomplete data
    Konstantin G Arbeev
    Center for Population Health and Aging, Duke University, Trent Hall, Room 002, Box 90408, Durham, NC 27708 0408, USA
    J Theor Biol 258:103-11. 2009
    ..Simulation studies illustrate the increase in the accuracy in different scenarios for datasets structurally similar to the Framingham Heart Study. Possible applications of the model and its further generalizations are discussed...
  6. pmc Exceptional survivors have lower age trajectories of blood glucose: lessons from longitudinal data
    Anatoli I Yashin
    Center for Population Health and Aging, Duke University, Durham, NC 27708 0408, USA
    Biogerontology 11:257-65. 2010
    ..We concluded that individuals whose age trajectories of BG are located around the curve minimizing chances of premature death at each given age have highest chances of reaching exceptional longevity...
  7. pmc Medical cost trajectories and onsets of cancer and noncancer diseases in US elderly population
    Igor Akushevich
    Center for Population Health and Aging, Duke University, Durham, NC 27708, USA
    Comput Math Methods Med 2011:857892. 2011
    ..5 years after the date of onset). The developed approach results in a family of new forecasting models with covariates...
  8. pmc Maintaining physiological state for exceptional survival: What is the normal level of blood glucose and does it change with age?
    Anatoli I Yashin
    Center for Population Health and Aging, Duke University, Durham, NC 27708 0408, USA
    Mech Ageing Dev 130:611-8. 2009
    ..The results show that analyzing longitudinal data using advanced methods may substantially increase our knowledge on factors and mechanisms responsible for aging-related changes in humans...
  9. pmc Age trajectories of physiological indices in relation to healthy life course
    Konstantin G Arbeev
    Centre for Population Health and Aging, Duke University, Department of Sociology, Durham, NC 27708 0408, USA
    Mech Ageing Dev 132:93-102. 2011
    ....
  10. pmc Age patterns of incidence of geriatric disease in the U.S. elderly population: Medicare-based analysis
    Igor Akushevich
    Center for Population Health and Aging, Duke University, Durham, North Carolina 27708, USA
    J Am Geriatr Soc 60:323-7. 2012
    ..To use the Medicare Files of Service Use (MFSU) to evaluate patterns in the incidence of aging-related diseases in the U.S. elderly population...
  11. pmc What age trajectories of cumulative deficits and medical costs tell us about individual aging and mortality risk: Findings from the NLTCS-Medicare data
    Anatoli I Yashin
    Center for Population Health and Aging, Duke University, Durham, NC 27708 0408, USA
    Mech Ageing Dev 129:191-200. 2008
    ..We found that males show a faster decline in stress resistance with age than females...
  12. pmc Model of hidden heterogeneity in longitudinal data
    Anatoli I Yashin
    Center for Population Health and Aging, Duke University, Trent Hall, Room 002, Box 90408, Durham, NC 27708 0408, USA
    Theor Popul Biol 73:1-10. 2008
    ..Simulation experiments confirm identifiability of model's parameters...
  13. pmc Trade-offs between cancer and other diseases: do they exist and influence longevity?
    Svetlana V Ukraintseva
    Center for Population Health and Aging, Duke University, Durham, North Carolina 27708, USA
    Rejuvenation Res 13:387-96. 2010
    ..We discuss factors modulating the potential trade-offs between major disorders in populations, e.g., disease treatments. Further study is needed to clarify possible impact of such trade-offs on longevity...
  14. pmc Variability in the treatment of elderly patients with stage IIIA (N2) non-small-cell lung cancer
    Mark F Berry
    Department of Surgery, Duke University, Durham, NC 27710, USA
    J Thorac Oncol 8:744-52. 2013
    ..We evaluated treatment patterns of elderly patients with stage IIIA (N2) non-small-cell lung cancer (NSCLC)...
  15. ncbi request reprint Cumulative index of elderly disorders and its dynamic contribution to mortality and longevity
    Anatoli I Yashin
    Sociology Department, Duke University, Durham, North Carolina 27708, USA
    Rejuvenation Res 10:75-86. 2007
    ..This suggests increasing the role of senescence per se in the increasing risk of death with age compared to the role of specific pathology...
  16. pmc Stochastic model for analysis of longitudinal data on aging and mortality
    Anatoli I Yashin
    Duke University, Center for Demographic Studies, 2117 Campus Drive, Box 90408, Durham, NC 27708 0408, USA
    Math Biosci 208:538-51. 2007
    ..The results show that the model may characterize complicated interplay among different components of aging-related changes in humans and that the model parameters are identifiable from the data...
  17. pmc New stochastic carcinogenesis model with covariates: an approach involving intracellular barrier mechanisms
    Igor Akushevich
    Center for Population Health and Aging, Duke University, Durham, NC 27708, USA
    Math Biosci 236:16-30. 2012
    ..Further generalizations of the model, opportunities to measure barrier systems, biomedical and mathematical aspects of the new model are discussed...
  18. pmc Studying health histories of cancer: a new model connecting cancer incidence and survival
    Anatoli I Yashin
    Department of Sociology, Duke University, 002 Trent Hall, Box 90408 Durham, NC 27708 0408, USA
    Math Biosci 218:88-97. 2009
    ..Further developments of this model are discussed...
  19. pmc Evaluation of genotype-specific survival using joint analysis of genetic and non-genetic subsamples of longitudinal data
    Konstantin G Arbeev
    Center for Population Health and Aging, Duke University, Durham, NC 27708 0408, USA
    Biogerontology 12:157-66. 2011
    ....
  20. doi request reprint Morbidity risks among older adults with pre-existing age-related diseases
    Igor Akushevich
    Center for Population Health and Aging, Duke University, Durham, NC 27708, United States Electronic address
    Exp Gerontol 48:1395-401. 2013
    ..The results can be used in optimization of screening, prevention and treatment strategies of chronic diseases among U.S. elderly population. ..
  21. pmc Does surgery improve outcomes for esophageal squamous cell carcinoma? An analysis using the surveillance epidemiology and end results registry from 1998 to 2008
    Mathias Worni
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    J Am Coll Surg 215:643-51. 2012
    ..We examined survival associated with locally advanced esophageal squamous cell cancer (SCC) to evaluate if treatment without surgery could be considered adequate...
  22. ncbi request reprint Body mass index and nine-year mortality in disabled and nondisabled older U.S. individuals
    Alexander M Kulminski
    Department of Sociology, Center for Population Health and Aging, Population Research Institute, Duke University, Durham, North Carolina 27708, USA
    J Am Geriatr Soc 56:105-10. 2008
    ..To investigate the relationship between body mass index (BMI) and 9-year mortality in older (> or = 65) Americans with and without disability...
  23. pmc Polymorphisms in the ACE and ADRB2 genes and risks of aging-associated phenotypes: the case of myocardial infarction
    Alexander M Kulminski
    Center for Population Health and Aging, Duke University Population Research Institute and Department of Sociology, Duke University, Durham, North Carolina 27708, USA
    Rejuvenation Res 13:13-21. 2010
    ..Multimarker genetic analyses should benefit studies of complex aging-associated phenotypes...
  24. pmc Trends in survival and recovery from stroke: evidence from the national long-term care survey/medicare data
    Anatoli Yashin
    ScD, Center for Population Health and Aging, Duke University, Box 90408, Durham, NC 27708 0408
    Stroke 41:563-5. 2010
    ..CONCLUSIONS: Time trends in recovery rate from stroke exist and can be detected from available data. The roles of influential factors and causes of sex difference in recovery improvement deserve further studies...
  25. pmc Recovery and survival from aging-associated diseases
    Igor Akushevich
    Center for Population Health and Aging, Duke University, Durham, NC 27708, United States
    Exp Gerontol 48:824-30. 2013
    ..Using two Medicare-based population datasets, we investigated the properties of recovery from eleven age-related diseases...
  26. doi request reprint Breast cancer as heterogeneous disease: contributing factors and carcinogenesis mechanisms
    Julia Kravchenko
    Duke Cancer Institute, Duke University Medical Center, 2424 Erwin Road, Box 2732, Hock Plaza, Suite G05, Durham, NC 27705, USA
    Breast Cancer Res Treat 128:483-93. 2011
    ..The results of this study could suggest stratification rather than unification of breast cancer prevention strategies, risk assessment, and treatment...
  27. pmc Cancer Risk and Behavioral Factors, Comorbidities, and Functional Status in the US Elderly Population
    Igor Akushevich
    Center for Population Health and Aging, Duke University, Durham, NC 27708, USA
    ISRN Oncol 2011:415790. 2011
    ..The most influential of potentially preventable risk factors can be detected with this approach using NLTCS-Medicare linked dataset and for further deeper analyses employing other datasets with detailed risk factors description...
  28. doi request reprint Is there a role for simultaneous hepatic and colorectal resections? A contemporary view from NSQIP
    Mathias Worni
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    J Gastrointest Surg 16:2074-85. 2012
    ..We aimed to compare perioperative outcomes of simultaneous colorectal/liver resection (SCLR) with isolated resections utilizing a national clinical database...
  29. pmc Health decline, aging and mortality: how are they related?
    Anatoli I Yashin
    Center for Demographic Studies, Duke University, 2117 Campus Drive, 90408, Durham, NC 27708, USA
    Biogerontology 8:291-302. 2007
    ..Comparison of these results with findings from early studies using the Cox's-like model of risk function indicates that the results are likely to describe regularities of deterioration in human health during the aging process...
  30. doi request reprint Adjuvant radiotherapy in the treatment of invasive intraductal papillary mucinous neoplasm of the pancreas: an analysis of the surveillance, epidemiology, and end results registry
    Mathias Worni
    Research on Research, Department of Surgery, Duke University Medical Center, Durham, NC, USA
    Ann Surg Oncol 19:1316-23. 2012
    ..We investigated whether adjuvant radiotherapy (RT) improved cancer-specific survival (CSS) and overall survival (OS) among patients undergoing surgical resection for invasive IPMN...
  31. pmc What can we learn from the age- and race/ethnicity- specific rates of inflammatory breast carcinoma?
    Dora Il'yasova
    Duke Cancer Institute, DUMC Box 2715, Durham, NC 27710, USA
    Breast Cancer Res Treat 130:691-7. 2011
    ..The number of critical transition carcinogenesis stages (m-stages) predicted by the model were 6.3 and 8.5 for IBC and non-inflammatory LABC, respectively, supporting different etiologies of these breast tumors...
  32. pmc Accumulation of health disorders as a systemic measure of aging: Findings from the NLTCS data
    Alexander Kulminski
    Center for Demographic Studies, Duke University, 2117 Campus Drive, Box 90408, Durham, NC 27708, USA
    Mech Ageing Dev 127:840-8. 2006
    ..In this study we provide further support toward this view focusing on the analysis of the FI age patterns in the participants of the National Long Term Care Survey (NLTCS)...
  33. ncbi request reprint Endothelial progenitor cell therapy for atherosclerosis: the philosopher's stone for an aging population?
    Julia Kravchenko
    Center for Demographic Studies, Duke University, Durham, NC 27708, USA
    Sci Aging Knowledge Environ 2005:pe18. 2005
    ..67 versus 3.37 years; in males, an additional 5.94 versus 2.86 years, respectively)...