Manal F Abdelmalek

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. ncbi Higher dietary fructose is associated with impaired hepatic adenosine triphosphate homeostasis in obese individuals with type 2 diabetes
    Manal F Abdelmalek
    Division of Gastroenterology and Hepatology, Duke University, Durham, NC 27710, USA
    Hepatology 56:952-60. 2012
  2. ncbi Sirolimus conversion regimen versus continued calcineurin inhibitors in liver allograft recipients: a randomized trial
    M F Abdelmalek
    University of Florida, Gainesville, FL, USA
    Am J Transplant 12:694-705. 2012
  3. ncbi Nonalcoholic fatty liver disease as a complication of insulin resistance
    Manal F Abdelmalek
    Division of Gastroenterology, Hepatology, and Nutrition, Duke University Medical Center, PO Box 3913, Durham, NC 27710, USA
    Med Clin North Am 91:1125-49, ix. 2007
  4. ncbi Familial aggregation of insulin resistance in first-degree relatives of patients with nonalcoholic fatty liver disease
    Manal F Abdelmalek
    Division of Gastroenterology, Hepatology and Nutrition, University of Florida, Gainesville, Florida, USA
    Clin Gastroenterol Hepatol 4:1162-9. 2006
  5. ncbi Betaine for nonalcoholic fatty liver disease: results of a randomized placebo-controlled trial
    Manal F Abdelmalek
    Division of Gastroenterology, Duke University, Durham, North Carolina 27710, USA
    Hepatology 50:1818-26. 2009
  6. ncbi Increased fructose consumption is associated with fibrosis severity in patients with nonalcoholic fatty liver disease
    Manal F Abdelmalek
    Division of Gastroenterology, Duke University, Durham, NC 27710, USA
    Hepatology 51:1961-71. 2010
  7. ncbi Cyclosporine suppresses hepatitis C virus in vitro and increases the chance of a sustained virological response after liver transplantation
    Roberto J Firpi
    Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Section of Hepatobiliary Diseases, University of Florida, Gainesville, FL 32610 0214, USA
    Liver Transpl 12:51-7. 2006
  8. ncbi Sustained viral response to interferon and ribavirin in liver transplant recipients with recurrent hepatitis C
    Manal F Abdelmalek
    Department of Medicine, Section of Hepatobiliary Diseases University of Florida, Gainesville, FL 32610 0214, USA
    Liver Transpl 10:199-207. 2004
  9. ncbi Association between puberty and features of nonalcoholic fatty liver disease
    Ayako Suzuki
    Division of Gastroenterology, Duke University, Durham, NC 27710, USA
    Clin Gastroenterol Hepatol 10:786-94. 2012
  10. ncbi Hedgehog pathway activation parallels histologic severity of injury and fibrosis in human nonalcoholic fatty liver disease
    Cynthia D Guy
    Department of Pathology, Duke University Medical Center, Durham, NC, USA
    Hepatology 55:1711-21. 2012

Research Grants

  1. Hyperinsulinemia and Insulin Resistance in Fatty Liver
    Manal Abdelmalek; Fiscal Year: 2007

Detail Information

Publications30

  1. ncbi Higher dietary fructose is associated with impaired hepatic adenosine triphosphate homeostasis in obese individuals with type 2 diabetes
    Manal F Abdelmalek
    Division of Gastroenterology and Hepatology, Duke University, Durham, NC 27710, USA
    Hepatology 56:952-60. 2012
    ..Both high dietary fructose intake and elevated UA level may predict more severe hepatic ATP depletion in response to fructose and hence may be risk factors for the development and progression of NAFLD...
  2. ncbi Sirolimus conversion regimen versus continued calcineurin inhibitors in liver allograft recipients: a randomized trial
    M F Abdelmalek
    University of Florida, Gainesville, FL, USA
    Am J Transplant 12:694-705. 2012
    ..001), primarily for adverse events. Adverse events were consistent with known safety profiles. In conclusion, liver transplantation patients showed no demonstrable benefit 1 year after conversion from CNI- to SRL-based immunosuppression...
  3. ncbi Nonalcoholic fatty liver disease as a complication of insulin resistance
    Manal F Abdelmalek
    Division of Gastroenterology, Hepatology, and Nutrition, Duke University Medical Center, PO Box 3913, Durham, NC 27710, USA
    Med Clin North Am 91:1125-49, ix. 2007
    ..This article briefly summarizes advances in our understanding of the relationship between NAFLD and the insulin resistance (metabolic) syndrome, its prevalence, natural history, and treatment...
  4. ncbi Familial aggregation of insulin resistance in first-degree relatives of patients with nonalcoholic fatty liver disease
    Manal F Abdelmalek
    Division of Gastroenterology, Hepatology and Nutrition, University of Florida, Gainesville, Florida, USA
    Clin Gastroenterol Hepatol 4:1162-9. 2006
    ..An association between nonalcoholic fatty liver disease (NAFLD) and the insulin resistance (IR) syndrome exists. Familial clustering of IR may support a genetic predisposition to NAFLD or cryptogenic cirrhosis (CC)...
  5. ncbi Betaine for nonalcoholic fatty liver disease: results of a randomized placebo-controlled trial
    Manal F Abdelmalek
    Division of Gastroenterology, Duke University, Durham, North Carolina 27710, USA
    Hepatology 50:1818-26. 2009
    ..Although betaine has been proven effective in treating hepatic steatosis in several animal models, translating novel therapeutic options noted in animal studies to humans with NASH will prove challenging...
  6. ncbi Increased fructose consumption is associated with fibrosis severity in patients with nonalcoholic fatty liver disease
    Manal F Abdelmalek
    Division of Gastroenterology, Duke University, Durham, NC 27710, USA
    Hepatology 51:1961-71. 2010
    ..These results identify a readily modifiable environmental risk factor that may ameliorate disease progression in patients with NAFLD...
  7. ncbi Cyclosporine suppresses hepatitis C virus in vitro and increases the chance of a sustained virological response after liver transplantation
    Roberto J Firpi
    Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Section of Hepatobiliary Diseases, University of Florida, Gainesville, FL 32610 0214, USA
    Liver Transpl 12:51-7. 2006
    ..In conclusion, Cyclosporine may offer an advantage to Tacrolimus in those patients undergoing interferon-based therapy and should be studied in a prospective randomized trial...
  8. ncbi Sustained viral response to interferon and ribavirin in liver transplant recipients with recurrent hepatitis C
    Manal F Abdelmalek
    Department of Medicine, Section of Hepatobiliary Diseases University of Florida, Gainesville, FL 32610 0214, USA
    Liver Transpl 10:199-207. 2004
    ..05). In conclusion, loss of HCV after treatment of recurrent chronic hepatitis C with interferon and ribavirin is durable, and the durability of the SVR is associated with improvement in hepatic inflammation and regression of fibrosis...
  9. ncbi Association between puberty and features of nonalcoholic fatty liver disease
    Ayako Suzuki
    Division of Gastroenterology, Duke University, Durham, NC 27710, USA
    Clin Gastroenterol Hepatol 10:786-94. 2012
    ..Physiological changes that occur during puberty might affect pathologic features of nonalcoholic fatty liver disease (NAFLD). We investigated associations between pubertal development and clinical and histopathologic features of NAFLD...
  10. ncbi Hedgehog pathway activation parallels histologic severity of injury and fibrosis in human nonalcoholic fatty liver disease
    Cynthia D Guy
    Department of Pathology, Duke University Medical Center, Durham, NC, USA
    Hepatology 55:1711-21. 2012
    ..Hence, deregulation of the HH-signaling network may contribute to the pathogenesis and sequelae of liver damage that develops with metabolic syndrome...
  11. ncbi Impact of implementation of the MELD scoring system on the prevalence and incidence of chronic renal disease following liver transplantation
    Victor I Machicao
    Division of Gastroenterology, Hepatology, and Nutrition, University of Florida, Gainesville, FL 32610-0214, USA
    Liver Transpl 12:754-61. 2006
    ..In conclusion, the implementation of the MELD allocation system is not associated with increased mortality or occurrence of CRD-3 or CRD-4 in the first 2 years after LT...
  12. ncbi Regional anthropometric measures and hepatic fibrosis in patients with nonalcoholic Fatty liver disease
    Ayako Suzuki
    Duke University, Durham, North Carolina, USA
    Clin Gastroenterol Hepatol 8:1062-9. 2010
    ..We investigated whether peripheral and/or abdominal adipose depot size correlates with stage of hepatic fibrosis in patients with NAFLD in sex- and/or menopausal stage-specific manners...
  13. ncbi One-year protocol liver biopsy can stratify fibrosis progression in liver transplant recipients with recurrent hepatitis C infection
    Roberto J Firpi
    Division of Gastroenterology, Hepatology, and Nutrition Section of Hepatobiliary Diseases, University of Florida, Gainesville, FL 32610 0214, USA
    Liver Transpl 10:1240-7. 2004
    ..A liver biopsy performed at 1 year posttransplant can help identify those patients more likely to develop progressive disease and may allow better targeting of antiviral therapy...
  14. ncbi NKT-associated hedgehog and osteopontin drive fibrogenesis in non-alcoholic fatty liver disease
    Wing Kin Syn
    Division of Gastroenterology, Department of Medicine, Duke University Medical Center, Durham, NC, USA
    Gut 61:1323-9. 2012
    ....
  15. ncbi Late presentation of a biliary tract complication after right hepatic donation resulting in secondary biliary cirrhosis
    Giuseppe Morelli
    Division of Gastroenterology and Hepatology and Nutrition Section of Biliary Diseases and Liver Transplantation, University of Florida, Gainesville, FL 32610-0214, USA
    Liver Transpl 12:306-9. 2006
  16. ncbi Fructose consumption as a risk factor for non-alcoholic fatty liver disease
    Xiaosen Ouyang
    Division of Nephrology, University of Florida, Gainesville, FL, USA
    J Hepatol 48:993-9. 2008
    ..Furthermore, the hepatic metabolism of fructose favors de novo lipogenesis and ATP depletion. We hypothesize that increased fructose consumption contributes to the development of NAFLD...
  17. ncbi Costaining for keratins 8/18 plus ubiquitin improves detection of hepatocyte injury in nonalcoholic fatty liver disease
    Cynthia D Guy
    Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA
    Hum Pathol 43:790-800. 2012
    ..Keratin 8/18 plus ubiquitin double immunohistochemical stain improves detection of hepatocyte injury in nonalcoholic fatty liver disease. Thus, it may help differentiate nonalcoholic steatohepatitis from nonalcoholic fatty liver...
  18. ncbi Increased production of sonic hedgehog by ballooned hepatocytes
    Fatima Rangwala
    Division of Cellular Therapy, Hematology and Oncology, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    J Pathol 224:401-10. 2011
    ..These results help to explain why fibrosis stage correlates with hepatocyte ballooning in NASH...
  19. ncbi Hedgehog pathway and pediatric nonalcoholic fatty liver disease
    Marzena Swiderska-Syn
    Division of Gastroenterology and Hepatology, Department of Medicine, Duke University Medical Center, Durham, NC
    Hepatology 57:1814-25. 2013
    ..This may explain the unique histologic features of pediatric NAFLD because Hh signaling promotes the fibroductular response. (HEPATOLOGY 2013)...
  20. ncbi Combination of interferon alfa-2b and ribavirin in liver transplant recipients with histological recurrent hepatitis C
    Roberto J Firpi
    Department of Medicine, Section of Hepatobiliary Diseases, University of Florida, Gainesville, FL 32610, USA
    Liver Transpl 8:1000-6. 2002
    ..In summary, combination therapy is a reasonable antiviral option for recurrent HCV infection for established post-LT hepatitis and appears to prevent histological progression of disease if viral eradication is successful...
  21. ncbi Noninvasive evaluation of hepatic fibrosis using acoustic radiation force-based shear stiffness in patients with nonalcoholic fatty liver disease
    Mark L Palmeri
    Department of Biomedical Engineering, Duke University, Durham, NC, USA
    J Hepatol 55:666-72. 2011
    ....
  22. ncbi Short recovery time after percutaneous liver biopsy: should we change our current practices?
    Roberto J Firpi
    Division of Gastroenterology, Hepatology and Nutrition Section of Hepatobiliary Diseases, University of Florida, 1600 SW Archer Road, PO Box 100214, Gainesville, FL 32610 0214, USA
    Clin Gastroenterol Hepatol 3:926-9. 2005
    ..The aim of this study was to determine whether ambulatory patients requiring percutaneous liver biopsy can be safely discharged after a short recovery time period...
  23. ncbi Betaine resolves severe alcohol-induced hepatitis and steatosis following liver transplantation
    Karim Samara
    Department of Internal Medicine, University of Florida, Gainesville, Florida 32608-0214, USA
    Dig Dis Sci 51:1226-9. 2006
  24. ncbi Effect of vitamin E or metformin for treatment of nonalcoholic fatty liver disease in children and adolescents: the TONIC randomized controlled trial
    Joel E Lavine
    Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Columbia University, New York, New York, USA
    JAMA 305:1659-68. 2011
    ..Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in US children and adolescents and can present with advanced fibrosis or nonalcoholic steatohepatitis (NASH). No treatment has been established...
  25. ncbi Subclinical reactivation of hepatitis B virus in liver transplant recipients with past exposure
    Manal F Abdelmalek
    Division of Gastroenterology and Hepatology, Mayo Clinic, Scottsdale, AZ, USA
    Liver Transpl 9:1253-7. 2003
    ..In our experience, infected donor livers are the most common source of de novo posttransplantation hepatitis B infection in transplant recipients...
  26. ncbi Osteopontin is induced by hedgehog pathway activation and promotes fibrosis progression in nonalcoholic steatohepatitis
    Wing Kin Syn
    Division of Gastroenterology, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Hepatology 53:106-15. 2011
    ..05). CONCLUSION: OPN is Hh-regulated and directly promotes profibrogenic responses. OPN induction correlates with Hh pathway activity and fibrosis stage. Therefore, OPN inhibition may be beneficial in NASH...
  27. ncbi Nonalcoholic fatty liver disease in women
    Ayako Suzuki
    Division of Gastroenterology and Hepatology, Duke University Medical Center, Durham, NC 27710, USA
    Womens Health (Lond Engl) 5:191-203. 2009
    ....
  28. ncbi Angiotensin-converting enzyme inhibitor-induced isolated visceral angioedema in a liver transplant recipient
    Eric I Rosenberg
    Department of Internal Medicine, University of Florida, Gainesville, FL, USA
    Transplantation 75:730-2. 2003
    ....
  29. ncbi Acute liver failure occurring immediately following anti-D immune globulin infusion in a patient with chronic hepatitis B infection
    Manal F Abdelmalek
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Florida, 1600 SW Archer Road, Gainesville, FL 32610, USA
    Dig Dis Sci 52:914-9. 2007
  30. ncbi De novo nonalcoholic fatty liver disease after liver transplantation
    Manal F Abdelmalek
    Liver Transpl 13:788-90. 2007

Research Grants2

  1. Hyperinsulinemia and Insulin Resistance in Fatty Liver
    Manal Abdelmalek; Fiscal Year: 2007
    ....