David H Dreyfus

Summary

Country: USA

Publications

  1. ncbi A review of recent patents concerning therapy of respiratory diseases using gene silencing by RNAi (RISC) and EGS (RNAse P)
    David H Dreyfus
    Pediatrics, Yale School of Medicine and Medical Director, Founder Keren Pharmaceutical Inc, 488 Norton Parkway, New Haven CT 06511, USA
    Recent Pat Inflamm Allergy Drug Discov 1:49-55. 2007
  2. ncbi Anaphylaxis to latex in patients without identified risk factors for latex allergy
    David H Dreyfus
    Waterbury Hospital, Yale School of Medicine, Waterbury, CT, USA
    Conn Med 68:217-22. 2004
  3. ncbi An RNA external guide sequence ribozyme targeting human interleukin-4 receptor alpha mRNA
    David H Dreyfus
    Department of Pediatrics, Yale School of Medicine, 488 Norton Parkway, New Haven, CT 06511, USA
    Int Immunopharmacol 4:1015-27. 2004
  4. pmc Modulation of p53 activity by IkappaBalpha: evidence suggesting a common phylogeny between NF-kappaB and p53 transcription factors
    David H Dreyfus
    Division of Basic Sciences, Department of Pediatrics, National Jewish Medical Research Center, Denver, CO 80262 USA
    BMC Immunol 6:12. 2005
  5. ncbi Characterization of an anaphylactoid reaction to omalizumab
    David H Dreyfus
    Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut, USA
    Ann Allergy Asthma Immunol 96:624-7. 2006
  6. ncbi The DDE recombinases: diverse roles in acquired and innate immunity
    David H Dreyfus
    Department of Pediatrics, Yale School of Medicine, New Haven, Connecticut 06511, USA
    Ann Allergy Asthma Immunol 97:567-76; quiz 576-8, 602. 2006
  7. pmc Analysis of an ankyrin-like region in Epstein Barr Virus encoded (EBV) BZLF-1 (ZEBRA) protein: implications for interactions with NF-κB and p53
    David H Dreyfus
    Department of Pediatrics, Yale SOM, 488 Norton Parkway, New Haven, CT 06511, USA
    Virol J 8:422. 2011
  8. doi Autoimmune disease: A role for new anti-viral therapies?
    David H Dreyfus
    Pediatrics, Yale University School of Medicine, New Haven, CT, United States
    Autoimmun Rev 11:88-97. 2011
  9. pmc Paleo-immunology: evidence consistent with insertion of a primordial herpes virus-like element in the origins of acquired immunity
    David H Dreyfus
    Allergy and Clinical Immunology Pediatrics, Yale School of Medicine New Haven, New Haven, CT, USA
    PLoS ONE 4:e5778. 2009
  10. ncbi The syndrome of thyroid autoimmunity and idiopathic chronic urticaria and angioedema presenting as anaphylaxis
    David H Dreyfus
    Department of Pediatrics, Waterbury Hospital, Yale School of Medicine, Waterbury, Connecticut, USA
    Allergy Asthma Proc 24:171-4. 2003

Detail Information

Publications14

  1. ncbi A review of recent patents concerning therapy of respiratory diseases using gene silencing by RNAi (RISC) and EGS (RNAse P)
    David H Dreyfus
    Pediatrics, Yale School of Medicine and Medical Director, Founder Keren Pharmaceutical Inc, 488 Norton Parkway, New Haven CT 06511, USA
    Recent Pat Inflamm Allergy Drug Discov 1:49-55. 2007
    ..The possibility of therapy designed exploit synergies between both RISC and RNAse P and therapeutic benefits of inhibiting either or both pathways are also considered...
  2. ncbi Anaphylaxis to latex in patients without identified risk factors for latex allergy
    David H Dreyfus
    Waterbury Hospital, Yale School of Medicine, Waterbury, CT, USA
    Conn Med 68:217-22. 2004
    ..Clinicians should consider the diagnosis of latex allergy in all cases of anaphylaxis without identified causes, even in patients without identified risk factors for latex allergy...
  3. ncbi An RNA external guide sequence ribozyme targeting human interleukin-4 receptor alpha mRNA
    David H Dreyfus
    Department of Pediatrics, Yale School of Medicine, 488 Norton Parkway, New Haven, CT 06511, USA
    Int Immunopharmacol 4:1015-27. 2004
    ..Potential applications of inhaled RNA oligonucleotides in therapy of pulmonary and related systemic diseases are discussed...
  4. pmc Modulation of p53 activity by IkappaBalpha: evidence suggesting a common phylogeny between NF-kappaB and p53 transcription factors
    David H Dreyfus
    Division of Basic Sciences, Department of Pediatrics, National Jewish Medical Research Center, Denver, CO 80262 USA
    BMC Immunol 6:12. 2005
    ..Interactions between the two proteins, both direct and indirect, have been noted previously and the two proteins play central roles in the control of proliferation and apoptosis...
  5. ncbi Characterization of an anaphylactoid reaction to omalizumab
    David H Dreyfus
    Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut, USA
    Ann Allergy Asthma Immunol 96:624-7. 2006
    ..A contraindication to therapy with omalizumab is allergy to the medication or previous immediate-type hypersensitivity or anaphylaxis to omalizumab or similar medications...
  6. ncbi The DDE recombinases: diverse roles in acquired and innate immunity
    David H Dreyfus
    Department of Pediatrics, Yale School of Medicine, New Haven, Connecticut 06511, USA
    Ann Allergy Asthma Immunol 97:567-76; quiz 576-8, 602. 2006
    ..A similar DDE-like magnesium binding site also is present in transposases, retroviral integrases, and the innate antiviral response enzymes RNAse H and RNA-induced silencing complex (RISC)...
  7. pmc Analysis of an ankyrin-like region in Epstein Barr Virus encoded (EBV) BZLF-1 (ZEBRA) protein: implications for interactions with NF-κB and p53
    David H Dreyfus
    Department of Pediatrics, Yale SOM, 488 Norton Parkway, New Haven, CT 06511, USA
    Virol J 8:422. 2011
    ..These interactions may play a role in immunopathology and viral carcinogenesis in B lymphocytes as well as other cell types transiently infected by EBV such as T lymphocytes, macrophages and epithelial cells...
  8. doi Autoimmune disease: A role for new anti-viral therapies?
    David H Dreyfus
    Pediatrics, Yale University School of Medicine, New Haven, CT, United States
    Autoimmun Rev 11:88-97. 2011
    ..Other novel anti-viral therapies of chronic autoimmune diseases, such as retroviral integrase inhibitors, could be effective, although not without risk...
  9. pmc Paleo-immunology: evidence consistent with insertion of a primordial herpes virus-like element in the origins of acquired immunity
    David H Dreyfus
    Allergy and Clinical Immunology Pediatrics, Yale School of Medicine New Haven, New Haven, CT, USA
    PLoS ONE 4:e5778. 2009
    ..Catalytic activities of the RAG proteins are related to the recombinase functions of a pre-existing mobile DNA element in the DDE recombinase/RNAse H family, sometimes termed the "RAG transposon"...
  10. ncbi The syndrome of thyroid autoimmunity and idiopathic chronic urticaria and angioedema presenting as anaphylaxis
    David H Dreyfus
    Department of Pediatrics, Waterbury Hospital, Yale School of Medicine, Waterbury, Connecticut, USA
    Allergy Asthma Proc 24:171-4. 2003
    ....
  11. pmc Gene silencing in the therapy of influenza and other respiratory diseases: Targeting to RNase P by use of External Guide Sequences (EGS)
    David H Dreyfus
    Department of Pediatrics, Yale University School of Medicine, New Haven, CT, USA
    Biologics 1:425-32. 2007
    ..Furthermore, EGS could be adapted to target other respiratory diseases of viral etiology as well as conditions such as asthma...
  12. doi Herpesviruses and the microbiome
    David H Dreyfus
    Department of Pediatrics, Clinical Faculty, Yale School of Medicine, New Haven, and the Center for Allergy, Asthma, and Immunology, Waterbury, Conn Electronic address
    J Allergy Clin Immunol 132:1278-86. 2013
    ..Antiviral therapy and vaccines should be administered promptly when indicated clinically. ..
  13. ncbi Urticaria & angioedema: a rational approach to diagnosis and therapy
    David H Dreyfus
    Department of Pediatrics, Waterbury Hospital, Waterbury, CT, USA
    Skin Therapy Lett 18:4-9. 2013
    ..This review focuses on a rational approach to differential diagnosis and therapy of the most common forms of urticaria and angioedema...
  14. doi Observations on the mechanism of omalizumab as a steroid-sparing agent in autoimmune or chronic idiopathic urticaria and angioedema
    David H Dreyfus
    Ann Allergy Asthma Immunol 100:624-5. 2008