Research Topics
Genomes and Genes
| Brian WigdahlSummaryAffiliation: Drexel University College of Medicine Country: USA Publications
Research Grants
| Collaborators
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Detail Information
Publications
Application and removal of polyanionic microbicide compounds enhances subsequent infection by HIV-1Vanessa Pirrone
Department of Microbiology and Immunology, and Center for Molecular Therapeutics and Resistance, Center for Sexually Transmitted Disease, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, PA 19102, USA
Virol J 9:33. 2012..One such variable is product retention and loss following topical application...- Cellular phenotype impacts human immunodeficiency virus type 1 viral protein R subcellular localizationAdriano Ferrucci
Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA 19129, USA
Virol J 8:397. 2011.... - Regulation of HIV-1 transcription in cells of the monocyte-macrophage lineageEvelyn M Kilareski
Center for Molecular Virology and Translational Neuroscience, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, 245 N 15th St, Philadelphia, Pennsylvania 19102, USA
Retrovirology 6:118. 2009..The impact of genetic variation on LTR-directed transcription during the course of retrovirus disease is also reviewed... 
Toxicity, inflammation, and anti-human immunodeficiency virus type 1 activity following exposure to chemical moieties of C31GBradley J Catalone
Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
Biomed Pharmacother 59:430-7. 2005..These results provide further insight into the activity of C31G, as well as mechanisms potentially associated with microbicide toxicity...- PMA-induced differentiation of a bone marrow progenitor cell line activates HIV-1 LTR-driven transcriptionAikaterini Alexaki
Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129, USA
DNA Cell Biol 26:387-94. 2007..These studies elucidate the impact of infected bone marrow monocytic cell differentiation on LTR activity and its potential impact on HIV-1-associated disease... - Persistent interactions between biguanide-based compound NB325 and CXCR4 result in prolonged inhibition of human immunodeficiency virus type 1 infectionNina Thakkar
Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA 19102, USA
Antimicrob Agents Chemother 54:1965-72. 2010..CXCL12-induced chemotaxis was also persistently inhibited following pre-exposure to NB325. These results demonstrate that persistent inhibition of X4 HIV-1 infection by NB325 involves extended perturbation of the viral coreceptor CXCR4... - Specific sequence configurations of HIV-1 LTR G/C box array result in altered recruitment of Sp isoforms and correlate with disease progressionMichael R Nonnemacher
Department of Microbiology and Immunology, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, PA 19129, USA
J Neuroimmunol 157:39-47. 2004..These results suggest LTR Sp binding site sequence variants may prove useful as viral molecular markers indicative of progressive HIV-1-induced disease... - CCAAT/enhancer-binding proteins modulate human T cell leukemia virus type 1 long terminal repeat activationChristian Grant
Department of Microbiology and Immunology, The Pennsylvania State University, College of Medicine, Hershey, 17033, USA
Virology 348:354-69. 2006..Inhibition of Tax-mediated transactivation of the HTLV-1 LTR was co-activator-independent, did not require C/EBP binding to the Tax-responsive elements, and may involve heterodimerization with CREB factors... - Identification of human T cell leukemia virus type 1 tax amino acid signals and cellular factors involved in secretion of the viral oncoproteinPooja Jain
Department of Microbiology and Immunology, Center for Molecular Virology and Neuroimmunology, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PA 19129, USA
J Biol Chem 282:34581-93. 2007.... - A styrene-alt-maleic acid copolymer is an effective inhibitor of R5 and X4 human immunodeficiency virus type 1 infectionVanessa Pirrone
Department of Microbiology and Immunology and Center for Molecular Therapeutics and Resistance, Drexel University College of Medicine, 245 N 15th Street MS1013A, Philadelphia, PA 19102, USA
J Biomed Biotechnol 2010:548749. 2010..These studies demonstrate that alt-PSMA is an effective HIV-1 inhibitor with properties that warrant further investigation... - Modulation of dendritic cell maturation and function by the Tax protein of human T cell leukemia virus type 1Pooja Jain
Department of Microbiology and Immunology, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PA 19129, USA
J Leukoc Biol 82:44-56. 2007.... - Polybiguanides, particularly polyethylene hexamethylene biguanide, have activity against human immunodeficiency virus type 1Fred C Krebs
Department of Microbiology and Immunology, and Center for Sexually Transmitted Disease, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129 USA
Biomed Pharmacother 59:438-45. 2005.... 
Structure-activity relationships of polybiguanides with activity against human immunodeficiency virus type 1Shendra R Passic
Department of Microbiology and Immunology, and Center for Sexually Transmitted Disease, Center for Molecular Therapeutics, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, Pennsylvania 19102, USA
Biomed Pharmacother 64:723-32. 2010....- High-affinity interaction between HIV-1 Vpr and specific sequences that span the C/EBP and adjacent NF-kappaB sites within the HIV-1 LTR correlate with HIV-1-associated dementiaTricia H Burdo
Department of Microbiology and Immunology, The Pennsylvania State University, College of Medicine, Hershey, Pennsylvania, USA
DNA Cell Biol 23:261-9. 2004.... - Structural and functional studies of CCAAT/enhancer binding sites within the human immunodeficiency virus type 1 subtype C LTRYujie Liu
Department of Microbiology and Immunology, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, Pennsylvania 19129, USA
Biomed Pharmacother 64:672-80. 2010..Furthermore, the synergistic interaction between C/EBPβ-2 and Tat with the subtype C LTR was also observed in U-937 cells as previously demonstrated with the subtype B LTR... - Secretion of the human T cell leukemia virus type I transactivator protein taxTimothy Alefantis
Department of Microbiology and Immunology, Pennsylvania State University, College of Medicine, Hershey, Pennsylvania 17033, USA
J Biol Chem 280:17353-62. 2005.... - Regulation of human T-cell leukemia virus type 1 gene expression by Sp1 and Sp3 interaction with TRE-1 repeat IIIJing Yao
Department of Microbiology and Immunology, College of Medicine, The Pennsylvania State University, Hershey, Pennsylvania, USA
DNA Cell Biol 25:262-76. 2006..These results suggest that both Sp1 and Sp3 transcription factor binding to TRE-1 repeat III participate in regulation of HTLV-1 viral gene expression... - Innate and adaptive factors regulating human immunodeficiency virus type 1 genomic activationSonia Shah
Department of Microbiology and Immunology, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PA 19129, USA
J Neuroimmune Pharmacol 5:278-93. 2010..Finally, this review is discussed from the viewpoint of how an understanding of the interplay of all of these factors will help guide the next generation of therapies... - Specific interactions between the viral coreceptor CXCR4 and the biguanide-based compound NB325 mediate inhibition of human immunodeficiency virus type 1 infectionNina Thakkar
Department of Microbiology and Immunology, Center for Molecular Therapeutics and Resistance, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, Pennsylvania 19102, USA
Antimicrob Agents Chemother 53:631-8. 2009..Collectively, these results demonstrate that the biguanide-based compound NB325 inhibits HIV-1 infection by specifically interacting with the HIV-1 coreceptor CXCR4... - Prolonged exposure to the candidate microbicide C31G differentially reduces cellular sensitivity to agent re-exposureBradley J Catalone
Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
Biomed Pharmacother 59:460-8. 2005.... - Biochemical analysis of human milk treated with sodium dodecyl sulfate, an alkyl sulfate microbicide that inactivates human immunodeficiency virus type 1Sandra Urdaneta Hartmann
Department of Microbiology and Immunology, Pennsylvania State University, College of Medicine, Hershey, USA
J Hum Lact 22:61-74. 2006..Therefore, the use of alkyl sulfate microbicides to treat milk from HIV-1-positive women may be a simple, practical, and nutritionally sound way to prevent or reduce transmission of HIV-1 while still feeding with mother's own milk... - Human T-cell leukemia virus type I Tax induces the expression of dendritic cell markers associated with maturation and activationKate Mostoller
Department of Microbiology and Immunology, The Pennsylvania State University, College of Medicine, Hershey, Pennsylvania, USA
J Neurovirol 10:358-71. 2004..The implication of the experimental results with respect to the generation of a Tax-specific CTL compartment that participates in the genesis of HAM/TSP is discussed... - Human T cell leukemia virus type I Tax activates CD40 gene expression via the NF-kappa B pathwayEdward W Harhaj
Department of Microbiology and Immunology, Sylvester Comprehensive Cancer Center, The University of Miami School of Medicine, Miami, FL 33136, USA
Virology 333:145-58. 2005..Collectively, these results indicate that CD40 is a novel Tax-regulated gene, and the regulation of CD40 by Tax may play a role in cellular activation and HTLV-I-induced disease pathogenesis... - DC-SIGN mediates cell-free infection and transmission of human T-cell lymphotropic virus type 1 by dendritic cellsPooja Jain
Department of Microbiology and Immunology, Institute of Molecular Medicine and Infectious Disease, Drexel University College of Medicine, New College Building, Rm 18311, 245 N 15th St, Philadelphia, PA 19102, USA
J Virol 83:10908-21. 2009.... - Inactivation of HIV-1 in breast milk by treatment with the alkyl sulfate microbicide sodium dodecyl sulfate (SDS)Sandra Urdaneta
Department of Microbiology and Immunology, Penn State College of Medicine, Hershey, Pennsylvania 17033, USA
Retrovirology 2:28. 2005..Microbicidal treatment was at 37 degrees C or room temperature for 10 min. SDS removal was performed with a commercially available resin. Infectivity of HIV-1 and HIV-1 load in breast milk were determined after treatment... - C/EBP- and Tat-mediated activation of the HIV-1 LTR in CD34+ hematopoietic progenitor cellsShane Quiterio
Department of Microbiology and Immunology, The Pennsylvania State University, College of Medicine, H107, 500 University Drive, P.O. Box 850, Hershey, PA 17033, USA
Biomed Pharmacother 57:49-56. 2003.... - CCAAT/enhancer-binding proteins and the pathogenesis of retrovirus infectionYujie Liu
Department of Microbiology and Immunology, Center for Molecular Virology and Neuroimmunology, Center for Cancer Biology, Philadelphia, PA 19129, USA
Future Microbiol 4:299-321. 2009..The structure and function of the C/EBPbeta gene and the related protein isoforms are discussed along with the transcription factors, coactivators, viral proteins, cytokines and chemokines that affect C/EBP function... - Region-specific distribution of human immunodeficiency virus type 1 long terminal repeats containing specific configurations of CCAAT/enhancer-binding protein site II in brains derived from demented and nondemented patientsTricia H Burdo
Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA
J Neurovirol 10:7-14. 2004.... - Use of human antigen presenting cell gene array profiling to examine the effect of human T-cell leukemia virus type 1 Tax on primary human dendritic cellsJaya Ahuja
Department of Microbiology and Immunology, Institute for Molecular Medicine and Infectious Disease, Center for Molecular Virology and Neuroimmunology, Center for Cancer Biology, Drexel University College of Medicine, Philadelphia, PA 19102, USA
J Neurovirol 12:47-59. 2006..These results have suggested that Tax-mediated DC gene regulation might play a critical role in cellular activation and the mechanisms resulting in HTLV-1-induced disease... - Role of resident CNS cell populations in HTLV-1-associated neuroinflammatory diseaseVeronique Lepoutre
Department of Microbiology and Immunology, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, Pennsylvania 19102, USA
Front Biosci 14:1152-68. 2009..This comprehensive review characterizes the available knowledge to date concerning the effects of HTLV-1 on CNS resident cell populations with emphasis on both viral and host factors contributing to the genesis of HAM/TSP... - Depletion of dendritic cells enhances susceptibility to cell-free infection of human T cell leukemia virus type 1 in CD11c-diphtheria toxin receptor transgenic miceSaifur Rahman
Drexel Institute for Biotechnology and Virology Research, Drexel University College of Medicine, Philadelphia, PA 19127, USA
J Immunol 184:5553-61. 2010.... - Development of co-selected single nucleotide polymorphisms in the viral promoter precedes the onset of human immunodeficiency virus type 1-associated neurocognitive impairmentLuna Li
Department of Microbiology and Immunology, Drexel University College of Medicine, 245 N 15th Street, MS 1013A, Philadelphia, PA 19102, USA
J Neurovirol 17:92-109. 2011.... - HIV-1 Vpr binding to HIV-1 LTR C/EBP cis-acting elements and adjacent regions is sequence-specificTricia H Hogan
Department of Microbiology and Immunology, The Pennsylvania State University, College of Medicine, H107, 500 University Drive, P O Box 850, Hershey, PA 17033, USA
Biomed Pharmacother 57:41-8. 2003..These studies suggest that Vpr may regulate the interaction of members of the C/EBP transcription factor family with the viral LTR... - Effects of highly active antiretroviral therapy on HIV-1-associated oral complicationsZahida Parveen
Division of Infectious Diseases, Department of Medicine, Thomas Jefferson University, Philadelphia, PA, USA
Curr HIV Res 5:281-92. 2007..Future directions envisioned by the National Institutes of Health as well as novel avenues to be explored are also presented... - Induction of pro-inflammatory cytokines by human T-cell leukemia virus type-1 Tax protein as determined by multiplexed cytokine protein array analyses of human dendritic cellsJaya Ahuja
Department of Microbiology and Immunology, Center for Cancer Biology, Institute of Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, PA 19102, USA
Biomed Pharmacother 61:201-8. 2007..Collectively, these findings suggest a role for Tax-induced cytokine secretion from MDDCs, which may be critical for the cellular activation and tissue damage that has been observed in HAM/TSP... - Cellular reservoirs of HIV-1 and their role in viral persistenceAikaterini Alexaki
Department of Microbiology and Immunology, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129, USA
Curr HIV Res 6:388-400. 2008..The contribution of these and other cell populations in HIV-1 persistence, as well as the possible strategies to eliminate latently infected cells are critically examined in this review... - Transcriptional regulation of the chemokine co-receptor CCR5 by the cAMP/PKA/CREB pathwayAnupam Banerjee
Department of Microbiology and Immunology, Center for Molecular Virology and Translational Neuroscience, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, 245 N 15th Street, MS 1013A, Philadelphia, Pennsylvania 19102, USA
Biomed Pharmacother 65:293-7. 2011..Our results lend critical insight into the precise mechanism governing the cAMP-CCR5 axis in progenitor cells and pose interesting questions regarding its functional role in HIV-1 infection... - Regulation of human immunodeficiency virus type 1 gene expression and pathogenesis by CCAAT/enhancer binding proteins in cells of the monocyte/macrophage lineageTricia H Hogan
Department of Microbiology and Immunology, The Pennsylvania State University, College of Medicine, Hershey, Pennsylvania 17033, USA
J Neurovirol 8:21-6. 2002.... - Combinatorial approaches to the prevention and treatment of HIV-1 infectionVanessa Pirrone
Department of Microbiology and Immunology, Drexel University College of Medicine, 245 N 15th Street, New College Building, Philadelphia PA 19102, USA
Antimicrob Agents Chemother 55:1831-42. 2011..The shift in focus within the microbicide development field from single compounds to combination approaches is also explored... - Cervicovaginal safety of the formulated, biguanide-based human immunodeficiency virus type 1 (HIV-1) inhibitor NB325 in a murine modelKarissa Lozenski
Department of Microbiology and Immunology, Center for Sexually Transmitted Disease, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, 245 N 15th Street, Philadelphia, PA 19102, USA
J Biomed Biotechnol 2011:941061. 2011..Although formulated NB325 appeared generally safe for application in these studies, the low but observable level of toxicity suggests the need for improvements in the compound and/or formulation... - Role of mu-opioids as cofactors in human immunodeficiency virus type 1 disease progression and neuropathogenesisAnupam Banerjee
Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA 19102, USA
J Neurovirol 17:291-302. 2011..Understanding the opioid-HIV-1 interface at the molecular level is vitally important in designing better treatment strategies for HIV-1-infected patients who abuse opioids... - HIV-1 infection of bone marrow hematopoietic progenitor cells and their role in trafficking and viral disseminationAikaterini Alexaki
Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA, USA
PLoS Pathog 4:e1000215. 2008..A monocyte subpopulation with these features has been shown to expand during the course of HIV-1 disease, particularly in HAD patients, and is characterized by low CD14 expression and the presence of cell surface CD16... - A novel high throughput quantum dot-based fluorescence assay for quantitation of virus binding and attachmentKaran Kampani
Department of Microbiology and Immunology, Institute for Molecular Medicine and Infectious Disease, Center for Molecular Virology and Neuroimmunology, Center for Cancer Biology, Drexel University College of Medicine, Philadelphia, PA 19102, USA
J Virol Methods 141:125-32. 2007.... - Characterization of a nuclear export signal within the human T cell leukemia virus type I transactivator protein TaxTimothy Alefantis
Department of Microbiology and Immunology, College of Medicine, Pennsylvania State University Hershey, 500 University Drive, PA 17033, USA
J Biol Chem 278:21814-22. 2003..These results suggest that Tax localization may be directed by specific changes in Tax conformation or by specific interactions with cellular proteins leading to changes in the availability of the Tax NES and nuclear localization signal... - Mediators of central nervous system damage during the progression of human T-cell leukemia type I-associated myelopathy/tropical spastic paraparesisKate Barmak
Laboratory for Molecular Retrovirology and Viral Neuropathogenesis, Department of Microbiology and Immunology, The Pennsylvania State University, College of Medicine, Hershey 17033, USA
J Neurovirol 9:522-9. 2003..This review focuses on potential mechanisms of central nervous system (CNS) damage associated with the genesis of HAM/TSP following HTLV-I infection, focusing on the role of the Tax-specific CTL compartment... - Mouse model of cervicovaginal toxicity and inflammation for preclinical evaluation of topical vaginal microbicidesBradley J Catalone
Department of Microbiology and Immunology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
Antimicrob Agents Chemother 48:1837-47. 2004..Collectively, these studies highlight the murine model of toxicity as a valuable tool for the preclinical assessment of toxicity and inflammation associated with exposure to candidate topical microbicides... - Dendritic cells in autoimmune diseases and neuroinflammatory disordersSharron L Manuel
Department of Microbiology and Immunology, Center for Cancer Biology, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, Pennsylvania 19102, USA
Front Biosci 12:4315-35. 2007..Overall, the goal of this review is to establish DCs in the interface of tolerance and autoimmunity and generate a global interest in this field in order to exploit DC potential for the therapy of inflammatory diseases... - Structural and functional evolution of human immunodeficiency virus type 1 long terminal repeat CCAAT/enhancer binding protein sites and their use as molecular markers for central nervous system disease progressionTricia H Hogan
Department of Microbiology and Immunology, The Pennsylvania State University, College of Medicine, Hershey 17033, USA
J Neurovirol 9:55-68. 2003..The C/EBP site I 3T variant appears to be exclusive to patients progressing to increasingly severe HIV-1-associated immunologic and neurologic disease... - Human T cell leukemia virus type I-induced disease: pathways to cancer and neurodegenerationKate Barmak
Department of Microbiology and Immunology, The Pennsylvania State University, College of Medicine, Hershey, PA 17033, USA
Virology 308:1-12. 2003.... - Breaking down the barrier: the effects of HIV-1 on the blood-brain barrierMarianne Strazza
Department of Microbiology and Immunology, and Center for Molecular Virology and Translational Neuroscience, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, PA 19102, USA
Brain Res 1399:96-115. 2011.... - The rise and fall of polyanionic inhibitors of the human immunodeficiency virus type 1Vanessa Pirrone
Department of Microbiology and Immunology, Center for Sexually Transmitted Disease, Center for Molecular Therapeutics and Resistance, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, PA 19102, USA
Antiviral Res 90:168-82. 2011.... - Cholesterol-depleting statin drugs protect postmitotically differentiated human neurons against ethanol- and human immunodeficiency virus type 1-induced oxidative stress in vitroEdward Acheampong
Dorrance H Hamilton Laboratories, Division of Infectious Diseases, Department of Medicine, Thomas Jefferson University, 1020 Locust Street, Suite 329, Philadelphia, Pennsylvania 19107, USA
J Virol 81:1492-501. 2007..The results of this study provide new insights into HIV-1 neuropathogenesis aimed at the development of future HIV-1 therapeutics to eradicate viral reservoirs from the brain... - Human immunodeficiency virus viral protein R as an extracellular protein in neuropathogenesisAdriano Ferrucci
School of Biomedical Engineering, Science, and Health Systems, Drexel University, Philadelphia, Pennsylvania, USA
Adv Virus Res 81:165-99. 2011.... - Alkylated porphyrins have broad antiviral activity against hepadnaviruses, flaviviruses, filoviruses, and arenavirusesHaitao Guo
Institute for Biotechnology and Virology Research, Department of Microbiology and Immunology, Drexel University College of Medicine, Doylestown, PA 18902, USA
Antimicrob Agents Chemother 55:478-86. 2011..The possible application of this family of compounds as antiviral agents, as microbicides and systemic virus neutralizing agents, is discussed... - Comparative in vitro sensitivities of human immune cell lines, vaginal and cervical epithelial cell lines, and primary cells to candidate microbicides nonoxynol 9, C31G, and sodium dodecyl sulfateFred C Krebs
Department of Microbiology and Immunology, The Pennsylvania State University, College of Medicine, Hershey, Pennsylvania 17033, USA
Antimicrob Agents Chemother 46:2292-8. 2002....
Research Grants
- High Specificity HIV-1 Markers Predictive of Neuro-AIDSBrian Wigdahl; Fiscal Year: 2010....
- High Specificity HIV-1 Markers Predictive of Neuro-AIDSBrian Wigdahl; Fiscal Year: 2007..These studies may lead to the identification of additional tools to predict the development of HIVD and, in turn, provide more information to guide the therapeutic management of the HIV-1-infected patient. ..
- HIV 1 LTR Activation in Peripheral Blood and BrainBrian Wigdahl; Fiscal Year: 2005..These studies may provide insight relevant to the development of new molecular diagnostic reagents and therapeutic strategies to monitor and control HIV-1-associated neurologic disease. ..
- REGULATION OF HTLV I LTR IN IMMUNE AND NERVOUS SYSTEMSBrian Wigdahl; Fiscal Year: 2005..These studies could lead to new therapeutic approaches to prevent and/or treat TSP or other neuroinflammatory diseases. ..
- HTLV-1 & Cellular Factors in Neuroinflammatory DiseaseBrian Wigdahl; Fiscal Year: 2007....
- HTLV-1 & Cellular Factors in Neuroinflammatory DiseaseBrian Wigdahl; Fiscal Year: 2010....
- HIV-1 LTR Activation in Peripheral Blood and BrainBrian Wigdahl; Fiscal Year: 2009..In lay language, the studies may lead to new ways to predict individuals more prone to developing brain disease and new ways to prevent, treat, and/or cure HIV-1-associated disease in the brain and perhaps other organ systems. ..
- Co-evolution of HIV-1 Regulators in CNS DiseaseBrian Wigdahl; Fiscal Year: 2009..This unique approach to studying regulated HIV-1 expression in the context of CNS disease and HAART will provide greater insights into HIV-1-associated pathogenesis and may lead to more efficacious treatments of HIV-1 CNS disease. ..
- HIV-1 LTR Activation in Peripheral Blood and BrainBrian Wigdahl; Fiscal Year: 2010..In lay language, the studies may lead to new ways to predict individuals more prone to developing brain disease and new ways to prevent, treat, and/or cure HIV-1-associated disease in the brain and perhaps other organ systems. ..
- HTLV-1 & Cellular Factors in Neuroinflammatory DiseaseBrian Wigdahl; Fiscal Year: 2009....
- HIV-1 LTR Activation in Peripheral Blood and BrainBrian Wigdahl; Fiscal Year: 2009..In lay language, the studies may lead to new ways to predict individuals more prone to developing brain disease and new ways to prevent, treat, and/or cure HIV-1-associated disease in the brain and perhaps other organ systems. ..
- PATHOGENESIS OF HTLV-1 IN DEVELOPING NERVOUS SYSTEMBrian Wigdahl; Fiscal Year: 1993..This information will be essential in the design of HTLV-I-specific therapies to prevent or treat HTLV-I-specific disorders...
- HIV INFECTION OF DEVELOPING HUMAN NERVOUS SYSTEMBrian Wigdahl; Fiscal Year: 1993..The long-range goal will be to provide information essential to understanding the molecular neuropathogenesis of HTLV-III/LAV infection in humans, and ultimately, in the control of human disease caused by HTLV-III/LAV...
- REGULATION OF HTLV I LTR IN IMMUNE AND NERVOUS SYSTEMSBrian Wigdahl; Fiscal Year: 2000..4) Examine properties of HTLV-1 variants containing mutations in specific promoter regions which disrupt interaction with SP:ATF/CREB and AP:ATF/CREB protein complexes. ..
- NEUROLOGICAL & LYMPHOID FACTORS IN HIV1 LTR ACTIVATIONBrian Wigdahl; Fiscal Year: 2000....