Brian Wigdahl

Summary

Affiliation: Drexel University College of Medicine
Country: USA

Publications

  1. pmc HIV-1 infection of bone marrow hematopoietic progenitor cells and their role in trafficking and viral dissemination
    Aikaterini Alexaki
    Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA, USA
    PLoS Pathog 4:e1000215. 2008
  2. pmc Impact of Tat Genetic Variation on HIV-1 Disease
    Luna Li
    Department of Microbiology and Immunology, Drexel University College of Medicine, 245 N 15th Street, MS no 1013A, Philadelphia, PA 19102, USA
    Adv Virol 2012:123605. 2012
  3. ncbi request reprint Toxicity, inflammation, and anti-human immunodeficiency virus type 1 activity following exposure to chemical moieties of C31G
    Bradley J Catalone
    Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Biomed Pharmacother 59:430-7. 2005
  4. ncbi request reprint PMA-induced differentiation of a bone marrow progenitor cell line activates HIV-1 LTR-driven transcription
    Aikaterini Alexaki
    Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129, USA
    DNA Cell Biol 26:387-94. 2007
  5. pmc Persistent interactions between biguanide-based compound NB325 and CXCR4 result in prolonged inhibition of human immunodeficiency virus type 1 infection
    Nina Thakkar
    Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA 19102, USA
    Antimicrob Agents Chemother 54:1965-72. 2010
  6. ncbi request reprint High-affinity interaction between HIV-1 Vpr and specific sequences that span the C/EBP and adjacent NF-kappaB sites within the HIV-1 LTR correlate with HIV-1-associated dementia
    Tricia H Burdo
    Department of Microbiology and Immunology, The Pennsylvania State University, College of Medicine, Hershey, Pennsylvania, USA
    DNA Cell Biol 23:261-9. 2004
  7. pmc Structural and functional studies of CCAAT/enhancer binding sites within the human immunodeficiency virus type 1 subtype C LTR
    Yujie Liu
    Department of Microbiology and Immunology, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, Pennsylvania 19129, USA
    Biomed Pharmacother 64:672-80. 2010
  8. pmc Modulation of dendritic cell maturation and function by the Tax protein of human T cell leukemia virus type 1
    Pooja Jain
    Department of Microbiology and Immunology, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PA 19129, USA
    J Leukoc Biol 82:44-56. 2007
  9. ncbi request reprint Specific sequence configurations of HIV-1 LTR G/C box array result in altered recruitment of Sp isoforms and correlate with disease progression
    Michael R Nonnemacher
    Department of Microbiology and Immunology, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    J Neuroimmunol 157:39-47. 2004
  10. ncbi request reprint CCAAT/enhancer-binding proteins modulate human T cell leukemia virus type 1 long terminal repeat activation
    Christian Grant
    Department of Microbiology and Immunology, The Pennsylvania State University, College of Medicine, Hershey, 17033, USA
    Virology 348:354-69. 2006

Collaborators

Detail Information

Publications67

  1. pmc HIV-1 infection of bone marrow hematopoietic progenitor cells and their role in trafficking and viral dissemination
    Aikaterini Alexaki
    Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA, USA
    PLoS Pathog 4:e1000215. 2008
    ..A monocyte subpopulation with these features has been shown to expand during the course of HIV-1 disease, particularly in HAD patients, and is characterized by low CD14 expression and the presence of cell surface CD16...
  2. pmc Impact of Tat Genetic Variation on HIV-1 Disease
    Luna Li
    Department of Microbiology and Immunology, Drexel University College of Medicine, 245 N 15th Street, MS no 1013A, Philadelphia, PA 19102, USA
    Adv Virol 2012:123605. 2012
    ..Tat as a therapeutic target for anti-HIV drugs has also been discussed...
  3. ncbi request reprint Toxicity, inflammation, and anti-human immunodeficiency virus type 1 activity following exposure to chemical moieties of C31G
    Bradley J Catalone
    Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Biomed Pharmacother 59:430-7. 2005
    ..These results provide further insight into the activity of C31G, as well as mechanisms potentially associated with microbicide toxicity...
  4. ncbi request reprint PMA-induced differentiation of a bone marrow progenitor cell line activates HIV-1 LTR-driven transcription
    Aikaterini Alexaki
    Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129, USA
    DNA Cell Biol 26:387-94. 2007
    ..These studies elucidate the impact of infected bone marrow monocytic cell differentiation on LTR activity and its potential impact on HIV-1-associated disease...
  5. pmc Persistent interactions between biguanide-based compound NB325 and CXCR4 result in prolonged inhibition of human immunodeficiency virus type 1 infection
    Nina Thakkar
    Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA 19102, USA
    Antimicrob Agents Chemother 54:1965-72. 2010
    ..CXCL12-induced chemotaxis was also persistently inhibited following pre-exposure to NB325. These results demonstrate that persistent inhibition of X4 HIV-1 infection by NB325 involves extended perturbation of the viral coreceptor CXCR4...
  6. ncbi request reprint High-affinity interaction between HIV-1 Vpr and specific sequences that span the C/EBP and adjacent NF-kappaB sites within the HIV-1 LTR correlate with HIV-1-associated dementia
    Tricia H Burdo
    Department of Microbiology and Immunology, The Pennsylvania State University, College of Medicine, Hershey, Pennsylvania, USA
    DNA Cell Biol 23:261-9. 2004
    ....
  7. pmc Structural and functional studies of CCAAT/enhancer binding sites within the human immunodeficiency virus type 1 subtype C LTR
    Yujie Liu
    Department of Microbiology and Immunology, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, Pennsylvania 19129, USA
    Biomed Pharmacother 64:672-80. 2010
    ..Furthermore, the synergistic interaction between C/EBPβ-2 and Tat with the subtype C LTR was also observed in U-937 cells as previously demonstrated with the subtype B LTR...
  8. pmc Modulation of dendritic cell maturation and function by the Tax protein of human T cell leukemia virus type 1
    Pooja Jain
    Department of Microbiology and Immunology, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PA 19129, USA
    J Leukoc Biol 82:44-56. 2007
    ....
  9. ncbi request reprint Specific sequence configurations of HIV-1 LTR G/C box array result in altered recruitment of Sp isoforms and correlate with disease progression
    Michael R Nonnemacher
    Department of Microbiology and Immunology, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    J Neuroimmunol 157:39-47. 2004
    ..These results suggest LTR Sp binding site sequence variants may prove useful as viral molecular markers indicative of progressive HIV-1-induced disease...
  10. ncbi request reprint CCAAT/enhancer-binding proteins modulate human T cell leukemia virus type 1 long terminal repeat activation
    Christian Grant
    Department of Microbiology and Immunology, The Pennsylvania State University, College of Medicine, Hershey, 17033, USA
    Virology 348:354-69. 2006
    ..Inhibition of Tax-mediated transactivation of the HTLV-1 LTR was co-activator-independent, did not require C/EBP binding to the Tax-responsive elements, and may involve heterodimerization with CREB factors...
  11. pmc A styrene-alt-maleic acid copolymer is an effective inhibitor of R5 and X4 human immunodeficiency virus type 1 infection
    Vanessa Pirrone
    Department of Microbiology and Immunology and Center for Molecular Therapeutics and Resistance, Drexel University College of Medicine, 245 N 15th Street MS1013A, Philadelphia, PA 19102, USA
    J Biomed Biotechnol 2010:548749. 2010
    ..These studies demonstrate that alt-PSMA is an effective HIV-1 inhibitor with properties that warrant further investigation...
  12. ncbi request reprint Identification of human T cell leukemia virus type 1 tax amino acid signals and cellular factors involved in secretion of the viral oncoprotein
    Pooja Jain
    Department of Microbiology and Immunology, Center for Molecular Virology and Neuroimmunology, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PA 19129, USA
    J Biol Chem 282:34581-93. 2007
    ....
  13. pmc Specific interactions between the viral coreceptor CXCR4 and the biguanide-based compound NB325 mediate inhibition of human immunodeficiency virus type 1 infection
    Nina Thakkar
    Department of Microbiology and Immunology, Center for Molecular Therapeutics and Resistance, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, Pennsylvania 19102, USA
    Antimicrob Agents Chemother 53:631-8. 2009
    ..Collectively, these results demonstrate that the biguanide-based compound NB325 inhibits HIV-1 infection by specifically interacting with the HIV-1 coreceptor CXCR4...
  14. pmc Structure-activity relationships of polybiguanides with activity against human immunodeficiency virus type 1
    Shendra R Passic
    Department of Microbiology and Immunology, and Center for Sexually Transmitted Disease, Center for Molecular Therapeutics, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, Pennsylvania 19102, USA
    Biomed Pharmacother 64:723-32. 2010
    ....
  15. ncbi request reprint Polybiguanides, particularly polyethylene hexamethylene biguanide, have activity against human immunodeficiency virus type 1
    Fred C Krebs
    Department of Microbiology and Immunology, and Center for Sexually Transmitted Disease, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129 USA
    Biomed Pharmacother 59:438-45. 2005
    ....
  16. ncbi request reprint C/EBP- and Tat-mediated activation of the HIV-1 LTR in CD34+ hematopoietic progenitor cells
    Shane Quiterio
    Department of Microbiology and Immunology, The Pennsylvania State University, College of Medicine, H107, 500 University Drive, P O Box 850, Hershey, PA 17033, USA
    Biomed Pharmacother 57:49-56. 2003
    ....
  17. pmc Development of co-selected single nucleotide polymorphisms in the viral promoter precedes the onset of human immunodeficiency virus type 1-associated neurocognitive impairment
    Luna Li
    Department of Microbiology and Immunology, Drexel University College of Medicine, 245 N 15th Street, MS 1013A, Philadelphia, PA 19102, USA
    J Neurovirol 17:92-109. 2011
    ....
  18. pmc Role of mu-opioids as cofactors in human immunodeficiency virus type 1 disease progression and neuropathogenesis
    Anupam Banerjee
    Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA 19102, USA
    J Neurovirol 17:291-302. 2011
    ..Understanding the opioid-HIV-1 interface at the molecular level is vitally important in designing better treatment strategies for HIV-1-infected patients who abuse opioids...
  19. ncbi request reprint Secretion of the human T cell leukemia virus type I transactivator protein tax
    Timothy Alefantis
    Department of Microbiology and Immunology, Pennsylvania State University, College of Medicine, Hershey, Pennsylvania 17033, USA
    J Biol Chem 280:17353-62. 2005
    ....
  20. ncbi request reprint Regulation of human T-cell leukemia virus type 1 gene expression by Sp1 and Sp3 interaction with TRE-1 repeat III
    Jing Yao
    Department of Microbiology and Immunology, College of Medicine, The Pennsylvania State University, Hershey, Pennsylvania, USA
    DNA Cell Biol 25:262-76. 2006
    ..These results suggest that both Sp1 and Sp3 transcription factor binding to TRE-1 repeat III participate in regulation of HTLV-1 viral gene expression...
  21. ncbi request reprint Biochemical analysis of human milk treated with sodium dodecyl sulfate, an alkyl sulfate microbicide that inactivates human immunodeficiency virus type 1
    Sandra Urdaneta Hartmann
    Department of Microbiology and Immunology, Pennsylvania State University, College of Medicine, Hershey, USA
    J Hum Lact 22:61-74. 2006
    ..Therefore, the use of alkyl sulfate microbicides to treat milk from HIV-1-positive women may be a simple, practical, and nutritionally sound way to prevent or reduce transmission of HIV-1 while still feeding with mother's own milk...
  22. pmc Innate and adaptive factors regulating human immunodeficiency virus type 1 genomic activation
    Sonia Shah
    Department of Microbiology and Immunology, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PA 19129, USA
    J Neuroimmune Pharmacol 5:278-93. 2010
    ..Finally, this review is discussed from the viewpoint of how an understanding of the interplay of all of these factors will help guide the next generation of therapies...
  23. ncbi request reprint Human T-cell leukemia virus type I Tax induces the expression of dendritic cell markers associated with maturation and activation
    Kate Mostoller
    Department of Microbiology and Immunology, The Pennsylvania State University, College of Medicine, Hershey, Pennsylvania, USA
    J Neurovirol 10:358-71. 2004
    ..The implication of the experimental results with respect to the generation of a Tax-specific CTL compartment that participates in the genesis of HAM/TSP is discussed...
  24. pmc Decreased cervical epithelial sensitivity to nonoxynol-9 (N-9) after four daily applications in a murine model of topical vaginal microbicide safety
    Karissa Lozenski
    Department of Microbiology and Immunology, and Center for Molecular Therapeutics and Resistance, Center for Sexually Transmitted Disease, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, 245 N 15th Street, Philadelphia, PA 19102, USA
    BMC Pharmacol Toxicol 13:9. 2012
    ....
  25. ncbi request reprint Human T cell leukemia virus type I Tax activates CD40 gene expression via the NF-kappa B pathway
    Edward W Harhaj
    Department of Microbiology and Immunology, Sylvester Comprehensive Cancer Center, The University of Miami School of Medicine, Miami, FL 33136, USA
    Virology 333:145-58. 2005
    ..Collectively, these results indicate that CD40 is a novel Tax-regulated gene, and the regulation of CD40 by Tax may play a role in cellular activation and HTLV-I-induced disease pathogenesis...
  26. pmc CCAAT/enhancer-binding proteins and the pathogenesis of retrovirus infection
    Yujie Liu
    Department of Microbiology and Immunology, Center for Molecular Virology and Neuroimmunology, Center for Cancer Biology, Philadelphia, PA 19129, USA
    Future Microbiol 4:299-321. 2009
    ..The structure and function of the C/EBPbeta gene and the related protein isoforms are discussed along with the transcription factors, coactivators, viral proteins, cytokines and chemokines that affect C/EBP function...
  27. ncbi request reprint Use of human antigen presenting cell gene array profiling to examine the effect of human T-cell leukemia virus type 1 Tax on primary human dendritic cells
    Jaya Ahuja
    Department of Microbiology and Immunology, Institute for Molecular Medicine and Infectious Disease, Center for Molecular Virology and Neuroimmunology, Center for Cancer Biology, Drexel University College of Medicine, Philadelphia, PA 19102, USA
    J Neurovirol 12:47-59. 2006
    ..These results have suggested that Tax-mediated DC gene regulation might play a critical role in cellular activation and the mechanisms resulting in HTLV-1-induced disease...
  28. pmc DC-SIGN mediates cell-free infection and transmission of human T-cell lymphotropic virus type 1 by dendritic cells
    Pooja Jain
    Department of Microbiology and Immunology, Institute of Molecular Medicine and Infectious Disease, Drexel University College of Medicine, New College Building, Rm 18311, 245 N 15th St, Philadelphia, PA 19102, USA
    J Virol 83:10908-21. 2009
    ....
  29. ncbi request reprint Region-specific distribution of human immunodeficiency virus type 1 long terminal repeats containing specific configurations of CCAAT/enhancer-binding protein site II in brains derived from demented and nondemented patients
    Tricia H Burdo
    Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA
    J Neurovirol 10:7-14. 2004
    ....
  30. pmc Genetic variation and HIV-associated neurologic disease
    Satinder Dahiya
    Department of Microbiology and Immunology, Center for Molecular Virology and Translational Neuroscience, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA
    Adv Virus Res 87:183-240. 2013
    ....
  31. pmc Transcriptional regulation of the chemokine co-receptor CCR5 by the cAMP/PKA/CREB pathway
    Anupam Banerjee
    Department of Microbiology and Immunology, Center for Molecular Virology and Translational Neuroscience, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, 245 N 15th Street, MS 1013A, Philadelphia, Pennsylvania 19102, USA
    Biomed Pharmacother 65:293-7. 2011
    ..Our results lend critical insight into the precise mechanism governing the cAMP-CCR5 axis in progenitor cells and pose interesting questions regarding its functional role in HIV-1 infection...
  32. pmc Extracellular HIV-1 viral protein R affects astrocytic glyceraldehyde 3-phosphate dehydrogenase activity and neuronal survival
    Adriano Ferrucci
    School of Biomedical Engineering, Science and Health Systems, Drexel University College of Medicine, Philadelphia, PA 19102, USA
    J Neurovirol 19:239-53. 2013
    ..We propose a model that may explain some of the neurological damage and therefore neurocognitive impairment observed during the course of HIV-1 disease. ..
  33. pmc Regulation of HIV-1 transcription in cells of the monocyte-macrophage lineage
    Evelyn M Kilareski
    Center for Molecular Virology and Translational Neuroscience, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, 245 N 15th St, Philadelphia, Pennsylvania 19102, USA
    Retrovirology 6:118. 2009
    ..The impact of genetic variation on LTR-directed transcription during the course of retrovirus disease is also reviewed...
  34. pmc Depletion of dendritic cells enhances susceptibility to cell-free infection of human T cell leukemia virus type 1 in CD11c-diphtheria toxin receptor transgenic mice
    Saifur Rahman
    Drexel Institute for Biotechnology and Virology Research, Drexel University College of Medicine, Philadelphia, PA 19127, USA
    J Immunol 184:5553-61. 2010
    ....
  35. pmc Role of resident CNS cell populations in HTLV-1-associated neuroinflammatory disease
    Veronique Lepoutre
    Department of Microbiology and Immunology, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, Pennsylvania 19102, USA
    Front Biosci (Landmark Ed) 14:1152-68. 2009
    ..This comprehensive review characterizes the available knowledge to date concerning the effects of HTLV-1 on CNS resident cell populations with emphasis on both viral and host factors contributing to the genesis of HAM/TSP...
  36. ncbi request reprint HIV-1 Vpr binding to HIV-1 LTR C/EBP cis-acting elements and adjacent regions is sequence-specific
    Tricia H Hogan
    Department of Microbiology and Immunology, The Pennsylvania State University, College of Medicine, H107, 500 University Drive, P O Box 850, Hershey, PA 17033, USA
    Biomed Pharmacother 57:41-8. 2003
    ..These studies suggest that Vpr may regulate the interaction of members of the C/EBP transcription factor family with the viral LTR...
  37. pmc Cervicovaginal safety of the formulated, biguanide-based human immunodeficiency virus type 1 (HIV-1) inhibitor NB325 in a murine model
    Karissa Lozenski
    Department of Microbiology and Immunology, Center for Sexually Transmitted Disease, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, 245 N 15th Street, Philadelphia, PA 19102, USA
    J Biomed Biotechnol 2011:941061. 2011
    ..Although formulated NB325 appeared generally safe for application in these studies, the low but observable level of toxicity suggests the need for improvements in the compound and/or formulation...
  38. ncbi request reprint Prolonged exposure to the candidate microbicide C31G differentially reduces cellular sensitivity to agent re-exposure
    Bradley J Catalone
    Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Biomed Pharmacother 59:460-8. 2005
    ....
  39. pmc Inactivation of HIV-1 in breast milk by treatment with the alkyl sulfate microbicide sodium dodecyl sulfate (SDS)
    Sandra Urdaneta
    Department of Microbiology and Immunology, Penn State College of Medicine, Hershey, Pennsylvania 17033, USA
    Retrovirology 2:28. 2005
    ..Microbicidal treatment was at 37 degrees C or room temperature for 10 min. SDS removal was performed with a commercially available resin. Infectivity of HIV-1 and HIV-1 load in breast milk were determined after treatment...
  40. pmc Cellular reservoirs of HIV-1 and their role in viral persistence
    Aikaterini Alexaki
    Department of Microbiology and Immunology, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129, USA
    Curr HIV Res 6:388-400. 2008
    ..The contribution of these and other cell populations in HIV-1 persistence, as well as the possible strategies to eliminate latently infected cells are critically examined in this review...
  41. ncbi request reprint Effects of highly active antiretroviral therapy on HIV-1-associated oral complications
    Zahida Parveen
    Division of Infectious Diseases, Department of Medicine, Thomas Jefferson University, Philadelphia, PA, USA
    Curr HIV Res 5:281-92. 2007
    ..Future directions envisioned by the National Institutes of Health as well as novel avenues to be explored are also presented...
  42. pmc Induction of pro-inflammatory cytokines by human T-cell leukemia virus type-1 Tax protein as determined by multiplexed cytokine protein array analyses of human dendritic cells
    Jaya Ahuja
    Department of Microbiology and Immunology, Center for Cancer Biology, Institute of Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, PA 19102, USA
    Biomed Pharmacother 61:201-8. 2007
    ..Collectively, these findings suggest a role for Tax-induced cytokine secretion from MDDCs, which may be critical for the cellular activation and tissue damage that has been observed in HAM/TSP...
  43. pmc Cellular phenotype impacts human immunodeficiency virus type 1 viral protein R subcellular localization
    Adriano Ferrucci
    Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    Virol J 8:397. 2011
    ....
  44. pmc Extracellular human immunodeficiency virus type 1 viral protein R causes reductions in astrocytic ATP and glutathione levels compromising the antioxidant reservoir
    Adriano Ferrucci
    School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA, USA
    Virus Res 167:358-69. 2012
    ..Studies are underway to better understand the intricate correlation between reductions in ATP and GSH metabolites and how they affect neuronal survival in end-stage disease...
  45. pmc Breaking down the barrier: the effects of HIV-1 on the blood-brain barrier
    Marianne Strazza
    Department of Microbiology and Immunology, and Center for Molecular Virology and Translational Neuroscience, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, PA 19102, USA
    Brain Res 1399:96-115. 2011
    ....
  46. ncbi request reprint Regulation of human immunodeficiency virus type 1 gene expression and pathogenesis by CCAAT/enhancer binding proteins in cells of the monocyte/macrophage lineage
    Tricia H Hogan
    Department of Microbiology and Immunology, The Pennsylvania State University, College of Medicine, Hershey, Pennsylvania 17033, USA
    J Neurovirol 8:21-6. 2002
    ....
  47. pmc Deployment of the human immunodeficiency virus type 1 protein arsenal: combating the host to enhance viral transcription and providing targets for therapeutic development
    Satinder Dahiya
    Department of Microbiology and Immunology, Center for Molecular Virology and Translational Neuroscience, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    J Gen Virol 93:1151-72. 2012
    ....
  48. pmc Functional properties of the HIV-1 long terminal repeat containing single-nucleotide polymorphisms in Sp site III and CCAAT/enhancer binding protein site I
    Sonia Shah
    Department of Microbiology and Immunology, and Center for Molecular Virology and Translational Neuroscience, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, Pennsylvania 19102, USA
    Virol J 11:92. 2014
    ....
  49. pmc Substance abuse, HIV-1 and hepatitis
    Nirzari Parikh
    Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA 19102, USA
    Curr HIV Res 10:557-71. 2012
    ..The impact of HIV-1 and substance abuse on hepatitis virus-induced disease is also a focal point...
  50. pmc A novel high throughput quantum dot-based fluorescence assay for quantitation of virus binding and attachment
    Karan Kampani
    Department of Microbiology and Immunology, Institute for Molecular Medicine and Infectious Disease, Center for Molecular Virology and Neuroimmunology, Center for Cancer Biology, Drexel University College of Medicine, Philadelphia, PA 19102, USA
    J Virol Methods 141:125-32. 2007
    ....
  51. pmc Combinatorial approaches to the prevention and treatment of HIV-1 infection
    Vanessa Pirrone
    Department of Microbiology and Immunology, Drexel University College of Medicine, 245 N 15th Street, New College Building, Philadelphia PA 19102, USA
    Antimicrob Agents Chemother 55:1831-42. 2011
    ..The shift in focus within the microbicide development field from single compounds to combination approaches is also explored...
  52. ncbi request reprint Characterization of a nuclear export signal within the human T cell leukemia virus type I transactivator protein Tax
    Timothy Alefantis
    Department of Microbiology and Immunology, College of Medicine, Pennsylvania State University Hershey, 500 University Drive, PA 17033, USA
    J Biol Chem 278:21814-22. 2003
    ..These results suggest that Tax localization may be directed by specific changes in Tax conformation or by specific interactions with cellular proteins leading to changes in the availability of the Tax NES and nuclear localization signal...
  53. ncbi request reprint Mediators of central nervous system damage during the progression of human T-cell leukemia type I-associated myelopathy/tropical spastic paraparesis
    Kate Barmak
    Laboratory for Molecular Retrovirology and Viral Neuropathogenesis, Department of Microbiology and Immunology, The Pennsylvania State University, College of Medicine, Hershey 17033, USA
    J Neurovirol 9:522-9. 2003
    ..This review focuses on potential mechanisms of central nervous system (CNS) damage associated with the genesis of HAM/TSP following HTLV-I infection, focusing on the role of the Tax-specific CTL compartment...
  54. pmc Epigenetics, drugs of abuse, and the retroviral promoter
    Jasmine Shirazi
    Department of Microbiology and Immunology, Drexel Institute for Biotechnology and Virology Research, Drexel University College of Medicine, 3805 Old Easton Road, Doylestown, PA, 18902, USA
    J Neuroimmune Pharmacol 8:1181-96. 2013
    ....
  55. pmc Human immunodeficiency virus viral protein R as an extracellular protein in neuropathogenesis
    Adriano Ferrucci
    School of Biomedical Engineering, Science, and Health Systems, Drexel University, Philadelphia, Pennsylvania, USA
    Adv Virus Res 81:165-99. 2011
    ....
  56. pmc Application and removal of polyanionic microbicide compounds enhances subsequent infection by HIV-1
    Vanessa Pirrone
    Department of Microbiology and Immunology, and Center for Molecular Therapeutics and Resistance, Center for Sexually Transmitted Disease, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, PA 19102, USA
    Virol J 9:33. 2012
    ..One such variable is product retention and loss following topical application...
  57. pmc Mouse model of cervicovaginal toxicity and inflammation for preclinical evaluation of topical vaginal microbicides
    Bradley J Catalone
    Department of Microbiology and Immunology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Antimicrob Agents Chemother 48:1837-47. 2004
    ..Collectively, these studies highlight the murine model of toxicity as a valuable tool for the preclinical assessment of toxicity and inflammation associated with exposure to candidate topical microbicides...
  58. ncbi request reprint Dendritic cells in autoimmune diseases and neuroinflammatory disorders
    Sharron L Manuel
    Department of Microbiology and Immunology, Center for Cancer Biology, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, Pennsylvania 19102, USA
    Front Biosci 12:4315-35. 2007
    ..Overall, the goal of this review is to establish DCs in the interface of tolerance and autoimmunity and generate a global interest in this field in order to exploit DC potential for the therapy of inflammatory diseases...
  59. ncbi request reprint Human T cell leukemia virus type I-induced disease: pathways to cancer and neurodegeneration
    Kate Barmak
    Department of Microbiology and Immunology, The Pennsylvania State University, College of Medicine, Hershey, PA 17033, USA
    Virology 308:1-12. 2003
    ....
  60. ncbi request reprint Structural and functional evolution of human immunodeficiency virus type 1 long terminal repeat CCAAT/enhancer binding protein sites and their use as molecular markers for central nervous system disease progression
    Tricia H Hogan
    Department of Microbiology and Immunology, The Pennsylvania State University, College of Medicine, Hershey 17033, USA
    J Neurovirol 9:55-68. 2003
    ..The C/EBP site I 3T variant appears to be exclusive to patients progressing to increasingly severe HIV-1-associated immunologic and neurologic disease...
  61. pmc In vivo immunogenicity of Tax(11-19) epitope in HLA-A2/DTR transgenic mice: implication for dendritic cell-based anti-HTLV-1 vaccine
    Divya Sagar
    Department of Microbiology and Immunology, Drexel Institute for Biotechnology and Virology Research, Drexel University College of Medicine, Philadelphia, PA, USA
    Vaccine 32:3274-84. 2014
    ..Thus, Tax(11-19) epitope is a potential candidate for the DC-based anti-HTLV-1 vaccine and the newly hybrid mouse strain could be used for investigating DC involvement in human class-I-restricted immune responses. ..
  62. pmc CCAAT enhancer binding protein and nuclear factor of activated T cells regulate HIV-1 LTR via a novel conserved downstream site in cells of the monocyte-macrophage lineage
    Satinder Dahiya
    Department of Microbiology and Immunology, and Center for Molecular Virology and Translational Neuroscience, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 9:e88116. 2014
    ..Thus, the events at DS3 positively regulate the HIV-1 promoter in cells of the monocyte-macrophage lineage. ..
  63. pmc Immunological control of herpes simplex virus infections
    Kevin P Egan
    Department of Microbiology and Immunology, Drexel University College of Medicine, 245 North 15th Street, Philadelphia, PA 19102, USA
    J Neurovirol 19:328-45. 2013
    ..Particular emphasis is placed on the evidence pointing to the HSV-1-specific CD8(+) T cells in the trigeminal belonging to the TRM class of memory T cells and the role of TRM cells in virus infection, pathogenesis, latency, and disease. ..
  64. doi request reprint The rise and fall of polyanionic inhibitors of the human immunodeficiency virus type 1
    Vanessa Pirrone
    Department of Microbiology and Immunology, Center for Sexually Transmitted Disease, Center for Molecular Therapeutics and Resistance, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, PA 19102, USA
    Antiviral Res 90:168-82. 2011
    ....
  65. pmc Cholesterol-depleting statin drugs protect postmitotically differentiated human neurons against ethanol- and human immunodeficiency virus type 1-induced oxidative stress in vitro
    Edward Acheampong
    Dorrance H Hamilton Laboratories, Division of Infectious Diseases, Department of Medicine, Thomas Jefferson University, 1020 Locust Street, Suite 329, Philadelphia, Pennsylvania 19107, USA
    J Virol 81:1492-501. 2007
    ..The results of this study provide new insights into HIV-1 neuropathogenesis aimed at the development of future HIV-1 therapeutics to eradicate viral reservoirs from the brain...
  66. pmc Alkylated porphyrins have broad antiviral activity against hepadnaviruses, flaviviruses, filoviruses, and arenaviruses
    Haitao Guo
    Institute for Biotechnology and Virology Research, Department of Microbiology and Immunology, Drexel University College of Medicine, Doylestown, PA 18902, USA
    Antimicrob Agents Chemother 55:478-86. 2011
    ..The possible application of this family of compounds as antiviral agents, as microbicides and systemic virus neutralizing agents, is discussed...
  67. pmc Comparative in vitro sensitivities of human immune cell lines, vaginal and cervical epithelial cell lines, and primary cells to candidate microbicides nonoxynol 9, C31G, and sodium dodecyl sulfate
    Fred C Krebs
    Department of Microbiology and Immunology, The Pennsylvania State University, College of Medicine, Hershey, Pennsylvania 17033, USA
    Antimicrob Agents Chemother 46:2292-8. 2002
    ....

Research Grants47

  1. High Specificity HIV-1 Markers Predictive of Neuro-AIDS
    Brian Wigdahl; Fiscal Year: 2010
    ....
  2. High Specificity HIV-1 Markers Predictive of Neuro-AIDS
    Brian Wigdahl; Fiscal Year: 2007
    ..These studies may lead to the identification of additional tools to predict the development of HIVD and, in turn, provide more information to guide the therapeutic management of the HIV-1-infected patient. ..
  3. HTLV-1 & Cellular Factors in Neuroinflammatory Disease
    Brian Wigdahl; Fiscal Year: 2006
    ....
  4. Co-evolution of HIV-1 Regulators in CNS Disease
    Brian Wigdahl; Fiscal Year: 2007
    ..This unique approach to studying regulated HIV-1 expression in the context of CNS disease and HAART will provide greater insights into HIV-1-associated pathogenesis and may lead to more efficacious treatments of HIV-1 CNS disease. ..
  5. High Specificity HIV-1 Markers Predictive of Neuro-AIDS
    Brian Wigdahl; Fiscal Year: 2006
    ..These studies may lead to the identification of additional tools to predict the development of HIVD and, in turn, provide more information to guide the therapeutic management of the HIV-1-infected patient. ..
  6. Co-evolution of HIV-1 Regulators in CNS Disease
    Brian Wigdahl; Fiscal Year: 2006
    ..This unique approach to studying regulated HIV-1 expression in the context of CNS disease and HAART will provide greater insights into HIV-1-associated pathogenesis and may lead to more efficacious treatments of HIV-1 CNS disease. ..
  7. High Specificity HIV-1 Markers Predictive of Neuro-AIDS
    Brian Wigdahl; Fiscal Year: 2005
    ..These studies may lead to the identification of additional tools to predict the development of HIVD and, in turn, provide more information to guide the therapeutic management of the HIV-1-infected patient. ..
  8. HIV 1 LTR Activation in Peripheral Blood and Brain
    Brian Wigdahl; Fiscal Year: 2005
    ..These studies may provide insight relevant to the development of new molecular diagnostic reagents and therapeutic strategies to monitor and control HIV-1-associated neurologic disease. ..
  9. High Specificity HIV-1 Markers Predictive of Neuro-AIDS
    Brian Wigdahl; Fiscal Year: 2004
    ..These studies may lead to the identification of additional tools to predict the development of HIVD and, in turn, provide more information to guide the therapeutic management of the HIV-1-infected patient. ..
  10. REGULATION OF HTLV I LTR IN IMMUNE AND NERVOUS SYSTEMS
    Brian Wigdahl; Fiscal Year: 2005
    ..These studies could lead to new therapeutic approaches to prevent and/or treat TSP or other neuroinflammatory diseases. ..
  11. HIV-1 LTR Activation in Peripheral Blood and Brain
    Brian Wigdahl; Fiscal Year: 2007
    ..In lay language, the studies may lead to new ways to predict individuals more prone to developing brain disease and new ways to prevent, treat, and/or cure HIV-1-associated disease in the brain and perhaps other organ systems. ..
  12. HTLV-1 & Cellular Factors in Neuroinflammatory Disease
    Brian Wigdahl; Fiscal Year: 2007
    ....
  13. HTLV-1 & Cellular Factors in Neuroinflammatory Disease
    Brian Wigdahl; Fiscal Year: 2010
    ....
  14. HIV-1 LTR Activation in Peripheral Blood and Brain
    Brian Wigdahl; Fiscal Year: 2009
    ..In lay language, the studies may lead to new ways to predict individuals more prone to developing brain disease and new ways to prevent, treat, and/or cure HIV-1-associated disease in the brain and perhaps other organ systems. ..
  15. Co-evolution of HIV-1 Regulators in CNS Disease
    Brian Wigdahl; Fiscal Year: 2009
    ..This unique approach to studying regulated HIV-1 expression in the context of CNS disease and HAART will provide greater insights into HIV-1-associated pathogenesis and may lead to more efficacious treatments of HIV-1 CNS disease. ..
  16. HIV-1 LTR Activation in Peripheral Blood and Brain
    Brian Wigdahl; Fiscal Year: 2010
    ..In lay language, the studies may lead to new ways to predict individuals more prone to developing brain disease and new ways to prevent, treat, and/or cure HIV-1-associated disease in the brain and perhaps other organ systems. ..
  17. HTLV-1 & Cellular Factors in Neuroinflammatory Disease
    Brian Wigdahl; Fiscal Year: 2009
    ....
  18. HIV-1 LTR Activation in Peripheral Blood and Brain
    Brian Wigdahl; Fiscal Year: 2009
    ..In lay language, the studies may lead to new ways to predict individuals more prone to developing brain disease and new ways to prevent, treat, and/or cure HIV-1-associated disease in the brain and perhaps other organ systems. ..
  19. Co-evolution of HIV-1 Regulators in CNS Disease
    Brian Wigdahl; Fiscal Year: 2005
    ..This unique approach to studying regulated HIV-1 expression in the context of CNS disease and HAART will provide greater insights into HIV-1-associated pathogenesis and may lead to more efficacious treatments of HIV-1 CNS disease. ..
  20. HIV 1 LTR Activation in Peripheral Blood and Brain
    Brian Wigdahl; Fiscal Year: 2003
    ..These studies may provide insight relevant to the development of new molecular diagnostic reagents and therapeutic strategies to monitor and control HIV-1-associated neurologic disease. ..
  21. REGULATION OF HTLV I LTR IN IMMUNE AND NERVOUS SYSTEMS
    Brian Wigdahl; Fiscal Year: 2004
    ..These studies could lead to new therapeutic approaches to prevent and/or treat TSP or other neuroinflammatory diseases. ..
  22. PATHOGENESIS OF HTLV-1 IN DEVELOPING NERVOUS SYSTEM
    Brian Wigdahl; Fiscal Year: 1992
    ..This information will be essential in the design of HTLV-I-specific therapies to prevent or treat HTLV-I-specific disorders...
  23. PATHOGENESIS OF HTLV-1 IN DEVELOPING NERVOUS SYSTEM
    Brian Wigdahl; Fiscal Year: 1991
    ..This information will be essential in the design of HTLV-I-specific therapies to prevent or treat HTLV-I-specific disorders...
  24. NEUROLOGICAL & LYMPHOID FACTORS IN HIV1 LTR ACTIVATION
    Brian Wigdahl; Fiscal Year: 1999
    ....
  25. REGULATION OF HTLV I LTR IN IMMUNE AND NERVOUS SYSTEMS
    Brian Wigdahl; Fiscal Year: 1999
    ..4) Examine properties of HTLV-1 variants containing mutations in specific promoter regions which disrupt interaction with SP:ATF/CREB and AP:ATF/CREB protein complexes. ..
  26. PATHOGENESIS OF HTLV-1 IN DEVELOPING NERVOUS SYSTEM
    Brian Wigdahl; Fiscal Year: 1993
    ..This information will be essential in the design of HTLV-I-specific therapies to prevent or treat HTLV-I-specific disorders...
  27. HIV INFECTION OF DEVELOPING HUMAN NERVOUS SYSTEM
    Brian Wigdahl; Fiscal Year: 1993
    ..The long-range goal will be to provide information essential to understanding the molecular neuropathogenesis of HTLV-III/LAV infection in humans, and ultimately, in the control of human disease caused by HTLV-III/LAV...
  28. REGULATION OF HTLV I LTR IN IMMUNE AND NERVOUS SYSTEMS
    Brian Wigdahl; Fiscal Year: 2000
    ..4) Examine properties of HTLV-1 variants containing mutations in specific promoter regions which disrupt interaction with SP:ATF/CREB and AP:ATF/CREB protein complexes. ..
  29. NEUROLOGICAL & LYMPHOID FACTORS IN HIV1 LTR ACTIVATION
    Brian Wigdahl; Fiscal Year: 2000
    ....
  30. HIV 1 LTR Activation in Peripheral Blood and Brain
    Brian Wigdahl; Fiscal Year: 2004
    ..These studies may provide insight relevant to the development of new molecular diagnostic reagents and therapeutic strategies to monitor and control HIV-1-associated neurologic disease. ..
  31. REGULATION OF HTLV I LTR IN IMMUNE AND NERVOUS SYSTEMS
    Brian Wigdahl; Fiscal Year: 2003
    ..These studies could lead to new therapeutic approaches to prevent and/or treat TSP or other neuroinflammatory diseases. ..
  32. Co-evolution of HIV-1 Regulators in CNS Disease
    Brian Wigdahl; Fiscal Year: 2004
    ..This unique approach to studying regulated HIV-1 expression in the context of CNS disease and HAART will provide greater insights into HIV-1-associated pathogenesis and may lead to more efficacious treatments of HIV-1 CNS disease. ..
  33. HIV 1 LTR Activation in Peripheral Blood and Brain
    Brian Wigdahl; Fiscal Year: 2002
    ..These studies may provide insight relevant to the development of new molecular diagnostic reagents and therapeutic strategies to monitor and control HIV-1-associated neurologic disease. ..
  34. HIV 1 LTR Activation in Peripheral Blood and Brain
    Brian Wigdahl; Fiscal Year: 2001
    ..These studies may provide insight relevant to the development of new molecular diagnostic reagents and therapeutic strategies to monitor and control HIV-1-associated neurologic disease. ..
  35. REGULATION OF HTLV I LTR IN IMMUNE AND NERVOUS SYSTEMS
    Brian Wigdahl; Fiscal Year: 2002
    ..These studies could lead to new therapeutic approaches to prevent and/or treat TSP or other neuroinflammatory diseases. ..
  36. HIV 1 LTR Activation in Peripheral Blood and Brain
    Brian Wigdahl; Fiscal Year: 2001
    ..These studies may provide insight relevant to the development of new molecular diagnostic reagents and therapeutic strategies to monitor and control HIV-1-associated neurologic disease. ..
  37. NEUROLOGICAL & LYMPHOID FACTORS IN HIV1 LTR ACTIVATION
    Brian Wigdahl; Fiscal Year: 2000
    ....
  38. REGULATION OF HTLV I LTR IN IMMUNE AND NERVOUS SYSTEMS
    Brian Wigdahl; Fiscal Year: 2001
    ..These studies could lead to new therapeutic approaches to prevent and/or treat TSP or other neuroinflammatory diseases. ..