Ilya A Rybak

Summary

Affiliation: Drexel University
Country: USA

Publications

  1. pmc Spatial organization and state-dependent mechanisms for respiratory rhythm and pattern generation
    Ilya A Rybak
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    Prog Brain Res 165:201-20. 2007
  2. pmc Modelling spinal circuitry involved in locomotor pattern generation: insights from deletions during fictive locomotion
    Ilya A Rybak
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    J Physiol 577:617-39. 2006
  3. pmc Sodium and calcium mechanisms of rhythmic bursting in excitatory neural networks of the pre-Bötzinger complex: a computational modelling study
    Patrick E Jasinski
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA, USA
    Eur J Neurosci 37:212-30. 2013
  4. doi request reprint Afferent control of locomotor CPG: insights from a simple neuromechanical model
    Sergey N Markin
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA
    Ann N Y Acad Sci 1198:21-34. 2010
  5. pmc Computational modelling of 5-HT receptor-mediated reorganization of the brainstem respiratory network
    Natalia A Shevtsova
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA, USA
    Eur J Neurosci 34:1276-91. 2011
  6. pmc Late-expiratory activity: emergence and interactions with the respiratory CpG
    Yaroslav I Molkov
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    J Neurophysiol 104:2713-29. 2010
  7. pmc Motoneuronal and muscle synergies involved in cat hindlimb control during fictive and real locomotion: a comparison study
    Sergey N Markin
    Dept of Neurobiology and Anatomy, Drexel Univ College of Medicine, Philadelphia, PA 19129, USA
    J Neurophysiol 107:2057-71. 2012
  8. pmc Intermittent hypoxia-induced sensitization of central chemoreceptors contributes to sympathetic nerve activity during late expiration in rats
    Yaroslav I Molkov
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    J Neurophysiol 105:3080-91. 2011
  9. ncbi request reprint Endogenous rhythm generation in the pre-Bötzinger complex and ionic currents: modelling and in vitro studies
    Ilya A Rybak
    School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA 19104, USA
    Eur J Neurosci 18:239-57. 2003
  10. ncbi request reprint Modelling respiratory rhythmogenesis: focus on phase switching mechanisms
    Ilya A Rybak
    School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA 19104, USA
    Adv Exp Med Biol 551:189-94. 2004

Collaborators

Detail Information

Publications19

  1. pmc Spatial organization and state-dependent mechanisms for respiratory rhythm and pattern generation
    Ilya A Rybak
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    Prog Brain Res 165:201-20. 2007
    ..The model predicts a continuum of respiratory network states relying on different contributions of intrinsic cellular properties versus synaptic interactions for the generation and control of the respiratory rhythm and pattern...
  2. pmc Modelling spinal circuitry involved in locomotor pattern generation: insights from deletions during fictive locomotion
    Ilya A Rybak
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    J Physiol 577:617-39. 2006
    ..The model also suggests criteria for the functional identification of spinal interneurones involved in the mammalian locomotor pattern generation...
  3. pmc Sodium and calcium mechanisms of rhythmic bursting in excitatory neural networks of the pre-Bötzinger complex: a computational modelling study
    Patrick E Jasinski
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA, USA
    Eur J Neurosci 37:212-30. 2013
    ....
  4. doi request reprint Afferent control of locomotor CPG: insights from a simple neuromechanical model
    Sergey N Markin
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA
    Ann N Y Acad Sci 1198:21-34. 2010
    ....
  5. pmc Computational modelling of 5-HT receptor-mediated reorganization of the brainstem respiratory network
    Natalia A Shevtsova
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA, USA
    Eur J Neurosci 34:1276-91. 2011
    ..The model shows how 5-HT(1A) R activation can produce a disinhibition of inspiratory neurons, leading to the recovery of respiratory rhythm from opioid-induced apnoeas...
  6. pmc Late-expiratory activity: emergence and interactions with the respiratory CpG
    Yaroslav I Molkov
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    J Neurophysiol 104:2713-29. 2010
    ..The extended model proposes mechanistic explanations for the emergence of RTN/pFRG oscillations and their interaction with the brain stem respiratory network...
  7. pmc Motoneuronal and muscle synergies involved in cat hindlimb control during fictive and real locomotion: a comparison study
    Sergey N Markin
    Dept of Neurobiology and Anatomy, Drexel Univ College of Medicine, Philadelphia, PA 19129, USA
    J Neurophysiol 107:2057-71. 2012
    ..g., PBSt and RF). These findings provide important insights into the organization of the spinal CPG in mammals, the motoneuronal and muscle synergies engaged during locomotion, and their afferent control...
  8. pmc Intermittent hypoxia-induced sensitization of central chemoreceptors contributes to sympathetic nerve activity during late expiration in rats
    Yaroslav I Molkov
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    J Neurophysiol 105:3080-91. 2011
    ..We conclude that CIH may sensitize central chemoreception and that this significantly contributes to the neural impetus for generation of sympathetic activity and hypertension...
  9. ncbi request reprint Endogenous rhythm generation in the pre-Bötzinger complex and ionic currents: modelling and in vitro studies
    Ilya A Rybak
    School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA 19104, USA
    Eur J Neurosci 18:239-57. 2003
    ..These findings are discussed in the context of the role of endogenous bursting activity in the respiratory rhythm generation in vivo vs. in vitro and during normal breathing in vivo vs. gasping...
  10. ncbi request reprint Modelling respiratory rhythmogenesis: focus on phase switching mechanisms
    Ilya A Rybak
    School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA 19104, USA
    Adv Exp Med Biol 551:189-94. 2004
  11. pmc Modelling spinal circuitry involved in locomotor pattern generation: insights from the effects of afferent stimulation
    Ilya A Rybak
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    J Physiol 577:641-58. 2006
    ..The results of modelling provide insights into proprioceptive control of locomotion...
  12. ncbi request reprint Sodium currents in neurons from the rostroventrolateral medulla of the rat
    Ilya A Rybak
    School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, Pennsylvania 19104, USA
    J Neurophysiol 90:1635-42. 2003
    ....
  13. pmc Control of breathing by interacting pontine and pulmonary feedback loops
    Yaroslav I Molkov
    Department of Neurobiology and Anatomy, Drexel University College of Medicine Philadelphia, PA, USA Department of Mathematical Sciences, Indiana University Purdue University Indianapolis, IN, USA
    Front Neural Circuits 7:16. 2013
    ....
  14. ncbi request reprint Intrinsic bursting activity in the pre-Bötzinger complex: role of persistent sodium and potassium currents
    Ilya A Rybak
    School of Biomedical Engineering, Drexel University, Science and Health Systems, Philadelphia, PA 19104, USA
    Biol Cybern 90:59-74. 2004
    ..These findings are discussed in the context of the possible role of population bursting activity in the pBC in the respiratory rhythm generation in vivo vs. in vitro and during normal breathing in vivo vs. gasping...
  15. ncbi request reprint Respiratory rhythm entrainment by somatic afferent stimulation
    Jeffrey T Potts
    Department of Physiology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Neurosci 25:1965-78. 2005
    ....
  16. ncbi request reprint Potential switch from eupnea to fictive gasping after blockade of glycine transmission and potassium channels
    Walter M St -John
    Department of Physiology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    Am J Physiol Regul Integr Comp Physiol 283:R721-31. 2002
    ..Results are consistent with the concept that the elicitation of gasping represents a switch from a network-based rhythmogenesis for eupnea to a pacemaker-driven mechanism...
  17. pmc Modeling the mammalian locomotor CPG: insights from mistakes and perturbations
    David A McCrea
    Spinal Cord Research Centre and Department of Physiology, University of Manitoba, Winnipeg, MB, R3E 3J7, Canada
    Prog Brain Res 165:235-53. 2007
    ..The model provides a basis for functional identification of spinal interneurons involved in generation and control of the locomotor pattern...
  18. ncbi request reprint Ionic currents and endogenous rhythm generation in the pre-Bötzinger complex: modelling and in vitro studies
    Olivier Pierrefiche
    GRAP JE UFR de Pharmacie, 80036 Amiens, France
    Adv Exp Med Biol 551:121-6. 2004
  19. ncbi request reprint Influence of levels of carbon dioxide and oxygen upon gasping in perfused rat preparation
    Walter M St -John
    Dartmouth Hitchcock Medical Center, Department of Physiology, Dartmouth Medical School, Borwell Building, Lebanon, NH 03756, USA
    Respir Physiol 129:279-87. 2002
    ..This release is caused by cellular mechanisms that change the balance between membrane ionic currents. Moreover, these cellular mechanisms may be explicitly induced by alterations in the ionic and metabolic homeostasis...

Research Grants1

  1. CRCNS: State dependent neural mechanisms for respiratory pattern generation
    ILYA RYBAK; Fiscal Year: 2006
    ..g., sleep apnea, brainstem/spinal cord injury, CCHS), and for developing and investigations new methods for their treatment. ..