Research Topics
| Ilya A RybakSummaryAffiliation: Drexel University Country: USA Publications
Research Grants
| Collaborators
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Detail Information
Publications
Spatial organization and state-dependent mechanisms for respiratory rhythm and pattern generationIlya A Rybak
Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USA
Prog Brain Res 165:201-20. 2007..The model predicts a continuum of respiratory network states relying on different contributions of intrinsic cellular properties versus synaptic interactions for the generation and control of the respiratory rhythm and pattern...- Modelling spinal circuitry involved in locomotor pattern generation: insights from deletions during fictive locomotionIlya A Rybak
Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USA
J Physiol 577:617-39. 2006..The model also suggests criteria for the functional identification of spinal interneurones involved in the mammalian locomotor pattern generation... 
Afferent control of locomotor CPG: insights from a simple neuromechanical modelSergey N Markin
Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA
Ann N Y Acad Sci 1198:21-34. 2010....- Computational modelling of 5-HT receptor-mediated reorganization of the brainstem respiratory networkNatalia A Shevtsova
Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA, USA
Eur J Neurosci 34:1276-91. 2011..The model shows how 5-HT(1A) R activation can produce a disinhibition of inspiratory neurons, leading to the recovery of respiratory rhythm from opioid-induced apnoeas... - Late-expiratory activity: emergence and interactions with the respiratory CpGYaroslav I Molkov
Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USA
J Neurophysiol 104:2713-29. 2010..The extended model proposes mechanistic explanations for the emergence of RTN/pFRG oscillations and their interaction with the brain stem respiratory network... - Motoneuronal and muscle synergies involved in cat hindlimb control during fictive and real locomotion: a comparison studySergey N Markin
Dept of Neurobiology and Anatomy, Drexel Univ College of Medicine, Philadelphia, PA 19129, USA
J Neurophysiol 107:2057-71. 2012..g., PBSt and RF). These findings provide important insights into the organization of the spinal CPG in mammals, the motoneuronal and muscle synergies engaged during locomotion, and their afferent control... - Intermittent hypoxia-induced sensitization of central chemoreceptors contributes to sympathetic nerve activity during late expiration in ratsYaroslav I Molkov
Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USA
J Neurophysiol 105:3080-91. 2011..We conclude that CIH may sensitize central chemoreception and that this significantly contributes to the neural impetus for generation of sympathetic activity and hypertension... 
Endogenous rhythm generation in the pre-Bötzinger complex and ionic currents: modelling and in vitro studiesIlya A Rybak
School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA 19104, USA
Eur J Neurosci 18:239-57. 2003..These findings are discussed in the context of the role of endogenous bursting activity in the respiratory rhythm generation in vivo vs. in vitro and during normal breathing in vivo vs. gasping...- Modelling respiratory rhythmogenesis: focus on phase switching mechanismsIlya A Rybak
School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA 19104, USA
Adv Exp Med Biol 551:189-94. 2004 - Modelling spinal circuitry involved in locomotor pattern generation: insights from the effects of afferent stimulationIlya A Rybak
Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USA
J Physiol 577:641-58. 2006..The results of modelling provide insights into proprioceptive control of locomotion... - Sodium currents in neurons from the rostroventrolateral medulla of the ratIlya A Rybak
School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, Pennsylvania 19104, USA
J Neurophysiol 90:1635-42. 2003.... - Sodium and calcium mechanisms of rhythmic bursting in excitatory neural networks of the pre-Bötzinger complex: a computational modelling studyPatrick E Jasinski
Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA, USA
Eur J Neurosci 37:212-30. 2013.... - Control of breathing by interacting pontine and pulmonary feedback loopsYaroslav I Molkov
Department of Neurobiology and Anatomy, Drexel University College of Medicine Philadelphia, PA, USA Department of Mathematical Sciences, Indiana University Purdue University Indianapolis, IN, USA
Front Neural Circuits 7:16. 2013.... - Intrinsic bursting activity in the pre-Bötzinger complex: role of persistent sodium and potassium currentsIlya A Rybak
School of Biomedical Engineering, Drexel University, Science and Health Systems, Philadelphia, PA 19104, USA
Biol Cybern 90:59-74. 2004..These findings are discussed in the context of the possible role of population bursting activity in the pBC in the respiratory rhythm generation in vivo vs. in vitro and during normal breathing in vivo vs. gasping... - Respiratory rhythm entrainment by somatic afferent stimulationJeffrey T Potts
Department of Physiology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
J Neurosci 25:1965-78. 2005.... - Potential switch from eupnea to fictive gasping after blockade of glycine transmission and potassium channelsWalter M St -John
Department of Physiology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
Am J Physiol Regul Integr Comp Physiol 283:R721-31. 2002..Results are consistent with the concept that the elicitation of gasping represents a switch from a network-based rhythmogenesis for eupnea to a pacemaker-driven mechanism... - Modeling the mammalian locomotor CPG: insights from mistakes and perturbationsDavid A McCrea
Spinal Cord Research Centre and Department of Physiology, University of Manitoba, Winnipeg, MB, R3E 3J7, Canada
Prog Brain Res 165:235-53. 2007..The model provides a basis for functional identification of spinal interneurons involved in generation and control of the locomotor pattern... - Ionic currents and endogenous rhythm generation in the pre-Bötzinger complex: modelling and in vitro studiesOlivier Pierrefiche
GRAP-JE-UFR de Pharmacie, 80036 Amiens, France
Adv Exp Med Biol 551:121-6. 2004 - Influence of levels of carbon dioxide and oxygen upon gasping in perfused rat preparationWalter M St -John
Dartmouth Hitchcock Medical Center, Department of Physiology, Dartmouth Medical School, Borwell Building, Lebanon, NH 03756, USA
Respir Physiol 129:279-87. 2002..This release is caused by cellular mechanisms that change the balance between membrane ionic currents. Moreover, these cellular mechanisms may be explicitly induced by alterations in the ionic and metabolic homeostasis...
Research Grants
- CRCNS: State dependent neural mechanisms for respiratory pattern generationILYA RYBAK; Fiscal Year: 2006..g., sleep apnea, brainstem/spinal cord injury, CCHS), and for developing and investigations new methods for their treatment. ..