Research Topics
Genomes and Genes | Ramesh RaghupathiSummaryAffiliation: Drexel University Country: USA Publications
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Publications
Acute activation of mitogen-activated protein kinases following traumatic brain injury in the rat: implications for posttraumatic cell deathRamesh Raghupathi
Department of Neurosurgery, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Exp Neurol 183:438-48. 2003....
Temporal alterations in cellular Bax:Bcl-2 ratio following traumatic brain injury in the ratRamesh Raghupathi
Department of Neurosurgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
J Neurotrauma 20:421-35. 2003....- TrkB gene transfer does not alter hippocampal neuronal loss and cognitive deficits following traumatic brain injury in miceValeria Conte
Traumatic Brain Injury Laboratory, Department of Neurosurgery, University of Pennsylvania, Philadelphia, PA, USA
Restor Neurol Neurosci 26:45-56. 2008.... - Midline brain injury in the immature rat induces sustained cognitive deficits, bihemispheric axonal injury and neurodegenerationJimmy W Huh
Department of Anesthesiology and Critical Care, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
Exp Neurol 213:84-92. 2008..These data suggest that diffuse TBI in the immature rat can lead to ongoing degeneration of both cell soma and axonal compartments of neurons, which may contribute, in part, to the observed sustained cognitive deficits... - Chronic cognitive deficits and long-term histopathological alterations following contusive brain injury in the immature ratJimmy W Huh
Department of Anesthesiology and Critical Care, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
J Neurotrauma 24:1460-74. 2007..These data suggest that contusive brain trauma in the immature rat is associated with chronic cognitive deficits, but underscore the effect of the age-at-injury on behavioral and histopathologic outcomes... - Concussive brain trauma in the mouse results in acute cognitive deficits and sustained impairment of axonal functionJennifer A Creed
Program in Neuroscience, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129, USA
J Neurotrauma 28:547-63. 2011..These data suggest that despite recovery from acute cognitive deficits, concussive brain trauma leads to axonal degeneration and a sustained perturbation of axonal function... - Regionally distinct patterns of calpain activation and traumatic axonal injury following contusive brain injury in immature ratsJimmy W Huh
Department of Anesthesiology and Critical Care, Children's Hospital of Philadelphia, and Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USA
Dev Neurosci 28:466-76. 2006..Collectively, these results provide evidence that calpain activation may participate in neuronal loss in the injured cortex, but may not contribute to the pathogenesis of TAI following contusive brain trauma in the immature rat... - Basic science; repetitive mild non-contusive brain trauma in immature rats exacerbates traumatic axonal injury and axonal calpain activation: a preliminary reportJimmy W Huh
Department of Anesthesiology and Critical Care, Children s Hospital of Philadelphia, Philadelphia, PA, USA
J Neurotrauma 24:15-27. 2007..While indicative of the graded nature of the pathologic response, these data suggest that repetitive mild brain injury in the immature rat results in pathologic features similar to those following inflicted brain injuries in infants... - Transient loss of microtubule-associated protein 2 immunoreactivity after moderate brain injury in miceJimmy W Huh
Department of Anesthesia and Critical Care, The Children s Hospital of Philadelphia, Pennsylvania, USA
J Neurotrauma 20:975-84. 2003..Rather, to the best of our knowledge, our data are the first to suggest an intrinsic ability of the traumatized brain for MAP2 recovery after injury of moderate severity... - Neuron-specific mRNA complexity responses during hippocampal apoptosis after traumatic brain injuryPaolo G Marciano
Departments of Neuroscience, Center for Bioinformatics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Neurosci 24:2866-76. 2004.... - Temporal profiles of cytoskeletal protein loss following traumatic axonal injury in miceGulyeter Serbest
Department of Neurosurgery, University of Pennsylvania, Philadelphia, PA, USA
Neurochem Res 32:2006-14. 2007..Protection of the axonal cytoskeleton represents a potential therapeutic target for axonal damage associated with injury or neurodegenerative diseases... - Traumatic mechanical injury to the hippocampus in vitro causes regional caspase-3 and calpain activation that is influenced by NMDA receptor subunit compositionMichael N DeRidder
Department of Bioengineering, University of Pennsylvania, 3320 Smith Walk, Room 105E, Hayden Hall, Philadelphia, PA 19104, USA
Neurobiol Dis 22:165-76. 2006.... - Transplanted neural stem cells survive, differentiate, and improve neurological motor function after experimental traumatic brain injuryPeter Riess
The Head Injury Center, Department of Neurosurgery, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
Neurosurgery 51:1043-52; discussion 1052-4. 2002..CONCLUSION: These data suggest that transplanted NSCs can survive in the traumatically injured brain, differentiate into neurons and/or glia, and attenuate motor dysfunction after traumatic brain injury... - Traumatic axonal injury is exacerbated following repetitive closed head injury in the neonatal pigRamesh Raghupathi
Department of Neurosurgery, University of Pennsylvania, Philadelphia, 19104, USA
J Neurotrauma 21:307-16. 2004..Collectively, these data are indicative of the graded response of the immature brain to rotational load magnitude, and importantly, the vulnerability to repeated, mild, non-impact loading conditions... - Impaired axonal transport and neurofilament compaction occur in separate populations of injured axons following diffuse brain injury in the immature ratAnn Mae DiLeonardi
Program in Neuroscience, Drexel University College of Medicine, Philadelphia, PA 19129, USA
Brain Res 1263:174-82. 2009..Importantly, these data are indicative of the heterogeneity of mechanisms underlying TAI in the traumatically-injured immature brain... - Inhibition of vascular endothelial growth factor receptor (VEGFR) signaling by BSF476921 attenuates regional cerebral edema following traumatic brain injury in ratsPhilipp M Lenzlinger
Head Injury Center, Department of Neurosurgery, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104-6316, USA
Restor Neurol Neurosci 22:73-9. 2004..05) when compared to vehicle treatment. CONCLUSIONS: To our knowledge, this is the first report of a small molecule VEGFR kinase inhibitor reducing cerebral edema in a widely accepted model of brain injury... - Structural and functional damage sustained by mitochondria after traumatic brain injury in the rat: evidence for differentially sensitive populations in the cortex and hippocampusJonathan Lifshitz
Head Injury Center, Department of Neurosurgery, University of Pensylvania, Philadelphia, Pensylvania 19104 6316, USA
J Cereb Blood Flow Metab 23:219-31. 2003..The heterogeneous mitochondrial response to TBI may underlie posttraumatic metabolic dysfunction and contribute to the pathophysiology of TBI... - Ex vivo gene therapy using targeted engraftment of NGF-expressing human NT2N neurons attenuates cognitive deficits following traumatic brain injury in miceLuca Longhi
Veterans Administration Medical Center, Philadelphia, Pennsylvania, USA
J Neurotrauma 21:1723-36. 2004..These data suggest that NGF gene therapy using transduced NT2N neurons (as a source of delivery) may selectively improve cognitive function following TBI... - Differential effects of injury severity on cognition and cellular pathology after contusive brain trauma in the immature ratJimmy W Huh
Department of Anesthesiology and Critical Care, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
J Neurotrauma 28:245-57. 2011.... - Differential effects of FK506 on structural and functional axonal deficits after diffuse brain injury in the immature ratAnn Mae DiLeonardi
Program in Neuroscience, Drexel University College of Medicine, Philadelphia, PA, USA
J Neuropathol Exp Neurol 71:959-72. 2012..Thus, in contrast to adult animals, FK506 treatment did not improve axonal function in brain-injured immature animals, suggesting that calcineurin may not contribute to impaired axonal function... - Common patterns of bcl-2 family gene expression in two traumatic brain injury modelsKenneth I Strauss
Department of Neurosurgery, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
Neurotox Res 6:333-42. 2004..Understanding the regulation of these genes may facilitate the development of new therapeutic strategies for a condition that currently has no proven pharmacologic treatments... - Rapid loss and partial recovery of neurofilament immunostaining following focal brain injury in miceJimmy W Huh
Department of Anesthesiology and Critical Care, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
Exp Neurol 175:198-208. 2002.... - Traumatic brain injury elevates glycogen and induces tolerance to ischemia in rat brainTatsuo Otori
Department of Neurosurgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
J Neurotrauma 21:707-18. 2004..2 +/- 1.5 mmol/kg in sham-injured animals (p < 0.001). These results demonstrate that TBI triggers a marked accumulation of glycogen that may protect the brain during ischemia by serving as an endogenous source of metabolic energy... - New concepts in treatment of pediatric traumatic brain injuryJimmy W Huh
Critical Care and Pediatrics, Department of Anesthesiology and Critical Care Medicine, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Critical Care Office, Philadelphia, PA 19104 4399, USA
Anesthesiol Clin 27:213-40. 2009..Areas of important clinical and basic science investigations germane to the anesthesiologist, such as the role of anesthetics and apoptosis in the developing brain, are discussed... - Temporal window of vulnerability to repetitive experimental concussive brain injuryLuca Longhi
Traumatic Brain Injury Laboratory, Department of Neurosurgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Neurosurgery 56:364-74; discussion 364-74. 2005..Repetitive concussive brain injury (CBI) is associated with cognitive alterations and increased risk of neurodegenerative disease... - Role of the transcription factor E2F1 in CXCR4-mediated neurotoxicity and HIV neuropathologySaori Shimizu
Department of Pharmacology and Physiology, Drexel University, College of Medicine, 245 North 15th Street, NCB 8804, Philadelphia, PA 19102, USA
Neurobiol Dis 25:17-26. 2007..Overall, these studies indicate that E2F1 is primarily involved in CXCR4-mediated neurotoxicity and HIV neuropathogenesis... - Shaken baby syndromeHeidi A Martin
Pediatric Intensive Care Unit, Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA
Crit Care Nurs Clin North Am 18:279-86. 2006..Further research must be done to improve the understanding of the mechanisms associated with this disorder in the ultimate hope of improving the lives and outcome of infants and children... - Cell death mechanisms following traumatic brain injuryRamesh Raghupathi
Drexel University College of Medicine, 2900 Queen Ln, Philadelphia, PA, USA
Brain Pathol 14:215-22. 2004..Together, these observations suggest that cell death mechanisms may be representative of a continuum between apoptotic and necrotic pathways... - Endothelin and the neurovascular unit in pediatric traumatic brain injuryWilliam M Armstead
Department of Anesthesiology and Critical Care and Department of Pharmacology, University of Pennsylvania, Philadelphia, PA 19104, USA
Neurol Res 33:127-32. 2011..This study characterized the association between endothelin-1, cerebral hemodynamics, and histopathology after fluid percussion brain injury in the newborn pig... - Effects of underwater sound exposure on neurological function and brain histologyHelmut L Laurer
Department of Neurosurgery, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Ultrasound Med Biol 28:965-73. 2002..No overt histological damage was detected in any group. These data suggest that underwater HI-LFS exposure may cause transient, mild motor dysfunction... - Cortical Fluoro-Jade staining and blunted adrenomedullary response to hypoglycemia after noncoma hypoglycemia in ratsNancy C Tkacs
School of Nursing, University of Pennsylvania, Philadelphia, PA 19104 6096, USA
J Cereb Blood Flow Metab 25:1645-55. 2005.... - Traumatic axonal injury after closed head injury in the neonatal pigRamesh Raghupathi
Department of Neurosurgery, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Neurotrauma 19:843-53. 2002..Together, these data demonstrate that rapid rotation of the piglet head without impact results in SAH and TAI, similar to that observed in children following severe brain trauma... - Age-dependent changes in material properties of the brain and braincase of the ratAmit Gefen
Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, USA
J Neurotrauma 20:1163-77. 2003..Specifically, these results will assist in the selection of forces to induce comparable mechanical stresses, strains and consequent injury profiles in brain tissues of immature and adult animals... - Differential behavioral and histopathological responses to graded cortical impact injury in miceKathryn E Saatman
Spinal Cord and Brain Injury Research Center, University of Kentucky, Lexington, KY 40536 0509, USA
J Neurotrauma 23:1241-53. 2006..Thus, increasing the depth of impact led to similar structural alterations in neurons, astrocytes and the vasculature, but resulted in greater behavioral deficits and cortical and hippocampal cell death... - Hyperthermia following traumatic brain injury: a critical evaluationHilaire J Thompson
School of Nursing, The University of Pennsylvania, Philadelphia 19104 6020, USA
Neurobiol Dis 12:163-73. 2003..This article represents a compendium of published work regarding the state of knowledge of the relationship between hyperthermia and TBI, as well as a critical examination of current management strategies... - Computational studies of strain exposures in neonate and mature rat brains during closed head impactAnna Levchakov
Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Ramat Aviv Campus, Tel Aviv, Israel
J Neurotrauma 23:1570-80. 2006..Additionally, the larger peak stresses and larger strain volumetric exposures observed in the neonatal brain support the hypothesis that the smaller size and stiffer tissue of the infant brain makes it more susceptible to TBI... - Diffuse brain injury in the immature rat: evidence for an age-at-injury effect on cognitive function and histopathologic damageRamesh Raghupathi
Department of Neurobiology and Anatomy, Drexel University College of Medicine, and Department of Anesthesiology and Critical Care, Children s Hospital of Philadelphia, Pennsylvania 19129, USA
J Neurotrauma 24:1596-608. 2007....