Ramesh Raghupathi

Summary

Affiliation: Drexel University
Country: USA

Publications

  1. ncbi request reprint Cell death mechanisms following traumatic brain injury
    Ramesh Raghupathi
    Drexel University College of Medicine, 2900 Queen Ln, Philadelphia, PA, USA
    Brain Pathol 14:215-22. 2004
  2. pmc TrkB gene transfer does not alter hippocampal neuronal loss and cognitive deficits following traumatic brain injury in mice
    Valeria Conte
    Traumatic Brain Injury Laboratory, Department of Neurosurgery, University of Pennsylvania, Philadelphia, PA, USA
    Restor Neurol Neurosci 26:45-56. 2008
  3. pmc Midline brain injury in the immature rat induces sustained cognitive deficits, bihemispheric axonal injury and neurodegeneration
    Jimmy W Huh
    Department of Anesthesiology and Critical Care, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Exp Neurol 213:84-92. 2008
  4. pmc Concussive brain trauma in the mouse results in acute cognitive deficits and sustained impairment of axonal function
    Jennifer A Creed
    Program in Neuroscience, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129, USA
    J Neurotrauma 28:547-63. 2011
  5. ncbi request reprint Chronic cognitive deficits and long-term histopathological alterations following contusive brain injury in the immature rat
    Jimmy W Huh
    Department of Anesthesiology and Critical Care, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    J Neurotrauma 24:1460-74. 2007
  6. ncbi request reprint Regionally distinct patterns of calpain activation and traumatic axonal injury following contusive brain injury in immature rats
    Jimmy W Huh
    Department of Anesthesiology and Critical Care, Children s Hospital of Philadelphia, and Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    Dev Neurosci 28:466-76. 2006
  7. ncbi request reprint Basic science; repetitive mild non-contusive brain trauma in immature rats exacerbates traumatic axonal injury and axonal calpain activation: a preliminary report
    Jimmy W Huh
    Department of Anesthesiology and Critical Care, Children s Hospital of Philadelphia, Philadelphia, PA, USA
    J Neurotrauma 24:15-27. 2007
  8. ncbi request reprint Acute activation of mitogen-activated protein kinases following traumatic brain injury in the rat: implications for posttraumatic cell death
    Ramesh Raghupathi
    Department of Neurosurgery, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Exp Neurol 183:438-48. 2003
  9. ncbi request reprint Neuron-specific mRNA complexity responses during hippocampal apoptosis after traumatic brain injury
    Paolo G Marciano
    Departments of Neuroscience, Center for Bioinformatics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 24:2866-76. 2004
  10. ncbi request reprint Ex vivo gene therapy using targeted engraftment of NGF-expressing human NT2N neurons attenuates cognitive deficits following traumatic brain injury in mice
    Luca Longhi
    Veterans Administration Medical Center, Philadelphia, Pennsylvania, USA
    J Neurotrauma 21:1723-36. 2004

Collaborators

Detail Information

Publications37

  1. ncbi request reprint Cell death mechanisms following traumatic brain injury
    Ramesh Raghupathi
    Drexel University College of Medicine, 2900 Queen Ln, Philadelphia, PA, USA
    Brain Pathol 14:215-22. 2004
    ..Together, these observations suggest that cell death mechanisms may be representative of a continuum between apoptotic and necrotic pathways...
  2. pmc TrkB gene transfer does not alter hippocampal neuronal loss and cognitive deficits following traumatic brain injury in mice
    Valeria Conte
    Traumatic Brain Injury Laboratory, Department of Neurosurgery, University of Pennsylvania, Philadelphia, PA, USA
    Restor Neurol Neurosci 26:45-56. 2008
    ....
  3. pmc Midline brain injury in the immature rat induces sustained cognitive deficits, bihemispheric axonal injury and neurodegeneration
    Jimmy W Huh
    Department of Anesthesiology and Critical Care, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Exp Neurol 213:84-92. 2008
    ..These data suggest that diffuse TBI in the immature rat can lead to ongoing degeneration of both cell soma and axonal compartments of neurons, which may contribute, in part, to the observed sustained cognitive deficits...
  4. pmc Concussive brain trauma in the mouse results in acute cognitive deficits and sustained impairment of axonal function
    Jennifer A Creed
    Program in Neuroscience, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129, USA
    J Neurotrauma 28:547-63. 2011
    ..These data suggest that despite recovery from acute cognitive deficits, concussive brain trauma leads to axonal degeneration and a sustained perturbation of axonal function...
  5. ncbi request reprint Chronic cognitive deficits and long-term histopathological alterations following contusive brain injury in the immature rat
    Jimmy W Huh
    Department of Anesthesiology and Critical Care, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    J Neurotrauma 24:1460-74. 2007
    ..These data suggest that contusive brain trauma in the immature rat is associated with chronic cognitive deficits, but underscore the effect of the age-at-injury on behavioral and histopathologic outcomes...
  6. ncbi request reprint Regionally distinct patterns of calpain activation and traumatic axonal injury following contusive brain injury in immature rats
    Jimmy W Huh
    Department of Anesthesiology and Critical Care, Children s Hospital of Philadelphia, and Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    Dev Neurosci 28:466-76. 2006
    ..Collectively, these results provide evidence that calpain activation may participate in neuronal loss in the injured cortex, but may not contribute to the pathogenesis of TAI following contusive brain trauma in the immature rat...
  7. ncbi request reprint Basic science; repetitive mild non-contusive brain trauma in immature rats exacerbates traumatic axonal injury and axonal calpain activation: a preliminary report
    Jimmy W Huh
    Department of Anesthesiology and Critical Care, Children s Hospital of Philadelphia, Philadelphia, PA, USA
    J Neurotrauma 24:15-27. 2007
    ..While indicative of the graded nature of the pathologic response, these data suggest that repetitive mild brain injury in the immature rat results in pathologic features similar to those following inflicted brain injuries in infants...
  8. ncbi request reprint Acute activation of mitogen-activated protein kinases following traumatic brain injury in the rat: implications for posttraumatic cell death
    Ramesh Raghupathi
    Department of Neurosurgery, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Exp Neurol 183:438-48. 2003
    ....
  9. ncbi request reprint Neuron-specific mRNA complexity responses during hippocampal apoptosis after traumatic brain injury
    Paolo G Marciano
    Departments of Neuroscience, Center for Bioinformatics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 24:2866-76. 2004
    ....
  10. ncbi request reprint Ex vivo gene therapy using targeted engraftment of NGF-expressing human NT2N neurons attenuates cognitive deficits following traumatic brain injury in mice
    Luca Longhi
    Veterans Administration Medical Center, Philadelphia, Pennsylvania, USA
    J Neurotrauma 21:1723-36. 2004
    ..These data suggest that NGF gene therapy using transduced NT2N neurons (as a source of delivery) may selectively improve cognitive function following TBI...
  11. ncbi request reprint Traumatic mechanical injury to the hippocampus in vitro causes regional caspase-3 and calpain activation that is influenced by NMDA receptor subunit composition
    Michael N DeRidder
    Department of Bioengineering, University of Pennsylvania, 3320 Smith Walk, Room 105E, Hayden Hall, Philadelphia, PA 19104, USA
    Neurobiol Dis 22:165-76. 2006
    ....
  12. ncbi request reprint Temporal profiles of cytoskeletal protein loss following traumatic axonal injury in mice
    Gulyeter Serbest
    Department of Neurosurgery, University of Pennsylvania, Philadelphia, PA, USA
    Neurochem Res 32:2006-14. 2007
    ..Protection of the axonal cytoskeleton represents a potential therapeutic target for axonal damage associated with injury or neurodegenerative diseases...
  13. pmc Differential effects of injury severity on cognition and cellular pathology after contusive brain trauma in the immature rat
    Jimmy W Huh
    Department of Anesthesiology and Critical Care, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    J Neurotrauma 28:245-57. 2011
    ....
  14. ncbi request reprint Traumatic axonal injury is exacerbated following repetitive closed head injury in the neonatal pig
    Ramesh Raghupathi
    Department of Neurosurgery, University of Pennsylvania, Philadelphia, 19104, USA
    J Neurotrauma 21:307-16. 2004
    ..Collectively, these data are indicative of the graded response of the immature brain to rotational load magnitude, and importantly, the vulnerability to repeated, mild, non-impact loading conditions...
  15. ncbi request reprint Diffuse brain injury in the immature rat: evidence for an age-at-injury effect on cognitive function and histopathologic damage
    Ramesh Raghupathi
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, and Department of Anesthesiology and Critical Care, Children s Hospital of Philadelphia, Pennsylvania 19129, USA
    J Neurotrauma 24:1596-608. 2007
    ....
  16. pmc Impaired axonal transport and neurofilament compaction occur in separate populations of injured axons following diffuse brain injury in the immature rat
    Ann Mae DiLeonardi
    Program in Neuroscience, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    Brain Res 1263:174-82. 2009
    ..Importantly, these data are indicative of the heterogeneity of mechanisms underlying TAI in the traumatically-injured immature brain...
  17. pmc Differential effects of FK506 on structural and functional axonal deficits after diffuse brain injury in the immature rat
    Ann Mae DiLeonardi
    Program in Neuroscience, Drexel University College of Medicine, Philadelphia, PA, USA
    J Neuropathol Exp Neurol 71:959-72. 2012
    ..Thus, in contrast to adult animals, FK506 treatment did not improve axonal function in brain-injured immature animals, suggesting that calcineurin may not contribute to impaired axonal function...
  18. ncbi request reprint Traumatic brain injury elevates glycogen and induces tolerance to ischemia in rat brain
    Tatsuo Otori
    Department of Neurosurgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Neurotrauma 21:707-18. 2004
    ..2 +/- 1.5 mmol/kg in sham-injured animals (p < 0.001). These results demonstrate that TBI triggers a marked accumulation of glycogen that may protect the brain during ischemia by serving as an endogenous source of metabolic energy...
  19. ncbi request reprint Inhibition of vascular endothelial growth factor receptor (VEGFR) signaling by BSF476921 attenuates regional cerebral edema following traumatic brain injury in rats
    Philipp M Lenzlinger
    Head Injury Center, Department of Neurosurgery, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104 6316, USA
    Restor Neurol Neurosci 22:73-9. 2004
    ....
  20. ncbi request reprint Structural and functional damage sustained by mitochondria after traumatic brain injury in the rat: evidence for differentially sensitive populations in the cortex and hippocampus
    Jonathan Lifshitz
    Head Injury Center, Department of Neurosurgery, University of Pensylvania, Philadelphia, Pensylvania 19104 6316, USA
    J Cereb Blood Flow Metab 23:219-31. 2003
    ..The heterogeneous mitochondrial response to TBI may underlie posttraumatic metabolic dysfunction and contribute to the pathophysiology of TBI...
  21. pmc New concepts in treatment of pediatric traumatic brain injury
    Jimmy W Huh
    Critical Care and Pediatrics, Department of Anesthesiology and Critical Care Medicine, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Critical Care Office, Philadelphia, PA 19104 4399, USA
    Anesthesiol Clin 27:213-40. 2009
    ..Areas of important clinical and basic science investigations germane to the anesthesiologist, such as the role of anesthetics and apoptosis in the developing brain, are discussed...
  22. pmc Temporal alterations in cellular Bax:Bcl-2 ratio following traumatic brain injury in the rat
    Ramesh Raghupathi
    Department of Neurosurgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    J Neurotrauma 20:421-35. 2003
    ....
  23. ncbi request reprint Shaken baby syndrome
    Heidi A Martin
    Pediatric Intensive Care Unit, Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA
    Crit Care Nurs Clin North Am 18:279-86. 2006
    ..Further research must be done to improve the understanding of the mechanisms associated with this disorder in the ultimate hope of improving the lives and outcome of infants and children...
  24. pmc Role of the transcription factor E2F1 in CXCR4-mediated neurotoxicity and HIV neuropathology
    Saori Shimizu
    Department of Pharmacology and Physiology, Drexel University, College of Medicine, 245 North 15th Street, NCB 8804, Philadelphia, PA 19102, USA
    Neurobiol Dis 25:17-26. 2007
    ..Overall, these studies indicate that E2F1 is primarily involved in CXCR4-mediated neurotoxicity and HIV neuropathogenesis...
  25. ncbi request reprint Temporal window of vulnerability to repetitive experimental concussive brain injury
    Luca Longhi
    Traumatic Brain Injury Laboratory, Department of Neurosurgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Neurosurgery 56:364-74; discussion 364-74. 2005
    ..Repetitive concussive brain injury (CBI) is associated with cognitive alterations and increased risk of neurodegenerative disease...
  26. pmc Endothelin and the neurovascular unit in pediatric traumatic brain injury
    William M Armstead
    Department of Anesthesiology and Critical Care and Department of Pharmacology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neurol Res 33:127-32. 2011
    ..This study characterized the association between endothelin-1, cerebral hemodynamics, and histopathology after fluid percussion brain injury in the newborn pig...
  27. ncbi request reprint Cortical Fluoro-Jade staining and blunted adrenomedullary response to hypoglycemia after noncoma hypoglycemia in rats
    Nancy C Tkacs
    School of Nursing, University of Pennsylvania, Philadelphia, PA 19104 6096, USA
    J Cereb Blood Flow Metab 25:1645-55. 2005
    ....
  28. ncbi request reprint Effects of underwater sound exposure on neurological function and brain histology
    Helmut L Laurer
    Department of Neurosurgery, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Ultrasound Med Biol 28:965-73. 2002
    ..No overt histological damage was detected in any group. These data suggest that underwater HI-LFS exposure may cause transient, mild motor dysfunction...
  29. ncbi request reprint Rapid loss and partial recovery of neurofilament immunostaining following focal brain injury in mice
    Jimmy W Huh
    Department of Anesthesiology and Critical Care, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Exp Neurol 175:198-208. 2002
    ....
  30. ncbi request reprint Traumatic axonal injury after closed head injury in the neonatal pig
    Ramesh Raghupathi
    Department of Neurosurgery, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurotrauma 19:843-53. 2002
    ..Together, these data demonstrate that rapid rotation of the piglet head without impact results in SAH and TAI, similar to that observed in children following severe brain trauma...
  31. ncbi request reprint Age-dependent changes in material properties of the brain and braincase of the rat
    Amit Gefen
    Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Neurotrauma 20:1163-77. 2003
    ..Specifically, these results will assist in the selection of forces to induce comparable mechanical stresses, strains and consequent injury profiles in brain tissues of immature and adult animals...
  32. ncbi request reprint Transient loss of microtubule-associated protein 2 immunoreactivity after moderate brain injury in mice
    Jimmy W Huh
    Department of Anesthesia and Critical Care, The Children s Hospital of Philadelphia, Pennsylvania, USA
    J Neurotrauma 20:975-84. 2003
    ..Rather, to the best of our knowledge, our data are the first to suggest an intrinsic ability of the traumatized brain for MAP2 recovery after injury of moderate severity...
  33. pmc Common patterns of bcl-2 family gene expression in two traumatic brain injury models
    Kenneth I Strauss
    Department of Neurosurgery, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    Neurotox Res 6:333-42. 2004
    ..Understanding the regulation of these genes may facilitate the development of new therapeutic strategies for a condition that currently has no proven pharmacologic treatments...
  34. ncbi request reprint Differential behavioral and histopathological responses to graded cortical impact injury in mice
    Kathryn E Saatman
    Spinal Cord and Brain Injury Research Center, University of Kentucky, Lexington, KY 40536 0509, USA
    J Neurotrauma 23:1241-53. 2006
    ..Thus, increasing the depth of impact led to similar structural alterations in neurons, astrocytes and the vasculature, but resulted in greater behavioral deficits and cortical and hippocampal cell death...
  35. ncbi request reprint Hyperthermia following traumatic brain injury: a critical evaluation
    Hilaire J Thompson
    School of Nursing, The University of Pennsylvania, Philadelphia 19104 6020, USA
    Neurobiol Dis 12:163-73. 2003
    ..This article represents a compendium of published work regarding the state of knowledge of the relationship between hyperthermia and TBI, as well as a critical examination of current management strategies...
  36. ncbi request reprint Transplanted neural stem cells survive, differentiate, and improve neurological motor function after experimental traumatic brain injury
    Peter Riess
    The Head Injury Center, Department of Neurosurgery, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Neurosurgery 51:1043-52; discussion 1052-4. 2002
    ..Using the neural stem cell (NSC) clone C17.2, we evaluated the ability of transplanted murine NSCs to attenuate cognitive and neurological motor deficits after traumatic brain injury...
  37. ncbi request reprint Computational studies of strain exposures in neonate and mature rat brains during closed head impact
    Anna Levchakov
    Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Ramat Aviv Campus, Tel Aviv, Israel
    J Neurotrauma 23:1570-80. 2006
    ..Additionally, the larger peak stresses and larger strain volumetric exposures observed in the neonatal brain support the hypothesis that the smaller size and stiffer tissue of the infant brain makes it more susceptible to TBI...