Birgit Neuhuber

Summary

Affiliation: Drexel University College of Medicine
Country: USA

Publications

  1. doi request reprint Stem cell delivery by lumbar puncture as a therapeutic alternative to direct injection into injured spinal cord
    Birgit Neuhuber
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129, USA
    J Neurosurg Spine 9:390-9. 2008
  2. pmc Effects of plating density and culture time on bone marrow stromal cell characteristics
    Birgit Neuhuber
    Drexel University College of Medicine, Department of Neurobiology and Anatomy, Philadelphia, PA, USA
    Exp Hematol 36:1176-85. 2008
  3. doi request reprint Transplantation of human marrow stromal cells and mono-nuclear bone marrow cells into the injured spinal cord: a comparative study
    Amer F Samdani
    Shriners Hospital for Children, and Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19140, USA
    Spine (Phila Pa 1976) 34:2605-12. 2009
  4. ncbi request reprint Combining motor training with transplantation of rat bone marrow stromal cells does not improve repair or recovery in rats with thoracic contusion injuries
    Hiroyuki Yoshihara
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    Brain Res 1119:65-75. 2006
  5. ncbi request reprint Lumbar puncture delivery of bone marrow stromal cells in spinal cord contusion: a novel method for minimally invasive cell transplantation
    Ajay Bakshi
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129, USA
    J Neurotrauma 23:55-65. 2006
  6. doi request reprint A pilot study of poly(N-isopropylacrylamide)-g-polyethylene glycol and poly(N-isopropylacrylamide)-g-methylcellulose branched copolymers as injectable scaffolds for local delivery of neurotrophins and cellular transplants into the injured spinal cord
    Lauren Conova
    Department of Chemical and Biological Engineering, Drexel University, Philadelphia, Pennsylvania, USA
    J Neurosurg Spine 15:594-604. 2011
  7. ncbi request reprint Analysis of allogeneic and syngeneic bone marrow stromal cell graft survival in the spinal cord
    Sharon A Swanger
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129, USA
    Cell Transplant 14:775-86. 2005
  8. pmc Transplantation of human glial restricted progenitors and derived astrocytes into a contusion model of spinal cord injury
    Ying Jin
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129, USA
    J Neurotrauma 28:579-94. 2011
  9. pmc Promoting directional axon growth from neural progenitors grafted into the injured spinal cord
    Joseph F Bonner
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania
    J Neurosci Res 88:1182-92. 2010
  10. ncbi request reprint Reevaluation of in vitro differentiation protocols for bone marrow stromal cells: disruption of actin cytoskeleton induces rapid morphological changes and mimics neuronal phenotype
    Birgit Neuhuber
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129, USA
    J Neurosci Res 77:192-204. 2004

Collaborators

Detail Information

Publications18

  1. doi request reprint Stem cell delivery by lumbar puncture as a therapeutic alternative to direct injection into injured spinal cord
    Birgit Neuhuber
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129, USA
    J Neurosurg Spine 9:390-9. 2008
    ..To avoid additional trauma and to simplify translation to the clinic, it is advantageous to use less invasive delivery methods...
  2. pmc Effects of plating density and culture time on bone marrow stromal cell characteristics
    Birgit Neuhuber
    Drexel University College of Medicine, Department of Neurobiology and Anatomy, Philadelphia, PA, USA
    Exp Hematol 36:1176-85. 2008
    ..This study is aimed at evaluating the effects of initial plating density and total time in culture on proliferation, cell morphology, and differentiation potential of heterogeneous MSC cultures and more homogeneous cloned subpopulations...
  3. doi request reprint Transplantation of human marrow stromal cells and mono-nuclear bone marrow cells into the injured spinal cord: a comparative study
    Amer F Samdani
    Shriners Hospital for Children, and Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19140, USA
    Spine (Phila Pa 1976) 34:2605-12. 2009
    ..Two groups of 6 rats received dorsolateral funiculotomies followed by direct injection of bone marrow stromal cells (MSC) or mono-nuclear fraction of bone marrow (mnBM). Animals were killed at 4 or 21 days...
  4. ncbi request reprint Combining motor training with transplantation of rat bone marrow stromal cells does not improve repair or recovery in rats with thoracic contusion injuries
    Hiroyuki Yoshihara
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    Brain Res 1119:65-75. 2006
    ..Our results indicate that combining the beneficial effects of rat MSC and this exercise protocol was not sufficient to enhance behavioral recovery...
  5. ncbi request reprint Lumbar puncture delivery of bone marrow stromal cells in spinal cord contusion: a novel method for minimally invasive cell transplantation
    Ajay Bakshi
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129, USA
    J Neurotrauma 23:55-65. 2006
    ..The techniques described here can easily be translated to patients, thus accelerating clinical application of stem cell therapies...
  6. doi request reprint A pilot study of poly(N-isopropylacrylamide)-g-polyethylene glycol and poly(N-isopropylacrylamide)-g-methylcellulose branched copolymers as injectable scaffolds for local delivery of neurotrophins and cellular transplants into the injured spinal cord
    Lauren Conova
    Department of Chemical and Biological Engineering, Drexel University, Philadelphia, Pennsylvania, USA
    J Neurosurg Spine 15:594-604. 2011
    ..The scaffolds were also evaluated for their ability to promote axonal growth through the action of released brain-derived neurotrophic factor (BDNF)...
  7. ncbi request reprint Analysis of allogeneic and syngeneic bone marrow stromal cell graft survival in the spinal cord
    Sharon A Swanger
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129, USA
    Cell Transplant 14:775-86. 2005
    ..These results indicate that allogeneic transplantation with appropriate immune suppression permits long-term survival of MSC; thus, both allogeneic and syngeneic strategies could be utilized in devising novel therapies for CNS injury...
  8. pmc Transplantation of human glial restricted progenitors and derived astrocytes into a contusion model of spinal cord injury
    Ying Jin
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129, USA
    J Neurotrauma 28:579-94. 2011
    ....
  9. pmc Promoting directional axon growth from neural progenitors grafted into the injured spinal cord
    Joseph F Bonner
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania
    J Neurosci Res 88:1182-92. 2010
    ..Together they can serve as a building block for neuronal cell replacement of local circuits and formation of neuronal relays...
  10. ncbi request reprint Reevaluation of in vitro differentiation protocols for bone marrow stromal cells: disruption of actin cytoskeleton induces rapid morphological changes and mimics neuronal phenotype
    Birgit Neuhuber
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129, USA
    J Neurosci Res 77:192-204. 2004
    ..A dissection of molecular signaling and commitment events may be necessary to verify the ability of MSC transdifferentiation to neuronal lineages...
  11. pmc Grafting of human bone marrow stromal cells into spinal cord injury: a comparison of delivery methods
    Courtney Paul
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    Spine (Phila Pa 1976) 34:328-34. 2009
    ..Animals survived for 4 or 21 days...
  12. ncbi request reprint Recovery of function following grafting of human bone marrow-derived stromal cells into the injured spinal cord
    B Timothy Himes
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    Neurorehabil Neural Repair 20:278-96. 2006
    ..However, the use of carefully characterized BMSCs improved transplantation protocols ensuring BMSC, survival, and systematic motor and sensory behavioral testing to identify robust recovery is imperative for further improvement...
  13. ncbi request reprint Axon growth and recovery of function supported by human bone marrow stromal cells in the injured spinal cord exhibit donor variations
    Birgit Neuhuber
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PA 19129, USA
    Brain Res 1035:73-85. 2005
    ..To qualify MSC lots for future clinical application, such notable differences in donor or lot-lot efficacy highlight the need for establishing adequate characterization, including the development of relevant efficacy assays...
  14. doi request reprint Neurite outgrowth of neural progenitors in presence of inhibitory proteoglycans
    Jill See
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129, USA
    J Neurotrauma 27:951-7. 2010
    ....
  15. pmc Phenotypic analysis of astrocytes derived from glial restricted precursors and their impact on axon regeneration
    Christopher Haas
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PA 19129, USA
    Exp Neurol 233:717-32. 2012
    ....
  16. doi request reprint Secretion profile of human bone marrow stromal cells: donor variability and response to inflammatory stimuli
    Victoria Zhukareva
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PA 19129, USA
    Cytokine 50:317-21. 2010
    ..Patterns of up-regulated cytokines were similar in MSC from different donors suggesting a comparable response to inflammatory stimuli...
  17. pmc Acute administration of AMPA/Kainate blocker combined with delayed transplantation of neural precursors improves lower urinary tract function in spinal injured rats
    Takahiko Mitsui
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PA 19129, USA
    Brain Res 1418:23-31. 2011
    ..In conclusion, transplants of NRP/GRP combined with NBQX promote recovery of micturition function following spinal cord injury, likely through increased neuroprotection...
  18. pmc In vitro analysis of PNIPAAm-PEG, a novel, injectable scaffold for spinal cord repair
    Noelle Comolli
    Department of Chemical and Biological Engineering, Drexel University, 3141 Chestnut Street, Philadelphia, PA 19104, USA
    Acta Biomater 5:1046-55. 2009
    ..The scaffold was also compatible with bone marrow stromal cells, allowing their survival and attachment for up to 31 days. These results indicate that PNIPAAm-PEG is a promising multifunctional scaffold for the treatment of SCI...