Carol F Lippa

Summary

Affiliation: Drexel University College of Medicine
Country: USA

Publications

  1. ncbi Dementia: many roads, but not built in a day
    Carol F Lippa
    Neurology 69:2193-4. 2007
  2. doi Neuritic pathology as a correlate of synaptic loss in dementia with lewy bodies
    Gonzalo J Revuelta
    Department of Neurology, Drexel University College of Medicine, Philadelphia, Pennsylvania 19102, USA
    Am J Alzheimers Dis Other Demen 23:97-102. 2008
  3. doi Loss of synaptophysin immunoexpression in primary progressive aphasia
    Carol F Lippa
    Department of Neurology, Drexel University College of Medicine, Philadelphia, PA 19102, USA
    Am J Alzheimers Dis Other Demen 27:250-3. 2012
  4. doi Levetiracetam: a practical option for seizure management in elderly patients with cognitive impairment
    Carol F Lippa
    Department of Neurology, Drexel University College of Medicine, 245 N 15th Street, Philadelphia, PA 19102, USA
    Am J Alzheimers Dis Other Demen 25:149-54. 2010
  5. pmc Transactive response DNA-binding protein 43 burden in familial Alzheimer disease and Down syndrome
    Carol F Lippa
    Drexel University College of Medicine Philadelphia, Philadelphia, Pennsylvania 19102, USA
    Arch Neurol 66:1483-8. 2009
  6. ncbi DLB and PDD boundary issues: diagnosis, treatment, molecular pathology, and biomarkers
    C F Lippa
    Department of Neurology, Drexel University College of Medicine, Philadelphia, PA 19102, USA
    Neurology 68:812-9. 2007
  7. ncbi An individualized approach to treatment for alzheimer's disease, pick's disease, and other dementias
    Carol F Lippa
    Department of Neurology, Drexel University College of Medicine, Philadelphia, Pennsylvania 19102, USA
    Am J Alzheimers Dis Other Demen 21:354-9. 2006
  8. pmc Lewy body dementia: the caregiver experience of clinical care
    James E Galvin
    Department of Neurology, New York University Langone School of Medicine, New York, NY 10016, USA
    Parkinsonism Relat Disord 16:388-92. 2010
  9. pmc Disruption of glutamate receptors at Shank-postsynaptic platform in Alzheimer's disease
    Yuesong Gong
    Department of Neurology, Drexel University College of Medicine, 245 N 15th Street, Philadelphia, PA 19102, USA
    Brain Res 1292:191-8. 2009
  10. ncbi Notch-1 immunoexpression is increased in Alzheimer's and Pick's disease
    Mehul H Nagarsheth
    Department of Neurology, Drexel University College of Medicine, Philadelphia, PA 19102, USA
    J Neurol Sci 244:111-6. 2006

Research Grants

Detail Information

Publications38

  1. ncbi Dementia: many roads, but not built in a day
    Carol F Lippa
    Neurology 69:2193-4. 2007
  2. doi Neuritic pathology as a correlate of synaptic loss in dementia with lewy bodies
    Gonzalo J Revuelta
    Department of Neurology, Drexel University College of Medicine, Philadelphia, Pennsylvania 19102, USA
    Am J Alzheimers Dis Other Demen 23:97-102. 2008
    ..694, P < .06). Correlations of beta-amyloid and of LB density with synaptophysin score were unimpressive. These data support the hypothesis that synaptic loss in DLB is related to neuritic degeneration...
  3. doi Loss of synaptophysin immunoexpression in primary progressive aphasia
    Carol F Lippa
    Department of Neurology, Drexel University College of Medicine, Philadelphia, PA 19102, USA
    Am J Alzheimers Dis Other Demen 27:250-3. 2012
    ..14 and 0.18). These data suggest that synaptic loss may be a factor underlying the language deficits in PPA...
  4. doi Levetiracetam: a practical option for seizure management in elderly patients with cognitive impairment
    Carol F Lippa
    Department of Neurology, Drexel University College of Medicine, 245 N 15th Street, Philadelphia, PA 19102, USA
    Am J Alzheimers Dis Other Demen 25:149-54. 2010
    ..Levetiracetam is an effective antiepileptic drug in elderly individuals with cognitive impairment. At 3 months, participants who remained on levetiracetam showed excellent cognitive tolerability...
  5. pmc Transactive response DNA-binding protein 43 burden in familial Alzheimer disease and Down syndrome
    Carol F Lippa
    Drexel University College of Medicine Philadelphia, Philadelphia, Pennsylvania 19102, USA
    Arch Neurol 66:1483-8. 2009
    ..To assess the transactive response DNA-binding protein 43 (TDP-43) burden in familial forms of Alzheimer disease (FAD) and Down syndrome (DS) to determine whether TDP-43 inclusions are also present...
  6. ncbi DLB and PDD boundary issues: diagnosis, treatment, molecular pathology, and biomarkers
    C F Lippa
    Department of Neurology, Drexel University College of Medicine, Philadelphia, PA 19102, USA
    Neurology 68:812-9. 2007
    ....
  7. ncbi An individualized approach to treatment for alzheimer's disease, pick's disease, and other dementias
    Carol F Lippa
    Department of Neurology, Drexel University College of Medicine, Philadelphia, Pennsylvania 19102, USA
    Am J Alzheimers Dis Other Demen 21:354-9. 2006
    ..This individualized approach has potential to increase the beneficial effects of medications, reduce the likelihood of side effects, and preserve health care resources...
  8. pmc Lewy body dementia: the caregiver experience of clinical care
    James E Galvin
    Department of Neurology, New York University Langone School of Medicine, New York, NY 10016, USA
    Parkinsonism Relat Disord 16:388-92. 2010
    ..Lewy body dementia (LBD) is the second most common cause of dementia, however, little is known about how the clinical diagnosis of LBD is obtained in the community or the caregiver experience while seeking the diagnosis...
  9. pmc Disruption of glutamate receptors at Shank-postsynaptic platform in Alzheimer's disease
    Yuesong Gong
    Department of Neurology, Drexel University College of Medicine, 245 N 15th Street, Philadelphia, PA 19102, USA
    Brain Res 1292:191-8. 2009
    ..Our findings suggest that disruption of glutamate receptors at the Shank-postsynaptic platform could contribute to destruction of the PSD which underlies the synaptic dysfunction and loss in AD...
  10. ncbi Notch-1 immunoexpression is increased in Alzheimer's and Pick's disease
    Mehul H Nagarsheth
    Department of Neurology, Drexel University College of Medicine, Philadelphia, PA 19102, USA
    J Neurol Sci 244:111-6. 2006
    ....
  11. doi Effects of prescribed medications on cognition and behavior in frontotemporal lobar degeneration
    David Irwin
    Department of Neurology, Drexel University College of Medicine, Philadelphia, PA 19102, USA
    Am J Alzheimers Dis Other Demen 25:566-71. 2010
    ..04). This data suggest a potential worsening of objective measures of cognitive and behavioral symptoms in FTLD with AChEI treatment...
  12. ncbi Cognition and amyotrophic lateral sclerosis (ALS)
    D Irwin
    Drexel University College of Medicine, Philadelphia, Pennsylvania 19102, USA
    Am J Alzheimers Dis Other Demen 22:300-12. 2007
    ..Diagnosis and treatment of cognitive symptoms in ALS patients may improve quality of life...
  13. doi Progranulin and beta-amyloid distribution: a case report of the brain from preclinical PS-1 mutation carrier
    Gediminas Gliebus
    Department of Neurology, Drexel University College of Medicine, Philadelphia, Pennsylvania 19102, USA
    Am J Alzheimers Dis Other Demen 24:456-60. 2009
    ..Mutations in the PGRN gene cause familial frontotemporal dementia with ubiquitin-positive inclusions. PGRN plaque-like structures have been described in Alzheimer's disease (AD), in association with beta-amyloid (Abeta) plaques...
  14. doi Association between progranulin and beta-amyloid in dementia with Lewy bodies
    Gonzalo J Revuelta
    Department of Neurology, Drexel University College of Medicine, Philadelphia, Pennsylvania 19102, USA
    Am J Alzheimers Dis Other Demen 23:488-93. 2008
    ..Progranulin and beta-amyloid colocalized in plaques in dementia with Lewy bodies, suggesting that there is likely a biological association between these 2 aggregated proteins...
  15. ncbi Lewy bodies in the amygdala: increase of alpha-synuclein aggregates in neurodegenerative diseases with tau-based inclusions
    Anca Popescu
    Department of Neurology, Drexel University College of Medicine, 3300 Henry Avenue, Philadelphia, PA 19129, USA
    Arch Neurol 61:1915-9. 2004
    ..However, the spectrum of disorders in which secondary inclusions are likely to occur has not been defined. Amygdala neurons commonly develop large numbers of secondary LBs, making it a practical region for studying this phenomenon...
  16. ncbi A 75-year-old man with cognitive impairment and gait changes
    Carol F Lippa
    Department of Neurology, Drexel University College of Medicine, Philadelphia, PA, USA
    Neurology 69:1183-9. 2007
  17. ncbi Synaptophysin immunoreactivity in Pick's disease: comparison with Alzheimer's disease and dementia with Lewy bodies
    Carol F Lippa
    Department of Neurology, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA
    Am J Alzheimers Dis Other Demen 19:341-4. 2004
    ..In contrast, perforant pathway synaptic losses in DLB were minimal. Our data supports the hypothesis that focal synaptic losses occur in PiD and AD and may contribute to the cognitive deficits in both conditions...
  18. ncbi The influence of beta-blockers on delayed memory function in people with cognitive impairment
    Gediminas Gliebus
    Department of Neurology, Drexel University College of Medicine, New College Building, 245 North 15th Street, Philadelphia, PA 19102, USA
    Am J Alzheimers Dis Other Demen 22:57-61. 2007
    ..These data support the notion that common medications used in cognitively impaired elderly patients can worsen cognition and that careful selection of medications may help to maximize retrieval of newly formed memories...
  19. ncbi Alpha-Synuclein aggregation in pathological aging and Alzheimer's disease: the impact of beta-amyloid plaque level
    Sara M Lippa
    Department of Neurology, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA
    Am J Alzheimers Dis Other Demen 20:315-8. 2005
    ..Overall, Abeta-40 plaque level was greater in cases with secondary AS aggregates. Abeta-42 plaque level was not associated with AS aggregation. Abeta-40 plaque levels cannot be ruled out as a factor involved in secondary LB formation...
  20. ncbi Selective reduction of soluble tau proteins in sporadic and familial frontotemporal dementias: an international follow-up study
    Victoria Zhukareva
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Maloney 3, HUP, 3600 Spruce Street, Philadelphia, PA 19104 4283, USA
    Acta Neuropathol 105:469-76. 2003
    ....
  21. pmc Evidence for a role of the rare p.A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimer's diseases
    Giovanni Coppola
    Department of Neurology, University of California, Los Angeles, CA, USA
    Hum Mol Genet 21:3500-12. 2012
    ....
  22. ncbi Caffeine: neuroprotective functions in cognition and Alzheimer's disease
    Andi Rosso
    Department of Neurology, Drexel University College of Medicine, Philadelphia, PA 19102, USA
    Am J Alzheimers Dis Other Demen 23:417-22. 2008
    ..Further studies are needed to determine whether caffeine consumption could have a major affect on the development of Alzheimer's disease or age-related cognitive decline...
  23. ncbi Presenilin-1 C410Y Alzheimer disease plaques contain synaptic proteins
    Kamran Haleem
    Drexel University College of Medicine, Philadelphia, Pennsylvania 19102, USA
    Am J Alzheimers Dis Other Demen 22:137-44. 2007
    ..These data suggest that in C410Y PS-1 AD patients, CWPs may constitute a major component of synaptic terminal-specific proteins, and that the C410Y PS-1 mutation may influence either synaptic structure or synaptic protein expression...
  24. pmc LR11/SorLA expression is reduced in sporadic Alzheimer disease but not in familial Alzheimer disease
    Sara E Dodson
    Center for Neurodegenerative Disease, Department of Neurology, Emory University Atlanta, Georgia 30322, USA
    J Neuropathol Exp Neurol 65:866-72. 2006
    ..We hypothesize that LR11 loss may be specific to sporadic AD and influence amyloid pathology through mechanisms independent of substrate-enzyme interactions regulated by FAD mutations...
  25. pmc Review: disruption of the postsynaptic density in Alzheimer's disease and other neurodegenerative dementias
    Yuesong Gong
    Department of Neurology, Drexel University College of Medicine, Philadelphia, PA 19102, USA
    Am J Alzheimers Dis Other Demen 25:547-55. 2010
    ..We suggest that the functional and structural plasticity changes of the PSD may contribute to the loss of molecular homeostasis within the synapse (and contribute to early symptoms) in these dementias...
  26. ncbi The corpus callosum in Pick's disease, Alzheimer's disease, and amyotrophic lateral sclerosis: gliosis implies possible clinical consequence
    Cynelle Murray
    Department of Neurology, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA
    Am J Alzheimers Dis Other Demen 21:37-43. 2006
    ..Clinical implications are discussed, and it is recommended that further studies be done to determine whether there is a relevant clinical correlate...
  27. doi Cerebrospinal immunoglobulin level changes and clinical response to treatment of Hashimoto's encephalopathy
    Gediminas Gliebus
    Department of Neurology, Drexel University College of Medicine, Philadelphia, Pennsylvania 19102, USA
    Am J Alzheimers Dis Other Demen 24:373-6. 2009
    ..He then underwent high dose steroid treatment after which patients' clinical condition stabilized and CSF analysis showed even further IgG decline...
  28. doi A clinical approach to early-onset inheritable dementia
    Brian S Rogers
    Department of Neurology, Drexel University College of Medicine, Philadelphia, PA 19102, USA
    Am J Alzheimers Dis Other Demen 27:154-61. 2012
    ..A discussion of the diagnosis and workup for early-onset dementia is included with an emphasis on conditions that may have other involved family members...
  29. pmc Lewy body dementia: caregiver burden and unmet needs
    James E Galvin
    Department of Neurology, Washington University, St Louis, MO, USA
    Alzheimer Dis Assoc Disord 24:177-81. 2010
    ..Community resources such as the Lewy Body Dementia Association may serve this end, while also providing practical information and support for caregivers...
  30. doi Lewy body dementia
    Jennifer C Hanson
    Drexel University College of Medicine, Mail Stop 423, Philadelphia, Pennsylvania 19107, USA
    Int Rev Neurobiol 84:215-28. 2009
    ..In this chapter, we will review DLB including clinical, pathological, and radiological features as well as biomarkers and treatments...
  31. ncbi Alzheimer's disease and other dementias: a review
    Shannon Rogan
    Department of Neurology, MCP Hahnemann University, Philadelphia, Pennsylvania, USA
    Am J Alzheimers Dis Other Demen 17:11-7. 2002
    ..Details of the various diseases remain only partially uncovered, raising extensive prospects for future research and therapy for patients with dementia...
  32. ncbi Dementia with Lewy bodies: improving diagnostic criteria
    Carol F Lippa
    Neurology 60:1571-2. 2003
  33. ncbi Hippocampal sclerosis dementia: expanding the phenotypes of frontotemporal dementias?
    Carol F Lippa
    Neurology 63:414-5. 2004
  34. ncbi Genetic aspects of Alzheimer's disease, Pick's disease, and other dementias
    Linda E Nee
    Family Studies Unit, National Institute of Neurological Disorders and Stroke, Clinical Center, Bethesda, Maryland, USA
    Am J Alzheimers Dis Other Demen 19:219-25. 2004
    ..The ethical use of DNA samples in research is another genetic testing issue to be considered...
  35. ncbi Alzheimer neuropathology in nondemented aging: keeping mind over matter
    Carol F Lippa
    Neurology 66:1801-2. 2006
  36. ncbi Characterizing clinical phenotypes: the Lewys in their life or the life of their Lewys?
    Carol F Lippa
    Neurology 67:1910-1. 2006
  37. ncbi Review of issue: studies on veterans, a useful pain scale, and plasma amyloid levels as a predictor of response to medications
    Carol F Lippa
    Am J Alzheimers Dis Other Demen 23:215-7. 2008
  38. ncbi Safety, end-of-life issues, and dealing with sexually inappropriate behavior in dementia patients
    Carol F Lippa
    Am J Alzheimers Dis Other Demen 23:311-2. 2008

Research Grants1