Mark S Lechner

Summary

Affiliation: Drexel University
Country: USA

Publications

  1. pmc Regulated recruitment of HP1 to a euchromatic gene induces mitotically heritable, epigenetic gene silencing: a mammalian cell culture model of gene variegation
    Kasirajan Ayyanathan
    The Wistar Institute, Philadelphia, Pennsylvania 19104 4268, USA
    Genes Dev 17:1855-69. 2003
  2. ncbi The mammalian heterochromatin protein 1 binds diverse nuclear proteins through a common motif that targets the chromoshadow domain
    Mark S Lechner
    The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
    Biochem Biophys Res Commun 331:929-37. 2005

Research Grants

Collaborators

  • David C Schultz
  • Kasirajan Ayyanathan
  • Yoshihiko Yamada
  • Frank J Rauscher
  • Gerd G Maul
  • Kiyoyuki Torigoe
  • Kazuhiro Tanaka
  • Peter Bell

Detail Information

Publications2

  1. pmc Regulated recruitment of HP1 to a euchromatic gene induces mitotically heritable, epigenetic gene silencing: a mammalian cell culture model of gene variegation
    Kasirajan Ayyanathan
    The Wistar Institute, Philadelphia, Pennsylvania 19104 4268, USA
    Genes Dev 17:1855-69. 2003
    ..Thus, like variegation in Drosophila, recruitment of mammalian HP1 to a euchromatic promoter can establish a silenced state that is epigenetically heritable...
  2. ncbi The mammalian heterochromatin protein 1 binds diverse nuclear proteins through a common motif that targets the chromoshadow domain
    Mark S Lechner
    The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
    Biochem Biophys Res Commun 331:929-37. 2005
    ..Thus, this spectrum of direct binding partners suggests an expanded role for HP1 as factor participating in promoter-enhancer communication, chromatin remodeling/assembly, and sub-nuclear compartmentalization...

Research Grants1

  1. A role for the CdLS gene NIPBL in HP1 gene silencing
    MARK LECHNER; Fiscal Year: 2007
    ....