Research Topics
| Andres KrieteSummaryAffiliation: Drexel University Country: USA Publications
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Detail Information
Publications
Computational systems biology of agingAndres Kriete
School of Biomedical Engineering, Science and Health Systems, Drexel University, Bossone Research Center, Philadelphia, PA, USA
Wiley Interdiscip Rev Syst Biol Med 3:414-28. 2011..We introduce the necessary key steps to build these applications and discuss their merits and future extensions for aging research. WIREs Syst Biol Med 2011 3 414-428 DOI: 10.1002/wsbm.126..
System-wide analysis of hepatotoxicological responses: tissomics is keyAndres Kriete
Icoria Inc, Pittsburgh, Pennsylvania, USA
Cytometry A 69:612-9. 2006....
Rule-based cell systems model of aging using feedback loop motifs mediated by stress responsesAndres Kriete
School of Biomedical Engineering, Science and Health Systems, Drexel University, Bossone Research Center, Philadelphia, Pennsylvania, United States of America
PLoS Comput Biol 6:e1000820. 2010..Our work establishes a novel extendable and scalable computational approach capable to connect tractable molecular mechanisms with cellular network dynamics underlying the emerging aging phenotype...- Systems approaches to the networks of agingAndres Kriete
School of Biomedical Engineering, Drexel University, Science and Health System, Chestnut Street 3401, Philadelphia, PA 19104, USA
Ageing Res Rev 5:434-48. 2006..As aging manifests on a systems level, it emerges as a highly networked process regulated through feedback loops between levels of biological organization... - Automated quantification of quantum-dot-labelled epidermal growth factor receptor internalization via multiscale image segmentationA Kriete
School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA 19104, USA
J Microsc 222:22-7. 2006..The capabilities realizable by simultaneous application of confocal imaging and functionalized QDs in conjunction with advanced image analysis are a prerequisite for automated and multiplexed cytomics assays... - Bridging biological scales by state-space analysis and modeling using molecular, tissue cytometric and physiological dataAndres Kriete
School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, Pennsylvania 19104, USA
Cytometry A 69:113-6. 2006..Concepts to statistically identify, correlate, and model relationships across scales are introduced, which rely on a state-space matrix derived by multi-omics data aggregation... - Biomarkers of aging: combinatorial or systems model?Andres Kriete
School of Biomedical Engineering, Science, and Health Systems, Drexel University, Philadelphia, PA 19104, USA
Sci Aging Knowledge Environ 2006:pe1. 2006..Such reverse engineered models not only indicate critical and diagnostic components (that is, potential biomarkers) but also should be able to predict the progression of aging through computer simulation... - Cytomics in the realm of systems biologyAndres Kriete
School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, Pennsylvania 19104, USA
Cytometry A 68:19-20. 2005 - Automated tissue analysis--a bioinformatics perspectiveA Kriete
Icoria, Pittsburgh, PA, USA
Methods Inf Med 44:32-7. 2005..The great potential of synergies between tissue analysis and bioinformatics and its perspectives in medical research and computational diagnostics are discussed... - Phenotypical enrichment strategies for microarray data analysis applied in a type II diabetes studyKeith Boyce
Icoria, Inc, Pittsburgh, Pennsylvania, USA
OMICS 9:251-65. 2005..Evaluation based on ontological classifications proves changes in prioritization of disease-related genes that would have been overlooked by conventional gene expression analyses strategies... - Gene expression analysis enrichedAndres Kriete
Drexel University and Coriell Bioinformatics Initiative, Coriell Institute for Medical Research, 403 Haddon Avenue, Camden, NJ 08103, USA
Drug Discov Today 9:913-4. 2004 - Atypical pathways of NF-kappaB activation and agingAndres Kriete
School of Biomedical Engineering, Science and Health Systems, Drexel University, Bossone Research Center, Philadelphia, PA 19104, USA
Exp Gerontol 44:250-5. 2009..Investigation of mechanisms of NF-kappaB in aging as an important marker of cellular stress provides guidance for the development of a systems view of cellular aging... - Comparing the yeast retrograde response and NF-κB stress responses: implications for agingVisish Srinivasan
Department of Biology, Drexel University, Philadelphia, PA 19104, USA
Aging Cell 9:933-41. 2010..Involvement of NF-κB in chromosomal stability, coregulation of mitochondrial respiration, and cross talk with the TOR (target of rapamycin) pathway points to a conserved mechanism also found in yeast... 
Combined histomorphometric and gene-expression profiling applied to toxicologyAndres Kriete
Tissue Informatics Inc, 711 Bingham Street, Suite 200, Pittsburgh, PA 15203, USA
Genome Biol 4:R32. 2003....- Age-associated loss of selectivity in human olfactory sensory neuronsNancy E Rawson
Monell Chemical Senses Center, Philadelphia, PA, USA
Neurobiol Aging 33:1913-9. 2012..It is also possible that chronic adaptation as a result of reduced specificity contributes to observed declines in absolute sensitivity... - Quantifying gene network connectivity in silico: scalability and accuracy of a modular approachN Yalamanchili
School of Biomedical Engineering and Health Sciences, Drexel University, Philadelphia, PA, USA
Syst Biol (Stevenage) 153:236-46. 2006..By employing a known biochemical network, the accuracy of the modular approach and its sensitivity to key assumptions are evaluated... - Micro-CT of the human lung: imaging of alveoli and virtual endoscopy of an alveolar duct in a normal lung and in a lung with centrilobular emphysema--initial observationsHenrik Watz
Department of Pneumology, University of Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt, Germany
Radiology 236:1053-8. 2005..Normal-size and enlarged alveoli became visible. A three-dimensional reconstruction of the terminal airspaces made virtual endoscopy of the alveolar ducts possible...