Peter D Katsikis

Summary

Affiliation: Drexel University
Country: USA

Publications

  1. pmc Decreased effector memory CD45RA+ CD62L- CD8+ T cells and increased central memory CD45RA- CD62L+ CD8+ T cells in peripheral blood of rheumatoid arthritis patients
    Anastacia Maldonado
    Department of Medicine, Drexel University College of Medicine, Drexel University, Philadelphia, Pennsylvania, USA
    Arthritis Res Ther 5:R91-6. 2003
  2. pmc IL-15 treatment during acute simian immunodeficiency virus (SIV) infection increases viral set point and accelerates disease progression despite the induction of stronger SIV-specific CD8+ T cell responses
    Yvonne M Mueller
    Department of Microbiology and Immunology, and Center for Immunology and Vaccine Science, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    J Immunol 180:350-60. 2008
  3. doi request reprint Dendritic cells and CD28 costimulation are required to sustain virus-specific CD8+ T cell responses during the effector phase in vivo
    Douglas V Dolfi
    Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    J Immunol 186:4599-608. 2011
  4. pmc Late signals from CD27 prevent Fas-dependent apoptosis of primary CD8+ T cells
    Douglas V Dolfi
    Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    J Immunol 180:2912-21. 2008
  5. pmc Type I interferon upregulates Bak and contributes to T cell loss during human immunodeficiency virus (HIV) infection
    Joseph A Fraietta
    Department of Microbiology and Immunology, Center for Immunology and Vaccine Science, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America
    PLoS Pathog 9:e1003658. 2013
  6. ncbi request reprint Actin integrity is indispensable for CD95/Fas-induced apoptosis of HIV-specific CD8+ T cells
    Constantinos Petrovas
    Department of Microbiology and Immunology, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Drexel University, 2900 Queen Lane, Philadelphia, PA 19129, USA
    Apoptosis 12:2175-86. 2007
  7. pmc Early establishment and antigen dependence of simian immunodeficiency virus-specific CD8+ T-cell defects
    Yvonne M Mueller
    Department of Microbiology and Immunology, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PA 19129, USA
    J Virol 81:10861-8. 2007
  8. pmc Memory T cells need CD28 costimulation to remember
    Alina C Boesteanu
    Drexel University College of Medicine, Department of Microbiology and Immunology, 2900 Queen Lane, Philadelphia, PA 19129, United States
    Semin Immunol 21:69-77. 2009
  9. ncbi request reprint Memory CD8+ T cells require CD28 costimulation
    Annie B Borowski
    Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    J Immunol 179:6494-503. 2007
  10. ncbi request reprint HIV-specific CD8+ T cells exhibit markedly reduced levels of Bcl-2 and Bcl-xL
    Constantinos Petrovas
    Departments of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    J Immunol 172:4444-53. 2004

Collaborators

Detail Information

Publications30

  1. pmc Decreased effector memory CD45RA+ CD62L- CD8+ T cells and increased central memory CD45RA- CD62L+ CD8+ T cells in peripheral blood of rheumatoid arthritis patients
    Anastacia Maldonado
    Department of Medicine, Drexel University College of Medicine, Drexel University, Philadelphia, Pennsylvania, USA
    Arthritis Res Ther 5:R91-6. 2003
    ....
  2. pmc IL-15 treatment during acute simian immunodeficiency virus (SIV) infection increases viral set point and accelerates disease progression despite the induction of stronger SIV-specific CD8+ T cell responses
    Yvonne M Mueller
    Department of Microbiology and Immunology, and Center for Immunology and Vaccine Science, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    J Immunol 180:350-60. 2008
    ..Finally, IL-15-treated acutely SIV-infected primates may serve as a useful model to investigate the poorly understood mechanisms that control viral set point and disease progression in HIV infection...
  3. doi request reprint Dendritic cells and CD28 costimulation are required to sustain virus-specific CD8+ T cell responses during the effector phase in vivo
    Douglas V Dolfi
    Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    J Immunol 186:4599-608. 2011
    ..These requirements would greatly impair effector responses against viruses and tumors that are known to inhibit DC maturation and in chronic infections and aging where CD28(-/-) CD8(+) T cells accumulate...
  4. pmc Late signals from CD27 prevent Fas-dependent apoptosis of primary CD8+ T cells
    Douglas V Dolfi
    Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    J Immunol 180:2912-21. 2008
    ....
  5. pmc Type I interferon upregulates Bak and contributes to T cell loss during human immunodeficiency virus (HIV) infection
    Joseph A Fraietta
    Department of Microbiology and Immunology, Center for Immunology and Vaccine Science, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America
    PLoS Pathog 9:e1003658. 2013
    ....
  6. ncbi request reprint Actin integrity is indispensable for CD95/Fas-induced apoptosis of HIV-specific CD8+ T cells
    Constantinos Petrovas
    Department of Microbiology and Immunology, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Drexel University, 2900 Queen Lane, Philadelphia, PA 19129, USA
    Apoptosis 12:2175-86. 2007
    ....
  7. pmc Early establishment and antigen dependence of simian immunodeficiency virus-specific CD8+ T-cell defects
    Yvonne M Mueller
    Department of Microbiology and Immunology, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PA 19129, USA
    J Virol 81:10861-8. 2007
    ....
  8. pmc Memory T cells need CD28 costimulation to remember
    Alina C Boesteanu
    Drexel University College of Medicine, Department of Microbiology and Immunology, 2900 Queen Lane, Philadelphia, PA 19129, United States
    Semin Immunol 21:69-77. 2009
    ..This requirement has important implications for host immunity, vaccine development and immunotherapeutics...
  9. ncbi request reprint Memory CD8+ T cells require CD28 costimulation
    Annie B Borowski
    Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    J Immunol 179:6494-503. 2007
    ..These findings also raise questions about the efficacy of CD8(+) T cell-based vaccines against such pathogens and tumors...
  10. ncbi request reprint HIV-specific CD8+ T cells exhibit markedly reduced levels of Bcl-2 and Bcl-xL
    Constantinos Petrovas
    Departments of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    J Immunol 172:4444-53. 2004
    ..Our data indicate that reduced Bcl-2 and Bcl-x(L) may play an important role in the increased sensitivity to apoptosis of HIV-specific CD8(+) T cells and suggest a possible mechanism by which IL-15 increases their survival...
  11. pmc Increased mitochondrial mass characterizes the survival defect of HIV-specific CD8(+) T cells
    Constantinos Petrovas
    Department of Microbiology and Immunology and Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PA, 19129, USA
    Blood 109:2505-13. 2007
    ....
  12. pmc CD8+ cell depletion of SHIV89.6P-infected macaques induces CD4+ T cell proliferation that contributes to increased viral loads
    Yvonne M Mueller
    Department of Microbiology and Immunology, and Center for Immunology and Vaccine Sciences, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    J Immunol 183:5006-12. 2009
    ....
  13. ncbi request reprint IL-15 enhances the function and inhibits CD95/Fas-induced apoptosis of human CD4+ and CD8+ effector-memory T cells
    Yvonne M Mueller
    Department of Microbiology and Immunology, Drexel University College of Medicine, Drexel University, 2900 Queen Lane, Philadelphia, PA 19129, USA
    Int Immunol 15:49-58. 2003
    ..These findings suggest that in addition to being a growth and survival factor for memory CD8(+) T cells, IL-15 is also a potent activator of human effector-memory CD8(+) T cells both in healthy and in HIV-infected individuals...
  14. ncbi request reprint Complement C5a receptor is essential for the optimal generation of antiviral CD8+ T cell responses
    Alfred H J Kim
    Department of Microbiology and Immunology and Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    J Immunol 173:2524-9. 2004
    ..These results demonstrate that the binding of the C5a component of complement to the C5a receptor plays an important role in CD8(+) T cell responses...
  15. pmc Chronic antigen stimulation alone is sufficient to drive CD8+ T cell exhaustion
    Christine M Bucks
    Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    J Immunol 182:6697-708. 2009
    ..These findings provide a novel insight into the mechanisms that control functional exhaustion of CD8(+) T cells in chronic infection...
  16. ncbi request reprint Bystander chronic infection negatively impacts development of CD8(+) T cell memory
    Erietta Stelekati
    Department of Microbiology, University of Pennsylvania Perelman School Medicine, Philadelphia, PA 19104, USA Institute for Immunology, University of Pennsylvania Perelman School Medicine, Philadelphia, PA 19104, USA
    Immunity 40:801-13. 2014
    ..Thus, exposure to prolonged bystander inflammation impairs the effector to memory transition. These data have relevance for immunity and vaccination during persisting infections and chronic inflammation...
  17. ncbi request reprint CD28 and CD27 costimulation of CD8+ T cells: a story of survival
    Douglas V Dolfi
    Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    Adv Exp Med Biol 590:149-70. 2007
    ....
  18. pmc Interleukin-15 increases effector memory CD8+ t cells and NK Cells in simian immunodeficiency virus-infected macaques
    Yvonne M Mueller
    Department of Microbiology and Immunology and Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, 2900 Queen Ln, Philadelphia, PA 19129, USA
    J Virol 79:4877-85. 2005
    ..The selective expansion of effector memory CD8+ T cells and NK cells by IL-15 further supports IL-15's possible therapeutic use in viral infections such as HIV infection...
  19. ncbi request reprint HIV-specific CD8+ T cells: serial killers condemned to die?
    Constantinos Petrovas
    Department of Microbiology and Immunology, and Institute of Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129, USA
    Curr HIV Res 2:153-62. 2004
    ..Understanding the intrinsic defects of CTL in HIV infection could lead to new therapeutic strategies and optimized vaccination protocols that enhance the HIV-specific cytotoxic response...
  20. pmc The microRNA miR-155 controls CD8(+) T cell responses by regulating interferon signaling
    Donald T Gracias
    Department of Microbiology and Immunology, Center for Immunology and Vaccine Science, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA
    Nat Immunol 14:593-602. 2013
    ..We have thus identified a previously unknown role for miR-155 in regulating responsiveness to interferon and CD8(+) T cell responses to pathogens in vivo...
  21. ncbi request reprint IL-15 enhances survival and function of HIV-specific CD8+ T cells
    Yvonne M Mueller
    Department of Microbiology and Immunology, Drexel University College of Medicine, Drexel University, Philadelphia, PA 19129, USA
    Blood 101:1024-9. 2003
    ..Thus, IL-15 potently enhances the survival and effector function of HIV-specific CD8(+) T cells and, therefore, may prove useful in augmenting the antiviral function of these cells...
  22. pmc The cytokine network of acute HIV infection: a promising target for vaccines and therapy to reduce viral set-point?
    Peter D Katsikis
    Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America
    PLoS Pathog 7:e1002055. 2011
    ....
  23. pmc Phosphorothioate 2' deoxyribose oligomers as microbicides that inhibit human immunodeficiency virus type 1 (HIV-1) infection and block Toll-like receptor 7 (TLR7) and TLR9 triggering by HIV-1
    Joseph A Fraietta
    Department of Microbiology and Immunology, Center for Immunology and Vaccine Science, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129, USA
    Antimicrob Agents Chemother 54:4064-73. 2010
    ..Phosphorothioate 2' deoxyribose oligomers may therefore be promising microbicide candidates that inhibit HIV-1 infection and also dampen the inflammation which is critical for the initial spread of the virus...
  24. pmc Costimulation signals for memory CD8+ T cells during viral infections
    Priyanka A Duttagupta
    Department of Microbiology and Immunology and Center for Immunology and Vaccine Science, Drexel University College of Medicine, Philadelphia, PA, USA
    Crit Rev Immunol 29:469-86. 2009
    ..Understanding the costimulatory requirements of memory CD8+ T cells, therefore, may lead to improved vaccines that target anti-viral CD8+ T-cell memory...
  25. ncbi request reprint Age-associated decrease in virus-specific CD8+ T lymphocytes during primary influenza infection
    John Leander Z Po
    Department of Microbiology and Immunology, MCP Hahnemann School of Medicine, 2900 Queen Lane, Philadelphia, PA 19129, USA
    Mech Ageing Dev 123:1167-81. 2002
    ..These data suggest that the age-related impairment of CD8+ lymphocyte activity during a primary influenza A infection is due to a defect in the expansion, rather than in effector activity, of influenza-specific CD8+ T cells...
  26. doi request reprint The inflammasome activating caspase 1 mediates fibrosis and myofibroblast differentiation in systemic sclerosis
    Carol M Artlett
    Drexel University College of Medicine, Philadelphia, Pennsylvania, USA
    Arthritis Rheum 63:3563-74. 2011
    ..This study was undertaken to assess the role of the inflammasome in SSc-related dermal or pulmonary fibrosis...
  27. pmc Biopolymer encapsulated live influenza virus as a universal CD8+ T cell vaccine against influenza virus
    Alina C Boesteanu
    Department of Microbiology and Immunology, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PA 19129, USA
    Vaccine 29:314-22. 2010
    ..Biopolymer encapsulation of live influenza virus could be used to develop universal CD8+ T cell vaccines against heterosubtypic and pandemic strains...
  28. doi request reprint IL-15 in HIV infection: pathogenic or therapeutic potential?
    Yvonne M Mueller
    Department of Microbiology and Immunology, and Center for Immunology and Vaccine Sciences, Drexel University College of Medicine, Philadelphia, PA, USA
    Eur Cytokine Netw 21:219-21. 2010
    ..Understanding IL-15's role in SIV infection may help us to design novel therapeutic approaches to HIV infection...
  29. ncbi request reprint T-cell and neuronal apoptosis in HIV infection: implications for therapeutic intervention
    Emmanuel G Regulier
    Center for Neurovirology and Cancer Biology, Temple University, Philadelphia, Pennsylvania 19122, USA
    Int Rev Immunol 23:25-59. 2004
    ..In this review, the mechanisms involved in T-cell and neuronal apoptosis, as well as antiapoptotic pathways potentially amenable to therapeutic application, are discussed...
  30. ncbi request reprint In vivo stimulation of CD137 broadens primary antiviral CD8+ T cell responses
    E Scott Halstead
    Department of Microbiology and Immunology, MCP Hahnemann University, Philadelphia, PA, USA
    Nat Immunol 3:536-41. 2002
    ..This suggests that CD137 stimulation may be useful as a strategy to enhance the CD8+ T cell response to viruses...