Pooja Jain

Summary

Affiliation: Drexel University College of Medicine
Country: USA

Publications

  1. pmc HTLV-1 Tax mediated downregulation of miRNAs associated with chromatin remodeling factors in T cells with stably integrated viral promoter
    Saifur Rahman
    Department of Microbiology and Immunology, Drexel Institute for Biotechnology and Virology Research, College of Medicine, Drexel University, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 7:e34490. 2012
  2. pmc Cotranscriptional Chromatin Remodeling by Small RNA Species: An HTLV-1 Perspective
    Nishat Aliya
    Department of Microbiology and Immunology, Drexel Institute for Biotechnology and Virology Research, Drexel University College of Medicine, 3805 Old Easton Road, Doylestown, PA 18902, USA
    Leuk Res Treatment 2012:984754. 2012
  3. pmc Unique and differential protein signatures within the mononuclear cells of HIV-1 and HCV mono-infected and co-infected patients
    Nawal M Boukli
    Department of Microbiology and Immunology, and the Drexel Institute for Biotechnology and Virology Research, Drexel University College of Medicine, 3805 Old Easton Road, Doylestown, PA, USA
    Clin Proteomics 9:11. 2012
  4. pmc Alpha4beta1 integrin mediates the recruitment of immature dendritic cells across the blood-brain barrier during experimental autoimmune encephalomyelitis
    Pooja Jain
    Department of Microbiology and Immunology and Drexel Institute for Biotechnology and Virology Research, Drexel University College of Medicine, Doylestown, PA 18902, USA
    J Immunol 184:7196-206. 2010
  5. ncbi request reprint Identification of human T cell leukemia virus type 1 tax amino acid signals and cellular factors involved in secretion of the viral oncoprotein
    Pooja Jain
    Department of Microbiology and Immunology, Center for Molecular Virology and Neuroimmunology, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PA 19129, USA
    J Biol Chem 282:34581-93. 2007
  6. pmc Presentation of human T cell leukemia virus type 1 (HTLV-1) Tax protein by dendritic cells: the underlying mechanism of HTLV-1-associated neuroinflammatory disease
    Sharron L Manuel
    Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, PA 19102, USA
    J Leukoc Biol 86:1205-16. 2009
  7. ncbi request reprint Use of human antigen presenting cell gene array profiling to examine the effect of human T-cell leukemia virus type 1 Tax on primary human dendritic cells
    Jaya Ahuja
    Department of Microbiology and Immunology, Institute for Molecular Medicine and Infectious Disease, Center for Molecular Virology and Neuroimmunology, Center for Cancer Biology, Drexel University College of Medicine, Philadelphia, PA 19102, USA
    J Neurovirol 12:47-59. 2006
  8. pmc Modulation of dendritic cell maturation and function by the Tax protein of human T cell leukemia virus type 1
    Pooja Jain
    Department of Microbiology and Immunology, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PA 19129, USA
    J Leukoc Biol 82:44-56. 2007
  9. pmc Depletion of dendritic cells enhances susceptibility to cell-free infection of human T cell leukemia virus type 1 in CD11c-diphtheria toxin receptor transgenic mice
    Saifur Rahman
    Drexel Institute for Biotechnology and Virology Research, Drexel University College of Medicine, Philadelphia, PA 19127, USA
    J Immunol 184:5553-61. 2010
  10. pmc DC-SIGN mediates cell-free infection and transmission of human T-cell lymphotropic virus type 1 by dendritic cells
    Pooja Jain
    Department of Microbiology and Immunology, Institute of Molecular Medicine and Infectious Disease, Drexel University College of Medicine, New College Building, Rm 18311, 245 N 15th St, Philadelphia, PA 19102, USA
    J Virol 83:10908-21. 2009

Collaborators

Detail Information

Publications27

  1. pmc HTLV-1 Tax mediated downregulation of miRNAs associated with chromatin remodeling factors in T cells with stably integrated viral promoter
    Saifur Rahman
    Department of Microbiology and Immunology, Drexel Institute for Biotechnology and Virology Research, College of Medicine, Drexel University, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 7:e34490. 2012
    ..Overall, these results are first in line establishing HTLV-1/Tax-miRNA-chromatin concept and open new avenues toward understanding retroviral latency and/or replication in a given cell type...
  2. pmc Cotranscriptional Chromatin Remodeling by Small RNA Species: An HTLV-1 Perspective
    Nishat Aliya
    Department of Microbiology and Immunology, Drexel Institute for Biotechnology and Virology Research, Drexel University College of Medicine, 3805 Old Easton Road, Doylestown, PA 18902, USA
    Leuk Res Treatment 2012:984754. 2012
    ..Herein we explore the possible interplay between HTLV-1 infection and miRNA pathways resulting in chromatin reorganization as one of the mechanisms determining HTLV-1 cell specificity and viral fate in different cell types...
  3. pmc Unique and differential protein signatures within the mononuclear cells of HIV-1 and HCV mono-infected and co-infected patients
    Nawal M Boukli
    Department of Microbiology and Immunology, and the Drexel Institute for Biotechnology and Virology Research, Drexel University College of Medicine, 3805 Old Easton Road, Doylestown, PA, USA
    Clin Proteomics 9:11. 2012
    ..abstract:..
  4. pmc Alpha4beta1 integrin mediates the recruitment of immature dendritic cells across the blood-brain barrier during experimental autoimmune encephalomyelitis
    Pooja Jain
    Department of Microbiology and Immunology and Drexel Institute for Biotechnology and Virology Research, Drexel University College of Medicine, Doylestown, PA 18902, USA
    J Immunol 184:7196-206. 2010
    ..Thus therapeutic targeting of alpha4 integrins affects DC trafficking into the CNS and may therefore lead to the resolution of the CNS autoimmune inflammation by reducing the number of CNS professional APCs...
  5. ncbi request reprint Identification of human T cell leukemia virus type 1 tax amino acid signals and cellular factors involved in secretion of the viral oncoprotein
    Pooja Jain
    Department of Microbiology and Immunology, Center for Molecular Virology and Neuroimmunology, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PA 19129, USA
    J Biol Chem 282:34581-93. 2007
    ....
  6. pmc Presentation of human T cell leukemia virus type 1 (HTLV-1) Tax protein by dendritic cells: the underlying mechanism of HTLV-1-associated neuroinflammatory disease
    Sharron L Manuel
    Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, PA 19102, USA
    J Leukoc Biol 86:1205-16. 2009
    ..Our studies clearly establish a role for this important immune cell component in HTLV-1 immuno/neuropathogenesis and suggest that modulation of DC functions could be an important tool for therapeutic interventions...
  7. ncbi request reprint Use of human antigen presenting cell gene array profiling to examine the effect of human T-cell leukemia virus type 1 Tax on primary human dendritic cells
    Jaya Ahuja
    Department of Microbiology and Immunology, Institute for Molecular Medicine and Infectious Disease, Center for Molecular Virology and Neuroimmunology, Center for Cancer Biology, Drexel University College of Medicine, Philadelphia, PA 19102, USA
    J Neurovirol 12:47-59. 2006
    ..These results have suggested that Tax-mediated DC gene regulation might play a critical role in cellular activation and the mechanisms resulting in HTLV-1-induced disease...
  8. pmc Modulation of dendritic cell maturation and function by the Tax protein of human T cell leukemia virus type 1
    Pooja Jain
    Department of Microbiology and Immunology, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PA 19129, USA
    J Leukoc Biol 82:44-56. 2007
    ....
  9. pmc Depletion of dendritic cells enhances susceptibility to cell-free infection of human T cell leukemia virus type 1 in CD11c-diphtheria toxin receptor transgenic mice
    Saifur Rahman
    Drexel Institute for Biotechnology and Virology Research, Drexel University College of Medicine, Philadelphia, PA 19127, USA
    J Immunol 184:5553-61. 2010
    ....
  10. pmc DC-SIGN mediates cell-free infection and transmission of human T-cell lymphotropic virus type 1 by dendritic cells
    Pooja Jain
    Department of Microbiology and Immunology, Institute of Molecular Medicine and Infectious Disease, Drexel University College of Medicine, New College Building, Rm 18311, 245 N 15th St, Philadelphia, PA 19102, USA
    J Virol 83:10908-21. 2009
    ....
  11. pmc Murine FLT3 ligand-derived dendritic cell-mediated early immune responses are critical to controlling cell-free human T cell leukemia virus type 1 infection
    Saifur Rahman
    Drexel Institute for Biotechnology and Virology Research, Doylestown, PA 18902, USA
    J Immunol 186:390-402. 2011
    ..Overall, these results highlight the critical early responses generated by FL-DCs on challenge with cell-free chimeric HTLV-1...
  12. pmc Lack of recall response to Tax in ATL and HAM/TSP patients but not in asymptomatic carriers of human T-cell leukemia virus type 1
    Sharron L Manuel
    Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA, 19104, USA
    J Clin Immunol 33:1223-39. 2013
    ....
  13. pmc Role of resident CNS cell populations in HTLV-1-associated neuroinflammatory disease
    Veronique Lepoutre
    Department of Microbiology and Immunology, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, Pennsylvania 19102, USA
    Front Biosci (Landmark Ed) 14:1152-68. 2009
    ..This comprehensive review characterizes the available knowledge to date concerning the effects of HTLV-1 on CNS resident cell populations with emphasis on both viral and host factors contributing to the genesis of HAM/TSP...
  14. pmc A novel high throughput quantum dot-based fluorescence assay for quantitation of virus binding and attachment
    Karan Kampani
    Department of Microbiology and Immunology, Institute for Molecular Medicine and Infectious Disease, Center for Molecular Virology and Neuroimmunology, Center for Cancer Biology, Drexel University College of Medicine, Philadelphia, PA 19102, USA
    J Virol Methods 141:125-32. 2007
    ....
  15. ncbi request reprint CCAAT/enhancer-binding proteins modulate human T cell leukemia virus type 1 long terminal repeat activation
    Christian Grant
    Department of Microbiology and Immunology, The Pennsylvania State University, College of Medicine, Hershey, 17033, USA
    Virology 348:354-69. 2006
    ..Inhibition of Tax-mediated transactivation of the HTLV-1 LTR was co-activator-independent, did not require C/EBP binding to the Tax-responsive elements, and may involve heterodimerization with CREB factors...
  16. pmc An altered maturation and adhesion phenotype of dendritic cells in diseased individuals compared to asymptomatic carriers of human T cell leukemia virus type 1
    Sharron L Manuel
    Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA
    AIDS Res Hum Retroviruses 29:1273-85. 2013
    ....
  17. pmc Dendritic cell CNS recruitment correlates with disease severity in EAE via CCL2 chemotaxis at the blood-brain barrier through paracellular transmigration and ERK activation
    Divya Sagar
    Drexel Institute for Biotechnology and Virology Research and Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    J Neuroinflammation 9:245. 2012
    ..Chemokine ligand 2 (CCL2) is a potent chemoattractant known to be secreted by the BBB but has not been implicated in the recruitment of DCs specifically at the BBB...
  18. ncbi request reprint Regulation of human T-cell leukemia virus type 1 gene expression by Sp1 and Sp3 interaction with TRE-1 repeat III
    Jing Yao
    Department of Microbiology and Immunology, College of Medicine, The Pennsylvania State University, Hershey, Pennsylvania, USA
    DNA Cell Biol 25:262-76. 2006
    ..These results suggest that both Sp1 and Sp3 transcription factor binding to TRE-1 repeat III participate in regulation of HTLV-1 viral gene expression...
  19. pmc Induction of pro-inflammatory cytokines by human T-cell leukemia virus type-1 Tax protein as determined by multiplexed cytokine protein array analyses of human dendritic cells
    Jaya Ahuja
    Department of Microbiology and Immunology, Center for Cancer Biology, Institute of Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, PA 19102, USA
    Biomed Pharmacother 61:201-8. 2007
    ..Collectively, these findings suggest a role for Tax-induced cytokine secretion from MDDCs, which may be critical for the cellular activation and tissue damage that has been observed in HAM/TSP...
  20. pmc In vivo immunogenicity of Tax(11-19) epitope in HLA-A2/DTR transgenic mice: implication for dendritic cell-based anti-HTLV-1 vaccine
    Divya Sagar
    Department of Microbiology and Immunology, Drexel Institute for Biotechnology and Virology Research, Drexel University College of Medicine, Philadelphia, PA, USA
    Vaccine 32:3274-84. 2014
    ..Thus, Tax(11-19) epitope is a potential candidate for the DC-based anti-HTLV-1 vaccine and the newly hybrid mouse strain could be used for investigating DC involvement in human class-I-restricted immune responses. ..
  21. ncbi request reprint Dendritic cells in autoimmune diseases and neuroinflammatory disorders
    Sharron L Manuel
    Department of Microbiology and Immunology, Center for Cancer Biology, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, Pennsylvania 19102, USA
    Front Biosci 12:4315-35. 2007
    ..Overall, the goal of this review is to establish DCs in the interface of tolerance and autoimmunity and generate a global interest in this field in order to exploit DC potential for the therapy of inflammatory diseases...
  22. pmc Investigation of plasma biomarkers in HIV-1/HCV mono- and coinfected individuals by multiplex iTRAQ quantitative proteomics
    Vivekananda Shetty
    Immunotope, Inc, Pennsylvania Biotechnology Center, Doylestown, Pennsylvania, USA
    OMICS 15:705-17. 2011
    ..Thus, we identified several differentially regulated proteins in HIV-1/HCV mono and coinfected plasma samples that may be potential biomarkers for liver disease...
  23. ncbi request reprint Human T-cell leukemia virus type I Tax induces the expression of dendritic cell markers associated with maturation and activation
    Kate Mostoller
    Department of Microbiology and Immunology, The Pennsylvania State University, College of Medicine, Hershey, Pennsylvania, USA
    J Neurovirol 10:358-71. 2004
    ..The implication of the experimental results with respect to the generation of a Tax-specific CTL compartment that participates in the genesis of HAM/TSP is discussed...
  24. pmc Effect of morphine and SIV on dendritic cell trafficking into the central nervous system of rhesus macaques
    Rebecca Hollenbach
    Department of Microbiology and Immunology, and the Drexel Institute for Biotechnology and Virology Research, Drexel University College of Medicine, 3805 Old Easton Road, Doylestown, PA, 18902, USA
    J Neurovirol 20:175-83. 2014
    ..Control animals did not exhibit any DC presence in their brains. These results provide first evidence of DCs' relevance in NeuroAIDS vis-à-vis drugs of abuse and open new avenues of understanding and investigative HIV-CNS inflictions. ..
  25. pmc Epigenetics, drugs of abuse, and the retroviral promoter
    Jasmine Shirazi
    Department of Microbiology and Immunology, Drexel Institute for Biotechnology and Virology Research, Drexel University College of Medicine, 3805 Old Easton Road, Doylestown, PA, 18902, USA
    J Neuroimmune Pharmacol 8:1181-96. 2013
    ....
  26. doi request reprint The tug-of-war between dendritic cells and human chronic viruses
    Saifur Rahman
    Department of Microbiology and Immunology, Drexel Institute for Biotechnology and Virology Research, Drexel University College of Medicine, 3805 Old Easton Road, Doylestown, PA 18902, USA
    Int Rev Immunol 30:341-65. 2011
    ..This review focuses on the interaction of different chronic viruses with dendritic cells and the viruses' ability to exploit this critical cell type to their advantage so as to establish persistence within the host...
  27. pmc Mechanisms of dendritic cell trafficking across the blood-brain barrier
    Divya Sagar
    Drexel Institute for Biotechnology and Virology Research, and Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    J Neuroimmune Pharmacol 7:74-94. 2012
    ..Overall, information provided will bring this important leukocyte population to the forefront as key players in the immune cascade in the light of the emerging contribution of DCs to CNS health and disease...

Research Grants3

  1. Define the role of dendritic cells in HTLV-1 associated neuroinflammatory disease
    Pooja Jain; Fiscal Year: 2009
    ..Additionally the results of these studies will shed light on the dynamics of immune cell interactions during chronic viral infections such as HTLV-1, HIV-1, hepatitis virus and herpes simplex virus. ..
  2. Define the role of dendritic cells in HTLV-1 associated neuroinflammatory disease
    Pooja Jain; Fiscal Year: 2010
    ..Additionally the results of these studies will shed light on the dynamics of immune cell interactions during chronic viral infections such as HTLV-1, HIV-1, hepatitis virus and herpes simplex virus. ..
  3. Define the role of dendritic cells in HTLV-1 associated neuroinflammatory disease
    Pooja Jain; Fiscal Year: 2011
    ..Additionally the results of these studies will shed light on the dynamics of immune cell interactions during chronic viral infections such as HTLV-1, HIV-1, hepatitis virus and herpes simplex virus. ..