Wen Jun Gao

Summary

Affiliation: Drexel University
Country: USA

Publications

  1. ncbi request reprint NMDA receptor-mediated epileptiform persistent activity requires calcium release from intracellular stores in prefrontal neurons
    Wen Jun Gao
    Department of Neurobiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA
    Exp Neurol 197:495-504. 2006
  2. ncbi request reprint Acute clozapine suppresses synchronized pyramidal synaptic network activity by increasing inhibition in the ferret prefrontal cortex
    Wen Jun Gao
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PA 19129, USA
    J Neurophysiol 97:1196-208. 2007
  3. ncbi request reprint Dopamine modulation of perisomatic and peridendritic inhibition in prefrontal cortex
    Wen Jun Gao
    Department of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Neurosci 23:1622-30. 2003
  4. doi request reprint Dopamine D(1) receptor-mediated enhancement of NMDA receptor trafficking requires rapid PKC-dependent synaptic insertion in the prefrontal neurons
    Yan Chun Li
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129, USA
    J Neurochem 114:62-73. 2010
  5. pmc Dopamine D1 receptor-mediated NMDA receptor insertion depends on Fyn but not Src kinase pathway in prefrontal cortical neurons
    Jian Li Hu
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    Mol Brain 3:20. 2010
  6. pmc Group II metabotropic glutamate receptor agonist LY379268 regulates AMPA receptor trafficking in prefrontal cortical neurons
    Min Juan Wang
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA
    PLoS ONE 8:e61787. 2013
  7. pmc Hyperdopaminergic modulation of inhibitory transmission is dependent on GSK-3β signaling-mediated trafficking of GABAA receptors
    Yan Chun Li
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA
    J Neurochem 122:308-20. 2012
  8. pmc Selective modulation of excitatory and inhibitory microcircuits by dopamine
    Wen Jun Gao
    Department of Neurobiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 100:2836-41. 2003
  9. pmc Prolonged exposure to NMDAR antagonist induces cell-type specific changes of glutamatergic receptors in rat prefrontal cortex
    Huai Xing Wang
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    Neuropharmacology 62:1808-22. 2012
  10. pmc Dizocilpine (MK-801) induces distinct changes of N-methyl-D-aspartic acid receptor subunits in parvalbumin-containing interneurons in young adult rat prefrontal cortex
    Dong Xi
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    Int J Neuropsychopharmacol 12:1395-408. 2009

Collaborators

Detail Information

Publications26

  1. ncbi request reprint NMDA receptor-mediated epileptiform persistent activity requires calcium release from intracellular stores in prefrontal neurons
    Wen Jun Gao
    Department of Neurobiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA
    Exp Neurol 197:495-504. 2006
    ..Our findings also raise the possibility that intracellular calcium release may be involved in the generation of pathologic synchronized activity in epilepsy in vivo and in physiological forms of synchronized cortical activity...
  2. ncbi request reprint Acute clozapine suppresses synchronized pyramidal synaptic network activity by increasing inhibition in the ferret prefrontal cortex
    Wen Jun Gao
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PA 19129, USA
    J Neurophysiol 97:1196-208. 2007
    ....
  3. ncbi request reprint Dopamine modulation of perisomatic and peridendritic inhibition in prefrontal cortex
    Wen Jun Gao
    Department of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Neurosci 23:1622-30. 2003
    ..These findings provide evidence for both a dual mode of inhibition in prefrontal circuitry and circuit-dependent modulation by dopamine...
  4. doi request reprint Dopamine D(1) receptor-mediated enhancement of NMDA receptor trafficking requires rapid PKC-dependent synaptic insertion in the prefrontal neurons
    Yan Chun Li
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129, USA
    J Neurochem 114:62-73. 2010
    ..Although both PKA and PKC mediate the D(1)-induced enhancement of NMDA receptors, the phospholipase C-PKC-Src pathway is only required for surface expression and new synaptic insertion of NMDA receptors...
  5. pmc Dopamine D1 receptor-mediated NMDA receptor insertion depends on Fyn but not Src kinase pathway in prefrontal cortical neurons
    Jian Li Hu
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    Mol Brain 3:20. 2010
    ..The aim of the work reported here is to explore the signaling pathway underlying D1 receptor-mediated trafficking of NMDA receptors in cultured rat prefrontal cortical neurons...
  6. pmc Group II metabotropic glutamate receptor agonist LY379268 regulates AMPA receptor trafficking in prefrontal cortical neurons
    Min Juan Wang
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA
    PLoS ONE 8:e61787. 2013
    ....
  7. pmc Hyperdopaminergic modulation of inhibitory transmission is dependent on GSK-3β signaling-mediated trafficking of GABAA receptors
    Yan Chun Li
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA
    J Neurochem 122:308-20. 2012
    ..The GSK-3β signaling pathway is involved in DA-induced decrease in BIG2-dependent insertion and an increase in the dynamin-dependent internalization of GABAA receptors, which results in suppression of inhibitory synaptic transmission...
  8. pmc Selective modulation of excitatory and inhibitory microcircuits by dopamine
    Wen Jun Gao
    Department of Neurobiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 100:2836-41. 2003
    ..Thus, dopamine's net inhibitory effect on cortical function is remarkably constrained by the nature of the microcircuit elements on which it acts...
  9. pmc Prolonged exposure to NMDAR antagonist induces cell-type specific changes of glutamatergic receptors in rat prefrontal cortex
    Huai Xing Wang
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    Neuropharmacology 62:1808-22. 2012
    ....
  10. pmc Dizocilpine (MK-801) induces distinct changes of N-methyl-D-aspartic acid receptor subunits in parvalbumin-containing interneurons in young adult rat prefrontal cortex
    Dong Xi
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    Int J Neuropsychopharmacol 12:1395-408. 2009
    ....
  11. pmc Distinct age-dependent effects of methylphenidate on developing and adult prefrontal neurons
    Kimberly R Urban
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129, USA
    Biol Psychiatry 72:880-8. 2012
    ..A clinically relevant dose range for rodents has been established in the adult animal; however, how this range will translate to juvenile animals has not been established...
  12. pmc Group II metabotropic glutamate receptor agonist ameliorates MK801-induced dysfunction of NMDA receptors via the Akt/GSK-3β pathway in adult rat prefrontal cortex
    Dong Xi
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    Neuropsychopharmacology 36:1260-74. 2011
    ....
  13. pmc Treatment with a clinically-relevant dose of methylphenidate alters NMDA receptor composition and synaptic plasticity in the juvenile rat prefrontal cortex
    Kimberly R Urban
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    Neurobiol Learn Mem 101:65-74. 2013
    ..Furthermore, since a single dosage resulted in significant changes in NMDA receptors, off-label usage by healthy individuals, especially children and adolescents, may result in altered potential for plastic learning...
  14. pmc Activation of glycogen synthase kinase-3 beta is required for hyperdopamine and D2 receptor-mediated inhibition of synaptic NMDA receptor function in the rat prefrontal cortex
    Yan Chun Li
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129, USA
    J Neurosci 29:15551-63. 2009
    ....
  15. pmc Cell type-specific development of NMDA receptors in the interneurons of rat prefrontal cortex
    Huai Xing Wang
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    Neuropsychopharmacology 34:2028-40. 2009
    ..These properties may make FS cells particularly sensitive and vulnerable to epigenetic stimulation, thus contributing to the onset of many psychiatric disorders, including schizophrenia...
  16. pmc D2 receptor overexpression in the striatum leads to a deficit in inhibitory transmission and dopamine sensitivity in mouse prefrontal cortex
    Yan Chun Li
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    Proc Natl Acad Sci U S A 108:12107-12. 2011
    ....
  17. pmc Development of calcium-permeable AMPA receptors and their correlation with NMDA receptors in fast-spiking interneurons of rat prefrontal cortex
    Huai Xing Wang
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PA 19129, USA
    J Physiol 588:2823-38. 2010
    ....
  18. pmc A specialized NMDA receptor function in layer 5 recurrent microcircuitry of the adult rat prefrontal cortex
    Huaixing Wang
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    Proc Natl Acad Sci U S A 105:16791-6. 2008
    ..The NR2B-rich synapses in the prefrontal circuitry may be critically implicated in online cognitive computations and plasticity in learning, as well as psychiatric disorders...
  19. pmc Gestational methylazoxymethanol exposure leads to NMDAR dysfunction in hippocampus during early development and lasting deficits in learning
    Melissa A Snyder
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    Neuropsychopharmacology 38:328-40. 2013
    ..These changes may be involved in disease initiation and cognitive impairment in the early stage of SZ...
  20. pmc Experimental strategies for investigating psychostimulant drug actions and prefrontal cortical function in ADHD and related attention disorders
    Kara L Agster
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129, USA
    Anat Rec (Hoboken) 294:1698-712. 2011
    ....
  21. pmc GSK-3β activity and hyperdopamine-dependent behaviors
    Yan Chun Li
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PA 19129, USA
    Neurosci Biobehav Rev 35:645-54. 2011
    ..We discuss the relevance of the Akt/GSK-3β signaling cascade for the expression of dopamine-dependent behaviors and the drug actions associated with dopaminergic systems...
  22. pmc Heterogeneous organization of the locus coeruleus projections to prefrontal and motor cortices
    Daniel J Chandler
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129
    Proc Natl Acad Sci U S A 111:6816-21. 2014
    ....
  23. pmc NMDA receptor subunit expression in GABAergic interneurons in the prefrontal cortex: application of laser microdissection technique
    Dong Xi
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PA 19129, United States
    J Neurosci Methods 176:172-81. 2009
    ..This approach provides the means to analyze relevant molecular mechanisms that are involved in the neuropathological process of a devastating brain disorder...
  24. pmc Methylphenidate and the juvenile brain: enhancement of attention at the expense of cortical plasticity?
    Kimberly R Urban
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, United States
    Med Hypotheses 81:988-94. 2013
    ....
  25. pmc NMDA hypofunction as a convergence point for progression and symptoms of schizophrenia
    Melissa A Snyder
    Department of Neurobiology and Anatomy, Drexel University College of Medicine Philadelphia, PA, USA
    Front Cell Neurosci 7:31. 2013
    ....
  26. ncbi request reprint Target-specific differences in somatodendritic morphology of layer V pyramidal neurons in rat motor cortex
    Wen Jun Gao
    Institute of Neuroscience formerly Shanghai Brain Research Institute, Chinese Academy of Sciences, Shanghai 200031, China
    J Comp Neurol 476:174-85. 2004
    ....