Manuel A Castro-Alamancos

Summary

Affiliation: Drexel University College of Medicine
Country: USA

Publications

  1. doi request reprint Cortical up and activated states: implications for sensory information processing
    Manuel A Castro-Alamancos
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129, USA
    Neuroscientist 15:625-34. 2009
  2. ncbi request reprint Area-specific resonance of excitatory networks in neocortex: control by outward currents
    Manuel A Castro-Alamancos
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PA 19129, U S A
    Epilepsia 48:1572-84. 2007
  3. ncbi request reprint Vibrissa myoclonus (rhythmic retractions) driven by resonance of excitatory networks in motor cortex
    Manuel A Castro-Alamancos
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PA 19129, USA
    J Neurophysiol 96:1691-8. 2006
  4. pmc Detection of low salience whisker stimuli requires synergy of tectal and thalamic sensory relays
    Jeremy D Cohen
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129, USA
    J Neurosci 30:2245-56. 2010
  5. pmc Influence of subcortical inhibition on barrel cortex receptive fields
    Akio Hirata
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, 2900 Queen Ln, Philadelphia, PA 19129, USA
    J Neurophysiol 102:437-50. 2009
  6. ncbi request reprint Absence of rapid sensory adaptation in neocortex during information processing states
    Manuel A Castro-Alamancos
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    Neuron 41:455-64. 2004
  7. pmc Neocortex network activation and deactivation states controlled by the thalamus
    Akio Hirata
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PA 19129, USA
    J Neurophysiol 103:1147-57. 2010
  8. pmc Neural correlates of active avoidance behavior in superior colliculus
    Jeremy D Cohen
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129, USA
    J Neurosci 30:8502-11. 2010
  9. pmc Resonance (approximately 10 Hz) of excitatory networks in motor cortex: effects of voltage-dependent ion channel blockers
    Manuel A Castro-Alamancos
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PA 19129, USA
    J Physiol 578:173-91. 2007
  10. pmc Synaptic cooperativity regulates persistent network activity in neocortex
    Morgana Favero
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129, USA
    J Neurosci 33:3151-63. 2013

Research Grants

  1. Dynamics of thalamo-cortico-thalamic networks
    MANUEL CASTRO ALAMANCOS; Fiscal Year: 2004
  2. Excitatory Network Oscillations in Somatosensory and Motor Areas of Neocortex
    Manuel A Castro Alamancos; Fiscal Year: 2010
  3. Sensory pathways for conditioned stimulus detection during avoidance behavior
    Manuel A Castro Alamancos; Fiscal Year: 2010
  4. Excitatory Network Oscillations in Somatosensory and Motor Areas of Neocortex
    MANUEL CASTRO ALAMANCOS; Fiscal Year: 2009
  5. Sensory pathways for conditioned stimulus detection during avoidance behavior
    MANUEL CASTRO ALAMANCOS; Fiscal Year: 2009
  6. Dynamics of thalamo-cortico-thalamic networks
    MANUEL CASTRO ALAMANCOS; Fiscal Year: 2007
  7. Dynamics of thalamo-cortico-thalamic networks
    MANUEL CASTRO ALAMANCOS; Fiscal Year: 2006
  8. Dynamics of thalamo-cortico-thalamic networks
    MANUEL CASTRO ALAMANCOS; Fiscal Year: 2005
  9. Sensory pathways for conditioned stimulus detection during avoidance behavior
    Manuel A Castro Alamancos; Fiscal Year: 2011

Collaborators

  • Jeremy D Cohen
  • MANUEL CASTRO ALAMANCOS
  • Manuel A Castro Alamancos
  • Akio Hirata
  • Tatiana Bezdudnaya
  • Morgana Favero
  • Pavlos Rigas
  • Juan Aguilar
  • Juan R Aguilar
  • Gladis Varghese

Detail Information

Publications32

  1. doi request reprint Cortical up and activated states: implications for sensory information processing
    Manuel A Castro-Alamancos
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129, USA
    Neuroscientist 15:625-34. 2009
    ..The excitability of cortical cells and synaptic networks is impacted by up states. This review describes the characteristics and putative functional role of up states and their similarity with activated states...
  2. ncbi request reprint Area-specific resonance of excitatory networks in neocortex: control by outward currents
    Manuel A Castro-Alamancos
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PA 19129, U S A
    Epilepsia 48:1572-84. 2007
    ..The results reveal that the propensity of distinct excitatory networks of neocortex to generate epileptiform oscillatory activities is controlled by outward currents...
  3. ncbi request reprint Vibrissa myoclonus (rhythmic retractions) driven by resonance of excitatory networks in motor cortex
    Manuel A Castro-Alamancos
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PA 19129, USA
    J Neurophysiol 96:1691-8. 2006
    ..Such motor output may be primarily expressed during abnormal states such as those related to cortical myoclonous, tremors, and cortical seizures...
  4. pmc Detection of low salience whisker stimuli requires synergy of tectal and thalamic sensory relays
    Jeremy D Cohen
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129, USA
    J Neurosci 30:2245-56. 2010
    ..We conclude that detection of low salient stimuli is achieved by a sparse neural code distributed through multiple sensory relays...
  5. pmc Influence of subcortical inhibition on barrel cortex receptive fields
    Akio Hirata
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, 2900 Queen Ln, Philadelphia, PA 19129, USA
    J Neurophysiol 102:437-50. 2009
    ..This transient adaptation caused by subcortical inhibition recovers within a few stimuli and gives way to a steady-state adaptation that is independent of subcortical inhibition...
  6. ncbi request reprint Absence of rapid sensory adaptation in neocortex during information processing states
    Manuel A Castro-Alamancos
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    Neuron 41:455-64. 2004
    ..The primary sensory thalamocortical pathway of alert and expectant animals is in the adapted state, which may be required for adequate sensory information processing...
  7. pmc Neocortex network activation and deactivation states controlled by the thalamus
    Akio Hirata
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PA 19129, USA
    J Neurophysiol 103:1147-57. 2010
    ....
  8. pmc Neural correlates of active avoidance behavior in superior colliculus
    Jeremy D Cohen
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129, USA
    J Neurosci 30:8502-11. 2010
    ..Therefore, a robust neural correlate of active avoidance behavior is found in the superior colliculus, emphasizing its role in the detection of salient sensory signals that require immediate action...
  9. pmc Resonance (approximately 10 Hz) of excitatory networks in motor cortex: effects of voltage-dependent ion channel blockers
    Manuel A Castro-Alamancos
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PA 19129, USA
    J Physiol 578:173-91. 2007
    ....
  10. pmc Synaptic cooperativity regulates persistent network activity in neocortex
    Morgana Favero
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129, USA
    J Neurosci 33:3151-63. 2013
    ..Regardless of the pathway's origin, cooperativity mediated by fast excitation is inversely related to the ability of excitatory synaptic pathways to trigger up-states in neocortex...
  11. ncbi request reprint Relief of synaptic depression produces long-term enhancement in thalamocortical networks
    Akio Hirata
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    J Neurophysiol 95:2479-91. 2006
    ..Because these changes in thalamic excitability are triggered by corticothalamic activity, this may be a useful top-down mechanism to regulate afferent sensory input to the neocortex during behavior as a function of experience...
  12. pmc Cortical transformation of wide-field (multiwhisker) sensory responses
    Akio Hirata
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129, USA
    J Neurophysiol 100:358-70. 2008
    ....
  13. ncbi request reprint Thalamocortical Up states: differential effects of intrinsic and extrinsic cortical inputs on persistent activity
    Pavlos Rigas
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129, USA
    J Neurosci 27:4261-72. 2007
    ..Thus, extrinsic and intrinsic cortical inputs differentially regulate persistent activity, which may serve to adjust the processing state of thalamocortical networks during behavior...
  14. pmc Effects of cortical activation on sensory responses in barrel cortex
    Akio Hirata
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PA 19129, USA
    J Neurophysiol 105:1495-505. 2011
    ..Overall, sensory responses become sharper and more reliable during cortical activation...
  15. pmc Vibrissa sensation in superior colliculus: wide-field sensitivity and state-dependent cortical feedback
    Jeremy D Cohen
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129, USA
    J Neurosci 28:11205-20. 2008
    ..In addition, their output is most robust during quiescent states because of the dependence of cortical feedback on forebrain activation, and this may serve as an alerting signal to drive orienting responses...
  16. pmc Impact of persistent cortical activity (up States) on intracortical and thalamocortical synaptic inputs
    Pavlos Rigas
    Department of Neurobiology, Drexel University College of Medicine, 2900 Queen Ln, Philadelphia, PA 19129, USA
    J Neurophysiol 102:119-31. 2009
    ..However, activity-dependent synaptic depression caused by increased presynaptic firing during up states and the enhancement of evoked inhibitory drive caused by depolarization suppress excitatory intracortical synaptic inputs...
  17. pmc Early sensory pathways for detection of fearful conditioned stimuli: tectal and thalamic relays
    Jeremy D Cohen
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129, USA
    J Neurosci 27:7762-76. 2007
    ....
  18. ncbi request reprint Dynamics of sensory thalamocortical synaptic networks during information processing states
    Manuel A Castro-Alamancos
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PA 19129, USA
    Prog Neurobiol 74:213-47. 2004
    ..Thus, during activated states, the temporal and spatial response properties of pathways in the thalamocortical network are transformed to allow the processing of sensory information...
  19. ncbi request reprint Spatiotemporal gating of sensory inputs in thalamus during quiescent and activated states
    Juan R Aguilar
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129, USA
    J Neurosci 25:10990-1002. 2005
    ..But, thalamocortical cells represent only the center (PW) of the receptive field when the center (PW) and surround (AWs) are stimulated simultaneously...
  20. pmc The motor cortex: a network tuned to 7-14 Hz
    Manuel A Castro-Alamancos
    Department of Neurobiology and Anatomy, Drexel University College of Medicine Philadelphia, PA, USA
    Front Neural Circuits 7:21. 2013
    ..Interestingly, augmenting responses are dependent on behavioral state. They are abolished during behavioral arousal. Here, I briefly review this evidence...
  21. pmc Behavioral state dependency of neural activity and sensory (whisker) responses in superior colliculus
    Jeremy D Cohen
    Department of Neurobiology, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PA 19129, USA
    J Neurophysiol 104:1661-72. 2010
    ....
  22. ncbi request reprint Noradrenergic activation amplifies bottom-up and top-down signal-to-noise ratios in sensory thalamus
    Akio Hirata
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129, USA
    J Neurosci 26:4426-36. 2006
    ..In conclusion, different modulators establish distinct modes of bottom-up and top-down information processing in the sensory thalamus...
  23. pmc Superior colliculus cells sensitive to active touch and texture during whisking
    Tatiana Bezdudnaya
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129, USA
    J Neurophysiol 106:332-46. 2011
    ..Thus, superior colliculus is part of a broader vibrissa neural network that can decode whisking movement, active touch, and texture...
  24. pmc The state of somatosensory cortex during neuromodulation
    Morgana Favero
    Dept of Neurobiology and Anatomy, Drexel Univ College of Medicine, Philadelphia, PA 19129, USA
    J Neurophysiol 108:1010-24. 2012
    ..Thus noradrenergic activation emphasizes thalamocortical (sensory) inputs relative to intracortical inputs, while cholinergic activation suppresses both...
  25. pmc Neuromodulation of whisking related neural activity in superior colliculus
    Tatiana Bezdudnaya
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129
    J Neurosci 34:7683-95. 2014
    ..The actions of neuromodulator and inhibitory afferents may be the basis of the different firing rates and sensory responsiveness observed in the superior colliculus of behaving animals during distinct behavioral states. ..
  26. ncbi request reprint Skilled motor learning does not enhance long-term depression in the motor cortex in vivo
    Jeremy D Cohen
    Deptartment of Neurobiology and Anatomy, Drexel University College of Medicine, 2900 Queen Ln, Philadelphia, PA 19129, USA
    J Neurophysiol 93:1486-97. 2005
    ..The results are incompatible with the idea that learning causes large unidirectional changes in the population response of these neural networks, which may occur instead during certain behavioral states, such as stress...
  27. ncbi request reprint What generates whisking? Focus on: "The whisking rhythm generator: a novel mammalian network for the generation of movement"
    Manuel A Castro-Alamancos
    J Neurophysiol 97:1883-4. 2007
  28. ncbi request reprint Role of thalamocortical sensory suppression during arousal: focusing sensory inputs in neocortex
    Manuel A Castro-Alamancos
    Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada
    J Neurosci 22:9651-5. 2002
    ....
  29. pmc Synchronized oscillations caused by disinhibition in rodent neocortex are generated by recurrent synaptic activity mediated by AMPA receptors
    Manuel A Castro-Alamancos
    Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada H3A 2B4
    J Physiol 542:567-81. 2002
    ..The results indicate that blocking GABA(B) receptors in the agranular neocortex unmasks recurrent synaptic activity mediated by AMPA receptors that results in the generation of these oscillations...
  30. pmc Cortical sensory suppression during arousal is due to the activity-dependent depression of thalamocortical synapses
    Manuel A Castro-Alamancos
    Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada H3A 2B4
    J Physiol 541:319-31. 2002
    ..Thalamocortical suppression may serve as a mechanism to focus sensory inputs to their appropriate representations in neocortex, which is helpful for the spatial processing of sensory information...
  31. pmc Different temporal processing of sensory inputs in the rat thalamus during quiescent and information processing states in vivo
    Manuel A Castro-Alamancos
    Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A2B4, Canada
    J Physiol 539:567-78. 2002
    ....
  32. ncbi request reprint Properties of primary sensory (lemniscal) synapses in the ventrobasal thalamus and the relay of high-frequency sensory inputs
    Manuel A Castro-Alamancos
    Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, 3801 University Street, Room WB210, Montreal, Quebec H3A 2B4, Canada
    J Neurophysiol 87:946-53. 2002
    ....

Research Grants11

  1. Dynamics of thalamo-cortico-thalamic networks
    MANUEL CASTRO ALAMANCOS; Fiscal Year: 2004
    ..abstract_text> ..
  2. Excitatory Network Oscillations in Somatosensory and Motor Areas of Neocortex
    Manuel A Castro Alamancos; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVACE These studies are directed at deciphering the neural substrate responsible for tremor, myoclonus and Jacksonian-type seizures, which are common symptoms of many neurological disorders. ..
  3. Sensory pathways for conditioned stimulus detection during avoidance behavior
    Manuel A Castro Alamancos; Fiscal Year: 2010
    ....
  4. Excitatory Network Oscillations in Somatosensory and Motor Areas of Neocortex
    MANUEL CASTRO ALAMANCOS; Fiscal Year: 2009
    ..PUBLIC HEALTH RELEVACE These studies are directed at deciphering the neural substrate responsible for tremor, myoclonus and Jacksonian-type seizures, which are common symptoms of many neurological disorders. ..
  5. Sensory pathways for conditioned stimulus detection during avoidance behavior
    MANUEL CASTRO ALAMANCOS; Fiscal Year: 2009
    ....
  6. Dynamics of thalamo-cortico-thalamic networks
    MANUEL CASTRO ALAMANCOS; Fiscal Year: 2007
    ..abstract_text> ..
  7. Dynamics of thalamo-cortico-thalamic networks
    MANUEL CASTRO ALAMANCOS; Fiscal Year: 2006
    ..abstract_text> ..
  8. Dynamics of thalamo-cortico-thalamic networks
    MANUEL CASTRO ALAMANCOS; Fiscal Year: 2005
    ..abstract_text> ..
  9. Sensory pathways for conditioned stimulus detection during avoidance behavior
    Manuel A Castro Alamancos; Fiscal Year: 2011
    ....