Timothy Block

Summary

Affiliation: Drexel University College of Medicine
Country: USA

Publications

  1. pmc Chronic hepatitis B: what should be the goal for new therapies?
    Timothy M Block
    Department of Microbiology and Immunology, Drexel University College of Medicine, 3805 Old Easton Road, Doylestown, PA 18902, USA
    Antiviral Res 98:27-34. 2013
  2. doi request reprint Hepatocellular carcinoma of the liver
    Timothy Block
    Department of Microbiology and Immunology, Drexel University College of Medicine and Hepatitis B Foundation, Pennsylvania Biotechnology Center, Doylestown, PA, USA
    Cancer Biomark 9:375-83. 2010
  3. pmc A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion
    Anne Marie Dougherty
    Institute for Hepatitis and Virus Research, Hepatitis B Foundation, 3805 Old Easton Road, Doylestown, PA 18902, USA
    Antimicrob Agents Chemother 51:4427-37. 2007
  4. pmc Novel changes in glycosylation of serum Apo-J in patients with hepatocellular carcinoma
    Mary Ann Comunale
    Department of Microbiology and Immunology, Drexel Institute for Biotechnology and Virus Research, Drexel University College of Medicine, Doylestown, Pennsylvania 18902, USA
    Cancer Epidemiol Biomarkers Prev 20:1222-9. 2011
  5. pmc Increased levels of tetra-antennary N-linked glycan but not core fucosylation are associated with hepatocellular carcinoma tissue
    Anand Mehta
    Department of Microbiology and Immunology, Drexel University College of Medicine, Doylestown, PA, USA
    Cancer Epidemiol Biomarkers Prev 21:925-33. 2012
  6. pmc Altered functionality of anti-bacterial antibodies in patients with chronic hepatitis C virus infection
    Anne Lamontagne
    Drexel University College of Medicine, and Department of Microbiology and Immunology and Drexel Institute for Biotechnology and Virology, Doylestown, Pennsylvania, USA
    PLoS ONE 8:e64992. 2013
  7. pmc Development of recombinant Aleuria aurantia lectins with altered binding specificities to fucosylated glycans
    Patrick R Romano
    Drexel University College of Medicine, Department of Microbiology and Immunology and Drexel Institute for Biotechnology and Virology, 3805 Old Easton Avenue, Doylestown, PA 18901, USA
    Biochem Biophys Res Commun 414:84-9. 2011
  8. pmc Inhibitors of endoplasmic reticulum alpha-glucosidases potently suppress hepatitis C virus virion assembly and release
    Xiaowang Qu
    Drexel Institute for Biotechnology and Virology Research, Department of Microbiology and Immunology, Drexel University College of Medicine, Doylestown, PA 18902, USA
    Antimicrob Agents Chemother 55:1036-44. 2011
  9. pmc Linkage specific fucosylation of alpha-1-antitrypsin in liver cirrhosis and cancer patients: implications for a biomarker of hepatocellular carcinoma
    Mary Ann Comunale
    Department of Microbiology and Immunology, Drexel Institute for Biotechnology and Virus Research, Drexel University College of Medicine, Doylestown, Pennsylvania, United States of America
    PLoS ONE 5:e12419. 2010
  10. pmc Screening and identification of compounds with antiviral activity against hepatitis B virus using a safe compound library and novel real-time immune-absorbance PCR-based high throughput system
    Jason Lamontagne
    Institute for Hepatitis and Virus Research, Doylestown, PA 18902, USA
    Antiviral Res 98:19-26. 2013

Research Grants

Collaborators

  • Anand Mehta
  • Pamela Norton
  • Adrian M Di Bisceglie
  • Ju Tao Guo
  • Baohua Gu
  • Kunwar Shailubhai
  • Xuanyong Lu
  • Eiji Miyoshi
  • Jinhong Chang
  • Andrew Klein
  • W Thomas London
  • Mary Ann Comunale
  • Anne Lamontagne
  • Yuanjie Liu
  • Julie Hafner
  • Lucy Rodemich-Betesh
  • Mengjun Wang
  • Ender Simsek
  • Jason Lamontagne
  • Nirzari Parikh
  • Jorge Marrero
  • Patrick R Romano
  • Xiaowang Qu
  • Haitao Guo
  • Sweeta R Choudhari
  • Tianlun Zhou
  • Anne Marie Dougherty
  • Andy Cuconati
  • Dawei Cai
  • Courtney Mills
  • Cally Goddard
  • Richeng Mao
  • Ronald E Long
  • Michael R Nonnemacher
  • Brian Wigdahl
  • Vanessa Pirrone
  • Dominic Alonzi
  • Andrew Mackay
  • Xiaodong Xu
  • Ryszard Lec
  • Robert Gish
  • Jessica Weidner
  • Wenquan Yu
  • Terry Butters
  • Xiaoben Pan
  • Johann Desa
  • Minh Vong
  • Donald Picker
  • Muhammad A Khan
  • Genesis Harris
  • Ramila Philip
  • Gomathinayagam Sinnathamby
  • Gary S Jacob
  • Andrea Cuconati
  • Gael Westby

Detail Information

Publications15

  1. pmc Chronic hepatitis B: what should be the goal for new therapies?
    Timothy M Block
    Department of Microbiology and Immunology, Drexel University College of Medicine, 3805 Old Easton Road, Doylestown, PA 18902, USA
    Antiviral Res 98:27-34. 2013
    ..We suggest that such a virological cure should be the goal of future therapeutics in all patients with chronic hepatitis B. The extent to which a virological cure predicts a functional cure will only be determined by long-term follow-up...
  2. doi request reprint Hepatocellular carcinoma of the liver
    Timothy Block
    Department of Microbiology and Immunology, Drexel University College of Medicine and Hepatitis B Foundation, Pennsylvania Biotechnology Center, Doylestown, PA, USA
    Cancer Biomark 9:375-83. 2010
    ..This Chapter reviews current methods of detection as well as leading new methods. Possible explanations as to why there are so many markers that are being discovered, but so few that make it to validation are discussed...
  3. pmc A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion
    Anne Marie Dougherty
    Institute for Hepatitis and Virus Research, Hepatitis B Foundation, 3805 Old Easton Road, Doylestown, PA 18902, USA
    Antimicrob Agents Chemother 51:4427-37. 2007
    ..Possible mechanisms of action and the implications for its development are discussed...
  4. pmc Novel changes in glycosylation of serum Apo-J in patients with hepatocellular carcinoma
    Mary Ann Comunale
    Department of Microbiology and Immunology, Drexel Institute for Biotechnology and Virus Research, Drexel University College of Medicine, Doylestown, Pennsylvania 18902, USA
    Cancer Epidemiol Biomarkers Prev 20:1222-9. 2011
    ..Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide and the occurrence of HCC has more than doubled in the United States in the past decade. Early detection is considered key to reducing the mortality of HCC...
  5. pmc Increased levels of tetra-antennary N-linked glycan but not core fucosylation are associated with hepatocellular carcinoma tissue
    Anand Mehta
    Department of Microbiology and Immunology, Drexel University College of Medicine, Doylestown, PA, USA
    Cancer Epidemiol Biomarkers Prev 21:925-33. 2012
    ..In the case of primary hepatocellular carcinoma (HCC), one alteration that has often been associated is increased amounts of fucose attached to the N-glycans of serum proteins secreted by the liver...
  6. pmc Altered functionality of anti-bacterial antibodies in patients with chronic hepatitis C virus infection
    Anne Lamontagne
    Drexel University College of Medicine, and Department of Microbiology and Immunology and Drexel Institute for Biotechnology and Virology, Doylestown, Pennsylvania, USA
    PLoS ONE 8:e64992. 2013
    ..Since the alpha gal epitope is found on gut enterobacteria, it has been hypothesized that anti-gal antibodies are generated as a result of increased bacterial exposure in patients with liver disease...
  7. pmc Development of recombinant Aleuria aurantia lectins with altered binding specificities to fucosylated glycans
    Patrick R Romano
    Drexel University College of Medicine, Department of Microbiology and Immunology and Drexel Institute for Biotechnology and Virology, 3805 Old Easton Avenue, Doylestown, PA 18901, USA
    Biochem Biophys Res Commun 414:84-9. 2011
    ..Taking a site-directed mutagenesis approach, we have created a set of recombinant AAL proteins that display altered binding affinities to different analytes containing various fucose linkages...
  8. pmc Inhibitors of endoplasmic reticulum alpha-glucosidases potently suppress hepatitis C virus virion assembly and release
    Xiaowang Qu
    Drexel Institute for Biotechnology and Virology Research, Department of Microbiology and Immunology, Drexel University College of Medicine, Doylestown, PA 18902, USA
    Antimicrob Agents Chemother 55:1036-44. 2011
    ..The low likelihood of drug-resistant virus emergence and potent antiviral efficacy of the novel glucosidase inhibitor hold promise for its development as a therapeutic agent for the treatment of chronic hepatitis C...
  9. pmc Linkage specific fucosylation of alpha-1-antitrypsin in liver cirrhosis and cancer patients: implications for a biomarker of hepatocellular carcinoma
    Mary Ann Comunale
    Department of Microbiology and Immunology, Drexel Institute for Biotechnology and Virus Research, Drexel University College of Medicine, Doylestown, Pennsylvania, United States of America
    PLoS ONE 5:e12419. 2010
    ....
  10. pmc Screening and identification of compounds with antiviral activity against hepatitis B virus using a safe compound library and novel real-time immune-absorbance PCR-based high throughput system
    Jason Lamontagne
    Institute for Hepatitis and Virus Research, Doylestown, PA 18902, USA
    Antiviral Res 98:19-26. 2013
    ....
  11. ncbi request reprint The degradation pathway for the HBV envelope proteins involves proteolysis prior to degradation via the cytosolic proteasome
    Yuanjie Liu
    Department of Microbiology and Immunology, Drexel University College of Medicine, Doylestown, PA 18902, USA
    Virology 369:69-77. 2007
    ..Thus, these results highlight an important way in which large protein aggregates, such as the HBsAg can be processed for efficient degradation via the proteasomes and allow for proper antigen presentation via the MHC I pathway...
  12. ncbi request reprint The role of the downstream signal sequences in the maturation of the HBV middle surface glycoprotein: development of a novel therapeutic vaccine candidate
    Yuanjie Liu
    Department of Microbiology and Immunology, Drexel University College of Medicine, Doylestown, PA 18902, USA
    Virology 365:10-9. 2007
    ..These results suggest that increased degradation of the HBV envelope proteins can lead to enhanced antigen presentation...
  13. ncbi request reprint Antiviral profiles of novel iminocyclitol compounds against bovine viral diarrhea virus, West Nile virus, dengue virus and hepatitis B virus
    Baohua Gu
    Drexel Institute for Biotechnology and Virology Research, Drexel University, College of Medicine, Doylestown, PA, USA
    Antivir Chem Chemother 18:49-59. 2007
    ..The implication of this modification to the development of broad-spectrum antiviral agents is discussed...
  14. ncbi request reprint Deactivation of Akt and STAT3 signaling promotes apoptosis, inhibits proliferation, and enhances the sensitivity of hepatocellular carcinoma cells to an anticancer agent, Atiprimod
    Sweeta R Choudhari
    Institute of Hepatitis and Virus Research Drexel Institute of Biotechnology and Virology Research, Pennsylvania Biotechnology Center, 3805 Old Easton Road, Room 254, Doylestown, PA 18902, USA
    Mol Cancer Ther 6:112-21. 2007
    ..Collectively, these results suggest that atiprimod could be useful as a multifunctional drug candidate for the treatment of HCC in humans...
  15. pmc Substance abuse, HIV-1 and hepatitis
    Nirzari Parikh
    Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA 19102, USA
    Curr HIV Res 10:557-71. 2012
    ..The impact of HIV-1 and substance abuse on hepatitis virus-induced disease is also a focal point...

Research Grants3

  1. Liver Cancer and the Role of Protein Hyper-Fucosylation
    Timothy M Block; Fiscal Year: 2010
    ..Understanding why will help in the development of new diagnostic methods, as well as provide clues for development of new therapies. ..
  2. Liver Cancer and the Role of Protein Hyper-Fucosylation
    Timothy Block; Fiscal Year: 2009
    ..Understanding why will help in the development of new diagnostic methods, as well as provide clues for development of new therapies. ..