Peter W Baas

Summary

Affiliation: Drexel University College of Medicine
Country: USA

Publications

  1. doi request reprint Microtubule stability in the axon: new answers to an old mystery
    Peter W Baas
    Drexel University College of Medicine, Philadelphia, PA 19129, USA Electronic address
    Neuron 78:3-5. 2013
  2. doi request reprint A novel role for retrograde transport of microtubules in the axon
    Peter W Baas
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, Pennsylvania 19129, USA
    Cytoskeleton (Hoboken) 69:416-25. 2012
  3. ncbi request reprint Microtubules cut and run
    Peter W Baas
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA, USA
    Trends Cell Biol 15:518-24. 2005
  4. ncbi request reprint Axonal transport of microtubules: the long and short of it
    Peter W Baas
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, 2900 W Queen Lane, Philadelphia, PA 19129, USA
    Traffic 7:490-8. 2006
  5. pmc Hooks and comets: The story of microtubule polarity orientation in the neuron
    Peter W Baas
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    Dev Neurobiol 71:403-18. 2011
  6. doi request reprint Cell migration: katanin gives microtubules a trim
    Peter W Baas
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    Curr Biol 21:R302-4. 2011
  7. pmc The microtubule-severing proteins spastin and katanin participate differently in the formation of axonal branches
    Wenqian Yu
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    Mol Biol Cell 19:1485-98. 2008
  8. pmc A novel role for doublecortin and doublecortin-like kinase in regulating growth cone microtubules
    Daphney C Jean
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    Hum Mol Genet 21:5511-27. 2012
  9. pmc Mitotic motors coregulate microtubule patterns in axons and dendrites
    Shen Lin
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129, USA
    J Neurosci 32:14033-49. 2012
  10. ncbi request reprint Antagonistic forces generated by cytoplasmic dynein and myosin-II during growth cone turning and axonal retraction
    Kenneth A Myers
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    Traffic 7:1333-51. 2006

Collaborators

Detail Information

Publications50

  1. doi request reprint Microtubule stability in the axon: new answers to an old mystery
    Peter W Baas
    Drexel University College of Medicine, Philadelphia, PA 19129, USA Electronic address
    Neuron 78:3-5. 2013
    ..In this issue of Neuron, Song et al. (2013) suggest that this unusual stability results from the polyamination of tubulin by transglutaminase...
  2. doi request reprint A novel role for retrograde transport of microtubules in the axon
    Peter W Baas
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, Pennsylvania 19129, USA
    Cytoskeleton (Hoboken) 69:416-25. 2012
    ..We speculate that pathological flaws in this mechanism may be a critical factor in the degeneration of axons during disease and injury, as well as in neuropathy caused by microtubule-active drugs...
  3. ncbi request reprint Microtubules cut and run
    Peter W Baas
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA, USA
    Trends Cell Biol 15:518-24. 2005
    ..Microtubule severing is also crucial for a variation of 'cut and run' in which the severed microtubules are reorganized by means of treadmilling...
  4. ncbi request reprint Axonal transport of microtubules: the long and short of it
    Peter W Baas
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, 2900 W Queen Lane, Philadelphia, PA 19129, USA
    Traffic 7:490-8. 2006
    ....
  5. pmc Hooks and comets: The story of microtubule polarity orientation in the neuron
    Peter W Baas
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    Dev Neurobiol 71:403-18. 2011
    ....
  6. doi request reprint Cell migration: katanin gives microtubules a trim
    Peter W Baas
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    Curr Biol 21:R302-4. 2011
    ..New evidence suggests that katanin - best known for severing microtubules in their more stable regions - localizes at the leading edge of migratory cells and trims microtubules at their dynamic plus ends...
  7. pmc The microtubule-severing proteins spastin and katanin participate differently in the formation of axonal branches
    Wenqian Yu
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    Mol Biol Cell 19:1485-98. 2008
    ....
  8. pmc A novel role for doublecortin and doublecortin-like kinase in regulating growth cone microtubules
    Daphney C Jean
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    Hum Mol Genet 21:5511-27. 2012
    ..These findings support a role for DCX and DCLK in enabling microtubules to overcome retrograde actin-based forces, thereby facilitating the ability of the growth cone to carry out its crucial path-finding functions...
  9. pmc Mitotic motors coregulate microtubule patterns in axons and dendrites
    Shen Lin
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129, USA
    J Neurosci 32:14033-49. 2012
    ..In this manner, these so-called "mitotic" motors coregulate the microtubule patterns of axons and dendrites...
  10. ncbi request reprint Antagonistic forces generated by cytoplasmic dynein and myosin-II during growth cone turning and axonal retraction
    Kenneth A Myers
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    Traffic 7:1333-51. 2006
    ..These dynein-driven forces oppose the tendency of the axon to retract and permit microtubules to advance into the peripheral zone of the growth cone so that they can invade filopodia...
  11. pmc Basic fibroblast growth factor elicits formation of interstitial axonal branches via enhanced severing of microtubules
    Liang Qiang
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    Mol Biol Cell 21:334-44. 2010
    ..Collectively, these results indicate that bFGF enhances axonal branch formation by augmenting the severing of microtubules through both a spastin-based mode and a katanin-based mode...
  12. pmc Kinesin-5, a mitotic microtubule-associated motor protein, modulates neuronal migration
    Aditi Falnikar
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    Mol Biol Cell 22:1561-74. 2011
    ..In so doing, kinesin-5 regulates the rate and directionality of neuronal migration and possibly the cessation of migration when the neuron reaches its destination...
  13. pmc Kinesin-12, a mitotic microtubule-associated motor protein, impacts axonal growth, navigation, and branching
    Mei Liu
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129, USA
    J Neurosci 30:14896-906. 2010
    ....
  14. pmc Septin-driven coordination of actin and microtubule remodeling regulates the collateral branching of axons
    Jianli Hu
    Department of Biology, Drexel University, Philadelphia, PA 19104, USA
    Curr Biol 22:1109-15. 2012
    ..Surprisingly, septins provide a novel mechanism for the collateral branching of axons by coordinating the remodeling of the actin and microtubule cytoskeleton...
  15. pmc Microtubule redistribution in growth cones elicited by focal inactivation of kinesin-5
    Vidya C Nadar
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129, USA
    J Neurosci 32:5783-94. 2012
    ....
  16. pmc Strategies for diminishing katanin-based loss of microtubules in tauopathic neurodegenerative diseases
    Haruka Sudo
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, 2900 W Queen Lane, Philadelphia, PA 19129, USA
    Hum Mol Genet 20:763-78. 2011
    ..These observations may be useful in developing therapeutic regimes for preserving microtubules against loss in the axons of patients suffering from tauopathies...
  17. pmc Regulation of microtubule severing by katanin subunits during neuronal development
    Wenqian Yu
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129, USA
    J Neurosci 25:5573-83. 2005
    ....
  18. doi request reprint Partial interruption of axonal transport due to microtubule breakage accounts for the formation of periodic varicosities after traumatic axonal injury
    Min D Tang-Schomer
    Penn Center for Brain Injury and Repair and Department of Neurosurgery, University of Pennsylvania, Philadelphia, PA 19104, USA
    Exp Neurol 233:364-72. 2012
    ..These data indicate a novel mechanism of mechanical microtubule damage leading to partial transport interruption and varicosity formation in traumatic axonal injury...
  19. ncbi request reprint Microtubule transport in the axon: Re-thinking a potential role for the actin cytoskeleton
    Kenneth A Myers
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    Neuroscientist 12:107-18. 2006
    ..The relevant forces that transport short microtubules may also be crucial for the manner by which the longer immobile microtubules interact with actin filaments during events such as axonal retraction and growth cone turning...
  20. ncbi request reprint Effects of dynactin disruption and dynein depletion on axonal microtubules
    Fridoon J Ahmad
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA, USA
    Traffic 7:524-37. 2006
    ..These results suggest that the forces generated by cytoplasmic dynein do not transport long microtubules, but may serve to align them with one another and also permit them to invade filopodia...
  21. ncbi request reprint Role of actin filaments in the axonal transport of microtubules
    Thomas P Hasaka
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129, USA
    J Neurosci 24:11291-301. 2004
    ..Moreover, the transport of microtubules against one another provides a surprisingly effective option for the deployment and orientation of microtubules in the absence of actin filaments...
  22. ncbi request reprint Tau protects microtubules in the axon from severing by katanin
    Liang Qiang
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129, USA
    J Neurosci 26:3120-9. 2006
    ..These results, which validate our hypothesis, also suggest a potential explanation for why axonal microtubules deteriorate in neuropathies involving the dissociation of tau from the microtubules...
  23. pmc Inhibition of Kinesin-5, a microtubule-based motor protein, as a strategy for enhancing regeneration of adult axons
    Shen Lin
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PA, USA
    Traffic 12:269-86. 2011
    ..Collectively, these results indicate that anti-kinesin-5 drugs may be a useful addition to the arsenal of tools used to treat nerve injury...
  24. pmc Acetylation of microtubules influences their sensitivity to severing by katanin in neurons and fibroblasts
    Haruka Sudo
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129, USA
    J Neurosci 30:7215-26. 2010
    ..In the neuron, this contributes to regional differences in the microtubule arrays of axons and dendrites...
  25. pmc Kinesin-5 is essential for growth-cone turning
    Vidya C Nadar
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    Curr Biol 18:1972-7. 2008
    ..We propose that kinesin-5 permits MTs to selectively invade one side of the growth cone by opposing their entry into the other side...
  26. pmc Quantitative and functional analyses of spastin in the nervous system: implications for hereditary spastic paraplegia
    Joanna M Solowska
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129, USA
    J Neurosci 28:2147-57. 2008
    ..These results are consistent with a "gain-of-function" mechanism underlying HSP wherein spastin mutations produce a cytotoxic protein in the case of M1 but not M85...
  27. ncbi request reprint Axonal growth is sensitive to the levels of katanin, a protein that severs microtubules
    Arzu Karabay
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129, USA
    J Neurosci 24:5778-88. 2004
    ..Other neurons are relatively unaffected by overexpression. Collectively, these observations indicate that axonal growth is sensitive to the levels of P60-katanin, but that other factors contribute to modulating this sensitivity...
  28. ncbi request reprint Monastrol, a prototype anti-cancer drug that inhibits a mitotic kinesin, induces rapid bursts of axonal outgrowth from cultured postmitotic neurons
    Saad A Haque
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129, USA
    Cell Motil Cytoskeleton 58:10-6. 2004
    ..The comparatively modest toxic effects on the neurons over time are a hopeful sign for clinicians interested in using anti-Eg5 drugs for cancer therapy...
  29. pmc Role of cytoplasmic dynein in the axonal transport of microtubules and neurofilaments
    Yan He
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    J Cell Biol 168:697-703. 2005
    ..These results support a cargo model for NF transport and a sliding filament model for MT transport...
  30. pmc Doublecortin associates with microtubules preferentially in regions of the axon displaying actin-rich protrusive structures
    Irina Tint
    Department of Anatomy and Cell Biology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    J Neurosci 29:10995-1010. 2009
    ..Based on the striking resemblance of these patches to growth cones, we discuss the possibility that they reflect a mechanism for locally boosting morphogenetic activity to facilitate axonal growth and collateral branching...
  31. doi request reprint Critical roles for microtubules in axonal development and disease
    Aditi Falnikar
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PA 19129, USA
    Results Probl Cell Differ 48:47-64. 2009
    ....
  32. ncbi request reprint Class III beta-tubulin and gamma-tubulin are co-expressed and form complexes in human glioblastoma cells
    Christos D Katsetos
    Department of Pediatrics, Drexel University College of Medicine and St Christopher s Hospital for Children, Philadelphia, PA 19134, USA
    Neurochem Res 32:1387-98. 2007
    ..We suggest that aberrant expression and interactions of betaIII-tubulin and gamma-tubulin may be linked to malignant changes in glial cells...
  33. pmc Evaluation of loss of function as an explanation for SPG4-based hereditary spastic paraplegia
    Joanna M Solowska
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PA 19129, USA
    Hum Mol Genet 19:2767-79. 2010
    ..These results indicate that there are cases of HSP-SPG4 that cannot be explained by insufficient spastin microtubule-severing activity...
  34. pmc Kinesin-5 regulates the growth of the axon by acting as a brake on its microtubule array
    Kenneth A Myers
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19104, USA
    J Cell Biol 178:1081-91. 2007
    ..These results indicate that kinesin-5 imposes restrictions on the growth of the axon and does so at least in part by generating forces on the axonal microtubule array...
  35. ncbi request reprint Microtubule reconfiguration during axonal retraction induced by nitric oxide
    Yan He
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129, USA
    J Neurosci 22:5982-91. 2002
    ....
  36. ncbi request reprint Growing and working with peripheral neurons
    Yan He
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129, USA
    Methods Cell Biol 71:17-35. 2003
    ..Information is provided on methods for dissection, preparation of culture dishes and substrates, composition of media, relevant growth factors, reduction of nonneuronal contamination, and maintenance of the cultures...
  37. ncbi request reprint Distribution of the microtubule-related protein ninein in developing neurons
    Douglas H Baird
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PA 19129, USA
    Neuropharmacology 47:677-83. 2004
    ....
  38. ncbi request reprint Expression of the mitotic kinesin Kif15 in postmitotic neurons: implications for neuronal migration and development
    Daniel W Buster
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    J Neurocytol 32:79-96. 2003
    ....
  39. ncbi request reprint Altered cellular distribution and subcellular sorting of gamma-tubulin in diffuse astrocytic gliomas and human glioblastoma cell lines
    Christos D Katsetos
    Department of Pediatrics, Drexel University College of Medicine, St Christopher s Hospital For Children, Philadelphia, Pennsylvania 19134, USA
    J Neuropathol Exp Neurol 65:465-77. 2006
    ....
  40. pmc Polarity in migrating neurons is related to a mechanism analogous to cytokinesis
    Aditi Falnikar
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PA 19129, USA
    Curr Biol 23:1215-20. 2013
    ....
  41. pmc The cytoskeleton of the neuron--an essay in celebration of Paul Letourneau's career
    Daphney C Jean
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA
    Dev Neurobiol 71:790-4. 2011
    ..This essay celebrates the career of Paul Letourneau, a pioneer of the neuronal cytoskeleton, to whom the community owes a debt of gratitude...
  42. ncbi request reprint Slow axonal transport and the genesis of neuronal morphology
    Peter W Baas
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, Pennsylvania 19129, USA
    J Neurobiol 58:3-17. 2004
    ..This new view, which is supported by both live-cell imaging and mechanistic analyses, suggests that slow axonal transport is both rapid and plastic, and hence could underlie transformations in neuronal morphology...
  43. pmc Mechanical breaking of microtubules in axons during dynamic stretch injury underlies delayed elasticity, microtubule disassembly, and axon degeneration
    Min D Tang-Schomer
    Center for Brain Injury and Repair and Department of Neurosurgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    FASEB J 24:1401-10. 2010
    ..While the disintegration of microtubules allows delayed recovery of the "normal" straight axon morphology, it comes at a great cost by interrupting axonal transport, leading to axonal swelling and degeneration...
  44. ncbi request reprint Neuronal microtubules: when the MAP is the roadblock
    Peter W Baas
    Drexel University College of Medicine, Dept of Neurobiology and Anatomy, 2900 W Queen Lane, Philadelphia, PA 19129, USA
    Trends Cell Biol 15:183-7. 2005
    ..Unfortunately, the hyperphosphorylated tau forms abnormal filaments that are deleterious to the axon, and the tau-depleted microtubules become highly sensitive to microtubule-severing proteins such as katanin...
  45. doi request reprint A gathering of neuronal cytoskeletal scientists in South America
    Peter W Baas
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Queen Lane, Philadelphia, Pennsylvania 19129, USA
    Cytoskeleton (Hoboken) 69:407-15. 2012
    ....
  46. ncbi request reprint Microtubule transport in the axon
    Peter W Baas
    Department of Neurobiology and Anatomy, MCP Hahnemann University, Philadelphia, Pennsylvania 19129, USA
    Int Rev Cytol 212:41-62. 2002
    ..The molecules and mechanisms that transport microtubules within axons are also under intense study...
  47. ncbi request reprint Rearrangement of microtubule polarity orientation during conversion of dendrites to axons in cultured pyramidal neurons
    Daisuke Takahashi
    Life Science Institute, Sophia University, Tokyo, Japan
    Cell Motil Cytoskeleton 64:347-59. 2007
    ....
  48. ncbi request reprint Neuronal polarity: microtubules strike back
    Peter W Baas
    Nat Cell Biol 4:E194-5. 2002
  49. pmc Tau-dependent microtubule disassembly initiated by prefibrillar beta-amyloid
    Michelle E King
    Department of Biology, University of Virginia, Charlottesville, VA 22904, USA
    J Cell Biol 175:541-6. 2006
    ..These results suggest that a seminal cell biological event in AD pathogenesis is acute, tau-dependent loss of microtubule integrity caused by exposure of neurons to readily diffusible Abeta...
  50. ncbi request reprint Functions of the cytoskeleton in neural development. Introduction
    Peter W Baas
    J Neurobiol 58:1-2. 2004