S Amini

Summary

Affiliation: Drexel University
Country: USA

Publications

  1. ncbi A 39-kD DNA-binding protein from mouse brain stimulates transcription of myelin basic protein gene in oligodendrocytic cells
    S Haas
    Jefferson Institute of Molecular Medicine, Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Cell Biol 130:1171-9. 1995
  2. ncbi A CNS-enriched factor that binds to NF-kappa B and is required for interaction with HIV-1 tat
    J P Taylor
    Jefferson Institute of Molecular Medicine, Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107
    Oncogene 10:395-400. 1995
  3. ncbi Interaction of YB-1 with human immunodeficiency virus type 1 Tat and TAR RNA modulates viral promoter activity
    S A Ansari
    Center for NeuroVirology and NeuroOncology, MCP Hahnemann University, Philadelphia, PA 19102, USA
    J Gen Virol 80:2629-38. 1999
  4. ncbi HIV-1 regulatory protein tat induces RNA binding proteins in central nervous system cells that associate with the viral trans-acting-response regulatory motif
    M Kundu
    Department of Neurology, MCP Hahnemann University, Philadelphia, Pennsylvania, USA
    J Hum Virol 2:72-80. 1999
  5. ncbi Functional interaction between cyclin T1/cdk9 and Puralpha determines the level of TNFalpha promoter activation by Tat in glial cells
    N Darbinian
    Center for Neurovirology and Cancer Biology, College of Science and Technology, Temple University, Philadelphia, PA 19122, USA
    J Neuroimmunol 121:3-11. 2001
  6. ncbi Transcription of the human immunodeficiency virus type 1 (HIV-1) promoter in central nervous system cells: effect of YB-1 on expression of the HIV-1 long terminal repeat
    B E Sawaya
    Center for NeuroVirology and NeuroOncology, Department of Neurology, Allegheny University of the Health Sciences, Philadelphia, PA 19102, USA
    J Gen Virol 79:239-46. 1998
  7. ncbi Regulation of myelin basic protein gene transcription by Sp1 and Puralpha: evidence for association of Sp1 and Puralpha in brain
    A Tretiakova
    Center for NeuroVirology and NeuroOncology, MCP Hahnemann University School of Medicine, Philadelphia, Pennsylvania 19102, USA
    J Cell Physiol 181:160-8. 1999
  8. ncbi Evidence for inhibition of MyEF-2 binding to MBP promoter by MEF-1/Pur alpha
    V Muralidharan
    Center for Neurovirology, Allegheny University of the Health Sciences, Philadelphia, Pennsylvania 19102, USA
    J Cell Biochem 66:524-31. 1997
  9. ncbi Cooperative interaction between HIV-1 regulatory proteins Tat and Vpr modulates transcription of the viral genome
    B E Sawaya
    Center for Neurovirology and Cancer Biology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122, USA
    J Biol Chem 275:35209-14. 2000
  10. ncbi p73 modulates HIV-1 Tat transcriptional and apoptotic activities in human astrocytes
    M Saunders
    Department of Neuroscience and Center for Neurovirology, Temple University, 1900 North 12th Street, 015 96, Philadelphia, PA 19122, USA
    Apoptosis 10:1419-31. 2005

Collaborators

  • K Khalili
  • S Haas
  • E M Johnson
  • S Morgello
  • A Giordano
  • A Srinivasan
  • L D Siracusa
  • M F Kiani
  • J Cui
  • N Morellet
  • S Bouaziz
  • R J Pomerantz
  • B P Roques
  • S Sharma
  • B E Sawaya
  • J Rappaport
  • L del Valle
  • S A Ansari
  • M Kundu
  • A Steplewski
  • K Siddiqui
  • V Muralidharan
  • A Tretiakova
  • K Reiss
  • N Darbinian-Sarkissian
  • M Saunders
  • L Denisova
  • T Fischer-Smith
  • N Darbinian
  • P Thatikunta
  • J P Taylor
  • M W Richardson
  • S Croul
  • A E Sverstiuk
  • M Safak
  • S Fan
  • M Ghafouri
  • R Mukerjee
  • C B Pattillo
  • K Urbanska
  • R Ansari
  • S L Deshmane
  • R Bonwetsch
  • A Darbinyan
  • G Chipitsyna
  • S Radhakrishnan
  • A Arzumanyan
  • J Otte
  • Y Popov
  • G Mameli
  • M B Eldeen
  • F Peruzzi
  • B B Gelman
  • T Sweet
  • Y Nadraga
  • N Jaffe
  • B Wortman
  • S Enam
  • C Capini
  • R Taube
  • J Gordon
  • L G Chepenik
  • C Lorenzana
  • G L Gallia
  • C Cupp
  • B Krynska
  • A De Luca
  • J Brady
  • W E Mercer
  • M Guermah
  • G Yusibova
  • C Cole
  • R G Roeder
  • J W Oakes
  • M Chowdhury
  • A Diaz
  • S A Jimenez
  • O Bagasra

Detail Information

Publications27

  1. ncbi A 39-kD DNA-binding protein from mouse brain stimulates transcription of myelin basic protein gene in oligodendrocytic cells
    S Haas
    Jefferson Institute of Molecular Medicine, Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Cell Biol 130:1171-9. 1995
    ..Thus, Pur alpha, a sequence-specific DNA-binding protein upon binding to MB1 regulatory region may play a significant role in determining the cell type-specific expression of MBP in brain...
  2. ncbi A CNS-enriched factor that binds to NF-kappa B and is required for interaction with HIV-1 tat
    J P Taylor
    Jefferson Institute of Molecular Medicine, Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107
    Oncogene 10:395-400. 1995
    ....
  3. ncbi Interaction of YB-1 with human immunodeficiency virus type 1 Tat and TAR RNA modulates viral promoter activity
    S A Ansari
    Center for NeuroVirology and NeuroOncology, MCP Hahnemann University, Philadelphia, PA 19102, USA
    J Gen Virol 80:2629-38. 1999
    ..The importance of these findings in light of the proposed mechanism of Tat function is discussed...
  4. ncbi HIV-1 regulatory protein tat induces RNA binding proteins in central nervous system cells that associate with the viral trans-acting-response regulatory motif
    M Kundu
    Department of Neurology, MCP Hahnemann University, Philadelphia, Pennsylvania, USA
    J Hum Virol 2:72-80. 1999
    ....
  5. ncbi Functional interaction between cyclin T1/cdk9 and Puralpha determines the level of TNFalpha promoter activation by Tat in glial cells
    N Darbinian
    Center for Neurovirology and Cancer Biology, College of Science and Technology, Temple University, Philadelphia, PA 19122, USA
    J Neuroimmunol 121:3-11. 2001
    ....
  6. ncbi Transcription of the human immunodeficiency virus type 1 (HIV-1) promoter in central nervous system cells: effect of YB-1 on expression of the HIV-1 long terminal repeat
    B E Sawaya
    Center for NeuroVirology and NeuroOncology, Department of Neurology, Allegheny University of the Health Sciences, Philadelphia, PA 19102, USA
    J Gen Virol 79:239-46. 1998
    ....
  7. ncbi Regulation of myelin basic protein gene transcription by Sp1 and Puralpha: evidence for association of Sp1 and Puralpha in brain
    A Tretiakova
    Center for NeuroVirology and NeuroOncology, MCP Hahnemann University School of Medicine, Philadelphia, Pennsylvania 19102, USA
    J Cell Physiol 181:160-8. 1999
    ..The importance of these findings in stage-specific expression of MBP during brain development is discussed...
  8. ncbi Evidence for inhibition of MyEF-2 binding to MBP promoter by MEF-1/Pur alpha
    V Muralidharan
    Center for Neurovirology, Allegheny University of the Health Sciences, Philadelphia, Pennsylvania 19102, USA
    J Cell Biochem 66:524-31. 1997
    ....
  9. ncbi Cooperative interaction between HIV-1 regulatory proteins Tat and Vpr modulates transcription of the viral genome
    B E Sawaya
    Center for Neurovirology and Cancer Biology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122, USA
    J Biol Chem 275:35209-14. 2000
    ..Moreover identification of R73S mutant of Vpr provides a new therapeutic avenue for controlling HIV-1 gene transcription and replication in the infected cells...
  10. ncbi p73 modulates HIV-1 Tat transcriptional and apoptotic activities in human astrocytes
    M Saunders
    Department of Neuroscience and Center for Neurovirology, Temple University, 1900 North 12th Street, 015 96, Philadelphia, PA 19122, USA
    Apoptosis 10:1419-31. 2005
    ..Thus, the interplay between Tat and p73 may affect Tat contribution to apoptotic events in the brain, limiting its involvement in the neuropathology often observed in the brains of HIV-1 patients...
  11. ncbi Regulation of Puralpha gene transcription: evidence for autoregulation of Puralpha promoter
    V Muralidharan
    Center for Neurovirology and Cancer Biology, College of Science and Technology, Temple University, 1900 North 12th Street, Philadelphia, PA 19122, USA
    J Cell Physiol 186:406-13. 2001
    ..The importance of this finding in light of earlier results showing down regulation of Puralpha during JCV infection of glial cells is discussed...
  12. ncbi HIV-1 Tat elongates the G1 phase and indirectly promotes HIV-1 gene expression in cells of glial origin
    M Kundu
    Center for NeuroVirology and NeuroOncology, Allegheny University of the Health Sciences, Philadelphia, Pennsylvania 19102, USA
    J Biol Chem 273:8130-6. 1998
    ..The significance of these findings relates to the current hypothesis that indirect effects of HIV-1 infection of the CNS may contribute to the neurological complications associated with AIDS dementia complex...
  13. ncbi Identification of a cellular protein that binds to Tat-responsive element of TGF beta-1 promoter in glial cells
    P Thatikunta
    Department of Neurology, Allegheny University of the Health Sciences, Philadelphia, Pennsylvania 19102, USA
    J Cell Biochem 67:466-77. 1997
    ..The importance of these findings with regard to deregulation of other cellular genes by HIV-1 Tat is discussed...
  14. ncbi Interaction between cell cycle regulator, E2F-1, and NF-kappaB mediates repression of HIV-1 gene transcription
    M Kundu
    Center for NeuroVirology and NeuroOncology, and Department of Neurology, Allegheny University of the Health Sciences, Philadelphia, Pennsylvania 19102, USA
    J Biol Chem 272:29468-74. 1997
    ..The results of this study suggest that NF-kappaB activity may be regulated by its interaction with the cell cycle regulatory protein, E2F-1...
  15. ncbi Regulation of TNFalpha and TGFbeta-1 gene transcription by HIV-1 Tat in CNS cells
    B E Sawaya
    Center for NeuroVirology and NeuroOncology, Department of Neurology, Allegheny University of Health Sciences, Philadelphia, PA 19102, USA
    J Neuroimmunol 87:33-42. 1998
    ..The importance of these findings in Tat-induced regulation of viral and cellular genes in various cell types is discussed...
  16. ncbi Cooperative actions of HIV-1 Vpr and p53 modulate viral gene transcription
    B E Sawaya
    Center for NeuroVirology and NeuroOncology, Allegheny University of the Health Sciences, Philadelphia, Pennsylvania 19102, USA
    J Biol Chem 273:20052-7. 1998
    ....
  17. ncbi MyEF-3, a developmentally controlled brain-derived nuclear protein which specifically interacts with myelin basic protein proximal regulatory sequences
    A Steplewski
    Department of Neurology, Allegheny University of the Health Sciences, Philadelphia, Pennsylvania 19102, USA
    Biochem Biophys Res Commun 243:295-301. 1998
    ..The biological importance of MyEF-3 in the cell type- and stage-specific expression of MBP during brain development is discussed...
  18. ncbi Cell cycle regulation of NF-kappa b-binding activity in cells from human glioblastomas
    S A Ansari
    Center for Neurovirology and Cancer Biology, College of Science and Technology, Temple University, 1900 North 12th Street, 015-96, Philadelphia, Pennsylvania 19122, USA
    Exp Cell Res 265:221-33. 2001
    ..The possible role of NF-kappa B in glioma cell formation and regulation of cellular genes by NF-kappa B in these tumor cells is discussed...
  19. ncbi CNS invasion by CD14+/CD16+ peripheral blood-derived monocytes in HIV dementia: perivascular accumulation and reservoir of HIV infection
    T Fischer-Smith
    Center for Neurovirology and Cancer Biology, Temple University, 1900 N. 12th St, Philadelphia, PA 19122, USA
    J Neurovirol 7:528-41. 2001
    ..CD14+/CD16+ monocytes may play a role in other neurological disorders and sCD14 may be useful for evaluating these conditions...
  20. ncbi p27(SJ), a novel protein in St John's Wort, that suppresses expression of HIV-1 genome
    N Darbinian-Sarkissian
    Department of Neuroscience, Center for Neurovirology, Temple University School of Medicine, Philadelphia, PA, USA
    Gene Ther 13:288-95. 2006
    ..These observations suggest the potential for the development of a therapeutic advance based on p27(SJ) protein to control HIV-1 transcription and replication in cells associated with HIV-1 infection in the brain...
  21. ncbi Identification of a sequence-specific single-stranded DNA binding protein that suppresses transcription of the mouse myelin basic protein gene
    S Haas
    Jefferson Institute of Molecular Medicine, Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 270:12503-10. 1995
    ..The myef-2 gene maps to mouse chromosome 2. The relevance of these findings for regulation of MBP gene expression and oligodendrocyte differentiation is discussed...
  22. ncbi Role of HIV-1 Tat and CC chemokine MIP-1alpha in the pathogenesis of HIV associated central nervous system disorders
    R Bonwetsch
    Department of Neurology, MCP Hahnemann University, 245 North 15th Street, Philadelphia, PA 19102, USA
    J Neurovirol 5:685-94. 1999
    ..Tat may play an important role in the pathogenesis of both HIV associated CNS disease states, acting indirectly through cytokine and chemokine dysregulation...
  23. ncbi Evidence for stimulation of the transforming growth factor beta 1 promoter by HIV-1 Tat in cells derived from CNS
    C Cupp
    Jefferson Institute of Molecular Medicine, Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, Pennsylvania
    Oncogene 8:2231-6. 1993
    ..Implications of the Tat-mediated induction of TGF-beta 1 expression and cytokine involvement in the regulation of immune response and central nervous system (CNS) pathology are discussed...
  24. ncbi Molecular mimicry in inducing DNA damage between HIV-1 Vpr and the anticancer agent, cisplatin
    K Siddiqui
    1Department of Biology, College of Science and Technology, Temple University, Philadelphia, PA, USA
    Oncogene 27:32-43. 2008
    ..This novel molecular mimicry function of Vpr might lead to its potential therapeutic use as a tumor suppressor...
  25. ncbi Regulation of mouse myelin basic protein gene transcription by a sequence-specific single-stranded DNA-binding protein in vitro
    A Steplewski
    Jefferson Institute of Molecular Medicine, Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Gene 154:215-8. 1995
    ..Results from the band-shift assays indicated that the bacterially produced MEF-2 recognizes specific nt in the MB1 motif, and its binding to these nt reduces the overall transcriptional activity of Mbp in a cell-free extract...
  26. ncbi TAR-independent transactivation by Tat in cells derived from the CNS: a novel mechanism of HIV-1 gene regulation
    J P Taylor
    Department of Biochemistry and Molecular Biology, Jefferson Institute of Molecular Medicine, Thomas Jefferson University, Philadelphia, PA 19107
    EMBO J 11:3395-403. 1992
    ..Further, we observe that TAR-deleted mutants of HIV-1 demonstrate normal late gene expression in glial cells as evidenced by syncytia formation and production of viral p24 antigen.(ABSTRACT TRUNCATED AT 250 WORDS)..
  27. ncbi Activation of expression of genes coding for extracellular matrix proteins in Tat-producing glioblastoma cells
    J P Taylor
    Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA 19107
    Proc Natl Acad Sci U S A 89:9617-21. 1992
    ..Possible mechanisms for this phenomenon and their significance with regard to AIDS are discussed...