G M Alexander

Summary

Affiliation: Drexel University
Country: USA

Publications

  1. ncbi request reprint Elevated cortical extracellular fluid glutamate in transgenic mice expressing human mutant (G93A) Cu/Zn superoxide dismutase
    G M Alexander
    Department of Neurology, MCP Hahnemann University, Philadelphia, Pennsylvania 19102 1192, USA
    J Neurochem 74:1666-73. 2000
  2. ncbi request reprint Effect of transgene copy number on survival in the G93A SOD1 transgenic mouse model of ALS
    Guillermo M Alexander
    Department of Neurology, College of Medicine, Drexel University, Mail Stop 423, 245 North 15th Street, Philadelphia, PA 19102, USA
    Brain Res Mol Brain Res 130:7-15. 2004
  3. ncbi request reprint Changes in cerebrospinal fluid levels of pro-inflammatory cytokines in CRPS
    Guillermo M Alexander
    Department of Neurology, Drexel University College of Medicine, Mail Stop 423, 245 North 15th Street, Philadelphia, PA 19102, USA
    Pain 116:213-9. 2005
  4. ncbi request reprint Background and gender effects on survival in the TgN(SOD1-G93A)1Gur mouse model of ALS
    T D Heiman-Patterson
    Department of Neurology, Drexel University College of Medicine, Mail Stop 423, 245 North 15th Street, Philadelphia, PA 19102, USA
    J Neurol Sci 236:1-7. 2005
  5. pmc Elevated blood levels of inflammatory monocytes (CD14+ CD16+ ) in patients with complex regional pain syndrome
    B W Ritz
    Department of Biology, Drexel University Department of Neurology, Drexel University College of Medicine, Philadelphia, PA 19102 1192, USA
    Clin Exp Immunol 164:108-17. 2011
  6. ncbi request reprint Intracerebral microdialysis study of glutamate reuptake in awake, behaving rats
    G M Alexander
    Department of Neurology, Allegheny University of the Health Sciences, Philadelphia, PA 19102, USA
    Brain Res 766:1-10. 1997
  7. ncbi request reprint GLT-1 glutamate transporter levels are unchanged in mice expressing G93A human mutant SOD1
    Jeffrey S Deitch
    Department of Neurology, MCP Hahnemann University, MS 423, 245 North 15th Street, Philadelphia, PA 19102 1192, USA
    J Neurol Sci 193:117-26. 2002
  8. ncbi request reprint Pathophysiology of complex regional pain syndrome
    Robert J Schwartzman
    Drexel University College of Medicine, Department of Neurology, 245 N 15 Street, MS 423 Philadelphia, PA 19102, USA
    Expert Rev Neurother 6:669-81. 2006
  9. ncbi request reprint Changes in immune and glial markers in the CSF of patients with Complex Regional Pain Syndrome
    Guillermo M Alexander
    Department of Neurology, Drexel University College of Medicine, Philadelphia, PA 19102, USA
    Brain Behav Immun 21:668-76. 2007
  10. ncbi request reprint The WldS gene modestly prolongs survival in the SOD1G93A fALS mouse
    Lindsey R Fischer
    Department of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Neurobiol Dis 19:293-300. 2005

Collaborators

Detail Information

Publications12

  1. ncbi request reprint Elevated cortical extracellular fluid glutamate in transgenic mice expressing human mutant (G93A) Cu/Zn superoxide dismutase
    G M Alexander
    Department of Neurology, MCP Hahnemann University, Philadelphia, Pennsylvania 19102 1192, USA
    J Neurochem 74:1666-73. 2000
    ....
  2. ncbi request reprint Effect of transgene copy number on survival in the G93A SOD1 transgenic mouse model of ALS
    Guillermo M Alexander
    Department of Neurology, College of Medicine, Drexel University, Mail Stop 423, 245 North 15th Street, Philadelphia, PA 19102, USA
    Brain Res Mol Brain Res 130:7-15. 2004
    ....
  3. ncbi request reprint Changes in cerebrospinal fluid levels of pro-inflammatory cytokines in CRPS
    Guillermo M Alexander
    Department of Neurology, Drexel University College of Medicine, Mail Stop 423, 245 North 15th Street, Philadelphia, PA 19102, USA
    Pain 116:213-9. 2005
    ..These increases showed no correlation with the patient's gender or weight. These results are consistent with studies that suggest that the pathogenesis of CRPS is due in part to central neuroimmune activation...
  4. ncbi request reprint Background and gender effects on survival in the TgN(SOD1-G93A)1Gur mouse model of ALS
    T D Heiman-Patterson
    Department of Neurology, Drexel University College of Medicine, Mail Stop 423, 245 North 15th Street, Philadelphia, PA 19102, USA
    J Neurol Sci 236:1-7. 2005
    ..This is the first report of a shortened lifespan when the G93A SOD1 transgene is placed on the SJL/J background and an increased survival with the loss of gender influences when the transgene is placed on the C57BL/6J background...
  5. pmc Elevated blood levels of inflammatory monocytes (CD14+ CD16+ ) in patients with complex regional pain syndrome
    B W Ritz
    Department of Biology, Drexel University Department of Neurology, Drexel University College of Medicine, Philadelphia, PA 19102 1192, USA
    Clin Exp Immunol 164:108-17. 2011
    ..Further evaluation of the role the immune system plays in the pathogenesis of CRPS may aid in elucidating disease mechanisms as well as the development of novel therapies for its treatment...
  6. ncbi request reprint Intracerebral microdialysis study of glutamate reuptake in awake, behaving rats
    G M Alexander
    Department of Neurology, Allegheny University of the Health Sciences, Philadelphia, PA 19102, USA
    Brain Res 766:1-10. 1997
    ..In addition, EL-glu is increased in a dose-dependent manner by the alpha1-adrenergic agonist phenylephrine, and this increase is blocked by the alpha-adrenergic antagonist phentolamine...
  7. ncbi request reprint GLT-1 glutamate transporter levels are unchanged in mice expressing G93A human mutant SOD1
    Jeffrey S Deitch
    Department of Neurology, MCP Hahnemann University, MS 423, 245 North 15th Street, Philadelphia, PA 19102 1192, USA
    J Neurol Sci 193:117-26. 2002
    ..These results show that a loss of GLT-1 protein is not necessary for ALS-like neurodegeneration in G93A mice. However, the changes in GLT-1 mobility and distribution indicate that GLT-1 is altered in mice with the SOD1 mutation...
  8. ncbi request reprint Pathophysiology of complex regional pain syndrome
    Robert J Schwartzman
    Drexel University College of Medicine, Department of Neurology, 245 N 15 Street, MS 423 Philadelphia, PA 19102, USA
    Expert Rev Neurother 6:669-81. 2006
    ..The role of the immune system and the sickness response is becoming clearer as microglia are activated following injury and can induce central sensitization while astrocytes may maintain the process...
  9. ncbi request reprint Changes in immune and glial markers in the CSF of patients with Complex Regional Pain Syndrome
    Guillermo M Alexander
    Department of Neurology, Drexel University College of Medicine, Philadelphia, PA 19102, USA
    Brain Behav Immun 21:668-76. 2007
    ..A better understanding of these mechanisms may lead to novel treatments for this very severe, life-altering illness...
  10. ncbi request reprint The WldS gene modestly prolongs survival in the SOD1G93A fALS mouse
    Lindsey R Fischer
    Department of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Neurobiol Dis 19:293-300. 2005
    ..We also report that SOD1G93A mice show significant degeneration of sensory axons during the course of disease, supporting previous data from humans demonstrating that ALS is not purely a motor disorder...
  11. doi request reprint The natural history of complex regional pain syndrome
    Robert J Schwartzman
    Department of Neurology, Drexel University College of Medicine, Philadelphia, PA 19102, USA
    Clin J Pain 25:273-80. 2009
    ..This study was undertaken to expand our current knowledge of the evolution of CRPS signs and symptoms with duration of disease...
  12. doi request reprint Outpatient intravenous ketamine for the treatment of complex regional pain syndrome: a double-blind placebo controlled study
    Robert J Schwartzman
    Department of Neurology, Drexel University College of Medicine, Philadelphia, PA 19102, USA
    Pain 147:107-15. 2009
    ..The results of this study warrant a larger randomized placebo controlled trial using higher doses of ketamine and a longer follow-up period...