W J Houlihan

Summary

Affiliation: Drew University
Country: USA

Publications

  1. ncbi Halogenated mazindol analogs as potential inhibitors of the cocaine binding site at the dopamine transporter
    W J Houlihan
    Charles A Dana Research Institute, Drew University, Madison, New Jersey 07940, USA
    J Med Chem 39:4935-41. 1996
  2. ncbi Mazindol analogues as potential inhibitors of the cocaine binding site at the dopamine transporter
    William J Houlihan
    Charles A Dana Research Institute, Drew University, Hall of Sciences, Madison, NJ 07940, USA
    J Med Chem 45:4097-109. 2002
  3. ncbi Benzo- and cyclohexanomazindol analogues as potential inhibitors of the cocaine binding site at the dopamine transporter
    William J Houlihan
    Charles A Dana Research Institute, Drew University, Hall of Sciences, Madison, NJ 07940, USA
    J Med Chem 45:4110-8. 2002
  4. ncbi Assessment of mazindane, a pro-drug form of mazindol, in assays used to define cocaine treatment agents
    William J Houlihan
    C A Dana Research Institute, Drew University, Madison, NJ 07940, USA
    Eur J Pharmacol 458:263-73. 2003
  5. ncbi Three-dimensional quantitative structure-activity relationships of mazindol analogues at the dopamine transporter
    Santosh S Kulkarni
    Medicinal Chemistry Section, National Institute on Drug Abuse-Intramural Research Program/NIH, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    J Med Chem 45:4119-27. 2002

Collaborators

Detail Information

Publications5

  1. ncbi Halogenated mazindol analogs as potential inhibitors of the cocaine binding site at the dopamine transporter
    W J Houlihan
    Charles A Dana Research Institute, Drew University, Madison, New Jersey 07940, USA
    J Med Chem 39:4935-41. 1996
    ....
  2. ncbi Mazindol analogues as potential inhibitors of the cocaine binding site at the dopamine transporter
    William J Houlihan
    Charles A Dana Research Institute, Drew University, Hall of Sciences, Madison, NJ 07940, USA
    J Med Chem 45:4097-109. 2002
    ..1 nM; SERT/DAT = 1283 and NET/DAT = 38). Experimental results strongly favor the cyclic or ol tautomers of 2 and 3 to bind more tightly at the DAT than the corresponding keto tautomers...
  3. ncbi Benzo- and cyclohexanomazindol analogues as potential inhibitors of the cocaine binding site at the dopamine transporter
    William J Houlihan
    Charles A Dana Research Institute, Drew University, Hall of Sciences, Madison, NJ 07940, USA
    J Med Chem 45:4110-8. 2002
    ..Compounds 25and 28 showed a considerable increase versus 1 in uptake/binding discrimination ratios at the DAT (311.0 and 182.1 vs 0.9), SERT (33.6 and 127.3 vs 1.9), and NET (7.3 and 10.0 vs 0.3)...
  4. ncbi Assessment of mazindane, a pro-drug form of mazindol, in assays used to define cocaine treatment agents
    William J Houlihan
    C A Dana Research Institute, Drew University, Madison, NJ 07940, USA
    Eur J Pharmacol 458:263-73. 2003
    ..These results demonstrate that mazindane could be a useful alternative to mazindol as a pharmacological tool because of its similar profile of activity and enhanced water solubility...
  5. ncbi Three-dimensional quantitative structure-activity relationships of mazindol analogues at the dopamine transporter
    Santosh S Kulkarni
    Medicinal Chemistry Section, National Institute on Drug Abuse-Intramural Research Program/NIH, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    J Med Chem 45:4119-27. 2002
    ..The aromatic rings C and D are involved in hydrophobic interactions in which ring D may bind in a large hydrophobic groove. The relative orientation of these two rings is also important for high binding affinity to the DAT...