W J Houlihan

Summary

Affiliation: Drew University
Country: USA

Publications

  1. ncbi request reprint Halogenated mazindol analogs as potential inhibitors of the cocaine binding site at the dopamine transporter
    W J Houlihan
    Charles A Dana Research Institute, Drew University, Madison, New Jersey 07940, USA
    J Med Chem 39:4935-41. 1996
  2. ncbi request reprint Mazindol analogues as potential inhibitors of the cocaine binding site at the dopamine transporter
    William J Houlihan
    Charles A Dana Research Institute, Drew University, Hall of Sciences, Madison, NJ 07940, USA
    J Med Chem 45:4097-109. 2002
  3. ncbi request reprint Benzo- and cyclohexanomazindol analogues as potential inhibitors of the cocaine binding site at the dopamine transporter
    William J Houlihan
    Charles A Dana Research Institute, Drew University, Hall of Sciences, Madison, NJ 07940, USA
    J Med Chem 45:4110-8. 2002
  4. ncbi request reprint Assessment of mazindane, a pro-drug form of mazindol, in assays used to define cocaine treatment agents
    William J Houlihan
    C A Dana Research Institute, Drew University, Madison, NJ 07940, USA
    Eur J Pharmacol 458:263-73. 2003
  5. ncbi request reprint Three-dimensional quantitative structure-activity relationships of mazindol analogues at the dopamine transporter
    Santosh S Kulkarni
    Medicinal Chemistry Section, National Institute on Drug Abuse Intramural Research Program NIH, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    J Med Chem 45:4119-27. 2002

Collaborators

Detail Information

Publications5

  1. ncbi request reprint Halogenated mazindol analogs as potential inhibitors of the cocaine binding site at the dopamine transporter
    W J Houlihan
    Charles A Dana Research Institute, Drew University, Madison, New Jersey 07940, USA
    J Med Chem 39:4935-41. 1996
    ....
  2. ncbi request reprint Mazindol analogues as potential inhibitors of the cocaine binding site at the dopamine transporter
    William J Houlihan
    Charles A Dana Research Institute, Drew University, Hall of Sciences, Madison, NJ 07940, USA
    J Med Chem 45:4097-109. 2002
    ..1 nM; SERT/DAT = 1283 and NET/DAT = 38). Experimental results strongly favor the cyclic or ol tautomers of 2 and 3 to bind more tightly at the DAT than the corresponding keto tautomers...
  3. ncbi request reprint Benzo- and cyclohexanomazindol analogues as potential inhibitors of the cocaine binding site at the dopamine transporter
    William J Houlihan
    Charles A Dana Research Institute, Drew University, Hall of Sciences, Madison, NJ 07940, USA
    J Med Chem 45:4110-8. 2002
    ..Compounds 25and 28 showed a considerable increase versus 1 in uptake/binding discrimination ratios at the DAT (311.0 and 182.1 vs 0.9), SERT (33.6 and 127.3 vs 1.9), and NET (7.3 and 10.0 vs 0.3)...
  4. ncbi request reprint Assessment of mazindane, a pro-drug form of mazindol, in assays used to define cocaine treatment agents
    William J Houlihan
    C A Dana Research Institute, Drew University, Madison, NJ 07940, USA
    Eur J Pharmacol 458:263-73. 2003
    ..These results demonstrate that mazindane could be a useful alternative to mazindol as a pharmacological tool because of its similar profile of activity and enhanced water solubility...
  5. ncbi request reprint Three-dimensional quantitative structure-activity relationships of mazindol analogues at the dopamine transporter
    Santosh S Kulkarni
    Medicinal Chemistry Section, National Institute on Drug Abuse Intramural Research Program NIH, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    J Med Chem 45:4119-27. 2002
    ..The aromatic rings C and D are involved in hydrophobic interactions in which ring D may bind in a large hydrophobic groove. The relative orientation of these two rings is also important for high binding affinity to the DAT...