Zhengming Chen

Summary

Affiliation: DOV Pharmaceutical
Country: USA

Publications

  1. ncbi request reprint Triple uptake inhibitors: therapeutic potential in depression and beyond
    Zhengming Chen
    DOV Pharmaceutical, Inc, Somerset, NJ 08873 4185, USA
    Expert Opin Investig Drugs 16:1365-77. 2007
  2. ncbi request reprint Designing new treatments for depression and anxiety
    Zhengming Chen
    DOV Pharmaceutical Inc, Somerset, NJ 08873 4185, USA
    IDrugs 11:189-97. 2008
  3. ncbi request reprint Design and parallel synthesis of piperidine libraries targeting the nociceptin (N/OFQ) receptor
    Zhengming Chen
    Computational, Combinatorial and Medicinal Chemistry, Purdue Pharma L P, 6 Cedar Brook Drive, Cranbury, NJ 08512, USA
    Bioorg Med Chem Lett 13:3247-52. 2003
  4. ncbi request reprint Design and synthesis of novel small molecule N/OFQ receptor antagonists
    Zhengming Chen
    Drug Discovery, Purdue Pharma L P, 6 Cedar Brook Drive, Cranbury, NJ 08512, USA
    Bioorg Med Chem Lett 14:1347-51. 2004
  5. ncbi request reprint The anxioselective agent 7-(2-chloropyridin-4-yl)pyrazolo-[1,5-a]-pyrimidin-3-yl](pyridin-2-yl)methanone (DOV 51892) is more efficacious than diazepam at enhancing GABA-gated currents at alpha1 subunit-containing GABAA receptors
    Piotr Popik
    Behavioral Neuroscience, Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
    J Pharmacol Exp Ther 319:1244-52. 2006

Detail Information

Publications5

  1. ncbi request reprint Triple uptake inhibitors: therapeutic potential in depression and beyond
    Zhengming Chen
    DOV Pharmaceutical, Inc, Somerset, NJ 08873 4185, USA
    Expert Opin Investig Drugs 16:1365-77. 2007
    ....
  2. ncbi request reprint Designing new treatments for depression and anxiety
    Zhengming Chen
    DOV Pharmaceutical Inc, Somerset, NJ 08873 4185, USA
    IDrugs 11:189-97. 2008
    ....
  3. ncbi request reprint Design and parallel synthesis of piperidine libraries targeting the nociceptin (N/OFQ) receptor
    Zhengming Chen
    Computational, Combinatorial and Medicinal Chemistry, Purdue Pharma L P, 6 Cedar Brook Drive, Cranbury, NJ 08512, USA
    Bioorg Med Chem Lett 13:3247-52. 2003
    ..Potent NOP receptor agonists and antagonists were obtained from these libraries as well as a few potent, mu selective agonists...
  4. ncbi request reprint Design and synthesis of novel small molecule N/OFQ receptor antagonists
    Zhengming Chen
    Drug Discovery, Purdue Pharma L P, 6 Cedar Brook Drive, Cranbury, NJ 08512, USA
    Bioorg Med Chem Lett 14:1347-51. 2004
    ..The resulting octahydrobenzimidazol-2-ones 14 and 23 show excellent antagonistic activity towards both N/OFQ and mu receptors with high affinity to the human N/OFQ receptor...
  5. ncbi request reprint The anxioselective agent 7-(2-chloropyridin-4-yl)pyrazolo-[1,5-a]-pyrimidin-3-yl](pyridin-2-yl)methanone (DOV 51892) is more efficacious than diazepam at enhancing GABA-gated currents at alpha1 subunit-containing GABAA receptors
    Piotr Popik
    Behavioral Neuroscience, Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
    J Pharmacol Exp Ther 319:1244-52. 2006
    ....