A Zlotnik

Summary

Affiliation: DNAX Research
Country: USA

Publications

  1. ncbi request reprint Chemokines: a new classification system and their role in immunity
    A Zlotnik
    DNAX Research Institute, Palo Alto, California 94304, USA
    Immunity 12:121-7. 2000
  2. ncbi request reprint Up-regulation of macrophage inflammatory protein-3 alpha/CCL20 and CC chemokine receptor 6 in psoriasis
    B Homey
    DNAX Research Institute, Palo Alto, CA 94304, USA
    J Immunol 164:6621-32. 2000
  3. ncbi request reprint Identification of a novel chemokine (CCL28), which binds CCR10 (GPR2)
    W Wang
    Department of Immunobiology, DNAX Research Institute, Palo Alto, California 94304, USA
    J Biol Chem 275:22313-23. 2000
  4. ncbi request reprint A molecular analysis of NKT cells: identification of a class-I restricted T cell-associated molecule (CRTAM)
    J Kennedy
    Department of Immunology, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, California 94304, USA
    J Leukoc Biol 67:725-34. 2000
  5. ncbi request reprint Lungkine, a novel CXC chemokine, specifically expressed by lung bronchoepithelial cells
    D L Rossi
    Department of Immunobiology, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA 94304, USA
    J Immunol 162:5490-7. 1999
  6. ncbi request reprint Involvement of chemokine receptors in breast cancer metastasis
    A Muller
    Department of Immunology, DNAX Research Institute, Palo Alto, California 94304, USA
    Nature 410:50-6. 2001
  7. ncbi request reprint Cutting edge: the orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC)
    B Homey
    DNAX Research Institute, Palo Alto, CA 94304, USA
    J Immunol 164:3465-70. 2000
  8. pmc CTACK, a skin-associated chemokine that preferentially attracts skin-homing memory T cells
    J Morales
    Department of Immunobiology, DNAX Research Institute, Palo Alto, CA 94304, USA
    Proc Natl Acad Sci U S A 96:14470-5. 1999
  9. pmc The CC chemokine 6Ckine binds the CXC chemokine receptor CXCR3
    H Soto
    DNAX Research Institute for Cellular and Molecular Biology, Palo Alto, CA 94304, USA
    Proc Natl Acad Sci U S A 95:8205-10. 1998
  10. ncbi request reprint IL-10 transgenic mice present a defect in T cell development reminiscent of SCID patients
    M Rouleau
    DNAX Research Institute, Palo Alto, CA 94304, USA
    J Immunol 163:1420-7. 1999

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Chemokines: a new classification system and their role in immunity
    A Zlotnik
    DNAX Research Institute, Palo Alto, California 94304, USA
    Immunity 12:121-7. 2000
  2. ncbi request reprint Up-regulation of macrophage inflammatory protein-3 alpha/CCL20 and CC chemokine receptor 6 in psoriasis
    B Homey
    DNAX Research Institute, Palo Alto, CA 94304, USA
    J Immunol 164:6621-32. 2000
    ..Taken together, these findings strongly suggest that CCL20/CCR6 may play a role in the recruitment of T cells to lesional psoriatic skin...
  3. ncbi request reprint Identification of a novel chemokine (CCL28), which binds CCR10 (GPR2)
    W Wang
    Department of Immunobiology, DNAX Research Institute, Palo Alto, California 94304, USA
    J Biol Chem 275:22313-23. 2000
    ..In vitro, recombinant human CCL28 displays chemotactic activity for resting CD4 or CD8 T cells...
  4. ncbi request reprint A molecular analysis of NKT cells: identification of a class-I restricted T cell-associated molecule (CRTAM)
    J Kennedy
    Department of Immunology, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, California 94304, USA
    J Leukoc Biol 67:725-34. 2000
    ..LPTN and CRTAM exhibit the same expression pattern in T cells, suggesting the existence of a gene expression program common to class I-MHC-restricted T cells...
  5. ncbi request reprint Lungkine, a novel CXC chemokine, specifically expressed by lung bronchoepithelial cells
    D L Rossi
    Department of Immunobiology, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA 94304, USA
    J Immunol 162:5490-7. 1999
    ..Using fluorescent in situ hybridization, we show that Lungkine maps to mouse chromosome 5...
  6. ncbi request reprint Involvement of chemokine receptors in breast cancer metastasis
    A Muller
    Department of Immunology, DNAX Research Institute, Palo Alto, California 94304, USA
    Nature 410:50-6. 2001
    ..Our findings indicate that chemokines and their receptors have a critical role in determining the metastatic destination of tumour cells...
  7. ncbi request reprint Cutting edge: the orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC)
    B Homey
    DNAX Research Institute, Palo Alto, CA 94304, USA
    J Immunol 164:3465-70. 2000
    ..Taken together, these observations suggest a role for this novel ligand/receptor pair in both skin homeostasis as well as a potential role in inflammatory responses...
  8. pmc CTACK, a skin-associated chemokine that preferentially attracts skin-homing memory T cells
    J Morales
    Department of Immunobiology, DNAX Research Institute, Palo Alto, CA 94304, USA
    Proc Natl Acad Sci U S A 96:14470-5. 1999
    ..CTACK is predominantly expressed in the skin and selectively attracts a tissue-specific subpopulation of memory lymphocytes...
  9. pmc The CC chemokine 6Ckine binds the CXC chemokine receptor CXCR3
    H Soto
    DNAX Research Institute for Cellular and Molecular Biology, Palo Alto, CA 94304, USA
    Proc Natl Acad Sci U S A 95:8205-10. 1998
    ..Its ability to attract T cells as well as its angiostatic properties suggest that 6Ckine may be an effective anti-tumor agent...
  10. ncbi request reprint IL-10 transgenic mice present a defect in T cell development reminiscent of SCID patients
    M Rouleau
    DNAX Research Institute, Palo Alto, CA 94304, USA
    J Immunol 163:1420-7. 1999
    ..These results demonstrate that IL-10 regulates T cell maturation and that dysregulation of IL-10 expression can lead to severe T cell immunodeficiency...
  11. ncbi request reprint Cloning and characterization of a new type of mouse chemokine
    D L Rossi
    Department of Immunobiology, DNAX Research Institute, Palo Alto, California 94304 1104, USA
    Genomics 47:163-70. 1998
    ..The novel location of this gene from other chemokine gene clusters adds to the notion that CX3C is a fundamentally new class of chemokine...
  12. ncbi request reprint Chemokines and lymphocyte biology
    J A Hedrick
    Department of Immunology, DNAX Research Institute, Palo Alto, California 94304, USA
    Curr Opin Immunol 8:343-7. 1996
    ..In particular, it appears that these molecules may represent major products of activated lymphocytes and that, in addition to chemotaxis, some of them may also regulate the growth, activation, and differentiation of lymphocytes...
  13. ncbi request reprint Chemokines in allergy
    B Homey
    Department of Immunology, DNAX Research Institute, Palo Alto, CA 93404 1104, USA
    Curr Opin Immunol 11:626-34. 1999
    ....
  14. ncbi request reprint Characterization of a novel CC chemokine, HCC-4, whose expression is increased by interleukin-10
    J A Hedrick
    DNAX Research Institute, Palo Alto, CA 94304, USA
    Blood 91:4242-7. 1998
    ..HCC-4 also induced a Ca2+ flux in THP-1 cells that was desensitized by prior exposure to RANTES. Taken together, these data indicate that HCC-4 is a novel chemokine whose expression is uniquely upregulated by IL-10...
  15. ncbi request reprint TECK: a novel CC chemokine specifically expressed by thymic dendritic cells and potentially involved in T cell development
    A P Vicari
    DNAX Research Institute, Palo Alto, California 94304 1104, USA
    Immunity 7:291-301. 1997
    ..We conclude that TECK represents a novel thymic dendritic cell-specific CC chemokine that is possibly involved in T cell development...
  16. ncbi request reprint Impaired pulmonary host defense in mice lacking expression of the CXC chemokine lungkine
    S C Chen
    Department of Immunology, Schering Plough Research Institute, Kenilworth, NJ 07033, USA
    J Immunol 166:3362-8. 2001
    ..Taken together, these findings demonstrate that Lungkine is an important mediator of neutrophil migration from the lung parenchyma into the airspace...
  17. pmc Aberrant in vivo T helper type 2 cell response and impaired eosinophil recruitment in CC chemokine receptor 8 knockout mice
    S W Chensue
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48105, USA
    J Exp Med 193:573-84. 2001
    ..These results indicate an important role for CCR8 in Th2 functional responses in vivo...
  18. ncbi request reprint Identification of viral macrophage inflammatory protein (vMIP)-II as a ligand for GPR5/XCR1
    L Shan
    Human Genome Research, Schering Plough Research Institute, Kenilworth, New Jersey 07033, USA
    Biochem Biophys Res Commun 268:938-41. 2000
    ..In addition, we have extended previous analyses of GPR5/XCR1 expression and show that this receptor is expressed in leukocyte cells previously shown to be responsive to lymphotactin...
  19. pmc The reduced expression of 6Ckine in the plt mouse results from the deletion of one of two 6Ckine genes
    G Vassileva
    Department of Immunology, Schering Plough Research Institute, Kenilworth, New Jersey 07033, USA
    J Exp Med 190:1183-8. 1999
    ..Here we demonstrate that mouse 6Ckine is encoded by two genes, one of which is expressed in lymphoid organs and is deleted in plt mice. A second 6Ckine gene is intact and expressed in the plt mouse...
  20. ncbi request reprint The chemokine receptor CCR8 is preferentially expressed in Th2 but not Th1 cells
    A Zingoni
    Laboratory of Pathophysiology, Regina Elena Cancer Institute, Rome, Italy
    J Immunol 161:547-51. 1998
    ..Taken together, these observations strongly suggest that CCR8 plays a role in the control of Th2 responses, and may represent a potential target for treatment of allergic diseases...
  21. pmc 6-C-kine (SLC), a lymphocyte adhesion-triggering chemokine expressed by high endothelium, is an agonist for the MIP-3beta receptor CCR7
    J J Campbell
    Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University Medical School, Stanford, California 94305, USA
    J Cell Biol 141:1053-9. 1998
    ....
  22. ncbi request reprint Identification of the CC chemokines TARC and macrophage inflammatory protein-1 beta as novel functional ligands for the CCR8 receptor
    G Bernardini
    Regina Elena Cancer Institute, Department of Experimental Medicine and Pathology, University of Rome, La Sapienza, Italy
    Eur J Immunol 28:582-8. 1998
    ..The pattern of CCR8 mRNA expression and the functional effects exerted by its ligand suggest that the triggering of this receptor may regulate multiple functions including activation, migration and proliferation of lymphoid cells...
  23. pmc CCR6, a CC chemokine receptor that interacts with macrophage inflammatory protein 3alpha and is highly expressed in human dendritic cells
    D R Greaves
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom
    J Exp Med 186:837-44. 1997
    ..The cloning and characterization of a dendritic cell CC chemokine receptor suggests a role for chemokines in the control of the migration of dendritic cells and the regulation of dendritic cell function in immunity and infection...
  24. ncbi request reprint Identification and characterization of a novel beta chemokine containing six conserved cysteines
    J A Hedrick
    DNAX Research Institute for Cellular and Molecular Biology, Palo Alto, CA 94304, USA
    J Immunol 159:1589-93. 1997
    ..Recombinant murine 6Ckine was chemotactic in vitro for thymocytes and activated T cells, but not for B cells, macrophages, or neutrophils. Together these data demonstrate that 6Ckine is a novel member of the chemokine superfamily...
  25. ncbi request reprint A new class of membrane-bound chemokine with a CX3C motif
    J F Bazan
    Department of Molecular Biology, DNAX Research Institute, Palo Alto, California 94304, USA
    Nature 385:640-4. 1997
    ....
  26. ncbi request reprint Experimental autoimmune encephalomyelitis develops in CC chemokine receptor 7-deficient mice with altered T-cell responses
    A Pahuja
    Departmen of Discovery Biology, Neurocrine Biosciences, Inc, San Diego, CA 92130, USA
    Scand J Immunol 64:361-9. 2006
    ..These results indicate that effective immune responses (with altered kinetics) can develop in the absence of CCR7 but develop in the spleen rather than lymph nodes as CCR7 is necessary for T and dendritic cells to enter lymph nodes...