Affiliation: DNAX Research
- Chemokines: a new classification system and their role in immunityA Zlotnik
DNAX Research Institute, Palo Alto, California 94304, USA
Immunity 12:121-7. 2000
- Identification of a novel chemokine (CCL28), which binds CCR10 (GPR2)W Wang
Department of Immunobiology, DNAX Research Institute, Palo Alto, California 94304, USA
J Biol Chem 275:22313-23. 2000..In vitro, recombinant human CCL28 displays chemotactic activity for resting CD4 or CD8 T cells...
- A new class of membrane-bound chemokine with a CX3C motifJ F Bazan
Department of Molecular Biology, DNAX Research Institute, Palo Alto, California 94304, USA
Nature 385:640-4. 1997....
- Aberrant in vivo T helper type 2 cell response and impaired eosinophil recruitment in CC chemokine receptor 8 knockout miceS W Chensue
Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48105, USA
J Exp Med 193:573-84. 2001..These results indicate an important role for CCR8 in Th2 functional responses in vivo...
- Impaired pulmonary host defense in mice lacking expression of the CXC chemokine lungkineS C Chen
Department of Immunology, Schering Plough Research Institute, Kenilworth, NJ 07033, USA
J Immunol 166:3362-8. 2001..Taken together, these findings demonstrate that Lungkine is an important mediator of neutrophil migration from the lung parenchyma into the airspace...
- Cutting edge: the orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC)B Homey
DNAX Research Institute, Palo Alto, CA 94304, USA
J Immunol 164:3465-70. 2000..Taken together, these observations suggest a role for this novel ligand/receptor pair in both skin homeostasis as well as a potential role in inflammatory responses...
- Identification of viral macrophage inflammatory protein (vMIP)-II as a ligand for GPR5/XCR1L Shan
Human Genome Research, Schering Plough Research Institute, Kenilworth, New Jersey 07033, USA
Biochem Biophys Res Commun 268:938-41. 2000..In addition, we have extended previous analyses of GPR5/XCR1 expression and show that this receptor is expressed in leukocyte cells previously shown to be responsive to lymphotactin...
- The reduced expression of 6Ckine in the plt mouse results from the deletion of one of two 6Ckine genesG Vassileva
Department of Immunology, Schering Plough Research Institute, Kenilworth, New Jersey 07033, USA
J Exp Med 190:1183-8. 1999..Here we demonstrate that mouse 6Ckine is encoded by two genes, one of which is expressed in lymphoid organs and is deleted in plt mice. A second 6Ckine gene is intact and expressed in the plt mouse...
- IL-10 transgenic mice present a defect in T cell development reminiscent of SCID patientsM Rouleau
DNAX Research Institute, Palo Alto, CA 94304, USA
J Immunol 163:1420-7. 1999..These results demonstrate that IL-10 regulates T cell maturation and that dysregulation of IL-10 expression can lead to severe T cell immunodeficiency...
- The chemokine receptor CCR8 is preferentially expressed in Th2 but not Th1 cellsA Zingoni
Laboratory of Pathophysiology, Regina Elena Cancer Institute, Rome, Italy
J Immunol 161:547-51. 1998..Taken together, these observations strongly suggest that CCR8 plays a role in the control of Th2 responses, and may represent a potential target for treatment of allergic diseases...
- 6-C-kine (SLC), a lymphocyte adhesion-triggering chemokine expressed by high endothelium, is an agonist for the MIP-3beta receptor CCR7J J Campbell
Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University Medical School, Stanford, California 94305, USA
J Cell Biol 141:1053-9. 1998....
- Identification of the CC chemokines TARC and macrophage inflammatory protein-1 beta as novel functional ligands for the CCR8 receptorG Bernardini
Regina Elena Cancer Institute, Department of Experimental Medicine and Pathology, University of Rome, La Sapienza, Italy
Eur J Immunol 28:582-8. 1998..The pattern of CCR8 mRNA expression and the functional effects exerted by its ligand suggest that the triggering of this receptor may regulate multiple functions including activation, migration and proliferation of lymphoid cells...
- Cloning and characterization of a new type of mouse chemokineD L Rossi
Department of Immunobiology, DNAX Research Institute, Palo Alto, California 94304 1104, USA
Genomics 47:163-70. 1998..The novel location of this gene from other chemokine gene clusters adds to the notion that CX3C is a fundamentally new class of chemokine...
- CCR6, a CC chemokine receptor that interacts with macrophage inflammatory protein 3alpha and is highly expressed in human dendritic cellsD R Greaves
Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom
J Exp Med 186:837-44. 1997..The cloning and characterization of a dendritic cell CC chemokine receptor suggests a role for chemokines in the control of the migration of dendritic cells and the regulation of dendritic cell function in immunity and infection...
- TECK: a novel CC chemokine specifically expressed by thymic dendritic cells and potentially involved in T cell developmentA P Vicari
DNAX Research Institute, Palo Alto, California 94304 1104, USA
Immunity 7:291-301. 1997..We conclude that TECK represents a novel thymic dendritic cell-specific CC chemokine that is possibly involved in T cell development...
- Identification and characterization of a novel beta chemokine containing six conserved cysteinesJ A Hedrick
DNAX Research Institute for Cellular and Molecular Biology, Palo Alto, CA 94304, USA
J Immunol 159:1589-93. 1997..Recombinant murine 6Ckine was chemotactic in vitro for thymocytes and activated T cells, but not for B cells, macrophages, or neutrophils. Together these data demonstrate that 6Ckine is a novel member of the chemokine superfamily...
- Experimental autoimmune encephalomyelitis develops in CC chemokine receptor 7-deficient mice with altered T-cell responsesA Pahuja
Departmen of Discovery Biology, Neurocrine Biosciences, Inc, San Diego, CA 92130, USA
Scand J Immunol 64:361-9. 2006..These results indicate that effective immune responses (with altered kinetics) can develop in the absence of CCR7 but develop in the spleen rather than lymph nodes as CCR7 is necessary for T and dendritic cells to enter lymph nodes...