W Wang

Summary

Affiliation: DNAX Research
Country: USA

Publications

  1. ncbi request reprint Molecular cloning and functional characterization of human MIP-1 delta, a new C-C chemokine related to mouse CCF-18 and C10
    W Wang
    Department of Immunobiology, DNAX Research Institute, Palo Alto, California 94304, USA
    J Clin Immunol 18:214-22. 1998
  2. ncbi request reprint Identification of a novel chemokine (CCL28), which binds CCR10 (GPR2)
    W Wang
    Department of Immunobiology, DNAX Research Institute, Palo Alto, California 94304, USA
    J Biol Chem 275:22313-23. 2000
  3. ncbi request reprint Cutting edge: the orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC)
    B Homey
    DNAX Research Institute, Palo Alto, CA 94304, USA
    J Immunol 164:3465-70. 2000
  4. ncbi request reprint Lungkine, a novel CXC chemokine, specifically expressed by lung bronchoepithelial cells
    D L Rossi
    Department of Immunobiology, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA 94304, USA
    J Immunol 162:5490-7. 1999
  5. pmc The CC chemokine 6Ckine binds the CXC chemokine receptor CXCR3
    H Soto
    DNAX Research Institute for Cellular and Molecular Biology, Palo Alto, CA 94304, USA
    Proc Natl Acad Sci U S A 95:8205-10. 1998
  6. ncbi request reprint A new class of membrane-bound chemokine with a CX3C motif
    J F Bazan
    Department of Molecular Biology, DNAX Research Institute, Palo Alto, California 94304, USA
    Nature 385:640-4. 1997
  7. ncbi request reprint Cloning of Trp1beta isoform from rat brain: immunodetection and localization of the endogenous Trp1 protein
    W Wang
    Secretory Physiology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    Am J Physiol 276:C969-79. 1999
  8. pmc Atrial G protein-activated K+ channel: expression cloning and molecular properties
    N Dascal
    Division of Biology, California Institute of Technology, Pasadena 91125
    Proc Natl Acad Sci U S A 90:10235-9. 1993
  9. ncbi request reprint Cloning and characterization of a human lysyl oxidase-like 3 gene (hLOXL3)
    Y Huang
    Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433, PR China
    Matrix Biol 20:153-7. 2001
  10. ncbi request reprint Cloning and characterization of a novel human TEKTIN1 gene
    M Xu
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433, People s Republic of China
    Int J Biochem Cell Biol 33:1172-82. 2001

Collaborators

Detail Information

Publications62

  1. ncbi request reprint Molecular cloning and functional characterization of human MIP-1 delta, a new C-C chemokine related to mouse CCF-18 and C10
    W Wang
    Department of Immunobiology, DNAX Research Institute, Palo Alto, California 94304, USA
    J Clin Immunol 18:214-22. 1998
    ..Human MIP-1 delta is chemotactic for T cells and monocytes, but not for neutrophils, eosinophils, or B cells. Human MIP-1 delta induced calcium flux in human CCR1-transfected cells...
  2. ncbi request reprint Identification of a novel chemokine (CCL28), which binds CCR10 (GPR2)
    W Wang
    Department of Immunobiology, DNAX Research Institute, Palo Alto, California 94304, USA
    J Biol Chem 275:22313-23. 2000
    ..In vitro, recombinant human CCL28 displays chemotactic activity for resting CD4 or CD8 T cells...
  3. ncbi request reprint Cutting edge: the orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC)
    B Homey
    DNAX Research Institute, Palo Alto, CA 94304, USA
    J Immunol 164:3465-70. 2000
    ..Taken together, these observations suggest a role for this novel ligand/receptor pair in both skin homeostasis as well as a potential role in inflammatory responses...
  4. ncbi request reprint Lungkine, a novel CXC chemokine, specifically expressed by lung bronchoepithelial cells
    D L Rossi
    Department of Immunobiology, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA 94304, USA
    J Immunol 162:5490-7. 1999
    ..Using fluorescent in situ hybridization, we show that Lungkine maps to mouse chromosome 5...
  5. pmc The CC chemokine 6Ckine binds the CXC chemokine receptor CXCR3
    H Soto
    DNAX Research Institute for Cellular and Molecular Biology, Palo Alto, CA 94304, USA
    Proc Natl Acad Sci U S A 95:8205-10. 1998
    ..Its ability to attract T cells as well as its angiostatic properties suggest that 6Ckine may be an effective anti-tumor agent...
  6. ncbi request reprint A new class of membrane-bound chemokine with a CX3C motif
    J F Bazan
    Department of Molecular Biology, DNAX Research Institute, Palo Alto, California 94304, USA
    Nature 385:640-4. 1997
    ....
  7. ncbi request reprint Cloning of Trp1beta isoform from rat brain: immunodetection and localization of the endogenous Trp1 protein
    W Wang
    Secretory Physiology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    Am J Physiol 276:C969-79. 1999
    ..The data demonstrate for the first time the presence of Trp1 protein in a nonexcitable cell...
  8. pmc Atrial G protein-activated K+ channel: expression cloning and molecular properties
    N Dascal
    Division of Biology, California Institute of Technology, Pasadena 91125
    Proc Natl Acad Sci U S A 90:10235-9. 1993
    ..The hypothesis that similar channels play a role in neuronal inhibition is supported by the cloning of a nearly identical channel (KGB1) from a rat brain cDNA library...
  9. ncbi request reprint Cloning and characterization of a human lysyl oxidase-like 3 gene (hLOXL3)
    Y Huang
    Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433, PR China
    Matrix Biol 20:153-7. 2001
    ..The hLOXL3 gene was mapped to human 2p13 locus by BLAST search and at least 14 exons were found. Expression of the hLOXL3 gene was detected in several human tissues and especially high in spleen and testis...
  10. ncbi request reprint Cloning and characterization of a novel human TEKTIN1 gene
    M Xu
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433, People s Republic of China
    Int J Biochem Cell Biol 33:1172-82. 2001
    ..By in-situ hybridization analysis, TEKTIN1 mRNA was localized to spermatocytes and round spermatids in the seminiferous tubules of the mouse testis, indicating that it may play a role in spermatogenesis...
  11. pmc CCR6, a CC chemokine receptor that interacts with macrophage inflammatory protein 3alpha and is highly expressed in human dendritic cells
    D R Greaves
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom
    J Exp Med 186:837-44. 1997
    ..The cloning and characterization of a dendritic cell CC chemokine receptor suggests a role for chemokines in the control of the migration of dendritic cells and the regulation of dendritic cell function in immunity and infection...
  12. ncbi request reprint Alternative transcripts of the GABA(A) receptor epsilon subunit in human and rat
    P A Davies
    Department of Pharmacology, The George Washington University Medical Center, 2300 Eye Street, N W, Washington, DC 20037, USA
    Neuropharmacology 43:467-75. 2002
    ....
  13. ncbi request reprint Cloning and characterization of the cDNA and gene encoding the gamma-subunit of cGMP-phosphodiesterase in canine retinal rod photoreceptor cells
    W Wang
    James A Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Gene 181:1-5. 1996
    ..The canine gene (2.8 kb) consists of four exons and is much smaller than the human gene (6 kb). The larger size of the human gene is primarily due to the presence of AluI repetitive elements in its first two introns...
  14. ncbi request reprint beta -Amyloid peptide-induced apoptosis regulated by a novel protein containing a g protein activation module
    E M Kajkowski
    Wyeth Neuroscience, Wyeth Ayerst Research, CN 8000, Princeton, New Jersey 08543 8000, USA
    J Biol Chem 276:18748-56. 2001
    ..These findings suggest that BBP is a target of neurotoxic beta-amyloid peptide and provide new insight into the molecular pathophysiology of Alzheimer's disease...
  15. pmc Expression cloning of two genes that together mediate organic solute and steroid transport in the liver of a marine vertebrate
    W Wang
    Department of Environmental Medicine, University of Rochester School of Medicine, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 98:9431-6. 2001
    ..These results identify an organic anion transporter composed of a putative seven-helix TM protein and an ancillary membrane polypeptide...
  16. ncbi request reprint Cloning and expression pattern of the human NDRG3 gene
    W Zhao
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433, People s Republic of China
    Biochim Biophys Acta 1519:134-8. 2001
    ..By in situ hybridization, the NDRG3 mRNA was localized to the outer layers of seminiferous epithelium, indicating that it may play a role in spermatogenesis...
  17. ncbi request reprint PDZ-binding kinase participates in spermatogenesis
    S Zhao
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, 200433, Shanghai, China
    Int J Biochem Cell Biol 33:631-6. 2001
    ..SPK mRNA was localized to the outer cell layer of seminiferous tubules by in situ hybridization, suggesting involvement of it in the process of spermatogenesis...
  18. ncbi request reprint Cloning and characterization of a novel human leptin receptor overlapping transcript-like 1 gene (LEPROTL1)
    Y Huang
    Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433, China
    Biochim Biophys Acta 1517:327-31. 2001
    ..Northern blot analysis showed that this new gene is widely expressed in human tissues and radiation hybrid mapping placed the gene to human chromosome 8p21.1-8p21.2...
  19. ncbi request reprint A functional interaction with CBP contributes to transcriptional activation by the Wilms tumor suppressor WT1
    W Wang
    Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Biol Chem 276:16810-6. 2001
    ..These observations support a model of WT1 as a transcriptional activator of genes required for cellular differentiation...
  20. ncbi request reprint Characterization of the 5' flanking region of the rat D(3) dopamine receptor gene
    W Wang
    Genetic Pharmacology Unit, Experimental Therapeutics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurochem 76:1736-44. 2001
    ..The D(3) promoter is inactive in C6 and COS7 cells. We conclude that the D(3) gene, similar to the closely related D(2) gene, is transcribed from a tissue specific promoter which is under intense negative control...
  21. ncbi request reprint Molecular cloning, mapping and characterization of the human neurocalcin delta gene (NCALD)
    W Wang
    The Institute of Genetics, School of Life Science, Fudan University, 200433, Shanghai, PR China
    Biochim Biophys Acta 1518:162-7. 2001
    ..Tissue in situ hybridization confirmed the existence of the NCALD mRNA in the adult human testis. Radiation hybrid panel mapping localized the gene to chromosome 8 between molecular markers D8S270 and D8S257...
  22. ncbi request reprint Zonula occludens toxin structure-function analysis. Identification of the fragment biologically active on tight junctions and of the zonulin receptor binding domain
    M Di Pierro
    Division of Pediatric Gastroenterology and Nutrition and Gastrointestinal Pathophysiology Section, Center for Vaccine Development, Department of Physiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Biol Chem 276:19160-5. 2001
    ..Amino acid comparison between the Zot active fragment and zonulin, combined with site-directed mutagenesis experiments, confirmed the presence of an octapeptide receptor-binding domain toward the amino terminus of the processed Zot...
  23. pmc Resistance of Streptococcus pneumoniae to deformylase inhibitors is due to mutations in defB
    P Margolis
    Versicor, Inc, Fremont, California 94555, USA
    Antimicrob Agents Chemother 45:2432-5. 2001
    ..pneumoniae ATCC 49619 harbor mutations in defB but not in fmt. Reintroduction of the mutated defB gene into wild-type S. pneumoniae R6x recreates the resistance phenotype. The altered enzyme displays decreased sensitivity to actinonin...
  24. ncbi request reprint Molecular and functional characterization of a vasotocin-sensitive aquaporin water channel in quail kidney
    Y Yang
    Dept of Physiology, Univ of Tennessee Health Science Center, 894 Union Ave, Memphis, TN 38163, USA
    Am J Physiol Regul Integr Comp Physiol 287:R915-24. 2004
    ..This is the first clear identification of AQP2 homolog in nonmammalian vertebrates...
  25. ncbi request reprint [Cloning and identification of an unknown gene encoding 10.6 kDa protein of Schistosoma japonicum]
    J J Shen
    Department of Parasitology, Anhui Medical University, Hefei 230032
    Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi 19:157-9. 2001
    ..6 kDa schistosome protein. The results provide foundation for further study of the protein for its possibility as candidate vaccine...
  26. ncbi request reprint Rate-dependency of calcitonin secretion in response to increased plasma Ca2+
    W Wang
    Nephrological Department P, Rigshospitalet, University of Copenhagen, Denmark
    Eur J Clin Invest 32:669-73. 2002
    ..The present study therefore further characterized the sigmoidal relationship between plasma ionized calcium (P-Ca2+) and CT in normal rats, and examined the possibility of rate-dependency of CT secretion in response to changes in P-Ca2+...
  27. ncbi request reprint MoeA, an enzyme in the molybdopterin synthesis pathway, is required for rifamycin SV production in Amycolatopsis mediterranei U32
    W Wang
    Laboratory of Molecular Microbiology, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 300 Fenglin Road, P R China
    Appl Microbiol Biotechnol 60:139-46. 2002
    ..mediterranei, and that the nitrogen assimilation pathway involved in nitrate reductase is the major pathway for the genesis of the amide nitrogen atom in the rifamycin SV molecule...
  28. ncbi request reprint Crystal structure and mechanism of catalysis of a pyrazinamidase from Pyrococcus horikoshii
    X Du
    Department of Chemistry, University of California, Berkeley 94720, USA
    Biochemistry 40:14166-72. 2001
    ..Because of extensive homology between PH999 and PZAase of M. tuberculosis (37% sequence identity), the structure of PH999 provides a structural basis for understanding PZA-resistance by M. tuberculosis harboring PZAase mutations...
  29. pmc Signal pathways which promote invasion and metastasis: critical and distinct contributions of extracellular signal-regulated kinase and Ral-specific guanine exchange factor pathways
    Y Ward
    Cell and Cancer Biology Branch, Center for Cancer Research, National Cancer Institute, Building 10, Bethesda, MD 20892, USA
    Mol Cell Biol 21:5958-69. 2001
    ..The generality of the role of the RalGEF pathway in metastasis is supported by the finding that Ras(12V,37G) increased the invasiveness of epithelial cells as well as fibroblasts...
  30. ncbi request reprint Phosphorylation of tau by glycogen synthase kinase 3beta in intact mammalian cells influences the stability of microtubules
    H Sang
    Department of Cell Biology and Genetics, College of Life Science, Peking University, Beijing 100871, China
    Neurosci Lett 312:141-4. 2001
    ..The bundles induced by GSK-3beta phosphorylated tau were sensitive to colchicine, and could be reversed by the addition of LiCl, an inhibitor of GSK-3beta...
  31. pmc RL-37, an alpha-helical antimicrobial peptide of the rhesus monkey
    C Zhao
    Department of Medicine, UCLA School of Medicine, 10833 LeConte Ave, Los Angeles, CA 90095, USA
    Antimicrob Agents Chemother 45:2695-702. 2001
    ....
  32. ncbi request reprint Identification, sequence analysis, and phylogeny of the immediate early gene 1 of the Trichoplusia ni single nucleocapsid polyhedrosis virus
    W Wang
    Department of Microbiology, University of the Western Cape, Bellville, South Africa
    Virus Genes 23:53-62. 2001
    ..The phylogenetic estimation of the ie-1 genes shows that TniSNPV is a member of the previously described lepidopteran NPV group II and it is most closely related to SeMNPV...
  33. pmc In vitro evaluation of cancer-specific NF-kappaB-CEA enhancer-promoter system for 5-fluorouracil prodrug gene therapy in colon cancer cell lines
    X Guo
    Oncology Group, Research Institute in Healthcare Science, School of Applied Sciences, University of Wolverhampton, Wolverhampton, UK
    Br J Cancer 97:745-54. 2007
    ..This is the first report that indicates that the NF-kappaB DNA-binding site could be used as a novel cancer-specific enhancer to improve cancer-specific promoter activity in gene-directed enzyme prodrug therapy...
  34. ncbi request reprint Identification of a human LNX protein containing multiple PDZ domains
    Y Xie
    Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433, People s Republic of China
    Biochem Genet 39:117-26. 2001
    ..We predict that LNX may be important for the organization of signaling complexes in Numb-involved pathways or pathways regulated by other PTB-containing proteins...
  35. ncbi request reprint Molecular cloning and expression analysis of a mouse UDP-GlcNAc:Gal(beta1-4)Glc(NAc)-R beta1,3-N-acetylglucosaminyltransferase homologous to Drosophila melanogaster Brainiac and the beta1,3-galactosyltransferase family
    S Egan
    The Programs in Developmental Biology, The Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8, Canada
    Glycoconj J 17:867-75. 2000
    ..The beta 3GnT gene is also expressed in a number of tumor cell lines. The human orthologue of beta 3GnT is located on chromosome 2pl5...
  36. ncbi request reprint Analyses of the genomic methylation status of the human cyclin A1 promoter by a novel real-time PCR-based methodology
    C Muller-Tidow
    Department of Medicine, Hematology and Oncology, University of Munster, Domagkstr 3, 48129 Munster, Germany
    FEBS Lett 490:75-8. 2001
    ..Taken together, our data provide evidence that CpG methylation patterns of the human cyclin A1 promoter in human organs do not generally correlate with cyclin A1 gene expression in vivo...
  37. ncbi request reprint Hmx: an evolutionary conserved homeobox gene family expressed in the developing nervous system in mice and Drosophila
    W Wang
    Brookdale Center for Developmental and Molecular Biology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029 6574, USA
    Mech Dev 99:123-37. 2000
    ....
  38. ncbi request reprint Transcriptional activation of E2F1 gene expression by 17beta-estradiol in MCF-7 cells is regulated by NF-Y-Sp1/estrogen receptor interactions
    W Wang
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station 77843 4466, USA
    Mol Endocrinol 13:1373-87. 1999
    ..This represents a unique trans-acting protein complex in which ligand-dependent transactivation by the ER is independent of direct ER interactions with promoter elements...
  39. pmc The EH and SH3 domain Ese proteins regulate endocytosis by linking to dynamin and Eps15
    A S Sengar
    Programs of Cancer and Blood Research, and Developmental Biology, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, M5G 1X8, Canada
    EMBO J 18:1159-71. 1999
    ..The Ese1-Eps15 scaffold therefore links dynamin, epsin and other endocytic pathway components...
  40. ncbi request reprint NURD, a novel complex with both ATP-dependent chromatin-remodeling and histone deacetylase activities
    Y Xue
    Laboratory of Genetics, National Institute on Aging, National Institute of Health, Gerontology Research Center, Baltimore, Maryland 21224, USA
    Mol Cell 2:851-61. 1998
    ..These results suggest that ATP-dependent chromatin remodeling can participate in transcriptional repression by assisting repressors in gaining access to chromatin...
  41. ncbi request reprint Processing of the notch ligand delta by the metalloprotease Kuzbanian
    H Qi
    Howard Hughes Medical Institute, Yale University School of Medicine, Boyer Center for Molecular Medicine, 295 Congress Avenue, New Haven, CT 06536 0812, USA
    Science 283:91-4. 1999
    ..The ADAM disintegrin metalloprotease Kuzbanian is required for this processing event. These observations raise the possibility that Notch signaling in vivo is modulated by soluble forms of the Notch ligands...
  42. ncbi request reprint Functional analysis and tissue-specific expression of Drosophila Na+,K+-ATPase subunits
    B Sun
    Division of Neurosciences, Beckman Research Institute of the City of Hope, Duarte, California 91010, USA
    J Neurochem 71:142-51. 1998
    ..It will now be possible to use the advantages of Drosophila molecular and classical genetics to investigate the phenotypic consequences of altering Na+,K+-ATPase expression in various cell and tissue types...
  43. ncbi request reprint Structure and organization of the Drosophila cholinergic locus
    T Kitamoto
    Beckman Research Institute of the City of Hope, Duarte, California 91010, USA
    J Biol Chem 273:2706-13. 1998
    ..These features of the VAChT 5'-UTR region suggest that a ribosome scanning model may not be used for VAChT translation initiation...
  44. ncbi request reprint Cloning and characterization of the cDNA encoding the alpha-subunit of cGMP-phosphodiesterase in canine retinal rod photoreceptor cells
    W Wang
    The James A Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Mol Vis 2:3. 1996
  45. ncbi request reprint Otp maps to mouse chromosome 13
    W Wang
    Brookdale Center for Developmental and Molecular Biology, Mount Sinai School of Medicine Box 1126, One Gustave L Levy Place, New York, New York 10029 6574, USA
    Mamm Genome 8:537-8. 1997
  46. ncbi request reprint Msx3: a novel murine homologue of the Drosophila msh homeobox gene restricted to the dorsal embryonic central nervous system
    W Wang
    Brookdale Center for Molecular Biology, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    Mech Dev 58:203-15. 1996
    ..By analogy with the expression of msh/Msx genes in other organisms, it is likely that one of the ancestral functions of the msh/Msx gene family is in patterning of the CNS...
  47. pmc Mammalian Sug1 and c-Fos in the nuclear 26S proteasome
    W Wang
    Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 93:8236-40. 1996
    ..We conclude that FZA-B is the mammalian homolog of SUG1 (mSug1) and that it is present in the nuclear 26S proteasome of cells. Our results suggest that mSug1 may be involved in the degradation of c-Fos and other transcription factors...
  48. ncbi request reprint Dlx5 and Dlx6: an evolutionary conserved pair of murine homeobox genes expressed in the embryonic skeleton
    X Chen
    Brookdale Center for Molecular Biology, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    Ann N Y Acad Sci 785:38-47. 1996
  49. ncbi request reprint Computational EST database analysis identifies a novel member of the neuropoietic cytokine family
    Y Shi
    Department of Molecular Biology, Department of Pharmacology, Department of Protein Expression, Human Genome Sciences, Inc, 9410 Key West Avenue, Rockville, Maryland 20850, USA
    Biochem Biophys Res Commun 262:132-8. 1999
    ..Furthermore, the signal transduction pathway for CLC was characterized in the neuroblastoma cell line SK-N-MC and found to involve tyrosine phosphorylation of gp130 and STAT-1...
  50. ncbi request reprint Molecular characterization and mapping of canine cGMP-phosphodiesterase delta subunit (PDE6D)
    W Wang
    The James A Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Gene 236:325-32. 1999
    ..This disease is characterized by abnormal retinal cGMP metabolism due to a deficiency in cGMP-PDE activity, yet the alpha, beta and gamma subunits of PDE have been excluded as candidate gene loci...
  51. ncbi request reprint Identification and cloning of a CD43-associated serine/threonine kinase
    W Wang
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cell Immunol 205:34-9. 2000
    ..The identification of this protein suggests that CD43 may mediate its biologic effects through activation of a kinase cascade, resulting in the regulation of cell growth...
  52. pmc A specificity and targeting subunit of a human SWI/SNF family-related chromatin-remodeling complex
    Z Nie
    Laboratory of Genetics, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
    Mol Cell Biol 20:8879-88. 2000
    ..Our data suggest that BAF250 confers specificity to the human BAF complex and may recruit the complex to its targets through either protein-DNA or protein-protein interactions...
  53. ncbi request reprint Expression and structural characterization of the recombinant human doppel protein
    K Lu
    Institute of Pathology and Mass Spectrometry Core Facility, Case Western Reserve University, 2085 Adelbert Road, Cleveland, Ohio 44106, USA
    Biochemistry 39:13575-83. 2000
    ..This study provides knowledge about the molecular features of human Dpl that will be useful in further investigation into its normal function and the role it may play in neurodegenerative diseases...
  54. ncbi request reprint The origin of the Jingwei gene and the complex modular structure of its parental gene, yellow emperor, in Drosophila melanogaster
    W Wang
    Department of Ecology and Evolution, University of Chicago Department of Molecular and Cellular Biology, Harvard University
    Mol Biol Evol 17:1294-301. 2000
    ..The composite gene structure of ymp manifests the complexity of the gene concept, which should be considered in genomic research, e.g., gene finding...
  55. ncbi request reprint Mouse RNA helicase II/Gu: cDNA and genomic sequences, chromosomal localization, and regulation of expression
    B C Valdez
    Department of Pharmacology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas, 77030, USA
    Genomics 66:184-94. 2000
    ..Both mouse and human RH II/Gu genes are localized on chromosome 10. The availability of the mouse RH II/Gu gene will facilitate its functional analysis including creation of a mouse deficient in RH II/Gu protein...
  56. ncbi request reprint A novel cytokine receptor-ligand pair. Identification, molecular characterization, and in vivo immunomodulatory activity
    Y Shi
    Departments of Molecular Biology, Protein Development, Strategic Drug Development, and Cell Biology, Human Genome Sciences, Inc, Rockville, Maryland 20850, USA
    J Biol Chem 275:19167-76. 2000
    ..Together these results suggest that IL-17B may be a novel proinflammatory cytokine acting on a restricted set of target cell types. They also demonstrate the strength of genomic approaches in the unraveling of novel biological pathways...
  57. pmc A family of chromatin remodeling factors related to Williams syndrome transcription factor
    D A Bochar
    The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 97:1038-43. 2000
    ..WCRF180 is a member of a family of proteins sharing a putative heterochromatin localization domain, a PHD finger, and a bromodomain, prevalent in factors involved in regulation of chromatin structure...
  58. pmc HuR regulates p21 mRNA stabilization by UV light
    W Wang
    Laboratory of Biological Chemistry, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Mol Cell Biol 20:760-9. 2000
    ..Our findings indicate that HuR plays a major role in regulating stress-induced p21 expression by enhancing p21 mRNA stability and that these effects are coupled to HuR's elevated presence in the cytoplasm...
  59. ncbi request reprint The alpha1-6-fucosyltransferase gene and its biological significance
    E Miyoshi
    Department of Biochemistry, Osaka University Medical School, Room B 1, 2 2 Yamadaoka, Suita, Osaka, Japan
    Biochim Biophys Acta 1473:9-20. 1999
    ..In this review, we focus on alpha1-6FucT and summarize its properties, gene expression and biological significance...
  60. ncbi request reprint Origin of new genes and source for N-terminal domain of the chimerical gene, jingwei, in Drosophila
    M Long
    Department of Ecology and Evolution, The University of Chicago, IL 60637, USA
    Gene 238:135-41. 1999
    ..Thus, the 5' exons/introns originated from a previously existing gene that provided new modules with specific sub-function to create jgw...
  61. pmc The Ski oncoprotein interacts with the Smad proteins to repress TGFbeta signaling
    K Luo
    Life Sciences Division, Lawrence Berkeley National Laboratory LBNL, Berkeley, California 94720 USA
    Genes Dev 13:2196-206. 1999
    ..Our studies suggest a new paradigm for inactivation of the Smad proteins by an oncoprotein through transcriptional repression...
  62. ncbi request reprint Isolation and characterization of the human sucrase-isomaltase gene and demonstration of intestine-specific transcriptional elements
    G D Wu
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor
    J Biol Chem 267:7863-70. 1992
    ....