J D Sedgwick

Summary

Affiliation: DNAX Research
Country: USA

Publications

  1. pmc Generation of splenic follicular structure and B cell movement in tumor necrosis factor-deficient mice
    M C Cook
    Centenary Institute of Cancer Medicine and Cell Biology, Sydney, NSW, Australia 2050
    J Exp Med 188:1503-10. 1998
  2. ncbi Tumor necrosis factor: a master-regulator of leukocyte movement
    J D Sedgwick
    DNAX Research Institute, 901 California Avenue, Palo Alto, CA 94304 1104, USA
    Immunol Today 21:110-3. 2000
  3. pmc Increased thymic B cells but maintenance of thymic structure, T cell differentiation and negative selection in lymphotoxin-alpha and TNF gene-targeted mice
    A P Grech
    Centenary Institute of Cancer Medicine and Cell Biology, Newtown, NSW, Australia
    Dev Immunol 8:61-74. 2000
  4. ncbi Membrane-bound TNF supports secondary lymphoid organ structure but is subservient to secreted TNF in driving autoimmune inflammation
    S R Ruuls
    DNAX, 901 California Avenue, Palo Alto, CA 94304, USA
    Immunity 15:533-43. 2001
  5. ncbi Distinct roles for lymphotoxin-alpha and tumor necrosis factor in organogenesis and spatial organization of lymphoid tissue
    H Korner
    Centenary Institute of Cancer Medicine and Cell Biology, Sydney, Australia
    Eur J Immunol 27:2600-9. 1997
  6. ncbi Lymphotoxin controls alphaEbeta7-integrin expression by peripheral CD8+ T cells
    M J Gabor
    Centenary Institute of Cancer Medicine and Cell Biology, Sydney, NSW, Australia
    Immunol Cell Biol 79:323-31. 2001
  7. ncbi Structural deficiencies in granuloma formation in TNF gene-targeted mice underlie the heightened susceptibility to aerosol Mycobacterium tuberculosis infection, which is not compensated for by lymphotoxin
    A G Bean
    Centenary Institute of Cancer Medicine and Cell Biology, Newtown, Australia
    J Immunol 162:3504-11. 1999
  8. pmc Challenging cytokine redundancy: inflammatory cell movement and clinical course of experimental autoimmune encephalomyelitis are normal in lymphotoxin-deficient, but not tumor necrosis factor-deficient, mice
    D Sean Riminton
    Centenary Institute of Cancer Medicine and Cell Biology, Sydney, New South Wales 2050, Australia
    J Exp Med 187:1517-28. 1998
  9. ncbi Central nervous system microglial cell activation and proliferation follows direct interaction with tissue-infiltrating T cell blasts
    J D Sedgwick
    Centenary Institute of Cancer Medicine and Cell Biology, Royal Prince Alfred Hospital, Camperdown, Sydney, Australia
    J Immunol 160:5320-30. 1998
  10. ncbi Down-regulation of the macrophage lineage through interaction with OX2 (CD200)
    R M Hoek
    DNAX Research Institute of Molecular and Cellular Biology, 901 California Avenue, Palo Alto, CA 94304, USA
    Science 290:1768-71. 2000

Collaborators

Detail Information

Publications23

  1. pmc Generation of splenic follicular structure and B cell movement in tumor necrosis factor-deficient mice
    M C Cook
    Centenary Institute of Cancer Medicine and Cell Biology, Sydney, NSW, Australia 2050
    J Exp Med 188:1503-10. 1998
    ..Thus, TNF is necessary for creating the permissive environment for B cell movement and function, but is not itself responsible for these processes...
  2. ncbi Tumor necrosis factor: a master-regulator of leukocyte movement
    J D Sedgwick
    DNAX Research Institute, 901 California Avenue, Palo Alto, CA 94304 1104, USA
    Immunol Today 21:110-3. 2000
  3. pmc Increased thymic B cells but maintenance of thymic structure, T cell differentiation and negative selection in lymphotoxin-alpha and TNF gene-targeted mice
    A P Grech
    Centenary Institute of Cancer Medicine and Cell Biology, Newtown, NSW, Australia
    Dev Immunol 8:61-74. 2000
    ....
  4. ncbi Membrane-bound TNF supports secondary lymphoid organ structure but is subservient to secreted TNF in driving autoimmune inflammation
    S R Ruuls
    DNAX, 901 California Avenue, Palo Alto, CA 94304, USA
    Immunity 15:533-43. 2001
    ..We conclude that memTNF supports many processes underlying lymphoid tissue structure, but secreted TNF is needed for optimal inflammatory lesion development...
  5. ncbi Distinct roles for lymphotoxin-alpha and tumor necrosis factor in organogenesis and spatial organization of lymphoid tissue
    H Korner
    Centenary Institute of Cancer Medicine and Cell Biology, Sydney, Australia
    Eur J Immunol 27:2600-9. 1997
    ....
  6. ncbi Lymphotoxin controls alphaEbeta7-integrin expression by peripheral CD8+ T cells
    M J Gabor
    Centenary Institute of Cancer Medicine and Cell Biology, Sydney, NSW, Australia
    Immunol Cell Biol 79:323-31. 2001
    ....
  7. ncbi Structural deficiencies in granuloma formation in TNF gene-targeted mice underlie the heightened susceptibility to aerosol Mycobacterium tuberculosis infection, which is not compensated for by lymphotoxin
    A G Bean
    Centenary Institute of Cancer Medicine and Cell Biology, Newtown, Australia
    J Immunol 162:3504-11. 1999
    ..Thus, the enhanced susceptibility of TNF-/- is not compensated for by the presence of LT alpha, and the critical role of TNF is not in the activation of T cells and macrophages but in the local organization of granulomas...
  8. pmc Challenging cytokine redundancy: inflammatory cell movement and clinical course of experimental autoimmune encephalomyelitis are normal in lymphotoxin-deficient, but not tumor necrosis factor-deficient, mice
    D Sean Riminton
    Centenary Institute of Cancer Medicine and Cell Biology, Sydney, New South Wales 2050, Australia
    J Exp Med 187:1517-28. 1998
    ..We conclude from these studies that TNF and LT are functionally distinct cytokines in vivo, and despite sharing common receptors, show no redundancy of function nor mutual compensation...
  9. ncbi Central nervous system microglial cell activation and proliferation follows direct interaction with tissue-infiltrating T cell blasts
    J D Sedgwick
    Centenary Institute of Cancer Medicine and Cell Biology, Royal Prince Alfred Hospital, Camperdown, Sydney, Australia
    J Immunol 160:5320-30. 1998
    ..These outcomes are consistent with direct tissue macrophage-T cell interactions in situ that lead to activation, proliferation, and expansion of the responding tissue-resident cell...
  10. ncbi Down-regulation of the macrophage lineage through interaction with OX2 (CD200)
    R M Hoek
    DNAX Research Institute of Molecular and Cellular Biology, 901 California Avenue, Palo Alto, CA 94304, USA
    Science 290:1768-71. 2000
    ..Thus, in diverse tissues OX2 delivers an inhibitory signal for the macrophage lineage...
  11. pmc Unlinking tumor necrosis factor biology from the major histocompatibility complex: lessons from human genetics and animal models
    S R Ruuls
    DNAX Research Institute, Palo Alto, CA 94304 1104, USA
    Am J Hum Genet 65:294-301. 1999
  12. pmc Tumor necrosis factor-dependent segmental control of MIG expression by high endothelial venules in inflamed lymph nodes regulates monocyte recruitment
    M J Janatpour
    DNAX Research Institute, Inc, Palo Alto, CA 94304, USA
    J Exp Med 194:1375-84. 2001
    ....
  13. ncbi Tumour necrosis factor and lymphotoxin: molecular aspects and role in tissue-specific autoimmunity
    H Korner
    Centenary Institute of Cancer Medicine and Cell Biology, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia
    Immunol Cell Biol 74:465-72. 1996
    ....
  14. ncbi Allele-specific PCR analysis for detection of the gld Fas-ligand point mutation
    R M Hoek
    Centenary Institute of Cancer Medicine and Cell Biology, Royal Prince Alfred Hospital, Sydney, NSW, Australia
    J Immunol Methods 210:109-12. 1997
    ..This approach permits the screening of back-crossed F1 progeny within one day, using whole blood samples as a source of genomic DNA. The technique is fast, robust, easily learnt, and unambiguous...
  15. ncbi Induction of intratumoral tumor necrosis factor (TNF) synthesis and hemorrhagic necrosis by 5,6-dimethylxanthenone-4-acetic acid (DMXAA) in TNF knockout mice
    L M Ching
    Auckland Cancer Society Research Centre, University of Auckland, New Zealand
    Cancer Res 59:3304-7. 1999
    ..TNF protein was undetectable in liver and spleen tissue from TNF knockout mice, but was evident in tissue from TNF-positive mice. These results confirm that DMXAA has the novel ability of inducing tumors to synthesize TNF in situ...
  16. pmc Tumor necrosis factor sustains the generalized lymphoproliferative disorder (gld) phenotype
    H Korner
    Interdisziplinäres Zentrum für Klinische Forschung der Universität Erlangen Nürnberg, D 91054 Erlangen, Germany
    J Exp Med 191:89-96. 2000
    ..We conclude that TNF is necessary for the full manifestation of the lymphoproliferative disorder, in particular playing a critical role in lymphoaccumulation. Most importantly, absence of TNF protects gld mice against premature death...
  17. pmc Lymphotoxin alpha/beta and tumor necrosis factor are required for stromal cell expression of homing chemokines in B and T cell areas of the spleen
    V N Ngo
    Department of Microbiology and Immunology, University of California San Francisco, San Francisco, California 94143, USA
    J Exp Med 189:403-12. 1999
    ..Together these findings indicate that LTalpha1beta2 and TNF are required for the development and function of B and T zone stromal cells that make chemokines necessary for lymphocyte compartmentalization in the spleen...
  18. pmc Critical points of tumor necrosis factor action in central nervous system autoimmune inflammation defined by gene targeting
    H Korner
    Centenary Institute of Cancer Medicine and Cell Biology, Royal Prince Alfred Hospital, Sydney, New South Wales, 2050 Australia
    J Exp Med 186:1585-90. 1997
    ..These results are consistent with the TNF dependence of processes controlling initial leukocyte movement within the CNS. Nevertheless, potent alternative mechanisms exist to mediate all other phases of EAE...
  19. ncbi TNF/lymphotoxin-alpha double-mutant mice resist septic arthritis but display increased mortality in response to Staphylococcus aureus
    O Hultgren
    Department of Rheumatology, University of Goteborg, Sweden
    J Immunol 161:5937-42. 1998
    ..Our results show the importance of TNF/LT alpha in defense against systemic S. aureus infections and point out the detrimental role of these cytokines as mediators of inflammatory response in S. aureus arthritis...
  20. pmc An essential role for tumor necrosis factor in natural killer cell-mediated tumor rejection in the peritoneum
    M J Smyth
    Cellular Cytotoxicity Laboratory, The Austin Research Institute, Heidelberg, Victoria 3084, Australia
    J Exp Med 188:1611-9. 1998
    ..Overall, these data show that NK cells delivering perforin are the major effectors of class I- tumor rejection in the peritoneum, and that TNF is specifically critical for their recruitment to the peritoneum...
  21. ncbi DAP12-deficient mice fail to develop autoimmunity due to impaired antigen priming
    A B Bakker
    Department of Microbiology and Immunology and Cancer Research Institute, University of California, San Francisco 94143, USA
    Immunity 13:345-53. 2000
    ..These data suggest that DAP12 signaling may be required for optimal antigen-presenting cell (APC) function or inflammation...
  22. ncbi A chemokine-driven positive feedback loop organizes lymphoid follicles
    K M Ansel
    Department of Microbiology and Immunology, University of California San Francisco, 94143, USA
    Nature 406:309-14. 2000
    ..In germinal centres the feedback loop is overridden, with B-cell lymphotoxin alpha1beta2 expression being induced by a mechanism independent of BLC...
  23. ncbi Multiple deficiencies underlie NK cell inactivity in lymphotoxin-alpha gene-targeted mice
    M J Smyth
    Cellular Cytotoxicity Laboratory, The Austin Research Institute, Heidelberg, Victoria, Australia
    J Immunol 163:1350-3. 1999
    ..5- to 3-fold in LT-alpha-deficient mice, as compared with wild-type mice. Combined defects in NK cell development and effector function contribute to compromised NK cell antitumor function in LT-alpha-deficient mice...