K W Moore

Summary

Affiliation: DNAX Research
Country: USA

Publications

  1. ncbi Interleukin-10 and the interleukin-10 receptor
    K W Moore
    Department of Molecular Biology, DNAX Research Institute of Molecular and Cellular Biology Inc, Palo Alto, California 94304, USA
    Annu Rev Immunol 19:683-765. 2001
  2. ncbi Stat3-dependent induction of p19INK4D by IL-10 contributes to inhibition of macrophage proliferation
    A M O'Farrell
    Department of Molecular Biology, DNAX Research Institute, Palo Alto, CA 94304, USA
    J Immunol 164:4607-15. 2000
  3. pmc IL-10 inhibits macrophage activation and proliferation by distinct signaling mechanisms: evidence for Stat3-dependent and -independent pathways
    A M O'Farrell
    Department of Molecular Biology, DNAX Research Institute, Palo Alto, CA 94304 1104, USA
    EMBO J 17:1006-18. 1998
  4. ncbi IL-18 receptors, their role in ligand binding and function: anti-IL-1RAcPL antibody, a potent antagonist of IL-18
    R Debets
    DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA 94304 1104, USA
    J Immunol 165:4950-6. 2000
  5. ncbi Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12
    B Oppmann
    DNAX Research Institute, Palo Alto, CA 94304, USA
    Immunity 13:715-25. 2000
  6. pmc Functional regions of the mouse interleukin-10 receptor cytoplasmic domain
    A S Ho
    Department of Molecular Biology, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, California 94304, USA
    Mol Cell Biol 15:5043-53. 1995
  7. ncbi Structure of the mouse IL-10 gene and chromosomal localization of the mouse and human genes
    J M Kim
    Department of Immunology, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA 94304
    J Immunol 148:3618-23. 1992
  8. ncbi Stat3 recruitment by two distinct ligand-induced, tyrosine-phosphorylated docking sites in the interleukin-10 receptor intracellular domain
    R M Weber-Nordt
    Center for Immunology, Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 271:27954-61. 1996
  9. ncbi Expression of interleukin-10 activity by Epstein-Barr virus protein BCRF1
    D H Hsu
    Department of Immunology, DNAX Research Institute, Palo Alto, CA 94304
    Science 250:830-2. 1990
  10. pmc Isolation and expression of human cytokine synthesis inhibitory factor cDNA clones: homology to Epstein-Barr virus open reading frame BCRFI
    P Vieira
    Department of Immunology, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA 94304
    Proc Natl Acad Sci U S A 88:1172-6. 1991

Collaborators

  • R A Kastelein
  • A L Mui
  • Y Liu
  • J Wang
  • Y Xu
  • M Liu
  • R Debets
  • K Yamada
  • A Miyajima
  • S Sharma
  • Jianming Xu
  • JAMES DARNELL
  • E Lees
  • ROBERT DAVID SCHREIBER
  • M G Roncarolo
  • A M O'Farrell
  • L Crepaldi
  • S Zurawski
  • B Oppmann
  • A S Ho
  • A Hagenbaugh
  • J F Bazan
  • R de Waal Malefyt
  • R M Weber-Nordt
  • S H Wei
  • S Gasperini
  • C Pinardi
  • F Calzetti
  • J A Lapinet
  • R de Waal-Malefyt
  • M A Cassatella
  • F Vega
  • C Hannum
  • F Zonin
  • N Yu
  • K Singh
  • J C Timans
  • D Gorman
  • M F Roussel
  • R Lesley
  • B Blom
  • E Vaisberg
  • T Churakova
  • T Taniyama
  • B Hunte
  • J Wagner
  • J S Abrams
  • F Zindy
  • D A Parry
  • D Rennick
  • H Cheroutre
  • S M Dubinett
  • R Aranda
  • R M Locksley
  • B Tsao
  • S Binder
  • M Kronenberg
  • D J Fowell
  • A C Greenlund
  • J K Riley
  • S Takai
  • E Miyazaki
  • T A Khan
  • T Hirakawa
  • D H Hsu
  • Y Kobayashi
  • R Fukumura
  • J Sato
  • J M Kim
  • P Vieira
  • T R Mosmann
  • M N Dang
  • C I Brannan
  • N G Copeland
  • N A Jenkins
  • D F Fiorentino
  • J E DeVries
  • J De Vries
  • K E Johnson
  • H Spits

Detail Information

Publications17

  1. ncbi Interleukin-10 and the interleukin-10 receptor
    K W Moore
    Department of Molecular Biology, DNAX Research Institute of Molecular and Cellular Biology Inc, Palo Alto, California 94304, USA
    Annu Rev Immunol 19:683-765. 2001
    ..This review highlights findings that have advanced our understanding of IL-10 and its receptor, as well as its in vivo function in health and disease...
  2. ncbi Stat3-dependent induction of p19INK4D by IL-10 contributes to inhibition of macrophage proliferation
    A M O'Farrell
    Department of Molecular Biology, DNAX Research Institute, Palo Alto, CA 94304, USA
    J Immunol 164:4607-15. 2000
    ..These data indicate that Stat3-dependent induction of p19INK4D and Stat3-independent induction of p21CIP1 are important components of the mechanism by which IL-10 blocks proliferation in macrophages...
  3. pmc IL-10 inhibits macrophage activation and proliferation by distinct signaling mechanisms: evidence for Stat3-dependent and -independent pathways
    A M O'Farrell
    Department of Molecular Biology, DNAX Research Institute, Palo Alto, CA 94304 1104, USA
    EMBO J 17:1006-18. 1998
    ..Thus signals mediating both anti-proliferative and macrophage de-activation responses to IL-10 require the two membrane-distal tyrosines of IL-10R, but Stat3 appears to function only in the anti-proliferative response...
  4. ncbi IL-18 receptors, their role in ligand binding and function: anti-IL-1RAcPL antibody, a potent antagonist of IL-18
    R Debets
    DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA 94304 1104, USA
    J Immunol 165:4950-6. 2000
    ....
  5. ncbi Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12
    B Oppmann
    DNAX Research Institute, Palo Alto, CA 94304, USA
    Immunity 13:715-25. 2000
    ..Similar to IL-12, human IL-23 stimulates IFN-gamma production and proliferation in PHA blast T cells, as well as in CD45RO (memory) T cells...
  6. pmc Functional regions of the mouse interleukin-10 receptor cytoplasmic domain
    A S Ho
    Department of Molecular Biology, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, California 94304, USA
    Mol Cell Biol 15:5043-53. 1995
    ..In cells expressing both wild-type and mutant IL-10R, stimulation with IL-10 leads to tyrosine phosphorylation of the kinases JAK1 and TYK2 but not JAK2 or JAK3 under the conditions tested...
  7. ncbi Structure of the mouse IL-10 gene and chromosomal localization of the mouse and human genes
    J M Kim
    Department of Immunology, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA 94304
    J Immunol 148:3618-23. 1992
    ..The mIL-10 gene was mapped to mouse chromosome 1 and the human IL-10 gene was also mapped to human chromosome 1...
  8. ncbi Stat3 recruitment by two distinct ligand-induced, tyrosine-phosphorylated docking sites in the interleukin-10 receptor intracellular domain
    R M Weber-Nordt
    Center for Immunology, Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 271:27954-61. 1996
    ....
  9. ncbi Expression of interleukin-10 activity by Epstein-Barr virus protein BCRF1
    D H Hsu
    Department of Immunology, DNAX Research Institute, Palo Alto, CA 94304
    Science 250:830-2. 1990
    ..Recombinant BCRF1 protein mimics the activity of interleukin-10, suggesting that BCRF1 may have a role in the interaction of the virus with the host's immune system...
  10. pmc Isolation and expression of human cytokine synthesis inhibitory factor cDNA clones: homology to Epstein-Barr virus open reading frame BCRFI
    P Vieira
    Department of Immunology, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA 94304
    Proc Natl Acad Sci U S A 88:1172-6. 1991
    ..Both hIL-10 and mouse IL-10 sustain the viability of a mouse mast cell line in culture, but BCRFI lacks comparable activity in this assay, suggesting that BCRFI may have conserved only a subset of hIL-10 activities...
  11. ncbi Up-regulation of IL-10R1 expression is required to render human neutrophils fully responsive to IL-10
    L Crepaldi
    Department of Pathology, General Pathology Unit, University of Verona, Verona, Italy
    J Immunol 167:2312-22. 2001
    ....
  12. pmc A receptor for interleukin 10 is related to interferon receptors
    A S Ho
    Department of Immunology, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA 94304
    Proc Natl Acad Sci U S A 90:11267-71. 1993
    ..mIL-10R is structurally related to interferon receptors (IFNRs). Since IL-10 inhibits macrophage activation by IFN-gamma, a possible implication of this relationship interaction of IL-10R and IFN-gamma R or their signaling pathways...
  13. pmc Follicular dendritic cells specifically express the long CR2/CD21 isoform
    Y J Liu
    Schering Plough, Laboratory for Immunological Research, Dardilly, France
    J Exp Med 185:165-70. 1997
    ..Thus, CD21L represents the first characterized human FDC-specific molecule, which may confer unique functions of FDCs in germinal center development...
  14. pmc Altered immune responses in interleukin 10 transgenic mice
    A Hagenbaugh
    Molecular Biology Institute, Department of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA
    J Exp Med 185:2101-10. 1997
    ..These mice will be useful in defining differences in inflammatory conditions and cellular immunity mediated by IL-10...
  15. ncbi Expression cloning and characterization of a human IL-10 receptor
    Y Liu
    Department of Immunology, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA 94304
    J Immunol 152:1821-9. 1994
    ..Like mIL-10R, hIL-10R is structurally related to IFNR. Because IL-10 inhibits macrophage activation by IFN-gamma, this relationship suggests possible shared receptor or signal transduction pathway components...
  16. ncbi The human interleukin-10 receptor gene maps to chromosome 11q23.3
    T Taniyama
    Department of Immunology, National Institute of Health, Tokyo, Japan
    Hum Genet 95:99-101. 1995
    ..Here, we have determined the precise location of the human IL-10R gene by the fluorescence in situ hybridization method, and have found that the IL-10R gene maps to chromosome 11q23.3...
  17. ncbi Homology of cytokine synthesis inhibitory factor (IL-10) to the Epstein-Barr virus gene BCRFI
    K W Moore
    Department of Immunology, DNAX Research Institute, Palo Alto, CA 94304
    Science 248:1230-4. 1990
    ....