L L Lanier

Summary

Affiliation: DNAX Research
Country: USA

Publications

  1. ncbi request reprint 2B4-mediated activation of human natural killer cells
    S G Tangye
    Centenary Institute for Cancer Medicine and Cell Biology, Immune Relation Group, University of Sydney, Locked Bag 6, Newtown, NSW 2042, Sydney, Australia
    Mol Immunol 37:493-501. 2000
  2. ncbi request reprint Inhibitory MHC class I receptors on NK cells and T cells
    L L Lanier
    DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA 94304, USA
    Immunol Today 17:86-91. 1996
  3. ncbi request reprint Immunoreceptor DAP12 bearing a tyrosine-based activation motif is involved in activating NK cells
    L L Lanier
    DNAX Research Institute of Molecular and Cellular Biology, Department of Immunobiology, Palo Alto, California 94304, USA
    Nature 391:703-7. 1998
  4. ncbi request reprint Natural killer cell receptors and MHC class I interactions
    L L Lanier
    DNAX Research Institute of Molecular and Cellular Biology, Department of Human Immunology, 901 California Avenue, Palo Alto, CA 94304 1104, USA
    Curr Opin Immunol 9:126-31. 1997
  5. ncbi request reprint Arousal and inhibition of human NK cells
    L L Lanier
    DNAX Research Institute of Molecular and Cellular Biology, Department of Human Immunology, Palo Alto, CA 94304, USA
    Immunol Rev 155:145-54. 1997
  6. ncbi request reprint Association of DAP12 with activating CD94/NKG2C NK cell receptors
    L L Lanier
    DNAX Research Institute of Molecular and Cellular Biology, Immunobiology Department, Palo Alto, California 94304, USA
    Immunity 8:693-701. 1998
  7. ncbi request reprint NK cell receptors
    L L Lanier
    DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, California 94304, USA
    Annu Rev Immunol 16:359-93. 1998
  8. ncbi request reprint CD94 and a novel associated protein (94AP) form a NK cell receptor involved in the recognition of HLA-A, HLA-B, and HLA-C allotypes
    J H Phillips
    Department of Human Immunology, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, California 94304, USA
    Immunity 5:163-72. 1996
  9. ncbi request reprint Ly-49D and Ly-49H associate with mouse DAP12 and form activating receptors
    K M Smith
    DNAX Research Institute, Palo Alto, CA 94304, USA
    J Immunol 161:7-10. 1998
  10. ncbi request reprint Human natural killer cell receptors involved in MHC class I recognition are disulfide-linked heterodimers of CD94 and NKG2 subunits
    S Lazetic
    Department of Human Immunology, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA 94304, USA
    J Immunol 157:4741-5. 1996

Collaborators

Detail Information

Publications69

  1. ncbi request reprint 2B4-mediated activation of human natural killer cells
    S G Tangye
    Centenary Institute for Cancer Medicine and Cell Biology, Immune Relation Group, University of Sydney, Locked Bag 6, Newtown, NSW 2042, Sydney, Australia
    Mol Immunol 37:493-501. 2000
    ..This may contribute to the phenotype and progression of this disease...
  2. ncbi request reprint Inhibitory MHC class I receptors on NK cells and T cells
    L L Lanier
    DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA 94304, USA
    Immunol Today 17:86-91. 1996
    ..Genes encoding the murine and human NK-cell receptors have been cloned, and studies of their structure, function and expression are progressing rapidly, as reviewed here by Lewis Lanier and Joseph Phillips...
  3. ncbi request reprint Immunoreceptor DAP12 bearing a tyrosine-based activation motif is involved in activating NK cells
    L L Lanier
    DNAX Research Institute of Molecular and Cellular Biology, Department of Immunobiology, Palo Alto, California 94304, USA
    Nature 391:703-7. 1998
    ..Phosphorylated DAP12 peptides bind ZAP-70 and Syk protein tyrosine kinases, suggesting that the activation pathway is similar to that of the T- and B-cell antigen receptors...
  4. ncbi request reprint Natural killer cell receptors and MHC class I interactions
    L L Lanier
    DNAX Research Institute of Molecular and Cellular Biology, Department of Human Immunology, 901 California Avenue, Palo Alto, CA 94304 1104, USA
    Curr Opin Immunol 9:126-31. 1997
    ....
  5. ncbi request reprint Arousal and inhibition of human NK cells
    L L Lanier
    DNAX Research Institute of Molecular and Cellular Biology, Department of Human Immunology, Palo Alto, CA 94304, USA
    Immunol Rev 155:145-54. 1997
    ..Here we review the membrane receptors on human NK cells that are known to initiate cell-mediated cytotoxicity and demonstrate regulation of these responses by the killer cell inhibitory (KIR) receptors...
  6. ncbi request reprint Association of DAP12 with activating CD94/NKG2C NK cell receptors
    L L Lanier
    DNAX Research Institute of Molecular and Cellular Biology, Immunobiology Department, Palo Alto, California 94304, USA
    Immunity 8:693-701. 1998
    ..These results provide a molecular basis for the assembly of NK cell receptors for MHC class I involved in cellular activation and inhibition...
  7. ncbi request reprint NK cell receptors
    L L Lanier
    DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, California 94304, USA
    Annu Rev Immunol 16:359-93. 1998
    ..Recent studies suggest these inhibitory NK cell receptors are members of a larger superfamily containing ITIM sequences, the inhibitory receptor superfamily (IRS)...
  8. ncbi request reprint CD94 and a novel associated protein (94AP) form a NK cell receptor involved in the recognition of HLA-A, HLA-B, and HLA-C allotypes
    J H Phillips
    Department of Human Immunology, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, California 94304, USA
    Immunity 5:163-72. 1996
    ..These findings suggest the existence of human inhibitory MHC class I receptors of the immunoglobulin and C-type lectin superfamilies and indicate overlap in ligand specificity...
  9. ncbi request reprint Ly-49D and Ly-49H associate with mouse DAP12 and form activating receptors
    K M Smith
    DNAX Research Institute, Palo Alto, CA 94304, USA
    J Immunol 161:7-10. 1998
    ..Stimulation of transfectants with Abs recognizing either Ly-49D or Ly-49H results in cellular activation, as assessed by induction of tyrosine phosphorylation of multiple cellular substrates...
  10. ncbi request reprint Human natural killer cell receptors involved in MHC class I recognition are disulfide-linked heterodimers of CD94 and NKG2 subunits
    S Lazetic
    Department of Human Immunology, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA 94304, USA
    J Immunol 157:4741-5. 1996
    ..Structural heterogeneity in the NKG2 gene family and the formation of heterodimers with CD94 provides for the creation of a diverse NK cell repertoire...
  11. ncbi request reprint Molecular and functional characterization of mouse signaling lymphocytic activation molecule (SLAM): differential expression and responsiveness in Th1 and Th2 cells
    A G Castro
    Department of Immunobiology, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA 94304, USA
    J Immunol 163:5860-70. 1999
    ..Mouse SLAM also associates with the recently described human SLAM-associated protein. These studies may provide new insights into the regulation of Th1 responses...
  12. ncbi request reprint An activating immunoreceptor complex formed by NKG2D and DAP10
    J Wu
    DNAX Research Institute, 901 California Avenue, Palo Alto, CA 94304, USA
    Science 285:730-2. 1999
    ..Thus, NKG2D-DAP10 receptor complexes may activate NK and T cell responses against MICA-bearing tumors...
  13. ncbi request reprint Cutting edge: human 2B4, an activating NK cell receptor, recruits the protein tyrosine phosphatase SHP-2 and the adaptor signaling protein SAP
    S G Tangye
    Department of Immunobiology, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA, USA
    J Immunol 162:6981-5. 1999
    ..These results suggest that the phenotype of XLP may result from perturbed signaling not only through SLAM, but also other cell surface molecules that utilize SAP as a signaling adaptor protein...
  14. pmc Myeloid DAP12-associating lectin (MDL)-1 is a cell surface receptor involved in the activation of myeloid cells
    A B Bakker
    Department of Immunobiology, DNAX Research Institute of Cellular and Molecular Biology, 901 California Avenue, Palo Alto, CA 94304 1104, USA
    Proc Natl Acad Sci U S A 96:9792-6. 1999
    ..Crosslinking of MDL-1/DAP12 complexes in J774 mouse macrophage cells resulted in calcium mobilization. These findings suggest that signaling via MDL-1/DAP12 complexes may constitute a significant activation pathway in myeloid cells...
  15. ncbi request reprint LAIR-1, a novel inhibitory receptor expressed on human mononuclear leukocytes
    L Meyaard
    Department of Immunobiology, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, California 94304 1104, USA
    Immunity 7:283-90. 1997
    ....
  16. ncbi request reprint Human NKR-P1A. A disulfide-linked homodimer of the C-type lectin superfamily expressed by a subset of NK and T lymphocytes
    L L Lanier
    DNAX Research Institute of Molecular and Cellular Biology, Inc, Department of Human Immunology, Palo Alto, CA 94304 1104
    J Immunol 153:2417-28. 1994
    ..Our findings demonstrate that NKR-P1A is a human homologue of the rodent NKR-P1 genes and suggest that this molecule may be involved in NK cell function...
  17. ncbi request reprint Leukocyte-associated Ig-like receptor-1 functions as an inhibitory receptor on cytotoxic T cells
    L Meyaard
    Department of Immunobiology, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA 94304, USA
    J Immunol 162:5800-4. 1999
    ..This indicates that LAIR-1 provides a mechanism of regulation of effector T cells and may play a role in the inhibition of unwanted bystander responses mediated by Ag-specific T cells...
  18. ncbi request reprint Negative regulation of human T cell activation by the receptor-type protein tyrosine phosphatase CD148
    S G Tangye
    Immunobiology Department, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA 94304, USA
    J Immunol 161:3803-7. 1998
    ..Taken together, these results suggest that CD148 is an important phosphatase involved in negatively regulating the proximal signaling events during activation of Ag-specific T cells...
  19. ncbi request reprint DNAM-1, a novel adhesion molecule involved in the cytolytic function of T lymphocytes
    A Shibuya
    DNAX Research Institute of Molecular and Cellular Biology, Department of Human Immunology, Palo Alto, California 94304 1104, USA
    Immunity 4:573-81. 1996
    ..In addition, DNAM-1 is a tyrosine-phosphorylated signal-transducing molecule that participates in primary adhesion during cytotoxic T lymphocyte (CTL)-mediated cytotoxicity...
  20. pmc NKB1: a natural killer cell receptor involved in the recognition of polymorphic HLA-B molecules
    V Litwin
    Department of Human Immunology, DNAX Research Institute of Molecular and Cellular Biology, Inc, Palo Alto, California 94304
    J Exp Med 180:537-43. 1994
    ..These findings demonstrate the existence of NK cell receptors involved in the recognition of HLA-B and imply the presence of multiple receptors for MHC on an individual NK clone...
  21. ncbi request reprint Expression of cytoplasmic CD3 epsilon proteins in activated human adult natural killer (NK) cells and CD3 gamma, delta, epsilon complexes in fetal NK cells. Implications for the relationship of NK and T lymphocytes
    L L Lanier
    DNAX Research Institute for Molecular and Cellular Biology, Palo Alto, CA 94304
    J Immunol 149:1876-80. 1992
    ..These results indicate that expression of CD3 gamma delta epsilon subunits is not restricted to T lymphocytes and supports the possibility that NK and T cells may be derived from common origins...
  22. ncbi request reprint Molecular cloning of NKB1. A natural killer cell receptor for HLA-B allotypes
    A D'ANDREA
    Department of Human Immunology, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA 94304, USA
    J Immunol 155:2306-10. 1995
    ....
  23. ncbi request reprint HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C
    V M Braud
    Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK
    Nature 391:795-9. 1998
    ....
  24. ncbi request reprint Molecular characterization of human CD94: a type II membrane glycoprotein related to the C-type lectin superfamily
    C Chang
    Department of Human Immunology, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA 94304 1104, USA
    Eur J Immunol 25:2433-7. 1995
    ..An unexpected feature of CD94 is the essential absence of a cytoplasmic domain, implying that association with other receptors may be necessary for the function of this molecule...
  25. pmc DAP10 and DAP12 form distinct, but functionally cooperative, receptor complexes in natural killer cells
    J Wu
    Department of Microbiology and Immunology and the Cancer Research Institute, University of California at San Francisco, San Francisco, California 94143, USA
    J Exp Med 192:1059-68. 2000
    ....
  26. ncbi request reprint The NKB1 and HP-3E4 NK cells receptors are structurally distinct glycoproteins and independently recognize polymorphic HLA-B and HLA-C molecules
    L L Lanier
    Department of Human Immunology, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA 94304
    J Immunol 154:3320-7. 1995
    ..These studies demonstrate that a single NK cell clone may possess multiple structurally distinct receptors for different polymorphic HLA class I molecules that function independently...
  27. ncbi request reprint CD148: a receptor-type protein tyrosine phosphatase involved in the regulation of human T cell activation
    S G Tangye
    Immunobiology Department, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA 94304, USA
    J Immunol 161:3249-55. 1998
    ..CD148-induced proliferation was significantly greater for CD8+ T cells than for CD4+ T cells. Thus, CD148 is a receptor-type protein tyrosine phosphatase involved in the activation of T lymphocytes...
  28. pmc Distinct cytokine profiles of neonatal natural killer T cells after expansion with subsets of dendritic cells
    N Kadowaki
    Department of Immunobiology, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, California 94304, USA
    J Exp Med 193:1221-6. 2001
    ..Thus, newly generated NKT cells may possess the potent ability to develop into IL-4(+)IFN-gamma(-) NKT2 cells in response to appropriate stimuli and may thereafter acquire the tendency to produce both IL-4 and IFN-gamma...
  29. ncbi request reprint Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA
    S Bauer
    Fred Hutchinson Cancer Research Center, Clinical Research Division, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Science 285:727-9. 1999
    ..These results define an activating immunoreceptor-MHC ligand interaction that may promote antitumor NK and T cell responses...
  30. ncbi request reprint CD80 (B7) and CD86 (B70) provide similar costimulatory signals for T cell proliferation, cytokine production, and generation of CTL
    L L Lanier
    Department of Human Immunology, DNAX Research Institute of Molecular and Cellular Biology, Inc, Palo Alto, CA 94304
    J Immunol 154:97-105. 1995
    ..Therefore, the role of CD80 and CD86 in an immune response may be determined primarily by their differential expression on APC...
  31. ncbi request reprint DAP12-deficient mice fail to develop autoimmunity due to impaired antigen priming
    A B Bakker
    Department of Microbiology and Immunology and Cancer Research Institute, University of California, San Francisco 94143, USA
    Immunity 13:345-53. 2000
    ..These data suggest that DAP12 signaling may be required for optimal antigen-presenting cell (APC) function or inflammation...
  32. pmc Tetrameric complexes of human histocompatibility leukocyte antigen (HLA)-G bind to peripheral blood myelomonocytic cells
    D S Allan
    Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, United Kingdom
    J Exp Med 189:1149-56. 1999
    ..These results suggest that the primary role of HLA-G may be the modulation of myelomonocytic cell behavior in pregnancy...
  33. ncbi request reprint Ligands for natural killer cell receptors: redundancy or specificity
    A Cerwenka
    Department of Microbiology and Immunology and the Cancer Research Institute, University of California, San Francisco, 94143-0414, USA
    Immunol Rev 181:158-69. 2001
    ..A better understanding about how targets signal their distress, which renders them susceptible to natural killer (NK)-cell attack, will help to define the role of NK cells in antimicrobial and antitumor immunity and transplantation...
  34. ncbi request reprint Functionally and structurally distinct NK cell receptor repertoires in the peripheral blood of two human donors
    N M Valiante
    Department of Structural Biology, Stanford University School of Medicine, California 94305, USA
    Immunity 7:739-51. 1997
    ..Because of these differences, the first donor has subpopulations of NK cells that kill cells of the second donor, whereas the NK cells of the second donor are universally tolerant of cells from the first donor...
  35. ncbi request reprint Rapid evolution of NK cell receptor systems demonstrated by comparison of chimpanzees and humans
    S I Khakoo
    Department of Structural Biology, Stanford University, California 94305, USA
    Immunity 12:687-98. 2000
    ..These results demonstrate the rapid evolution of NK cell receptor systems and imply that "catching up" with class I is not the only force driving this evolution...
  36. ncbi request reprint CD94/NKG2 is the predominant inhibitory receptor involved in recognition of HLA-G by decidual and peripheral blood NK cells
    K Soderstrom
    Department of Immunobiology, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA 94304, USA
    J Immunol 159:1072-5. 1997
    ..In contrast, mAbs against the killer cell inhibitory receptors recognizing HLA-Cw3-related, HLA-Cw4-related, or HLA-Bw4 ligands did not affect NK cell killing of the HLA-G transfectants...
  37. ncbi request reprint Loss-of-function mutations in TYROBP (DAP12) result in a presenile dementia with bone cysts
    J Paloneva
    Department of Human Molecular Genetics, National Public Health Institute, Helsinki, Finland
    Nat Genet 25:357-61. 2000
    ..No abnormalities in NK cell function were detected in PLOSL patients homozygous for a null allele of TYROBP...
  38. ncbi request reprint Biphasic response of NK cells expressing both activating and inhibitory killer Ig-like receptors
    H S Warren
    Cancer Research Unit, The Canberra Hospital, Canberra, ACT 2606, Australia
    Int Immunol 13:1043-52. 2001
    ..These results demonstrate that the activating KIR2DS2 can function on cells co-expressing the inhibitory KIR2DL2 and/or KIR2DL3, indicating the potential for independent function of activating KIR with natural ligand...
  39. ncbi request reprint Physical and functional association of LFA-1 with DNAM-1 adhesion molecule
    K Shibuya
    Department of Immunology, Institute of Basic Medical Sciences, Center for TARA, University of Tsukuba, Japan
    Immunity 11:615-23. 1999
    ..In addition, cross-linking of LFA-1 induces tyrosine phosphorylation of DNAM-1, for which the Fyn protein tyrosine kinase is responsible. These results indicate that DNAM-1 is involved in the LFA-1-mediated intracellular signals...
  40. ncbi request reprint The repertoire of killer cell Ig-like receptor and CD94:NKG2A receptors in T cells: clones sharing identical alpha beta TCR rearrangement express highly diverse killer cell Ig-like receptor patterns
    M Uhrberg
    Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Immunol 166:3923-32. 2001
    ..Remarkably, among 55 T cell clones sharing the same TCR alpha beta rearrangement 18 different KIR phenotypes were seen, suggesting that KIR expression was initiated subsequently to TCR rearrangement...
  41. ncbi request reprint Molecular cloning, gene structure, and expression pattern of pig immunoreceptor DAP12
    D Yim
    Department of Microbiology and Immunology, Finch University of Health Sciences The Chicago Medical School, North Chicago, IL 60064, USA
    Immunogenetics 51:436-42. 2000
    ..In Northern blot analysis, DAP12 transcripts were detected in spleen, liver, thymus, and lymph node. DAP12 transcripts are expressed not only in PBLs, but also in granulocytes, macrophages, and monocytes...
  42. ncbi request reprint Cutting edge: the mouse NK cell-associated antigen recognized by DX5 monoclonal antibody is CD49b (alpha 2 integrin, very late antigen-2)
    H Arase
    Department of Microbiology and Immunology and Cancer Research Institute, University of California, San Francisco, CA 94143, USA
    J Immunol 167:1141-4. 2001
    ..Cytotoxicity mediated by the DX5(+) NK cells was dramatically higher as compared with DX5(-) NK cells. Therefore, DX5 mAb recognizes CD49b and can be used to define functionally distinct subsets of NK cells...
  43. ncbi request reprint The human natural killer gene complex is located on chromosome 12p12-p13
    M Renedo
    Unidad de Biologia Molecular, Hospital de la Princesa, Universidad Autonoma de Madrid, C Diego de Leon 62, Madrid 28006, Spain
    Immunogenetics 46:307-11. 1997
    ..6 cM interval flanked by the genetic markers D12S397 and D12S89. The physical distance spanned by the NK gene complex in humans ranges between 0.7 and 2.4 megabases...
  44. pmc Ontogeny of human natural killer (NK) cells: fetal NK cells mediate cytolytic function and express cytoplasmic CD3 epsilon,delta proteins
    J H Phillips
    DNAX Research Institute for Molecular and Cellular Biology, Palo Alto, California 94304
    J Exp Med 175:1055-66. 1992
    ....
  45. pmc Modulation of natural killer cell cytotoxicity in human cytomegalovirus infection: the role of endogenous class I major histocompatibility complex and a viral class I homolog
    C C Leong
    Department of Immunobiology, DNAX Institute of Molecular and Cell Biology, Palo Alto, California 94304, USA
    J Exp Med 187:1681-7. 1998
    ....
  46. ncbi request reprint Human diversity in killer cell inhibitory receptor genes
    M Uhrberg
    Department of Structural Biology, Stanford University School of Medicine, California 94305, USA
    Immunity 7:753-63. 1997
    ..Group B comprises more noninhibitory KIR genes and contains at least one additional gene not represented in group A. The KIR locus therefore appears to be polygenic and polymorphic within the human population...
  47. ncbi request reprint Transgenic expression of Ly-49A in thymocytes alters repertoire selection
    M Pauza
    Department of Immunology IMM 25, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 164:884-92. 2000
    ..Since Ly-49A may shift the signaling threshold of TCR-induced triggering, inducible expression of Ly-49A may regulate peripheral memory/activated T cells by raising the threshold for T cell reactivation...
  48. ncbi request reprint Molecular competition for NKG2D: H60 and RAE1 compete unequally for NKG2D with dominance of H60
    C A O'Callaghan
    Division of Biology 156 29, California Institute of Technology, Pasadena, CA 91125, USA
    Immunity 15:201-11. 2001
    ..The distinct thermodynamic profiles provide insights into the different molecular mechanisms of the binding interactions...
  49. pmc Ectopic expression of retinoic acid early inducible-1 gene (RAE-1) permits natural killer cell-mediated rejection of a MHC class I-bearing tumor in vivo
    A Cerwenka
    Department of Microbiology and Immunology and the Cancer Research Institute, University of California, San Francisco, CA 94143-0414, USA
    Proc Natl Acad Sci U S A 98:11521-6. 2001
    ..Therefore, NK cells are able to reject a tumor expressing RAE-1 molecules, despite expression of self MHC class I on the tumor, demonstrating the potential for NK cells to participate in immunity against class I-bearing malignancies...
  50. ncbi request reprint Interactions of human NKG2D with its ligands MICA, MICB, and homologs of the mouse RAE-1 protein family
    A Steinle
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle WA 98109, USA
    Immunogenetics 53:279-87. 2001
    ..Varying affinities of MICA alleles for NKG2D may affect thresholds of NK-cell triggering and T-cell modulation...
  51. ncbi request reprint NK cell recognition of mouse cytomegalovirus-infected cells
    S M Vidal
    McGill Center for Host Resistance, and Department of Microbiology and Immunology, McGill University, 3775 University St, Montreal Quebec, H3A 2B4, Canada
    Curr Top Microbiol Immunol 298:183-206. 2006
    ..While reviewing these attack-counterattack measures, this chapter points to the central role that recognition of the MCMV-infected cells by NK cells plays in host resistance to infection...
  52. ncbi request reprint Cloning and characterization of a novel mouse myeloid DAP12-associated receptor family
    M R Daws
    Department of Immunology, VA Medical Center San Francisco, San Francisco, USA
    Eur J Immunol 31:783-91. 2001
    ..Our studies define TREM-2 as a receptor family in mouse macrophages and demonstrate the capacity of these receptors to activate macrophage function through DAP12...
  53. ncbi request reprint Retinoic acid early inducible genes define a ligand family for the activating NKG2D receptor in mice
    A Cerwenka
    Department of Microbiology and Immunology and the Cancer Research Institute, University of California, San Francisco 94143, USA
    Immunity 12:721-7. 2000
    ..These studies identify a family of ligands for the activating NKG2D receptor on NK and T cells, which may play an important role in innate and adaptive immunity...
  54. ncbi request reprint Membrane anchoring of a human IgG Fc receptor (CD16) determined by a single amino acid
    L L Lanier
    Becton Dickinson Monoclonal Center, Inc, Mountain View, CA 94043
    Science 246:1611-3. 1989
    ..Conversion of Phe to Ser in CD16-II permits expression of a PI-glycan-anchored glycoprotein, whereas conversion of Ser to Phe in CD16-I prevents PI-glycan linkage...
  55. ncbi request reprint Natural killer cell cytolytic activity is inhibited by NKG2-A and activated by NKG2-C
    J P Houchins
    Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis 55455, USA
    J Immunol 158:3603-9. 1997
    ..These data indicate that NKG2-A and NKG2-C deliver, respectively, inhibitory and activating transmembrane signals in NK cells...
  56. ncbi request reprint Sequential involvement of Lck and SHP-1 with MHC-recognizing receptors on NK cells inhibits FcR-initiated tyrosine kinase activation
    B A Binstadt
    Department of Immunology, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Immunity 5:629-38. 1996
    ..These results suggest sequential roles for Lck and SHP-1 in the inhibition of PTK following MHC recognition by NK cells...
  57. ncbi request reprint B70 antigen is a second ligand for CTLA-4 and CD28
    M Azuma
    Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan
    Nature 366:76-9. 1993
    ..These findings indicate that B70 is a second ligand for CD28 and CTLA-4 and may play an important role for costimulation of T cells in a primary immune response...
  58. ncbi request reprint Fc alpha/mu receptor mediates endocytosis of IgM-coated microbes
    A Shibuya
    Department of Immunology, Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki, Japan
    Nat Immunol 1:441-6. 2000
    ..Fc alpha/microR also mediated primary B lymphocyte endocytosis of IgM-coated Staphylococcus aureus. Thus, Fc alpha/microR is involved in the primary stages of the immune response to microbes...
  59. ncbi request reprint NKG2D ligands: unconventional MHC class I-like molecules exploited by viruses and cancer
    A Cerwenka
    German Cancer Center DKFZ 0080 IM Neuenheimerfeld D 69120 Heidelberg 280 Germany
    Tissue Antigens 61:335-43. 2003
    ..Moreover, we describe how viruses and cancer have developed strategies to evade this recognition pathway...
  60. ncbi request reprint Molecular and functional analysis of human natural killer cell-associated neural cell adhesion molecule (N-CAM/CD56)
    L L Lanier
    Becton Dickinson Immunocytometry Systems, San Jose, CA 95131
    J Immunol 146:4421-6. 1991
    ..Collectively, these studies indicate that homophilic N-CAM interactions probably do not mediate a major role in the cytolytic interaction between NK cells and N-CAM+ tumor cell targets...
  61. ncbi request reprint Molecular cloning and characterization of pig immunoreceptor DAP10 and NKG2D
    D Yim
    Department of Microbiology and Immunology, Finch University of Health Sciences, The Chicago Medical School, IL 60064, USA
    Immunogenetics 53:243-9. 2001
    ..RT-PCR analysis reveals that pig NKG2D transcripts are expressed in PBLs, NK cells, macrophages, and monocytes. When transiently transfected into COS-7 cells, pig NKG2D requires DAP10 for cell surface expression...
  62. pmc Identification of a common T/natural killer cell progenitor in human fetal thymus
    M J Sanchez
    Department of Human Immunology, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, California 94304
    J Exp Med 180:569-76. 1994
    ..These results represent the first definitive evidence of a common T/NK cell progenitor in the human fetal thymus and delineate the point in thymocyte differentiation where T and NK cells diverge...
  63. ncbi request reprint The Ets-1 transcription factor is required for the development of natural killer cells in mice
    K Barton
    Department of Medicine, The University of Chicago, Illinois 60637, USA
    Immunity 9:555-63. 1998
    ..Thus, Ets-1 defines a novel transcriptional pathway that is required for the development of the NK cell lineage in mice...
  64. pmc The epithelial cellular adhesion molecule (Ep-CAM) is a ligand for the leukocyte-associated immunoglobulin-like receptor (LAIR)
    L Meyaard
    Department of Immunology, University Medical Center, 3584 CX Utrecht, Netherlands
    J Exp Med 194:107-12. 2001
    ..We propose that LAIR-1--Ep-CAM interaction may contribute to mucosal tolerance and that LAIR-2 possibly modulates this function...
  65. ncbi request reprint Natural killer cells, viruses and cancer
    A Cerwenka
    Department of Microbiology and Immunology and the Cancer Research Institute, University of California, San Francisco, 94143-0414, USA
    Nat Rev Immunol 1:41-9. 2001
    ..Here, we review the emerging evidence that natural killer cells have an important role in vivo in immune defence...
  66. ncbi request reprint NKG2D
    L L Lanier
    Department of Microbiology and Immunology, Cancer Research Institute, University of California San Francisco, 94143 0414, USA
    J Biol Regul Homeost Agents 17:338-40. 2003
  67. ncbi request reprint Lym 7.3: new murine specificity defining third allele of the Ly 7 locus
    L L Lanier
    Hybridoma 2:177-85. 1983
    ..Three distinct phenotypes were presented: (1) Lym 7.2+ Lym 7.3+; (2) Lym 7.2+ Lym 7.3-; and (3) Lym 7.2- Lym 7.3-. Genetic studies suggested both specificities were encoded by a single locus...
  68. ncbi request reprint Identification and sequence of a fourth human T cell antigen receptor chain
    E Y Loh
    Department of Medical Microbiology, Stanford University School of Medicine, California 94305
    Nature 330:569-72. 1987
    ....
  69. ncbi request reprint Polymerase chain reaction with single-sided specificity: analysis of T cell receptor delta chain
    E Y Loh
    Departments of Medicine and Microbiology and Immunology, Stanford University School of Medicine, CA 94305 5402
    Science 243:217-20. 1989
    ..Most of these cells had a V delta gene segment not previously described (V delta 3), and the delta chain junctional sequences formed a discrete subpopulation compared with those previously reported...